CN103877301A - Medicine for preparing epilepsy and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine for preparing epilepsy and a preparation method thereof. The medicine comprises following components: calculus bovis, antelope horn, centipede, heepseed, bile arisaema and the like. The preparation method comprises following four steps of preparing mineral medicine powder, preparing Chinese herbal medicine powder, preparing placental powder, and preparing a capsule or tablet. The medicine can be prepared into other conventional oral preparation according to a conventional method, not only has obvious effect in treating epilepsy and is safe and reliable, but also can tone the organs of a human body comprehensively, and has particular effect to heart and brain and emotional diseases, like insomnia, repression, psychoneurosis, dizziness and headache and schizophrenia.

Description

A kind of medicine for the treatment of epileptics and preparation method thereof

Technical field

The invention belongs to traditional Chinese medical science field, be specifically related to a kind of medicine for the treatment of epileptics and preparation method thereof.

Background technology

Epileptics has another name called sheep and hangs wind, is the of short duration brain function imbalance of chronic repeated relapsing syndrome.Cause repeatedly that taking brain neuron paradoxical discharge epilepsy outbreak is as feature.Epilepsy is one of nervous system common disease, and prevalence is only second to apoplexy.The sickness rate of epilepsy is relevant with the age.It is the highest with interior prevalence to it is generally acknowledged 1 years old, is secondly to reduce gradually for 1～10 years old later.China men and women's ratio is 1.15: 1～1.7: 1.In epileptics when morbidity,, fall down to the ground suddenly, unconscious, and gnathospasma turns over tic of the limbs, Kou Tu Bai Droplets on two.General each continuous outbreak 1 to 10 minute, wakes up rear as ordinary person.This disease is a kind of non-commonly encountered diseases.The reason of its morbidity is mainly: 1. craniocerebral trauma 2. hereditary 5. pressure of 3. brain inflammation 4. of having a high fever are excessive etc.The above cause of disease can directly or indirectly cause that patient's cerebral tissue is impaired, further causes patient's brain neuron paradoxical discharge and shows as epileptics outbreak.Epileptics outbreak does not generally directly cause patient's injures and deaths.This onste is too unexpected, where all can show effect whenever, so usually cause that patient dies unexpectedly.Such as traffic accident, drowned, high-altitude pendant is died etc.In recent years, due to the impact of Various Complex sexual factor, clinical onset rate is also on the rise.

The treatment of epileptics can be divided into controls outbreak, etiological treatment, surgical intervention, general health and five aspects of prevention.Wherein the most important thing is to control outbreak and remove the cause of disease.At present general doctor's Therapeutic Method is main mainly with western medical treatment, can select antiepileptic according to epilepsy type clinically, and such as grand mal is selected phenytoin Sodium carbamazepine O'Casey equality, petit mal is selected sodium valproate, ethosuximide, diazepam etc.Once find medicine and the dosage that can control outbreak completely, will apply incessantly.But along with taking the time lengthening of Western medicine, the generation of drug resistance, doctor can only continue to strengthen the dosage of Western medicine or drug combination and could control the outbreak of epileptics, takes the increase of dose and the prolongation of administration time, and the side effect of Western medicine is just more obvious.Observe discovery according to me, phenytoin Sodium 0.3g every day, takes medicine and exceedes 3 years, and gingiva and hair hypertrophy are obvious.Carbamazepine Tablets 0.6g every day, takes medicine and exceedes 4 years, and liver function and hemopoietic system are easily abnormal, and sodium valproate sheet 0.6g every day, takes medicine and exceed 2 years, and gastric duodenal ulcer is obvious.Epilepsy class Western medicine is all to reduce brain paradoxical discharge by reduction brain cell irritability to realize anti-seizure.Suppress neural so have, bradykinesia, drowsiness, hypomnesis, the side effect such as lethargy, so a lot of epileptics bears torment that can't stand side effect, can only stop the treatment of Western medicine.According to the relevent statistics, although drug combination or heavy dose of medication at least also have 18%～27% patient to be difficult to control outbreak at present.For the epileptic of some encephalosis, after its drug withdrawal, relapse rate is higher, needs Long-term taking medicine or takes medicine all the life.Though obtain many progress through western medicine recent decades, but because of cannot be for protopathy because giving treatment to, the medication of can only suiting the medicine to the illness, suppress epilepsy, reduce attack times, but Western medicine can not be controlled the progress of the state of an illness, can only suppress brain paradoxical discharge, cure the symptoms, not the disease, so do not reach the object of radical cure.

Domestic patent database disclosed some relevant treatment epileptics patented technologies in recent years:

For example: patent documentation [application number] CN201210015637.9; open (bulletin) number [CN102526520A]; disclose " a kind of medicine for the treatment of epileptics and preparation method thereof ", this medicine is counted the effective ingredient that contains following raw material by weight: 95～105 parts, Radix Glycyrrhizae, 95～105 parts of the Rhizoma Pinelliaes, 140～160 parts of the Radix Paeoniae Albas, 30～40 parts of Radix Kansuis, 25～35 parts of succinums, 4～6 parts, Cinnabaris, 25～35 parts of Concretio Silicea Bambusaes, 25～35 parts of Calculus Boviss, 25～35 parts of Cornu Saigae Tataricae.Prepare the method for this medicine for taking Radix Glycyrrhizae, the Rhizoma Pinelliae, the Radix Paeoniae Alba, add suitable quantity of water, 30～40 minutes at a simmer, leaching, obtained medicinal liquid; In the medicinal liquid obtaining, add appropriate refined honey again, mix, cooling; The fine powder that adds again Radix Kansui, succinum, Cinnabaris, Concretio Silicea Bambusae, Calculus Bovis and the Cornu Saigae Tataricae of ormal weight, mixes.

