AU2012301605A1 - Thioether-,ether-, and alkylamine-linked hydrogen bond surrogate pertidomimentics - Google Patents

Thioether-,ether-, and alkylamine-linked hydrogen bond surrogate pertidomimentics Download PDF

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Publication number
AU2012301605A1
AU2012301605A1 AU2012301605A AU2012301605A AU2012301605A1 AU 2012301605 A1 AU2012301605 A1 AU 2012301605A1 AU 2012301605 A AU2012301605 A AU 2012301605A AU 2012301605 A AU2012301605 A AU 2012301605A AU 2012301605 A1 AU2012301605 A1 AU 2012301605A1
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AU
Australia
Prior art keywords
formula
alkyl
aryl
compound
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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AU2012301605A
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English (en)
Inventor
Paramjit Arora
Andrew Mahon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York University
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New York University
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Filing date
Publication date
Application filed by New York University filed Critical New York University
Publication of AU2012301605A1 publication Critical patent/AU2012301605A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
AU2012301605A 2011-08-31 2012-08-31 Thioether-,ether-, and alkylamine-linked hydrogen bond surrogate pertidomimentics Abandoned AU2012301605A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161529414P 2011-08-31 2011-08-31
US61/529,414 2011-08-31
PCT/US2012/053538 WO2013033645A1 (en) 2011-08-31 2012-08-31 Thioether-,ether-, and alkylamine-linked hydrogen bond surrogate pertidomimentics

Publications (1)

Publication Number Publication Date
AU2012301605A1 true AU2012301605A1 (en) 2014-04-17

Family

ID=47756932

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012301605A Abandoned AU2012301605A1 (en) 2011-08-31 2012-08-31 Thioether-,ether-, and alkylamine-linked hydrogen bond surrogate pertidomimentics

Country Status (6)

Country Link
US (1) US20130123196A1 (cg-RX-API-DMAC7.html)
EP (1) EP3041491A1 (cg-RX-API-DMAC7.html)
CN (1) CN103889437A (cg-RX-API-DMAC7.html)
AU (1) AU2012301605A1 (cg-RX-API-DMAC7.html)
IN (1) IN2014CN02398A (cg-RX-API-DMAC7.html)
WO (1) WO2013033645A1 (cg-RX-API-DMAC7.html)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2686827C (en) 2006-12-14 2014-09-16 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
CN109627287A (zh) 2007-02-23 2019-04-16 爱勒让治疗公司 三唑大环系统
EP2508531B1 (en) 2007-03-28 2016-10-19 President and Fellows of Harvard College Stitched polypeptides
US8524653B2 (en) 2008-09-22 2013-09-03 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2010060112A1 (en) 2008-11-24 2010-05-27 Aileron Therapeutics, Inc. Peptidomimetic macrocycles with improved properties
EP2376100B1 (en) 2009-01-14 2017-10-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
JP2015504048A (ja) 2011-12-21 2015-02-05 ニューヨーク・ユニバーシティ タンパク質分解抵抗性水素結合サロゲートヘリックス
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
WO2014113792A1 (en) * 2013-01-19 2014-07-24 New York University Hydrogen-bond surrogate peptides and peptidomimetics for p53 reactivation
EP3041492A4 (en) * 2013-09-03 2017-08-02 New York University INHIBITING INTERACTION BETWEEN HIF-1alfa AND P300/CBP WITH HYDROGEN BOND SURROGATE-BASED HELICES
JP2018503595A (ja) 2014-09-24 2018-02-08 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその製剤
BR112017005598A2 (pt) 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
AU2016347456B2 (en) 2015-10-27 2018-12-13 F. Hoffmann-La Roche Ag Peptide macrocycles against acinetobacter baumannii
EP3388444A1 (en) 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Anti-bacterial peptide macrocycles and use thereof
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1483290E (pt) * 2002-01-17 2008-09-19 Takeda Pharmaceutical Peptídeos e peptidomiméticos possuindo actividade antiproliferativa e/ou que aumentam os agentes ou tratamentos de danificação dos ácidos nucleicos
AU2002342618C1 (en) * 2002-08-20 2008-10-30 Polyphor Ltd. Template-fixed peptidomimetics with antibacterial activity
WO2005118620A2 (en) * 2004-05-27 2005-12-15 New York University Methods for preparing internally constraied peptides and peptidomimetics
US8524653B2 (en) * 2008-09-22 2013-09-03 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2010060112A1 (en) * 2008-11-24 2010-05-27 Aileron Therapeutics, Inc. Peptidomimetic macrocycles with improved properties
JP2015504048A (ja) * 2011-12-21 2015-02-05 ニューヨーク・ユニバーシティ タンパク質分解抵抗性水素結合サロゲートヘリックス
EP2817023A4 (en) * 2012-02-22 2015-11-25 Univ New York REVERSIBLE NETWORKED SCREW-MOUNTED HYDROGEN BONDING SUPPLY MACROCYCLES
EP3041492A4 (en) * 2013-09-03 2017-08-02 New York University INHIBITING INTERACTION BETWEEN HIF-1alfa AND P300/CBP WITH HYDROGEN BOND SURROGATE-BASED HELICES

Also Published As

Publication number Publication date
US20130123196A1 (en) 2013-05-16
WO2013033645A1 (en) 2013-03-07
IN2014CN02398A (cg-RX-API-DMAC7.html) 2015-06-19
EP3041491A1 (en) 2016-07-13
CN103889437A (zh) 2014-06-25

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Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period