CN103877541B - A kind of umbilicus for the treatment of chronic bronchitis, bronchial asthma and allergic rhinitis treats medicine - Google Patents
A kind of umbilicus for the treatment of chronic bronchitis, bronchial asthma and allergic rhinitis treats medicine Download PDFInfo
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Abstract
The present invention relates to a kind of umbilicus for the treatment of chronic bronchitis, bronchial asthma and allergic rhinitis and treat medicine and preparation method thereof, this medicine is made primarily of crude drug such as Rhizoma Zingiberis, Herba Asari, Radix Polygalae, the Radix Angelicae Dahuricae, Semen Sinapis Albae (parched), Radix Ginseng, the Radix Astragali, Poria, Herba Menthaes; Through extracting volatile oil, mix, soak, decoct, purify, the final obtained product of operation such as dry; Medicine of the present invention is that powder can be used for the direct administration of umbilical part, clinical practice is convenient, be easy to carry, cost is lower, there is tonifying the lung spleen invigorating, antiasthmatic-antitussive, clear the nasal passage, only to roar the eliminating evil effect of lung qi dispersing, lowering the adverse-rising QI to resolve phlegm, correction, effectively can improve the clinical symptoms such as the cough of chronic bronchitis, bronchial asthma and Allergic Rhinitis, expectoration, uncomfortable in chest, dyspnea, nasal obstruction, many tears, headache, giddy, clinical therapeutic efficacy is remarkable, curative effect is lasting, through clinicaling curative effect contrast observation, total effective rate can reach more than 90%.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of umbilicus for the treatment of chronic bronchitis, bronchial asthma and allergic rhinitis and treat medicine.
Background technology
Along with the change of people living condition and living environment, the sickness rate of chronic bronchitis, bronchial asthma and allergic rhinitis presents and increases trend year by year.Chronic bronchitis is a kind of chronic nonspecific inflammation betiding trachea-bronchial epithelial cell mucosa and surrounding tissue thereof, in clinical with cough, expectoration or with recurrent exerbation such as asthma for cardinal symptom, the state of an illness is slow Progressive symmetric erythrokeratodermia progress, it is not yet completely clear at present that it forms the cause of disease, and thinking that primary disease is formed according to domestic and international investigation and research is the long-term synergistic result of many factors; Bronchial asthma is a kind of by the various kinds of cell particularly chronic airway inflammation that participates in of mastocyte, eosinophilic granulocyte and T lymphocyte, in susceptible person, this kind of inflammation can cause panting of recurrent exerbation, the symptoms such as tachypnea, uncomfortable in chest and (or) cough, how to occur at night and (or) morning, the pathogenesis of current bronchitis asthma still imperfectly understands, and mainly comprises the interaction of the factor such as allergy, chronic airway inflammation.Allergic rhinitis, also known as allergic rhinitis, is the allergic disease of nasal membrane.There is certain contact in three kinds of diseases, chronic bronchitis recurrent exerbation can bring out asthma in pathogenic process, and the two merges and occurs often being referred to as asthmatic bronchitis.In clinical, most of asthmatic patient belongs to allergic constitution, itself may with allergic rhinitis and/atopic dermatitis, or to the allergen (acarid, pollen, house pet, mycete etc.) of common air-borne transmission, some food (nut, milk, Semen arachidis hypogaeae, seafood etc.) and drug allergy etc.Three kinds of disease courses are all longer, touching, clinically not easily thoroughly cure, and have a strong impact on people's quality of life.
At present, for chronic bronchitis patient, doctor trained in Western medicine primary treatment regimen is etiological treatment and symptomatic treatment, and these two kinds of Therapeutic Method all can improve and alleviate patient clinical symptom, but fundamentally can not remove the root causing primary disease; Though short-period clinical more easily obtains patient satisfaction, often easier recurrent exerbation, the course of disease is longer; For asthma, the most widely used treatment means of doctor trained in Western medicine is Drug therapy, therapeutic purposes mainly suppress airway inflammation, reduce airway hyperreactivity, to reach control symptom, prevention of asthma shows effect, and maintains normal lung function, ensure normal activity, make the diurnal variation rate of expiration peak velocity (PEF) lower than 20% as far as possible; Therefore western medicine fundamentally can not remove the cause of disease of primary disease, only can improve patient clinical symptom to a certain extent, and need apply Western medicine drug for a long time, medical expense is higher.For Allergic Rhinitis, the most frequently used in western medical treatment means is Claritin, its treatment principle is similar to above two kinds of diseases, also can not fundamentally eradicate disease, only clinical symptoms can be improved, and this class of prolonged application Claritin easily causes toxic and side effects in various degree to patient.
Chronic bronchitis belongs to Chinese medicine " the syndrome of dyspnea " category, Chinese medicine think primary disease dialectical when focusing on lung, spleen, kidney three are dirty, the spleen by lung and kidney represents that the state of an illness increases the weight of gradually.The lung being the dominator of QI, for storing the device of expectorant, lung loses and controls joint, and during this disease being located in the lung, symptom is based on cough; The spleen being the source of producing phlegm, in spleen symptom to cough up phlegm; The kidney being the root of QI, gives birth to expectorant originally, in kidney symptom based on asthma.Lung is not hindered and is not coughed, and spleen does not hinder not chronic cough, and kidney does not hinder not dyspnea with rapid and short breath.Therefore primary disease is marked on lung, built in spleen, this is controlled when tonifying the lung spleen invigorating, antiasthmatic-antitussive at kidney.Bronchial asthma belongs to Chinese medicine " bronchial wheezing " category; it is retained phlegm volt lung that Chinese medicine thinks that primary disease forms main cause; the inducement such as exopathogen invasion and attack whenever, improper diet, emotional stimulation, body asthenia are tired and triggering; phlegm rising following QI, obstruction of QI due to retention of phlegm, mutually fight knot, be jammed air flue, lung pipe is narrow, unobstructed unfavorable; lung qi is declared and falls malfunction; priming stops the expectorant amassed, and causes rale as shouted, breath dyspnea with rapid and short breath.Therefore control when only heavy breathing relieving asthma, lowering the adverse-rising QI to resolve phlegm, correction be eliminating evil; Allergic rhinitis belongs to Chinese medicine " allergic rhinitis " category, and main reason is insufficiency of lung-QI, instability of surface, and the heresy of wind and cold is taken advantage of a weak point, violate and nose key, pathogen conflicting with vital QI, lung qi must not lead to tune, body fluid stops gathering, and nose key is jammed, and then causes sneeze, snivel, and insufficiency of the spleen, temper defeatedly can not be distributed in lung, also can cause insufficiency of lung-QI, and the root of lung qi is at kidney, suffers from a deficiency of the kidney, take the photograph to receive and have no right, gas does not return unit, invades within ailment said due to cold or exposure obtains.Therefore allergic rhinitis pathological changes is at lung, but its pathological change and spleen, kidney have certain relation.The normal simulataneous insufficiency and excessive of clinical manifestation, also answers clear the nasal passage, strengthening vital QI to eliminate pathogenic factors during treatment, helps with tonifying the lung gas, Gu Wei table simultaneously.