For example: patent documentation [application number] CN201010161856.9; open (bulletin) number [CN101816751A]; disclose " medicine for the treatment of epileptics and Gilles de la Tourette's syndrome and preparation method thereof ", it is the medicament of being made up of the raw material of following weight parts proportioning: Rhizoma Gastrodiae 8-12 part, Pericarpium Citri Reticulatae 8-12 part, Bombyx Batryticatus 12-18 part, Poria 8-12 part, Bulbus Fritillariae Uninbracteatae 8-12 part, Radix Polygalae 8-12 part, Scorpio 4.8-7.2 part, Ramulus Uncariae Cum Uncis 12-18 part, Radix Paeoniae Alba 16-24 part, Rhizoma Acori Graminei 12-18 part, vinegar Carapax et Plastrum Testudinis 16-24 part, Arisaema Cum Bile 8-12 part and artificial Calculus Bovis 4-6 part.Its preparation method is that Scorpio, vinegar Carapax et Plastrum Testudinis, Bombyx Batryticatus, artificial Calculus Bovis are ground into fine powder, and Rhizoma Acori Graminei, the medicinal steam distillation of Pericarpium Citri Reticulatae two taste extract volatile oil, and aqueous solution filters, and another device storage is for subsequent use; The medicinal residues water of the seven flavor medicines such as all the other Rhizoma Gastrodiaes and Rhizoma Acori Graminei, Pericarpium Citri Reticulatae decocts twice, and decocting liquid filters, and leaves standstill; filter; filtrate decompression is condensed into thick paste, adds the powder of Scorpio, vinegar Carapax et Plastrum Testudinis, Bombyx Batryticatus, artificial Calculus Bovis's four Chinese medicine, mixes; granulate; dry, cooling, evenly spray into volatile oil; incapsulate, to obtain final product.

From the above, in epileptics treatment with western process, after drug withdrawal, easily have a rebound, relapse rate is higher.Because long-term, high-dose is taken antiepileptic, health is had side effects, there is potential safety hazard, increase financial burden to patient.Above prescription is comprehensive not again, and curative effect is poor.The tcm therapy that finds undoubtedly a more effective treatment epileptics in Chinese medicine has been to have forced in the thing of the eyebrows and eyelashes.

Summary of the invention

The invention provides medicine of a kind of more remarkable treatment effect, treatment epileptics safe and reliable and each organ of across-the-board regulation human body more and preparation method thereof.

For reaching this object, the present invention treats the medicine of epileptics, it is the medicament of making by the raw material of following weight parts proportioning: Calculus Bovis 30-70 part, Cornu Saigae Tataricae 180-220 part, pearl powder 480-520 part, Os Draconis 530-570 part, Concha Ostreae 530-570 part, the pig iron 380-420 part that falls, Pumex 430-470 part, Talcum 480-520 part, Haematitum 380-420 part, Halloysitum Rubrum 380-420 part, Ramulus Uncariae Cum Uncis 630-670 part, Bombyx Batryticatus 260-300 part, Shichuan QuanXing 80-120 part, Scorpio 80-120 part, Endothelium Corneum Gigeriae Galli 280-320 part, Herba Paederiae 480-520 part, Fructus Crataegi 280-320 part, Lignum Dalbergiae Odoriferae 130-170 part, Aloe powder 280-320 part, Fructus Cannabis 280-320 part, Arisaema Cum Bile 80-120 part, Borneolum Syntheticum 10-50 part, Rhizoma Acori Graminei 80-120 part, Radix Polygalae 130-170 part, Ramulus Cinnamomi 130-170 part, Radix Glycyrrhizae 130-170 part.

Preferably of good quality, the weight portion of described each crude drug is: 50 parts of Calculus Boviss, 200 parts of Cornu Saigae Tataricae, 500 parts of pearl powders, 550 parts of Os Draconis, 550 parts of Concha Ostreaes, the pig iron fall 400 parts, 450 parts of Pumexs, 500 parts, Talcum, 400 parts of Haematitums, 400 parts of Halloysitum Rubrums, 650 parts of Ramulus Uncariae Cum Uncis, 280 parts of Bombyx Batryticatus, 100 parts of Shichuan QuanXings, 100 parts of Scorpios, 300 parts of Endothelium Corneum Gigeriae Galli, 500 parts of Herba Paederiaes, 300 parts of Fructus Crataegis, 150 parts of Lignum Dalbergiae Odoriferaes, 300 parts of Aloe powder, 300 parts of Fructus Cannabiss, 100 parts of Arisaema Cum Bile, 30 parts of Borneolum Syntheticums, 100 parts of Rhizoma Acori Graminei, 150 parts of Radix Polygalaes, 150 parts of Ramulus Cinnamomi, 150 parts, Radix Glycyrrhizae.

In described each crude drug, also comprise the Placenta Hominis powder of being made by two Placenta Hominiss.

The invention also discloses a kind of method of preparing the medicine for the treatment of epileptics, comprise the following steps:

One, get the raw materials ready:

1. produce mineral medicated powder: proportioning by weight chooses that Calculus Bovis, Cornu Saigae Tataricae, pearl powder, Os Draconis, Concha Ostreae, the pig iron fall, Pumex, Talcum, Haematitum, Halloysitum Rubrum; remove impurity; then putting together and being broken into fineness is 180-220 object pulverulent mixture, obtains mineral medicated powder.

