CA2846503A1 - Use of 1h-quinazoline-2,4-diones for use in the prevention or treatment of photosensitive epilepsy - Google Patents
Use of 1h-quinazoline-2,4-diones for use in the prevention or treatment of photosensitive epilepsy Download PDFInfo
- Publication number
- CA2846503A1 CA2846503A1 CA2846503A CA2846503A CA2846503A1 CA 2846503 A1 CA2846503 A1 CA 2846503A1 CA 2846503 A CA2846503 A CA 2846503A CA 2846503 A CA2846503 A CA 2846503A CA 2846503 A1 CA2846503 A1 CA 2846503A1
- Authority
- CA
- Canada
- Prior art keywords
- dihydro
- quinazolin
- dioxo
- methanesulfonamide
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 201000003040 photosensitive epilepsy Diseases 0.000 title claims abstract description 118
- 201000005070 reflex epilepsy Diseases 0.000 title claims abstract description 69
- 238000011282 treatment Methods 0.000 title claims abstract description 65
- 230000002265 prevention Effects 0.000 title claims abstract description 24
- SDQJTWBNWQABLE-UHFFFAOYSA-N 1h-quinazoline-2,4-dione Chemical class C1=CC=C2C(=O)NC(=O)NC2=C1 SDQJTWBNWQABLE-UHFFFAOYSA-N 0.000 title description 31
- 150000001875 compounds Chemical class 0.000 claims description 135
- 229940002612 prodrug Drugs 0.000 claims description 43
- 239000000651 prodrug Substances 0.000 claims description 43
- 150000003839 salts Chemical class 0.000 claims description 36
- 239000001961 anticonvulsive agent Substances 0.000 claims description 34
- 239000000203 mixture Substances 0.000 claims description 24
- 239000003814 drug Substances 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 16
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 14
- 238000009472 formulation Methods 0.000 claims description 11
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 125000001424 substituent group Chemical group 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
- 230000002829 reductive effect Effects 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 3
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2011/050687 WO2013036224A1 (en) | 2011-09-07 | 2011-09-07 | Use of 1h-quinazoline- 2, 4 -diones for use in the prevention or treatment photosensitive epilepsy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2846503A1 true CA2846503A1 (en) | 2013-03-14 |
Family
ID=44652020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2846503A Abandoned CA2846503A1 (en) | 2011-09-07 | 2011-09-07 | Use of 1h-quinazoline-2,4-diones for use in the prevention or treatment of photosensitive epilepsy |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP2753331A1 (enExample) |
| JP (1) | JP2014525474A (enExample) |
| KR (1) | KR20140071405A (enExample) |
| CN (1) | CN103889427A (enExample) |
| AU (1) | AU2011376333A1 (enExample) |
| BR (1) | BR112014005210A2 (enExample) |
| CA (1) | CA2846503A1 (enExample) |
| IN (1) | IN2014DN01791A (enExample) |
| MX (1) | MX2014002693A (enExample) |
| WO (1) | WO2013036224A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201609719A (zh) * | 2014-05-28 | 2016-03-16 | 美國禮來大藥廠 | 作為ＴＡＲＰ－γ８依賴性ＡＭＰＡ受體拮抗劑之６－經取代－３Ｈ－１，３－苯并噻唑－２－酮化合物 |
| EP3397253A1 (en) | 2015-12-30 | 2018-11-07 | Adamas Pharmaceuticals, Inc. | Methods and compositions for the treatment of seizure-related disorders |
Family Cites Families (10)
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| GB0128996D0 (en) | 2001-12-04 | 2002-01-23 | Novartis Ag | Organic compounds |
| SE0201943D0 (sv) | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | New use |
| WO2005044266A1 (en) | 2003-10-31 | 2005-05-19 | Astrazeneca Ab | Alkynes i |
| JP2007509935A (ja) | 2003-10-31 | 2007-04-19 | アストラゼネカ アクチボラグ | アルキンズｉｉ |
| WO2005044265A1 (en) | 2003-10-31 | 2005-05-19 | Astrazeneca Ab | Alkynes iii |
| EP1715867A4 (en) | 2004-02-12 | 2009-04-15 | Merck & Co Inc | BIPYRIDYLAMIDE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 |
| GB0507298D0 (en) | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
| GB0508319D0 (en) | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
| BRPI0620066A2 (pt) | 2005-12-20 | 2011-11-01 | Novartis Ag | derivados de ácido nicotìnico como moduladores do receptor de glutamato metabotrópico, processo para preparação dos mesmos, composição farmacêutica e uso dos referidos derivados |
| ES2753141T3 (es) * | 2009-11-03 | 2020-04-07 | Lupin Ltd | Formulación de liberación modificada de lacosamida |
-
2011
- 2011-09-07 CA CA2846503A patent/CA2846503A1/en not_active Abandoned
- 2011-09-07 WO PCT/US2011/050687 patent/WO2013036224A1/en not_active Ceased
- 2011-09-07 MX MX2014002693A patent/MX2014002693A/es not_active Application Discontinuation
- 2011-09-07 BR BR112014005210A patent/BR112014005210A2/pt not_active IP Right Cessation
- 2011-09-07 AU AU2011376333A patent/AU2011376333A1/en not_active Abandoned
- 2011-09-07 IN IN1791DEN2014 patent/IN2014DN01791A/en unknown
- 2011-09-07 EP EP11757513.4A patent/EP2753331A1/en not_active Withdrawn
- 2011-09-07 CN CN201180073318.7A patent/CN103889427A/zh active Pending
- 2011-09-07 KR KR1020147008752A patent/KR20140071405A/ko not_active Withdrawn
- 2011-09-07 JP JP2014529647A patent/JP2014525474A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014525474A (ja) | 2014-09-29 |
| WO2013036224A1 (en) | 2013-03-14 |
| IN2014DN01791A (enExample) | 2015-05-15 |
| CN103889427A (zh) | 2014-06-25 |
| MX2014002693A (es) | 2014-06-04 |
| AU2011376333A1 (en) | 2014-03-13 |
| KR20140071405A (ko) | 2014-06-11 |
| BR112014005210A2 (pt) | 2017-03-21 |
| EP2753331A1 (en) | 2014-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20160908 |