In the clinical report of Chinese patent drugs for treatment chronic bronchitis, bronchial asthma and allergic rhinitis, all show that the course for the treatment of is shorter, quick result, curative effect are safe and reliable, and have the effect for the treatment of both the principal and the secondary aspects of a disease at the same time.But mostly be decoction during existing Chinese patent drugs for treatment and square medicine constituent is comparatively complicated, therefore patient is not too convenient during Clinical practice, and decoct often cause because decocting method is improper drug effect reduce, although powder, the granular preparation of clinical middle use are taken more for convenience, but clinical efficacy is lower, the object for the treatment of both the principal and the secondary aspects of a disease at the same time cannot be played.
Summary of the invention
For many weak points that existing said medicine and Therapeutic Method exist, inventor provides a kind of umbilicus for the treatment of chronic bronchitis, bronchial asthma and allergic rhinitis and treats medicine and preparation method thereof, and this medicine is made primarily of crude drug such as Rhizoma Zingiberis, Herba Asari, Radix Polygalae, the Radix Angelicae Dahuricae, Semen Sinapis Albae (parched), Radix Ginseng, the Radix Astragali, Poria, Herba Menthaes.Through extracting volatile oil, mix, soak, decoct, purify, the final obtained product of operation such as dry.Medicine of the present invention is that powder can be directly used in umbilical region administration, clinical practice is convenient, be easy to carry, cost is lower, there is tonifying the lung spleen invigorating, antiasthmatic-antitussive, clear the nasal passage, only to roar the eliminating evil effect of lung qi dispersing, lowering the adverse-rising QI to resolve phlegm, correction, effectively can improve the clinical symptoms such as the cough of chronic bronchitis, bronchial asthma and Allergic Rhinitis, expectoration, uncomfortable in chest, dyspnea, nasal obstruction, many tears, headache, giddy, clinical therapeutic efficacy is remarkable, curative effect is lasting, through clinicaling curative effect contrast observation, total effective rate can reach more than 90%.
Concrete technical scheme of the present invention is: a kind of umbilicus for the treatment of chronic bronchitis, bronchial asthma and allergic rhinitis treats medicine, is made up: Rhizoma Zingiberis 2-4 part, Herba Asari 0.5-2 part, Radix Polygalae 4-6 part, Radix Angelicae Dahuricae 2-4 part, Semen Sinapis Albae (parched) 2-4 part, Radix Ginseng 2-4 part, Radix Astragali 4-6 part, Poria 2-4 part, Radix Saposhnikoviae 2-4 part, Rhizoma Atractylodis Macrocephalae (parched) 2-4 part, Herba Epimedii 2-4 part, Herba Ardisiae Japonicae 4-6 part, Flos Caryophylli 1-3 part, Herba Menthae 1-3 part of the crude drug of following portions by weight.
Above-mentioned medicine is commercially available Chinese herbal medicine medicine.
Radix Astragali sweet in the mouth in medicine of the present invention, slightly warm in nature, has air making-up and spleen enlivening, a merit that ascending up spleen-Qi and Yang, benefit defend consolidating superficial resistance; Herba Ardisiae Japonicae has another name called Herba Ardisiae Japonicae, acrid in the mouth, micro-hardship, and property is put down, and have preventing phlegm from forming and stopping coughing, dampness removing, the merit of invigorating blood circulation, two medicines share as monarch, can replenishing and restoring lung-QI, the merit of enhancing body defence; Rhizoma Zingiberis acrid in the mouth, hot in nature, there is warming spleen and stomach for dispelling cold, recuperating depleted YANG promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention merit; Herba Asari acrid in the mouth, hot in nature, the effect of energy warming the lung to resolve fluid-retention, understand things pain-stopping, the cold expelling that induces sweat; Radix Angelicae Dahuricae acrid in the mouth, warm in nature, there is the merit of the cold expelling that induces sweat, clearing the nasal passage, detumescence and apocenosis; Semen Sinapis Albae (parched) acrid in the mouth, warm in nature, there is the merit of warming the lung to resolve fluid-retention, promoting the circulation of QI eliminating stagnation, removing obstruction in the collateral to relieve pain; Radix Saposhnikoviae acrid in the mouth, sweet, slightly warm in nature, has the merit of expelling pathogenic wind from the body surface, removing dampness to relieve pain; Rhizoma Atractylodis Macrocephalae sweet in the mouth, hardship, warm in nature, the effect of energy replenishing QI to invigorate the spleen, dampness diuretic, hidroschesis; Herba Epimedii acrid in the mouth, sweet, warm in nature, there is the merit of expelling wind and removing dampness; All medicines share as minister, can replenishing and restoring lung-QI, enhancing body body constitution, strengthen the merit that lung defends, and strengthen the effect resisting exopathogen; Flos Caryophylli acrid in the mouth, warm in nature, there is the effect of dispersing cold for relieving pain, warming middle-JIAO to send down the adverse QI; Radix Polygalae bitter in the mouth, pungent, warm in nature, having eliminates the phlegm calms the nerves, the merit of dissipation carbuncle; Radix Ginseng sweet in the mouth, micro-hardship, slightly warm in nature, has the merit of invigorating the spleen to benefit the lung, promoting the production of body fluid and inducing sedation of the mind; Poria sweet in the mouth, light, property is put down, and have the merit of promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, all medicines share as adjuvant drug, can play effect of spleen invigorating lung benefiting; Herba Menthae acrid in the mouth, cool in nature, there is the merit of the sharp clearly head, sore-throat relieving rash, for making medicine, with the heat of coordinating the actions of various ingredients in a prescription, preventing all medicine property of medicine too warm.