2. produce Chinese herbal medicine powder: proportioning is by weight chosen Ramulus Uncariae Cum Uncis, Bombyx Batryticatus, Shichuan QuanXing, Scorpio, Endothelium Corneum Gigeriae Galli, Herba Paederiae, Fructus Crataegi, Lignum Dalbergiae Odoriferae, Aloe powder, Fructus Cannabis, Arisaema Cum Bile, Borneolum Syntheticum, Rhizoma Acori Graminei, Radix Polygalae, Ramulus Cinnamomi, Radix Glycyrrhizae, washing is clean, dry, then putting together and being broken into fineness is 180-220 object pulverulent mixture, obtains Chinese herbal medicine powder.

3. produce Placenta Hominis powder: take out two and do not carry the Placenta Hominis of any infectious disease, first cleaned up, then steaming and decocting 10-20 minute, dries, after drying, dry with microwave oven again, being finally broken into fineness is 180-220 object smalls, obtains Placenta Hominis powder.

Two, prepare capsule: mineral medicated powder, Chinese herbal medicine powder medicine, Placenta Hominis powder mix and blend that above-mentioned steps one is obtained, after stirring, pack gelatine capsule into, the weight of every seed lac wafer is 0.25 gram, can be made into the capsule for the treatment of epilepsy medicament.

Described medicine can be prepared into other conventional oral preparations according to conventional method, and such as tablet, its method is mineral medicated powder, Chinese herbal medicine powder medicine, the Placenta Hominis powder mix and blend that above-mentioned steps one is obtained, and after stirring, adds adjuvant, and compacting in flakes.

Medicine of the present invention has following character and effect:

(1) waking up the patient from unconsciousness by dissipating phlegm

Calculus Bovis: selecting Calculus Bovis, is that removing heat in the liver to subdue the wind syndrome, has calmness, anticonvulsant action because cattle sulphur is good at waking up the patient from unconsciousness by dissipating phlegm.Treatment apoplexy, infantile convulsion, the first-selected good medicine of epileptics.

Cornu Saigae Tataricae: select Cornu Saigae Tataricae to be because Cornu Saigae Tataricae suppressing the hyperactive liver to relieve the wind syndrome.It is containing keratoprotein, and calcium phosphate and plurality of inorganic salt are share and strengthened convulsion and sedation together with Calculus Bovis.

(2) feel at ease to allay excitement

Pearl powder, Os Draconis, Concha Ostreae, the pig iron fall, Pumex, Talcum, Haematitum, Halloysitum Rubrum all belong to mineral drug, have the calming effects of feeling at ease very by force.Wherein:

Margarita is not: suppressing the hyperactive liver and subsiding YANG is calmed the nerves.

Os Draconis, Concha Ostreae and Haematitum: it is also fine that liver-yang effect falls in YANG hyperactivity suppressing nourishing YIN, also have the very strong effect of allaying excitement of feeling at ease.

The pig iron falls: pungent, cool, return liver, heart channel.Be good at suppressing the hyperactive liver, can tranquillizing and subduing the manner of impetuousness, have the effect of promoting blood circulation to disperse blood clots and relieves pain, pain is sprained in treatment, can be used for treating demented, easily frightened susceptible to get angry, insomnia, sore swollen toxin, joint aches, sprain the symptoms such as pain.

Pumex: nature and flavor are salty, cold.There is lung heat clearing fire, change effect of old expectorant, relieving stranguria by diuresis, hard masses softening and resolving.Cure mainly that phlegm-heat obstructing in the lung, the thick difficulty of cough with asthma expectorant are coughed up, the puckery pain of dribbling urination, goiter scrofula etc.

Talcum: sweet, light, cold.Return bladder, lung, stomach warp.There is inducing diuresis for treating stranguria syndrome, clearing away summer-heat, effect of damp eliminating sore.For pyretic stranguria, stranguria caused by urinary stone, urinates hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea; External treatment eczema, eczema, miliaria etc.

Halloysitum Rubrum: nature and flavor are sweet, puckery, sour, warm, nontoxic.There is effect of astringing intestine to stop diarrhea, astringing to arrest bleeding, removing dampness sore, granulation promoting.Cure mainly chronic diarrhea, chronic dysentery, have blood in stool, proctoptosis, seminal emission, metrorrhagia, leukorrhagia, ulcer being unable to heal, eczema, traumatic hemorrhage.

Modern medicine shows: mineral drug contains nearly all trace element that needed by human body is wanted.As ferrum magnesium zinc-copper chromium manganese cobalt selenium etc.These trace element are slowly absorbed by human body through for oral administration, produce special ' photoelectric effect ' focusing energy storage.Formation is equivalent to the similar electromagnetism of electronic computer resonator and human body generation resonance, every Human Physiology internal recycle function is turned round more in phase, so epileptic's cerebral neuron paradoxical discharge is liquidated and suppresses.Thereby epileptics attack times is obviously reduced.My teacher's traditional Chinese medical science great master Lu Guangxin once instructed me to say: perhaps " people comes from central spleen soil, finally also returns central spleen soil to go " be exactly this medicinal reason.Chivalrous say all things on earth and the mankind are that central spleen soil comes, and have just needed all substances in spleen soil, and mineral can not make an exception certainly.These mineral drugs, have both supplemented the required trace element of health, strengthen health body constitution, also suppressed the outbreak of epileptics and kill two birds with one stone, thereby treating both the principal and secondary aspects of a disease is difficult for recurrence.

(3) relieving spasm by subduing liver-wind

Shichuan QuanXing: be the another name of Scolopendra, warm in nature, poisonous.There is effect of wind, spasmolytic, removing toxic substances, eliminating stagnation.Can treat apoplexy, infantile convulsion, tic, tetanus, facial paralysis, rheumatalgia, pertussis etc.

