CN103877223B - A kind of pharmaceutical composition and application thereof for the treatment of oral candidiasis - Google Patents
A kind of pharmaceutical composition and application thereof for the treatment of oral candidiasis Download PDFInfo
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- CN103877223B CN103877223B CN201410073263.5A CN201410073263A CN103877223B CN 103877223 B CN103877223 B CN 103877223B CN 201410073263 A CN201410073263 A CN 201410073263A CN 103877223 B CN103877223 B CN 103877223B
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- oral candidiasis
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Abstract
The invention discloses a kind of pharmaceutical composition for the treatment of oral candidiasis, by weight, this pharmaceutical composition is prepared from through decocting by following traditional Chinese medicinal material raw materials: Herba Asari 13-18 part, Herba azollae imbricatae 42-60 part, Fructus Evodiae 7-10 part and Cortex Phellodendri 8-12 part.Pharmaceutical composition of the present invention has effect of heat-clearing and toxic substances removing, Antifungi, and medicinal liquid directly acts on the position of infection, and good absorbing is rapid-action.
Description
Technical field
The invention belongs to technical field of Chinese medicine, be specifically related to a kind of pharmaceutical composition and application thereof for the treatment of oral candidiasis.
Background technology
Candidiasis is a kind of opportunistic fungus, exists in the oral cavity, can show as without clinical symptoms health carrier or have the oral candidiasis of clinical sign.There is scholar to isolate yeast-like fungus from the lesion of aphtha patient, think this kind of Pseudomonas candidiasis, candida pseudotropicalis in the candidiasis, height of Cryptococcaeceae.Wherein Candida albicans is topmost pathogen.When body dysbacteriosis, immunologic function degression or immunity are lost, and its infection rate and sickness rate can raise.Long-term chronic oral cavity monilial infection, particularly proliferous type candidiasis stomatitis has the possibility cancerated, therefore thoroughly treatment oral candidiasis is very important early.Especially gerontal patient, because its body's immunity goes down, once use antibiotic, hormone and chemotherapy etc. for a long time, very easily concurrent oral cavity monilial infection.It shows as that oral mucosa hyperemia is rubescent, erythema or white chorion or speckle, the atrophy of back nipple, and have xerostomia, mucosa burning sensation and pain, parageusia or forfeiture etc., Relapse rate, not easily thoroughly cures, and brings misery to patient, jeopardizes the health of patient.
At present, the common drug of this disease of clinical treatment mainly contains nystatin, ketoconazole, fluconazol.Nystatin is the common medicine of clinical treatment oral candidiasis, but its mouthfeel is poor, has the side effect such as Nausea and vomiting, makes patient be difficult to accept.The health azole drugs such as ketoconazole can the biosynthesis of Antifungi cell membrane ergosterol, and affect membrane passage, thus suppress it to grow, but health azole drug has headache, gastrointestinal upset, skin pruritus, long-term taking has the side effect such as hepatic injury.
Summary of the invention
In view of the deficiencies in the prior art, the pharmaceutical composition of the treatment oral candidiasis that the object of the present invention is to provide a kind of side effect low and application thereof.
The object of the present invention is achieved like this:
Treat a pharmaceutical composition for oral candidiasis, by weight, described pharmaceutical composition is prepared from through decocting by following traditional Chinese medicinal material raw materials: Herba Asari 13-18 part, Herba azollae imbricatae 42-60 part, Fructus Evodiae 7-10 part and Cortex Phellodendri 8-12 part.
Preferably, the pharmaceutical composition for the treatment of oral candidiasis as mentioned above, wherein by weight, described pharmaceutical composition is prepared from through decocting by following traditional Chinese medicinal material raw materials: Herba Asari 15 parts, Herba azollae imbricatae 50 parts, Fructus Evodiae 8 parts and Cortex Phellodendri 10 parts.
Further preferably, the pharmaceutical composition for the treatment of oral candidiasis as mentioned above, wherein said pharmaceutical composition is gargarism.
Found by a large amount of clinical practice, pharmaceutical composition of the present invention treated by rinsing the mouth after curative effect highly significant to old oral Candida patient.Therefore, second object of the present invention is to provide a kind of pharmaceutical applications, i.e. the application of aforementioned pharmaceutical compositions in the medicine of the old oral candidiasis of preparation treatment.