Modern pharmacology research shows, the Radix Astragali can play the effect of two-ways regulation body's immunity, has facilitation to humoral immune function, can improve hypersensitive state in allergic disease patient body, by the immunity of enhancing body, reaches anti-allergic effects; Abstract in Herba Ardisiae Japonicae has obvious antitussive action, and its decoct has obvious phlegm-dispelling functions to mouse stomach, and the effective ingredient eliminated the phlegm is flavonoid glycoside, and it can also reduce the effect of rat trachea-lung tissue oxygen consumption simultaneously; The water extract of Rhizoma Zingiberis all has obvious antiinflammatory action, and ether extract has the effect of anti-hypoxia, can extend normobaric hypoxia situation; Herba Asari has anti inflammatory immunity, local anesthesia, raising metabolism, antibacterial clinical effect, and its component contained has the relexation of highly significant to the tracheal smooth muscle that histamine or acetylcholine cause convulsion, therefore has the function improving respiratory system; Radix Polygalae has phlegm-dispelling functions, and be that saponin is to the stimulation of gastric mucosa contained by it, reflexive promotes caused by the increase of bronchial secretion liquid; The Radix Angelicae Dahuricae can improve microcirculation in human body, promotes skin metabolism, has and improve microcirculation, antipyretic, analgesia and the effect of antiinflammatory; Semen Sinapis Albae water logging agent has antifungic action, and Semen Sinapis Albae volatile oil has pungent acid and stimulation, and its glycoside hydrolysate stimulates gastric mucosa simultaneously, and reflexive causes bronchial secretion to increase, and makes sputum thinning and plays phlegm-dispelling functions; Radix Ginseng and extract thereof, can improve the ability of animal anoxia enduring significantly, keto consumpting speed be slowed down, prolonged survival period, and can make atrium contraction time prolongation under anoxic conditions; Main component in Poria is pachyman, and content is very high, has inhibitory action to various bacteria, can reduce gastric acid, therefore has significant preventive effect for digestive tract ulcer, and has certain sedation; Radix Saposhnikoviae has dual regulation, can diaphoresis, again can hidroschesis, can antidiarrheal, again can relieving constipation, can stop blooding, can stimulate the menstrual flow again, therefore clinical middle application is comparatively extensive; The Rhizoma Atractylodis Macrocephalae has obvious and lasting diuresis, and the Rhizoma Atractylodis Macrocephalae can also improve lymhocyte transformation rate and natural Flos Rosae Rugosae formation rate, promotes cellular immune function, and obviously can increase IgG, so have the effect of strengthening the spleen and stomach, strengthening body and raising resistance against diseases; Herba Epimedii can significantly improve the phagocytic function of macrophage, its total flavones included can make the antibody of " yang deficiency " body be formed, to be conducive to the recovery of body cell function and antibody titer further, and significantly can promote " yang deficiency " body lymphocyte stimulation indices, make it close to normal; Flos Caryophylli can alleviate abdominal bloating, increases gastric secretion, and strengthen digestion power, alleviate nausea and vomiting, water decoction has inhibitory action to staphylococcus, streptococcus, escherichia coli, Bacillus typhi, bacillus pyocyaneus etc.; Herba Menthae contains menthol, this material can fresh breath have the multiple property of medicine, stomachache, gallbladder spasm can be alleviated, also there is antisepsis and sterilization, diuresis, reduce phlegm, stomach invigorating and the effect such as aid digestion, often contain menthol in the various ointment being used for the treatment of headache and myalgia.
Above-mentioned all medicines share by the present invention, give full play to the drug effect of various component, and be finally made into umbilicus medicine and can be used for the direct administration of umbilical part, more be conducive to the abundant absorption of medicine, act on also more remarkable, and onset time is fast, clinical practice is convenient, be easy to carry, cost is lower, there is tonifying the lung spleen invigorating, antiasthmatic-antitussive, clear the nasal passage, only to roar lung qi dispersing, lowering the adverse-rising QI to resolve phlegm, effect that correction is eliminating evil, effectively can improve chronic bronchitis, the cough of bronchial asthma and Allergic Rhinitis, expectoration, breast is vexed, dyspnea, nasal obstruction, many tears, headache, the clinical symptoms such as giddy, therapeutic effect is remarkable, curative effect is lasting, through clinicaling curative effect contrast observation, total effective rate can reach more than 90%.
Its component proportion is optimized by further inventor, finds that its optimum proportioning is as follows: count by weight: Rhizoma Zingiberis 3 parts, Herba Asari 1 part, Radix Polygalae 5 parts, the Radix Angelicae Dahuricae 3 parts, Semen Sinapis Albae (parched) 3 parts, Radix Ginseng 3 parts, the Radix Astragali 5 parts, 3 parts, Poria, Radix Saposhnikoviae 3 parts, Rhizoma Atractylodis Macrocephalae (parched) 3 parts, Herba Epimedii 3 parts, Herba Ardisiae Japonicae 5 parts, Flos Caryophylli 2 parts, Herba Menthae 2 parts.
The medicine obtained under said ratio, effect is better; It is finally prepared as powder, is beneficial to umbilical region administration.
