CN103889427A - 1h-喹唑啉-2,4-二酮用于预防或治疗光敏性癫痫的应用 - Google Patents

1h-喹唑啉-2,4-二酮用于预防或治疗光敏性癫痫的应用 Download PDF

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Publication number
CN103889427A
CN103889427A CN201180073318.7A CN201180073318A CN103889427A CN 103889427 A CN103889427 A CN 103889427A CN 201180073318 A CN201180073318 A CN 201180073318A CN 103889427 A CN103889427 A CN 103889427A
Authority
CN
China
Prior art keywords
dihydro
dioxo
quinazolin
methanesulfonamide
trifluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201180073318.7A
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English (en)
Chinese (zh)
Inventor
K·库彻
D·约翰斯
G·因贝特
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Novartis AG
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Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN103889427A publication Critical patent/CN103889427A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201180073318.7A 2011-09-07 2011-09-07 1h-喹唑啉-2,4-二酮用于预防或治疗光敏性癫痫的应用 Pending CN103889427A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2011/050687 WO2013036224A1 (en) 2011-09-07 2011-09-07 Use of 1h-quinazoline- 2, 4 -diones for use in the prevention or treatment photosensitive epilepsy

Publications (1)

Publication Number Publication Date
CN103889427A true CN103889427A (zh) 2014-06-25

Family

ID=44652020

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180073318.7A Pending CN103889427A (zh) 2011-09-07 2011-09-07 1h-喹唑啉-2,4-二酮用于预防或治疗光敏性癫痫的应用

Country Status (10)

Country Link
EP (1) EP2753331A1 (enExample)
JP (1) JP2014525474A (enExample)
KR (1) KR20140071405A (enExample)
CN (1) CN103889427A (enExample)
AU (1) AU2011376333A1 (enExample)
BR (1) BR112014005210A2 (enExample)
CA (1) CA2846503A1 (enExample)
IN (1) IN2014DN01791A (enExample)
MX (1) MX2014002693A (enExample)
WO (1) WO2013036224A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201609719A (zh) * 2014-05-28 2016-03-16 美國禮來大藥廠 作為ＴＡＲＰ－γ８依賴性ＡＭＰＡ受體拮抗劑之６－經取代－３Ｈ－１，３－苯并噻唑－２－酮化合物
JP6902033B2 (ja) 2015-12-30 2021-07-14 アダマス ファーマシューティカルズ， インコーポレイテッド 発作−関連障害の処置のための方法および組成物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0128996D0 (en) 2001-12-04 2002-01-23 Novartis Ag Organic compounds
SE0201943D0 (sv) 2002-06-20 2002-06-20 Astrazeneca Ab New use
EP1677790A1 (en) 2003-10-31 2006-07-12 AstraZeneca AB Alkynes ii
EP1677789A1 (en) 2003-10-31 2006-07-12 AstraZeneca AB Alkynes i
EP1677788A1 (en) 2003-10-31 2006-07-12 AstraZeneca AB Alkynes iii
CN1933838A (zh) 2004-02-12 2007-03-21 默克公司 作为代谢型谷氨酸受体－5调节剂的联吡啶酰胺
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
GB0508319D0 (en) 2005-04-25 2005-06-01 Novartis Ag Organic compounds
US20090005363A1 (en) 2005-12-20 2009-01-01 Ralf Glatthar Organic Compounds
BR112012010201A2 (pt) * 2009-11-03 2017-08-08 Lupin Ltd formulação de libertação modificada da lacosamida

Also Published As

Publication number Publication date
JP2014525474A (ja) 2014-09-29
BR112014005210A2 (pt) 2017-03-21
WO2013036224A1 (en) 2013-03-14
EP2753331A1 (en) 2014-07-16
AU2011376333A1 (en) 2014-03-13
IN2014DN01791A (enExample) 2015-05-15
MX2014002693A (es) 2014-06-04
KR20140071405A (ko) 2014-06-11
CA2846503A1 (en) 2013-03-14

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Application publication date: 20140625