Scorpio: be because Scorpio nature and flavor are salty pungent, dry, poisonous, return meridian of Foot-JUE YIN, have dispel the wind, the function of relieving convulsion, dredging collateral, removing toxic substances, cure mainly convulsion with spasms, epilepsy, apoplexy, hemiplegia, facial hemiparalysis, migraine, tetanus etc.

Bombyx Batryticatus, Ramulus Uncariae Cum Uncis: selecting Bombyx Batryticatus, Ramulus Uncariae Cum Uncis is because they have very strong suppressing the hyperactive liver to relieve the wind syndrome and very strong relieving convulsion effect.Wherein Ramulus Uncariae Cum Uncis is containing multiple alkaloids such as Ramulus Uncariae cum Uncis alkali and isorhynchophyllines.Have the effect of only jerking of obvious calmness and spasmolytic, its heat clearing away suppressing the hyperactive liver is effective, and relieving dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion has special effect.Moreover Scorpio and Shichuan QuanXing are that animal is searched wind medicine, it is stronger that it chases after the wind power of surely jerking, and is the cloudy Liver Channel medicine dedicated of fainting, and the power of walking to alter is strong, inside reaches internal organs, and outward to meridians, all QI and blood cohesion parts all can be opened it, then share with Bombyx Batryticatus, Ramulus Uncariae Cum Uncis, the multiplication of relieving spasm by subduing liver-wind effect.

(4) spleen-invigorating stomach-protecting

Endothelium Corneum Gigeriae Galli, Fructus Crataegi: selecting Endothelium Corneum Gigeriae Galli, is that invigorating the spleen and stomach, changes hard Sal Nitri sand, stranguria caused by urinary stone because Endothelium Corneum Gigeriae Galli nature and flavor are sweet flat, and Fructus Crataegi share, not only strengthened appetite but also can the side's of dissolving Minerals medicine deposition.

Herba Paederiae: not only have digestion-promoting spleen-invigorating, and contain Herba Paederiae total alkaloids, have convulsion and sedation.

Lignum Dalbergiae Odoriferae: selecting Lignum Dalbergiae Odoriferae is incense wood class, has the merit of fragrant stomach invigorating, can prevent that mineral drug from injuring gastric qi.

This four Chinese medicine share and not only can prevent that mineral drug from injuring gastric qi, and can also strengthening the spleen and stomach, increases appetite, indirectly strengthens patient's premunition, reduces epileptics seizure frequency.

(5) battalion defends relieving constipation

Ramulus Cinnamomi, Placenta Hominis powder, Aloe powder, Fructus Cannabis: because multiplex mineral drug just can reach and feel at ease to allay excitement above.The medicine of metal and stone, medicine is cool, can not stay for a long time in body.Deliver so select Ramulus Cinnamomi battalion to defend expelling pathogenic factors from muscles, and share Placenta Hominis powder tonify deficiency, the traditional Chinese medical science thinks that Placenta Hominis powder nature and flavor are sweet, salty, warm, enters lung, the heart, kidney channel, has the kidney invigorating and essence nourishing, the merit of benefiting QI and nourishing blood.Modern medicine shows that Placenta Hominis contains various immune proteins, aminoacid, and vitamin, the trace element that mineral and the mankind are necessary etc., can improve human body resistance against diseases.Moreover both share can also and overcome the cold and cool of ore deposit medicine, then we carry out intestine moistening internal organs with Aloe powder and Fructus Cannabis, and the medicine of metal and stone can not be stayed for a long time in body, walk and do not keep.

(6) refreshment

Arisaema Cum Bile, Borneolum Syntheticum, Rhizoma Acori Graminei, Radix Polygalae: because the frequent grand mal of epileptic patient twitches, large cerebral anoxia and injure brain neuron, memory and intelligence decline.So selected have the Arisaema Cum Bile of refreshment effect, Borneolum Syntheticum, Rhizoma Acori Graminei, Radix Polygalae carry out sensible refreshment, memory reinforcing, recovers cerebral nerve function.

(7) mediation effect

Radix Glycyrrhizae: nature and flavor are sweet, flat.Last Herba indigoferae Pseudotinctoriae is selected Radix Glycyrrhizae, has solution poison of drug, coordinating the actions of various ingredients in a prescription effect.For insufficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse, deficiency of spleen-QI and stomach-QI, fatigue and weakness, ulcer sores, laryngopharynx swelling and pain, asthma and cough, stomachache, stomachache and gastrocnemius contraction urgency pain etc., and have the strong effect of separating poison of drug, being in harmonious proportion some drugs, can reduce other medicines stimulates gastrointestinal.

These raw material things are used in combination, between each efficacy of drugs, produce synergism, not only epileptics is had to good efficacy, and each organ of energy across-the-board regulation human body, particularly various heart and brain feelings will diseases are also had to specially good effect, such as insomnia, constrain disease, neurosis, dizzy headache, schizophrenia etc. also have special effect.

Detailed description of the invention

Medicine for the treatment of epileptics of the present invention and preparation method thereof:

Formula one:

Medicine is made up of following raw material medicaments: 50 parts of Calculus Boviss, 200 parts of Cornu Saigae Tataricae, 500 parts of pearl powders, 550 parts of Os Draconis, 550 parts of Concha Ostreaes, the pig iron fall 400 parts, 450 parts of Pumexs, 500 parts, Talcum, 400 parts of Haematitums, 400 parts of Halloysitum Rubrums, 650 parts of Ramulus Uncariae Cum Uncis, 280 parts of Bombyx Batryticatus, 100 parts of Shichuan QuanXings, 100 parts of Scorpios, 300 parts of Endothelium Corneum Gigeriae Galli, 500 parts of Herba Paederiaes, 300 parts of Fructus Crataegis, 150 parts of Lignum Dalbergiae Odoriferaes, 300 parts of Aloe powder, 300 parts of Fructus Cannabiss, 100 parts of Arisaema Cum Bile, 30 parts of Borneolum Syntheticums, 100 parts of Rhizoma Acori Graminei, 150 parts of Radix Polygalaes, 150 parts of Ramulus Cinnamomi, 150 parts, Radix Glycyrrhizae, 2, Placenta Hominis.