In addition, the present inventor gives the above-mentioned preparation method being used for the treatment of the medicine of chronic bronchitis, bronchial asthma and allergic rhinitis, and concrete steps comprise:
A. the volatile oil of extraction by steam distillation Flos Caryophylli, Herba Menthae is adopted, by for subsequent use for the medicinal residues extracting the Flos Caryophylli after volatile oil and Herba Menthae;
B. the Rhizoma Zingiberis of prescription amount, Herba Asari, Radix Polygalae, the Radix Angelicae Dahuricae, Semen Sinapis Albae (parched), Radix Ginseng, the Radix Astragali, Poria, Radix Saposhnikoviae, Rhizoma Atractylodis Macrocephalae (parched), Herba Epimedii, Herba Ardisiae Japonicae are mixed, add medicinal residues described in step a and be mixed to get total mixture, then the water of total mixture gross weight 6-8 times amount is added, soak after 0.5 hour and start to decoct, temperature controls at 100-150 DEG C, decocting time 1.5-2 hour, filters after decocting, obtains filtrate and medicinal residues;
C. gross weight 4-6 times of water gaging is added by filtering gained medicinal residues in step b, carry out second time to decoct, temperature controls at 100-150 DEG C, and decocting time is 1-1.5 hour, refilter to obtain filtrate and medicinal residues after decoction, the merging of gained filtrate obtain total filtrate by gained filtrate in this step and step b;
D. obtain thick paste by after total for gained in step c filtrate row concentration, under room temperature, gained thick paste relative density is 1.45-1.50, adds the starch of 4-6 times of weight, make granule after mixing in thick paste, carries out drying, granulate process to it;
E. the volatile oil of obtained Flos Caryophylli and Herba Menthae in granule obtained in steps d and step a is mixed, be developed into powder after being carried out drying, obtain final products.
The volatile oil of extraction by steam distillation Flos Caryophylli, Herba Menthae in wherein said step a, its concrete steps are:
The Flos Caryophylli of prescription amount and Herba Menthae are added respectively 6-8 times of weight water and soak 24h, connect volatile oil determination apparatus respectively, being heated to temperature is 100 DEG C-120 DEG C, and reaction 5h, till the amount of volatile oil no longer increases; Collected volatile oil is independent separated for subsequent use.
Why select the mode of this separately preparation; all be retained in its volatile oil because of the effective ingredient in Flos Caryophylli and Herba Menthae; if fried together with other components, its utilization ratio can reduce greatly; cause the waste of medicine; also can reduce the curative effect of medicine simultaneously; so inventor has selected the first mode of the volatile oil of employing extraction by steam distillation Flos Caryophylli, Herba Menthae; and in the end just the granule that above-mentioned volatile oil and other drug obtain is mixed, avoid the loss of volatile oil in preparation process.
By further test is with preferred, inventor gives following best implementation step:
Wherein said step b is: the Rhizoma Zingiberis of prescription amount, Herba Asari, Radix Polygalae, the Radix Angelicae Dahuricae, Semen Sinapis Albae (parched), Radix Ginseng, the Radix Astragali, Poria, Radix Saposhnikoviae, Rhizoma Atractylodis Macrocephalae (parched), Herba Epimedii, Herba Ardisiae Japonicae are mixed, add medicinal residues described in step a and be mixed to get total mixture, then total mixture gross weight 8 times of water gagings are added, start after total mixture being soaked 0.5 hour to decoct, temperature controls at 150 DEG C, decocting time 2 hours; After decocting, row filtration treatment obtains filtrate and medicinal residues.
Described step c is: after after being filtered by step b, the medicinal residues of gained add gross weight 6 times of water gagings, carry out second time to decoct, temperature controls at 150 DEG C, and decocting time is 1.5 hours, filter to get filtrate after decoction and medicinal residues, final total filtrate that gained filtrate in this step and step b gained filtrate are merged.
Adopt the various Chinese patent medicine raw materials of said ratio, combine the drug effect of each taste Chinese herbal medicine, and reasonably combined more thorough to make various drug effect play to its row, avoid drug effect between each Chinese medicine to offset the generation of situation simultaneously.In conjunction with modern pharmacology effect, medicine of the present invention is carried out to the research of modern pharmacodynamics, so each medicine in the present invention has after reasonably combined strengthen the effect of immunologic function, the effect of antiinflammatory and antibacterial effect.And the cost of the various Chinese patent medicine raw materials chosen is lower, be applicable to large-scale production, convenient more patient clinicals use.
The concrete using method of this medicine is: get powder 15-20g during use at every turn, ointment shape is reconciled into vinegar, full-filling is in patient's umbilical part, in order to reach better effect, Moxa can be carried out with Ai Zhu to it simultaneously, every day 1 time, each Moxa time 30min-45min, the complete rear immobilization with adhesive tape medicine of Moxa takes off in umbilical part 3-4 hour.
In sum, adopt medicine provided by the present invention and preparation method thereof, give full play to the drug effect of its various component, and be finally made into umbilicus medicine and can be used for the direct administration of umbilical part, more be conducive to Absorption more remarkable, and onset time is fast, clinical practice is convenient, be easy to carry, cost is lower, there is tonifying the lung spleen invigorating, antiasthmatic-antitussive, clear the nasal passage, only to roar lung qi dispersing, lowering the adverse-rising QI to resolve phlegm, effect that correction is eliminating evil, effectively can improve chronic bronchitis, the cough of bronchial asthma and Allergic Rhinitis, expectoration, breast is vexed, dyspnea, nasal obstruction, many tears, headache, the clinical symptoms such as giddy, clinical therapeutic efficacy is remarkable, curative effect is lasting, through clinicaling curative effect contrast observation, total effective rate can reach more than 90%.