The preparation method of this group medicine is:

One, get the raw materials ready:

1. proportioning by weight choose that Calculus Bovis, Cornu Saigae Tataricae, pearl powder, Os Draconis, Concha Ostreae, the pig iron fall, Pumex, Talcum, Haematitum, Halloysitum Rubrum; remove impurity; then putting together and being broken into fineness is 180-220 object pulverulent mixture, obtains mineral medicated powder.

2. proportioning is by weight chosen Ramulus Uncariae Cum Uncis, Bombyx Batryticatus, Shichuan QuanXing, Scorpio, Endothelium Corneum Gigeriae Galli, Herba Paederiae, Fructus Crataegi, Lignum Dalbergiae Odoriferae, Aloe powder, Fructus Cannabis, Arisaema Cum Bile, Borneolum Syntheticum, Rhizoma Acori Graminei, Radix Polygalae, Ramulus Cinnamomi, Radix Glycyrrhizae, washing is clean, dry, then putting together and being broken into fineness is 180-220 object pulverulent mixture, obtains Chinese herbal medicine powder.

3. take out two Placenta Hominiss that do not carry any infectious disease, first cleaned up, then steaming and decocting 10-20 minute, dries, and after drying, dries with microwave oven again, and being finally broken into fineness is 180-220 object smalls, obtains Placenta Hominis powder.

Two, prepare capsule, tablet:

Mineral medicated powder, Chinese herbal medicine powder medicine, Placenta Hominis powder mix and blend that above-mentioned steps one is obtained, pack gelatine capsule into after stirring, and the weight of every seed lac wafer is 0.25 gram, can be made into the capsule for the treatment of epilepsy medicament; Or after stirring, add adjuvant, compacting in flakes.

Further, described medicine can be prepared into other conventional oral preparations according to conventional method.

Formula two:

Medicine is made up of following raw material medicaments: 30 parts of Calculus Boviss, 180 parts of Cornu Saigae Tataricae, 480 parts of pearl powders, 530 parts of Os Draconis, 530 parts of Concha Ostreaes, the pig iron falls 380 parts, 430 parts of Pumexs, 480 parts, Talcum, 380 parts of Haematitums, 380 parts of Halloysitum Rubrums, 630 parts of Ramulus Uncariae Cum Uncis, 260 parts of Bombyx Batryticatus, 80 parts of Shichuan QuanXings, 80 parts of Scorpios, 280 parts of Endothelium Corneum Gigeriae Galli, 480 parts of Herba Paederiaes, 280 parts of Fructus Crataegis, 130 parts of Lignum Dalbergiae Odoriferaes, 280 parts of Aloe powder, 280 parts of Fructus Cannabiss, 80 parts of Arisaema Cum Bile, 10 parts of Borneolum Syntheticums, 80 parts of Rhizoma Acori Graminei, 130 parts of Radix Polygalaes, 130 parts of Ramulus Cinnamomi, 130 parts, Radix Glycyrrhizae, 2, Placenta Hominis.

Formula three:

Medicine is made up of following raw material medicaments: 70 parts of Calculus Boviss, 220 parts of Cornu Saigae Tataricae, 520 parts of pearl powders, 570 parts of Os Draconis, 570 parts of Concha Ostreaes, the pig iron fall 420 parts, 470 parts of Pumexs, 520 parts, Talcum, 420 parts of Haematitums, 420 parts of Halloysitum Rubrums, 670 parts of Ramulus Uncariae Cum Uncis, 300 parts of Bombyx Batryticatus, 120 parts of Shichuan QuanXings, 120 parts of Scorpios, 320 parts of Endothelium Corneum Gigeriae Galli, 520 parts of Herba Paederiaes, 320 parts of Fructus Crataegis, 170 parts of Lignum Dalbergiae Odoriferaes, 320 parts of Aloe powder, 320 parts of Fructus Cannabiss, 120 parts of Arisaema Cum Bile, 50 parts of Borneolum Syntheticums, 120 parts of Rhizoma Acori Graminei, 170 parts of Radix Polygalaes, 170 parts of Ramulus Cinnamomi, 170 parts, Radix Glycyrrhizae, 2, Placenta Hominis.

The preparation method of formula two, three medicines is similar with the preparation method of formula one, just no longer explains.

Further set forth below the beneficial effect of medicine of the present invention by test example, these test examples have comprised animal experiment and the clinical observation on the therapeutic effect test of medicine of the present invention.

One, the animal experiment of medicine

Animal toxicity test:

1. animal is selected: select 40 of healthy new zealand rabbits, and male and female dual-purpose, body weight 2-2.5kg, is divided into 2 groups, and 20 every group, wherein one group is normal dose test group, the matched group that another group is overdose.

2. test method: adopt administration by gavage, test group gavages the preparation of 0.32 gram of preparation of this medicine or capsule also or tablet, every day 1 time, serve on 7 days; Matched group dosage gavages the preparation of 0.35 gram of preparation of this medicine, every day 1 time, serve on 7 days.

3. result of the test, 20 of test group, rabbit physical agility, appetite are normal, none routine generation poisoning symptom and untoward reaction.20 rabbit of matched group have 5 after taking medicine, to occur obvious sedation, extend phenomenon the length of one's sleep, within 3 hours, recover normal later.After taking medicine, occur slight constipation phenomenon, feed green vegetable more, constipation phenomenon is removed.