Detailed description of the invention
Embodiment 1
The umbilicus for the treatment of chronic bronchitis, bronchial asthma and allergic rhinitis treats a medicine, is made up: Rhizoma Zingiberis 120g, Herba Asari 30g, Radix Polygalae 130g, Radix Angelicae Dahuricae 150g, Semen Sinapis Albae (parched) 150g, Radix Ginseng 100g, Radix Astragali 250g, Poria 160g, Radix Saposhnikoviae 140g, Rhizoma Atractylodis Macrocephalae (parched) 160g, Herba Epimedii 150g, Herba Ardisiae Japonicae 180g, Flos Caryophylli 140g, Herba Menthae 80g of the crude drug of following portions by weight.
Its concrete preparation method is:
A. adopt the volatile oil of extraction by steam distillation Flos Caryophylli, Herba Menthae, concrete steps are:
140g Flos Caryophylli is added 6 times of weight water and soak 24h, connect volatile oil determination apparatus, be heated to micro-(temperature is 100 DEG C) 5h that boils, till the amount of volatile oil no longer increases;
80g Herba Menthae is added 7 times of weight water and soak 60min, connect volatile oil determination apparatus, be heated to micro-(temperature is 110 DEG C) 3h that boils, till the amount of volatile oil no longer increases, collect volatile oil respectively also separated separately; The medicinal residues extracting the Flos Caryophylli after volatile oil and Herba Menthae are placed on one side, in order to using again;
B. Chinese medicine Rhizoma Zingiberis 120g, Herba Asari 30g, Radix Polygalae 130g, Radix Angelicae Dahuricae 150g, Semen Sinapis Albae (parched) 150g, Radix Ginseng 100g, Radix Astragali 250g, Poria 160g, Radix Saposhnikoviae 140g, Rhizoma Atractylodis Macrocephalae (parched) 160g, Herba Epimedii 150g, Herba Ardisiae Japonicae 180g are mixed, add medicinal residues described in step a and be mixed to get total mixture, then the water of total mixture gross weight 7 times amount is added, soak after 0.5 hour and start to decoct, temperature controls at 150 DEG C, decocting time 1.5 hours; Filter after decocting, obtain filtrate and medicinal residues;
C. gross weight 4 times of water gagings are added by filtering gained medicinal residues in step b, carry out second time to decoct, temperature controls at 150 DEG C, and decocting time is 1 hour, refilter to obtain filtrate and medicinal residues after decoction, the merging of gained filtrate obtain total filtrate by gained filtrate in this step and step b;
D. obtain thick paste by after total for gained in step c filtrate row concentration, under room temperature, gained thick paste relative density is 1.45, adds the starch of its 5 times of weight, make granule after mixing in thick paste, carries out drying, granulate process to it;
E. the volatile oil of obtained Flos Caryophylli and Herba Menthae in granule obtained in steps d and step a is mixed, be developed into powder after being dried, obtain final products.
Embodiment 2
The umbilicus for the treatment of chronic bronchitis, bronchial asthma and allergic rhinitis treats a medicine, is made up: Rhizoma Zingiberis 100g, Herba Asari 40g, Radix Polygalae 120g, Radix Angelicae Dahuricae 130g, Semen Sinapis Albae (parched) 130g, Radix Ginseng 110g, Radix Astragali 200g, Poria 130g, Radix Saposhnikoviae 120g, Rhizoma Atractylodis Macrocephalae (parched) 130g, Herba Epimedii 110g, Herba Ardisiae Japonicae 160g, Flos Caryophylli 100g, Herba Menthae 90g of the crude drug of following portions by weight.
Its concrete preparation method is:
A. adopt the volatile oil of extraction by steam distillation Flos Caryophylli, Herba Menthae, concrete steps are:
100g Flos Caryophylli is added 5 times of weight water and soak 24h, connect volatile oil determination apparatus, be heated to micro-(temperature is 120 DEG C) 5h that boils, till the amount of volatile oil no longer increases;
90g Herba Menthae is added 6 times of weight water and soak 60min, connect volatile oil determination apparatus, be heated to micro-(temperature is 100 DEG C) 3h that boils, till the amount of volatile oil no longer increases, collect volatile oil respectively also separated separately; The medicinal residues extracting the Flos Caryophylli after volatile oil and Herba Menthae are placed on one side, in order to using again;
B. Chinese medicine Rhizoma Zingiberis 100g, Herba Asari 40g, Radix Polygalae 120g, Radix Angelicae Dahuricae 130g, Semen Sinapis Albae (parched) 130g, Radix Ginseng 110g, Radix Astragali 200g, Poria 130g, Radix Saposhnikoviae 120g, Rhizoma Atractylodis Macrocephalae (parched) 130g, Herba Epimedii 110g, Herba Ardisiae Japonicae 160g are mixed, add medicinal residues described in step a and be mixed to get total mixture, then the water of total mixture gross weight 6 times amount is added, soak after 0.5 hour and start to decoct, temperature controls at 120 DEG C, decocting time 1.5 hours; Filter after decocting, obtain filtrate and medicinal residues;
C. gross weight 5 times of water gagings are added by filtering gained medicinal residues in step b, carry out second time to decoct, temperature controls at 100 DEG C, and decocting time is 1 hour, refilter to obtain filtrate and medicinal residues after decoction, the merging of gained filtrate obtain total filtrate by gained filtrate in this step and step b;
D. obtain thick paste by after total for gained in step c filtrate row concentration, under room temperature, gained thick paste relative density is 1.47, adds the starch of its 5 times of weight, make granule after mixing in thick paste, carries out drying, granulate process to it;
E. the volatile oil of obtained Flos Caryophylli and Herba Menthae in granule obtained in steps d and step a is mixed, be developed into powder after being dried, obtain final products.
Embodiment 3
The umbilicus for the treatment of chronic bronchitis, bronchial asthma and allergic rhinitis treats a medicine, is made up: Rhizoma Zingiberis 120g, Herba Asari 50g, Radix Polygalae 100g, Radix Angelicae Dahuricae 140g, Semen Sinapis Albae (parched) 140g, Radix Ginseng 130g, Radix Astragali 220g, Poria 150g, Radix Saposhnikoviae 150g, Rhizoma Atractylodis Macrocephalae (parched) 170g, Herba Epimedii 160g, Herba Ardisiae Japonicae 180g, Flos Caryophylli 110g, Herba Menthae 80g of the crude drug of following portions by weight.