4. conclusion: show through test in 7 days, take in the situation of medicine of the present invention by normal dose standard, poisoning symptom and untoward reaction occur none example, proves medicine of the present invention without any side effects and reaction in normal amount is taken.

Two, clinical observation on the therapeutic effect test

1. physical data

Accept out-patient's 784 examples for medical treatment, male's 430 examples, 354 examples, 1-10 years old age, 248 examples, 10-20 years old 218 example, 20-40 years old 172 example, 40 years old above 146 example.Wherein: merge insomnia, nervous patient 354 people, 8 of anemia of pregnant woman.

2. diagnostic criteria

Clinical cure: epilepsy completes control, does not recur after drug withdrawal.

Effective: attack times obviously reduces, grand mal shortening continuous time.Sleep obviously improves, and spirit is obviously improved.

Effective: attack times reduces, grand mal shortening continuous time.

Invalid: attack times and duration of seizure do not improve.

3. Therapeutic Method

Oral 3 times of every day, each 2.8 grams, before sleeping every night clothes, within 3 months, be a course for the treatment of, former take Western medicine gradually decrement to withdrawing, serve on 3-8 the course for the treatment of.Electroencephalogram Microcirculation of Nailfold etc. is improved effect extremely.

4. therapeutic outcome:

Cure 203 examples, cure rate is 25.89%, effective 324 examples, and obvious effective rate is 41.32%, effective 188 examples, effective percentage is 23.98%, invalid 69 examples, total effective rate is 99.19%; Wherein 8 anemia of pregnant woman took medicine to production in the pregnancy period always, and neonatal development is normal illustrates medicine instant effect of the present invention without deformity, and cure rate is high, has no side effect, and safety is good.Concrete condition is as following table:

Model case:

Case 1:

Yang, female, 26 years old, Guangxi Qinzhou people, peasant, consultation time on March 9th, 2011.Patient's readme starts to occur without under inducement 17 years old that year: be unreasonable, suddenly fall down to the ground, turn over tic of the limbs on two.When outbreak, spit out white foams, at ordinary times abundant expectoration.Be outbreak on daytime, evening is without outbreak.After morbidity, MRI(nuclear magnetic resonance, NMR) check repeatedly all without abnormal; EEG (electrocardiogram) examination is shown: severe is abnormal, and sharp wave increases.After morbidity, take Carbamazepine Tablets always and carry out epilepsy treatment.2 years, morbidity back, takes 0.3g every day and substantially can control outbreak, and along with the growth of medicine time, the enhancing of drug resistance, when medical to my institute, has reached the consumption of 0.9g every day, and grand mal monthly still has 2--3 time, and 3--8 minute shows effect at every turn.During taking Carbamazepine Tablets, excessive because of side effect, patient once changed and took phenobarbital phenytoin Sodium and sodium valproate etc., and curative effect is very micro-.So can only continuing to strengthen the dose of taking Carbamazepine Tablets always, patient controls the outbreak of epileptics.Transfer Dianbai County, Guangdong, next year pregnancy 23 year old that year.In phenolics, Carbamazepine Tablets is withdrawn in local gynaecologist's suggestion, the generation of prevention monster.But a drug withdrawal, shows effect more frequent, the outbreak persistent period is longer.So doctor advises again its Mr. and Mrs' termination of pregnancy, but is come down hard upon.So phenolics, can only reduce the number of times of outbreak by taking a large amount of Carbamazepine Tablets always.Pregnant 28 weeks, patient's unregular vaginal bleeding, threatened abortion, polydactylia stillborn fetus of output.In March, 11 is when medical to my institute, CT(-) electroencephalogram shows: very abnormal electroencephalogram, companion's epilepsy sample electric discharge sharp wave.Routine blood test (-) liver function is shown: glutamate pyruvate transaminase 84u/l, glutamic oxaloacetic transaminase, GOT 59, glutamyl transpeptidase 111, hepatitis B surface antibody (-).And B ultrasonic also shows: liver luminous point increases, increase thick.When medical, patient takes Western medicine and is: Carbamazepine Tablets 0.3tid, vitamin B6 .2 sheet tid, 2 tid of glucuronolatone, 2 tid of bifendate.As can be seen here: patient is abnormal except electroencephalogram, and liver function and liver B ultrasonic are also abnormal.Hepatitis B virus on inspection, gets rid of patient's hepatitis B virus infection.Moreover patient is at ordinary times without excessive drinking and other bad impairing the liver living habit.Therefore consider that abnormal liver function is to cause because patient takes Carbamazepine Tablets for a long time in a large number.Doctor selects glucuronolatone and bifendate, and estimation is to consider that hepatoprotective falls enzyme and carries out symptomatic treatment hepatic injury.

The traditional Chinese medical science checks: rolling pulse, yellowish fur; Saliva is clamminess, dentation tongue (being hypertrophied tongue) chest distress.Pale complexion, lethargy.Like at ordinary times eating cold drink food.