Its concrete preparation method is:
A. adopt the volatile oil of extraction by steam distillation Flos Caryophylli, Herba Menthae, concrete steps are:
110g Flos Caryophylli is added 4 times of weight water and soak 24h, connect volatile oil determination apparatus, be heated to micro-(temperature is 110 DEG C) 5h that boils, till the amount of volatile oil no longer increases;
80g Herba Menthae is added 5 times of weight water and soak 60min, connect volatile oil determination apparatus, be heated to micro-(temperature is 110 DEG C) 3h that boils, till the amount of volatile oil no longer increases, collect volatile oil respectively also separated separately; The medicinal residues extracting the Flos Caryophylli after volatile oil and Herba Menthae are placed on one side, in order to using again;
B. Chinese medicine Rhizoma Zingiberis 120g, Herba Asari 50g, Radix Polygalae 100g, Radix Angelicae Dahuricae 140g, Semen Sinapis Albae (parched) 140g, Radix Ginseng 130g, Radix Astragali 220g, Poria 150g, Radix Saposhnikoviae 150g, Rhizoma Atractylodis Macrocephalae (parched) 170g, Herba Epimedii 160g, Herba Ardisiae Japonicae 180g are mixed, add medicinal residues described in step a and be mixed to get total mixture, then the water of total mixture gross weight 7 times amount is added, soak after 0.5 hour and start to decoct, temperature controls at 150 DEG C, decocting time 2 hours; Filter after decocting, obtain filtrate and medicinal residues;
C. gained medicinal residues will be filtered in step b add the water of gross weight 5 times, carry out second time to decoct, temperature controls at 150 DEG C, and decocting time is 1 hour, refilter to obtain filtrate and medicinal residues after decoction, the merging of gained filtrate obtain total filtrate by gained filtrate in this step and step b;
D. obtain thick paste by after total for gained in step c filtrate row concentration, under room temperature, gained thick paste relative density is 1.50, adds the starch of its gross weight 6 times, make granule after mixing at thick paste, carries out drying, granulate process to it;
E. the volatile oil of obtained Flos Caryophylli and Herba Menthae in granule obtained in steps d and step a is mixed, be developed into powder after being dried, obtain final products.
Embodiment 4
A kind of umbilicus for the treatment of chronic bronchitis, bronchial asthma and allergic rhinitis treats medicine: be made up of the crude drug of following portions by weight: Rhizoma Zingiberis 160g, Herba Asari 60g, Radix Polygalae 160g, Radix Angelicae Dahuricae 170g, Semen Sinapis Albae (parched) 170g, Radix Ginseng 160g, Radix Astragali 270g, Poria 170g, Radix Saposhnikoviae 170g, Rhizoma Atractylodis Macrocephalae (parched) 200g, Herba Epimedii 210g, Herba Ardisiae Japonicae 220g, Flos Caryophylli 160g, Herba Menthae 130g.
Its concrete preparation method is:
A. adopt the volatile oil of extraction by steam distillation Flos Caryophylli, Herba Menthae, concrete steps are:
160g Flos Caryophylli is added 6 times of weight water and soak 24h, connect volatile oil determination apparatus, be heated to micro-(temperature is 120 DEG C) 5h that boils, till the amount of volatile oil no longer increases;
130g Herba Menthae is added 6 times of weight water and soak 60min, connect volatile oil determination apparatus, be heated to micro-(temperature is 120 DEG C) 3h that boils, till the amount of volatile oil no longer increases, collect volatile oil respectively also separated separately; The medicinal residues extracting the Flos Caryophylli after volatile oil and Herba Menthae are placed on one side, in order to using again;
B. Chinese medicine Rhizoma Zingiberis 160g, Herba Asari 60g, Radix Polygalae 160g, Radix Angelicae Dahuricae 170g, Semen Sinapis Albae (parched) 170g, Radix Ginseng 160g, Radix Astragali 270g, Poria 170g, Radix Saposhnikoviae 170g, Rhizoma Atractylodis Macrocephalae (parched) 200g, Herba Epimedii 210g, Herba Ardisiae Japonicae 220g are mixed, add medicinal residues described in step a and be mixed to get total mixture, then the water of total mixture gross weight 8 times amount is added, soak after 0.5 hour and start to decoct, temperature controls at 150 DEG C, decocting time 2 hours; Filter after decocting, obtain filtrate and medicinal residues;
C. gross weight 6 times of water gagings are added by filtering gained medicinal residues in step b, carry out second time to decoct, temperature controls at 150 DEG C, and decocting time is 1.5 hours, refilter to obtain filtrate and medicinal residues after decoction, the merging of gained filtrate obtain total filtrate by gained filtrate in this step and step b;
D. obtain thick paste by after total for gained in step c filtrate row concentration, under room temperature, gained thick paste relative density is 1.50, adds the starch of 5 times of weight, make granule after mixing in thick paste, carries out drying, granulate process to it;
E. the volatile oil of obtained Flos Caryophylli and Herba Menthae in granule obtained in steps d and step a is mixed, be developed into powder after being dried, obtain final products.
Embodiment 5
A kind of umbilicus for the treatment of chronic bronchitis, bronchial asthma and allergic rhinitis treats medicine: be made up of the crude drug of following portions by weight: Rhizoma Zingiberis 130g, Herba Asari 40g, Radix Polygalae 140g, Radix Angelicae Dahuricae 160g, Semen Sinapis Albae (parched) 160g, Radix Ginseng 110g, Radix Astragali 270g, Poria 170g, Radix Saposhnikoviae 150g, Rhizoma Atractylodis Macrocephalae (parched) 170g, Herba Epimedii 160g, Herba Ardisiae Japonicae 230g, Flos Caryophylli 150g, Herba Menthae 100g.