The traditional Chinese medical science is analyzed: though this patient's readme without obviously falling ill under inducement, each outbreak is all spat out white foams, abundant expectoration at ordinary times, learn that through questioning closely it likes eating cold drink food at ordinary times, therefore the raw expectorant of gastric heat causes mental confusion due to phlegm, so be classified as epilepsy due to accumulation of phlegm scope, should be taking waking up the patient from unconsciousness by dissipating phlegm as main.Just there is in ancient times saying of " without the lame expectorant of not doing ".Think that epilepsy is caused by expectorant." danxi's experiential therapy epilepsy " points out the generation of intrinsic, is exactly that sputum is jammed, and is confused vexed hole key.In " medical science ancestor's mirror ", record: epilepsy due to accumulation of phlegm person, has 3 kinds of causes of disease because expectorant causes epilepsy: the 1st, the raw expectorant of retention of heat in the spleen and stomach usually; The 2nd, the raw not to the utmost expectorant of waste heat after infantile convulsion, the 3rd, the raw expectorant of insufficiency of the spleen intermittent infantile convulsion, falls ill because expectorant fan closes brain key.Look back this patient, excessive phlegm at ordinary times, chest distress, saliva is clamminess, dentation tongue (being hypertrophied tongue), when outbreak, gurgling with sputum is obvious, spit out white foams, moreover its good cold drinks and snachs at ordinary times, therefore the raw expectorant of gastric heat causes that mental confusion due to phlegm is serious.Rolling pulse is shown in pulse-taking, yellowish fur.Belong to undoubtedly epilepsy due to accumulation of phlegm type.Just show effect its daytime, is YANG epilepsy, and yang-energy is crossed Sheng, and is prone to the quick-fried behaviour of temper, insomnia and dreamful sleep, and What is more there is mattoid symptom, therefore feel at ease to allay excitement and can not ignore in treatment.Take 0.9g Carbamazepine Tablets and still do not control epileptics grand mal its every day, therefore relieving spasm by subduing liver-wind is particularly important again.

Therapeutic Method: the waking up the patient from unconsciousness by dissipating phlegm relieving spasm by subduing liver-wind of allaying excitement of feeling at ease

By taking continuously 2 courses for the treatment of of medicament of above-mentioned formula one, advise that patient decontrols psychological pressure and strikes a proper balance between work and rest simultaneously, and all Western medicine such as Carbamazepine Tablets of progressively stopping using, patient's attack times obviously reduces, sleep and appetite are obviously improved, liver function recovery is normal, and electroencephalogram shows: mile abnormality, sharp wave obviously reduces.After continuing to take 1 course for the treatment of, cure, epileptics symptom all disappears again, and it is normal that electroencephalogram recovers.It is normal that liver function regulating liver-QI B ultrasonic recovers.In order to prevent that symptomatic recurrence from having continued to take the medicine of 6 courses for the treatment of again, after drug withdrawal, visit so far, have no recurrence.It is worth mentioning that: during the 3rd course for the treatment of that this patient treats in my institute, unplanned pregnancy.I considered that she once had the experience of monster of producing at that time, moreover in case produce monster or stillborn fetus brings unnecessary medical tangle at period in a medicine, I also advise her Mr. and Mrs' termination of pregnancy.But its husband has been the people of more than 40 year old, expect that son is anxious, refuse, and signed relief agreement with me.Pregnancy duration, strengthens the super inspection of b every month.After 40 weeks, give birth to smoothly a bouncing boy baby.Also the side effect of visible Western medicine is more much bigger than Chinese medicine thus.

Case 2:

Lee, 38 years old, caused injury of head hospitalization because of traffic accident 27 years old that year, the epileptics outbreak after half a year of leaving hospital, whenever work fatigue or cat fever, or when malnutrition, always have an attack of one's old illness, before outbreak, left hand and left foot first have paralysis sense, start with that grand mal, syncope, suddenly fall down to the ground, tic of the limbs, spits out white foams, and 3--8 minute shows effect at every turn.All show effect 5-8 time every month.Due to outbreak frequently, cause Lee's memory and intelligence slump of disastrous proportions, all day is dizzy dizzy, love knot anxiety dysphoria, insomnia and dreamful sleep.Finally develop into murmur to oneself, ruin the psychotic symptoms that thing is hit the person.Once go to local large hospital and mental hospital to be in hospital according to epileptics and psychiatric treatment, effect is still undesirable, after discontinuing medication, still can recur.In February, 2012, by the agency of was to our hospital, finds by inspection, and patient's deep pulse number, tongue is dark red, and dentation tongue is obvious, and trick is ice-cold, green around the gills, symptom, especially dimly red tongue that spirit is wan and sallow, illustrate that he has intentionally vexatious vexed existence of interior-heat.Dentation tongue illustrates that his mental confusion due to phlegm is serious.Trick is ice-cold, green around the gills, and spiritual his course of disease of wan and sallow explanation is remote, health deficiency and coldness, what is called: prolonged illness must become empty.

Analyze: patient belongs to the epileptics that head is caused by wound.Patient's tongue is dark red, and scatters a large amount of punctations, and temple pain is fixed, especially eyeball swell, visual deterioration, patient head passages through which vital energy circulates blood stasis is described, resistance is closed serious, compressing optic nerve causes visual deterioration, considers that brain has the occupy-place of blood stasis focus.When patient falls ill, have the pins and needles, send out cool, spit out white foams, belong to " acupuncture point is how empty " deficiency of YIN stagnation of QI, the clear key of phlegm and stagnant QI attacking upwards.Patient's emotion is irritable uneasy, and the dry hyperactivity of fire Sheng of patient is described, inside scratches gods, and occurs impatience and irascibility.Memory in patients slump of disastrous proportions, the large cerebral blood flow of patient is described, and kidney is not smooth, therefore there is dizzy, memory slump of disastrous proportions, state of mind bradykinesia.

Therapeutic Method:

First patient is treated at heart, make patient happy, lay down the burden, then by taking continuously 2 courses for the treatment of of medicament of above-mentioned formula one, patient's attack times obviously reduces, duration of seizure also obviously reduces, sleep is clearly better, dizzy dizzy minimizing, and memory is recovered gradually, emotion is also more stable, after continuing to take 1 course for the treatment of, cure, epileptics symptom and mattoid symptom all disappear again, in order to prevent that symptomatic recurrence from having continued to take the medicine of 5 courses for the treatment of again, after drug withdrawal, visit so far, there are no rebound phenomenon.

Case 3:

Lee, man, 28 years old, shake fast without the two upper limb of obvious cause burst, self-induction numbness, insomnia, ictal loss of consciousness, limbs are twitched 4 years, and local hospital is diagnosed as " epilepsy ", combined with westem treatment, effect is not good enough, and epilepsy does not take a turn for the better, and after a period of time of discontinuing medication, still can recur, intermittently treat 3 years, still could not cure.Start to take medicine of the present invention in June, 2012, after 3 courses for the treatment of, limbs tic phenomenon reduces, and insomnia phenomenon alleviates, then continues to take after 1 course for the treatment of, and limbs tic phenomenon disappears, and sleep is normal, and epileptics symptom disappears completely, follows up a case by regular visits to and within 1 year, does not find rebound phenomenon.

Claims (5)

1. treat a medicine for epileptics, it is characterized in that it is the medicament of making by the raw material of following weight parts proportioning:

Calculus Bovis 30-70 part, Cornu Saigae Tataricae 180-220 part, pearl powder 480-520 part, Os Draconis 530-570 part, Concha Ostreae 530-570 part, the pig iron 380-420 part that falls, Pumex 430-470 part, Talcum 480-520 part, Haematitum 380-420 part, Halloysitum Rubrum 380-420 part, Ramulus Uncariae Cum Uncis 630-670 part, Bombyx Batryticatus 260-300 part, Shichuan QuanXing 80-120 part, Scorpio 80-120 part, Endothelium Corneum Gigeriae Galli 280-320 part, Herba Paederiae 480-520 part, Fructus Crataegi 280-320 part, Lignum Dalbergiae Odoriferae 130-170 part, Aloe powder 280-320 part, Fructus Cannabis 280-320 part, Arisaema Cum Bile 80-120 part, Borneolum Syntheticum 10-50 part, Rhizoma Acori Graminei 80-120 part, Radix Polygalae 130-170 part, Ramulus Cinnamomi 130-170 part, Radix Glycyrrhizae 130-170 part.

2. the medicine for the treatment of epileptics according to claim 1, the weight portion that it is characterized in that described each crude drug is: 50 parts of Calculus Boviss, 200 parts of Cornu Saigae Tataricae, 500 parts of pearl powders, 550 parts of Os Draconis, 550 parts of Concha Ostreaes, the pig iron falls 400 parts, 450 parts of Pumexs, 500 parts, Talcum, 400 parts of Haematitums, 400 parts of Halloysitum Rubrums, 650 parts of Ramulus Uncariae Cum Uncis, 280 parts of Bombyx Batryticatus, 100 parts of Shichuan QuanXings, 100 parts of Scorpios, 300 parts of Endothelium Corneum Gigeriae Galli, 500 parts of Herba Paederiaes, 300 parts of Fructus Crataegis, 150 parts of Lignum Dalbergiae Odoriferaes, 300 parts of Aloe powder, 300 parts of Fructus Cannabiss, 100 parts of Arisaema Cum Bile, 30 parts of Borneolum Syntheticums, 100 parts of Rhizoma Acori Graminei, 150 parts of Radix Polygalaes, 150 parts of Ramulus Cinnamomi, 150 parts, Radix Glycyrrhizae.

3. the medicine for the treatment of epileptics according to claim 1 and 2, is characterized in that: in described each crude drug, also comprise the Placenta Hominis powder of being made up of two Placenta Hominiss.

4. a method of preparing the medicine for the treatment of epileptics as claimed in claim 3, is characterized in that: described preparation method comprises the following steps:

(1) get the raw materials ready:

1. produce mineral medicated powder: proportioning by weight chooses that Calculus Bovis, Cornu Saigae Tataricae, pearl powder, Os Draconis, Concha Ostreae, the pig iron fall, Pumex, Talcum, Haematitum, Halloysitum Rubrum, remove impurity, then putting together and being broken into fineness is 180-220 object pulverulent mixture, obtains mineral medicated powder;

2. produce Chinese herbal medicine powder: proportioning is by weight chosen Ramulus Uncariae Cum Uncis, Bombyx Batryticatus, Shichuan QuanXing, Scorpio, Endothelium Corneum Gigeriae Galli, Herba Paederiae, Fructus Crataegi, Lignum Dalbergiae Odoriferae, Aloe powder, Fructus Cannabis, Arisaema Cum Bile, Borneolum Syntheticum, Rhizoma Acori Graminei, Radix Polygalae, Ramulus Cinnamomi, Radix Glycyrrhizae, washing is clean, dry, then putting together and being broken into fineness is 180-220 object pulverulent mixture, obtains Chinese herbal medicine powder;

3. produce Placenta Hominis powder: take out two and do not carry the Placenta Hominis of any infectious disease, first cleaned up, then steaming and decocting 10-20 minute, dries, after drying, dry with microwave oven again, being finally broken into fineness is 180-220 object smalls, obtains Placenta Hominis powder;

(2) prepare capsule: mineral medicated powder, Chinese herbal medicine powder medicine, Placenta Hominis powder mix and blend that above-mentioned steps one is obtained, after stirring, pack gelatine capsule into, the weight of every seed lac wafer is 0.25 gram, can be made into the capsule for the treatment of epilepsy medicament.

5. the method for the medicine of preparation treatment epileptics according to claim 4, is characterized in that: mineral medicated powder, Chinese herbal medicine powder medicine, Placenta Hominis powder mix and blend that above-mentioned steps () is obtained, after stirring, add adjuvant, and be pressed into tablet.