Its concrete preparation method is:
A. adopt the volatile oil of extraction by steam distillation Flos Caryophylli, Herba Menthae, concrete steps are:
150g Flos Caryophylli is added 5 times of weight water and soak 24h, connect volatile oil determination apparatus, be heated to micro-(temperature is 110 DEG C) 5h that boils, till the amount of volatile oil no longer increases;
100g Herba Menthae is added 5 times of weight water and soak 60min, connect volatile oil determination apparatus, be heated to micro-(temperature is 110 DEG C) 3h that boils, till the amount of volatile oil no longer increases, collect volatile oil respectively also separated separately; The medicinal residues extracting the Flos Caryophylli after volatile oil and Herba Menthae are placed on one side, in order to using again;
B. Chinese medicine Rhizoma Zingiberis 130g, Herba Asari 40g, Radix Polygalae 140g, Radix Angelicae Dahuricae 160g, Semen Sinapis Albae (parched) 160g, Radix Ginseng 110g, Radix Astragali 270g, Poria 170g, Radix Saposhnikoviae 150g, Rhizoma Atractylodis Macrocephalae (parched) 170g, Herba Epimedii 160g, Herba Ardisiae Japonicae 230g are mixed, add medicinal residues described in step a and be mixed to get total mixture, then the water of total mixture gross weight 8 times amount is added, soak after 0.5 hour and start to decoct, temperature controls at 150 DEG C, decocting time 2 hours; Filter after decocting, obtain filtrate and medicinal residues;
C. gross weight 6 times of water gagings are added by filtering gained medicinal residues in step b, row second time decocts, and temperature controls at 150 DEG C, and decocting time is 1.5 hours, refilter to obtain filtrate and medicinal residues after decoction, the merging of gained filtrate obtain total filtrate by gained filtrate in this step and step b;
D. obtain thick paste by after total for gained in step c filtrate row concentration, under room temperature, gained thick paste relative density is 1.46, adds the starch of its 6 times of weight, make granule after mixing in thick paste, carries out drying, granulate process to it;
E. the volatile oil of obtained Flos Caryophylli and Herba Menthae in granule obtained in steps d and step a is mixed, be developed into powder after being dried, obtain final products.
Experimental example
Medicine obtained in above-described embodiment 1-5 and Haizhu Chuanxiding sheet (Xiamen Chinese Medicine Co., Ltd), Qingshi granules (Henan Lingrui Pharmacy Stock Co., Ltd), cocklebur fruit drop-pills for treating rhinitis (Sichuan He Run pharmaceutical Co. Ltd produces) are carried out the efficient test for the treatment of chronic bronchitis, bronchial asthma and allergic rhinitis.For showing the therapeutic effect of medicine of the present invention to chronic bronchitis, bronchial asthma and allergic rhinitis, 300 routine chronic bronchitiss, 180 routine Bronchial Asthmas and 240 routine Allergic Rhinitis are selected to carry out clinical observation on the therapeutic effect altogether, wherein male 410 example, women 310 example, age 21-67 year.Be divided into six groups at random.Wherein five groups is embodiment group, and one group is matched group.Embodiment group application medicine of the present invention, gets appropriate powder 15-20g at every turn, reconciles into ointment shape with vinegar, full-filling in patient's umbilical part, and carries out Moxa with Ai Zhu to it, every day 1 time, each time 30min-45min, the complete rear immobilization with adhesive tape medicine of Moxa is in umbilical part 3-4 hour; Matched group takes Haizhu Chuanxiding sheet (Xiamen Chinese Medicine Co., Ltd), Qingshi granules (Henan Lingrui Pharmacy Stock Co., Ltd) or cocklebur fruit drop-pills for treating rhinitis (production of Sichuan He Run pharmaceutical Co. Ltd), 4 or 1 bag or 14 balls, 2 times on the one.Often group was all a course for the treatment of with 2 weeks.
Chronic bronchitis clinical efficacy standard is as follows:
Effective: cough symptom turns for the better by and large, and pulmonary's wheezing sound disappears; Effective: the cardinal symptom such as expectoration or cough with asthma recovers more than 60% before comparatively treating, and pulmonary's wheezing sound obviously diminishes; Take a turn for the better: the cardinal symptom such as expectoration or cough with asthma takes a turn for the better a little to some extent, symptom recovers more than 30% before comparatively treating, and pulmonary's wheezing sound is without obvious change; Invalid: patient fundamental symptoms is without obviously alleviating or increasing the weight of.Total effective rate=(effective+effectively+take a turn for the better)/total number of persons × 100%.The results are shown in Table 1.
Table 1
Result as can be seen from table 1, the total effective rate of embodiment group is better than matched group, and the umbilicus of visible treatment bronchial asthma provided by the present invention is treated the more existing medicine clinical efficacy of Chinese patent medicine medicine and improved a lot, and total effective rate can reach more than 90%.
Bronchial asthma clinical efficacy standard is as follows:
Clinic control: symptoms of asthma complete incidence graph, has mild episode not need medication to alleviate FEV1(or PEF even if even) recruitment >35%, or FEV1(PEF)≤80% predicted value after treatment.PEF day and night fluctuation rate <20%.Effective: asthma attack obviously alleviates before comparatively treating, FEV1(PEF) recruitment scope 25%-35%, or FEV1(PEF after treatment) reaching the 60%-79% of predicted value, PEF day and night fluctuation rate <20%, still needs with glucocorticoid or bronchodilator.Take a turn for the better (effectively): symptoms of asthma alleviates to some extent, FEV1(or PEF) recruitment 15%-24%, still need with glucocorticoid and (or) bronchodilator.Invalid: clinical symptoms and FEV1(or PEF) measured value is without improvement or increase the weight of on the contrary.Effective percentage=(clinic control+effective+effectively)/total number of persons × 100%.The results are shown in Table 2.
Table 2
Result as can be seen from table 2, the total effective rate of embodiment group is better than matched group, and the umbilicus of visible treatment bronchial asthma provided by the present invention is treated the more existing medicine clinical efficacy of Chinese patent medicine medicine and improved a lot, and total effective rate can reach more than 90%.
Allergic rhinitis evaluation of clinical curative effect is as follows:
According to the efficacy evaluation about " allergic rhinitis " in " Chinese medical disease Standardization of diagnosis and curative effect " be: cure (effective): symptom, sign disappear, more than 3 months without recurrence; Take a turn for the better (effectively): during outbreak, symptom, sign alleviate, attack times reduces; Do not heal (invalid): symptom and sign are not improved.Effective percentage=(effective+effectively)/total number of persons × 100%.The results are shown in Table 3.
Table 3
Result as can be seen from table 3, embodiment group total effective rate is better than matched group, and the more existing medicine curative effect of medicine of visible treatment of allergic rhinitis provided by the present invention improves a lot, and total effective rate can reach more than 90%.
Claims (5)
1. the umbilicus for the treatment of chronic bronchitis, bronchial asthma and allergic rhinitis treats a medicine, it is characterized in that: be made up of the crude drug of following portions by weight: Rhizoma Zingiberis 2-4 part, Herba Asari 0.5-2 part, Radix Polygalae 4-6 part, Radix Angelicae Dahuricae 2-4 part, Semen Sinapis Albae (parched) 2-4 part, Radix Ginseng 2-4 part, Radix Astragali 4-6 part, Poria 2-4 part, Radix Saposhnikoviae 2-4 part, Rhizoma Atractylodis Macrocephalae (parched) 2-4 part, Herba Epimedii 2-4 part, Herba Ardisiae Japonicae 4-6 part, Flos Caryophylli 1-3 part, Herba Menthae 1-3 part.
2. the medicine for the treatment of chronic bronchitis according to claim 1, bronchial asthma and allergic rhinitis, is characterized in that: be made up of the crude drug of following portions by weight: Rhizoma Zingiberis 3 parts, Herba Asari 1 part, Radix Polygalae 5 parts, the Radix Angelicae Dahuricae 3 parts, Semen Sinapis Albae (parched) 3 parts, Radix Ginseng 3 parts, the Radix Astragali 5 parts, 3 parts, Poria, Radix Saposhnikoviae 3 parts, Rhizoma Atractylodis Macrocephalae (parched) 3 parts, Herba Epimedii 3 parts, Herba Ardisiae Japonicae 5 parts, Flos Caryophylli 2 parts, Herba Menthae 2 parts.
3. the medicine for the treatment of chronic bronchitis according to claim 1 and 2, bronchial asthma and allergic rhinitis, is characterized in that: described medicine is powder.
4. the umbilicus for the treatment of chronic bronchitis, bronchial asthma and the allergic rhinitis of preparation described in claim 1 or 2 treats the method for medicine, it is characterized in that: concrete steps comprise:
A. the volatile oil of extraction by steam distillation Flos Caryophylli, Herba Menthae is adopted, by for subsequent use for the medicinal residues extracting the Flos Caryophylli after volatile oil and Herba Menthae;
B. the Rhizoma Zingiberis of prescription amount, Herba Asari, Radix Polygalae, the Radix Angelicae Dahuricae, Semen Sinapis Albae (parched), Radix Ginseng, the Radix Astragali, Poria, Radix Saposhnikoviae, Rhizoma Atractylodis Macrocephalae (parched), Herba Epimedii, Herba Ardisiae Japonicae are mixed, add medicinal residues described in step a and be mixed to get total mixture, then the water of total mixture gross weight 6-8 times amount is added, soak after 0.5 hour and start to decoct, temperature controls at 100-150 DEG C, decocting time 1.5-2 hour, filters after decocting, obtains filtrate and medicinal residues;
C. gross weight 4-6 times of water gaging is added by filtering gained medicinal residues in step b, carry out second time to decoct, temperature controls at 100-150 DEG C, and decocting time is 1-1.5 hour, refilter to obtain filtrate and medicinal residues after decoction, the merging of gained filtrate obtain total filtrate by gained filtrate in this step and step b;
D. obtain thick paste by after total for gained in step c filtrate row concentration, under room temperature, gained thick paste relative density is 1.45-1.50, adds the starch of 4-6 times of weight, make granule after mixing in thick paste, carries out drying, granulate process to it;
E. the volatile oil of obtained Flos Caryophylli and Herba Menthae in granule obtained in steps d and step a is mixed, be developed into powder after being carried out drying, obtain final products.
5. preparation method according to claim 4, is characterized in that: the volatile oil of extraction by steam distillation Flos Caryophylli, Herba Menthae in described step a, and its concrete steps are:
The Flos Caryophylli of prescription amount and Herba Menthae are added respectively 6-8 times of weight water and soak 24h, connect volatile oil determination apparatus respectively, being heated to temperature is 100 DEG C-120 DEG C, maintains 5h, till the amount of volatile oil no longer increases; By independent for collected volatile oil separated for subsequent use.
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|---|---|---|---|---|
| CN1127121A (en) * | 1995-01-20 | 1996-07-24 | 杨贵森 | Xiaozhoutian (small circulation in Qigong) external curing heath care band and use method |
| CN1140087A (en) * | 1996-06-11 | 1997-01-15 | 王来运 | Liquid medicine for treatment of tracheitis and preparing method thereof |
| CN1289614A (en) * | 1999-09-27 | 2001-04-04 | 鲍利 | Multifunctional health-care bag for baby |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1127121A (en) * | 1995-01-20 | 1996-07-24 | 杨贵森 | Xiaozhoutian (small circulation in Qigong) external curing heath care band and use method |
| CN1140087A (en) * | 1996-06-11 | 1997-01-15 | 王来运 | Liquid medicine for treatment of tracheitis and preparing method thereof |
| CN1289614A (en) * | 1999-09-27 | 2001-04-04 | 鲍利 | Multifunctional health-care bag for baby |
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