The preparation method of the gargarism that the present invention relates to comprises the steps: to take Herba Asari, Herba azollae imbricatae, Fructus Evodiae and Cortex Phellodendri, clean roguing, dry, with bundle it, put in people's marmite, soak post-heating to boiling, continue to decoct 20-40 minute, filter, filtrate is concentrated into every milliliter containing 2.5-3.5g crude drug, obtains gargarism.
Using method: patient adopts 2% sodium bicarbonate to gargle after solution gargles, gargarism to be contained in mouth 3 ~ 5 minutes, allow medicinal liquid fully contact disease damage place, then spue, rinsing the mouth is for 4-5 time seance amount so repeatedly.
Pharmaceutical composition of the present invention has effect of heat-clearing and toxic substances removing, Antifungi, and medicinal liquid directly acts on the position of monilial infection, and good absorbing is rapid-action, the preparation of medicinal liquid of the present invention is simple simultaneously, and draw materials conveniently, price is excellent honest and clean, easy to use, effective, have no side effect, relapse rate is low.
Detailed description of the invention
It should be noted that, the traditional Chinese medicinal material raw materials that various embodiments of the present invention adopt has following source: Herba Asari selects aristolochiaceae plant Herba Asari Asarum heterotropoides Fr.Schmidt var.mandshuricum(Maxim.) the dry herb of Kitag..Herba azollae imbricatae selects fern Herba azollae imbricatae section azolla plant Herba azollae imbricatae Azolla imbricata(Roxb.) the dry herb of Nakai.Fructus Evodiae selects rutaceae Fructus Evodiae Evodia rutaecarpa(Juss.) the dry immature fruit of Benth..Cortex Phellodendri selects the dry bark of rutaceae wampee Phellodendron chinense Schneid. or Cortex Phellodendri Phellodendron amurense Rupr..
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1
Take Herba Asari 15g, Herba azollae imbricatae 50g, Fructus Evodiae 8g and Cortex Phellodendri 10g, clean roguing, dry, with bundle it, put in people's marmite, add 0.8L water, soak 30 minutes post-heating to boiling, continue decoction 30 minutes, filter, filtrate is concentrated into every milliliter containing 3g crude drug, obtains gargarism.
Embodiment 2
Take Herba Asari 18g, Herba azollae imbricatae 42g, Fructus Evodiae 8g and Cortex Phellodendri 12g, clean roguing, dry, with bundle it, put in people's marmite, add 1L water, soak 30 minutes post-heating to boiling, continue decoction 30 minutes, filter, filtrate is concentrated into every milliliter containing 3g crude drug, obtains gargarism.
Embodiment 3
Take Herba Asari 13g, Herba azollae imbricatae 60g, Fructus Evodiae 8g and Cortex Phellodendri 8g, clean roguing, dry, with bundle it, put in people's marmite, add 1L water, soak 30 minutes post-heating to boiling, continue decoction 30 minutes, filter, filtrate is concentrated into every milliliter containing 3g crude drug, obtains gargarism.
Embodiment 4
Take Herba Asari 16g, Herba azollae imbricatae 55g, Fructus Evodiae 10g, Cortex Phellodendri 10g, clean roguing, dry, with bundle it, put in people's marmite, add 0.8L water, soak 30 minutes post-heating to boiling, continue decoction 30 minutes, filter, filtrate is concentrated into every milliliter containing 3g crude drug, obtains gargarism.
Clinical practice example
52 routine gerontal patients, all have the clinical manifestation of oral candidiasis in various degree, and disease damage district smear cultivation results is that candidiasis is positive.Man 35 example in all patients, female 17 example, the oldest 80 years old, minimum 62 years old, 69.2 ± 2.5 years old mean age.52 routine patients are divided into test group and matched group at random, test group 26 example, matched group 26 example, two groups of there was no significant differences in sex, age, the state of an illness etc., have comparability.
Matched group patient gargles to 2% sodium bicarbonate solution, every day three times, meanwhile, gives ketoconazole capsules in Chinese l00mg, and once a day, decoction being taken at a draught after lunch, treats 7 days altogether.Test group patient gargles to 2% sodium bicarbonate after solution gargles, and gargles with gargarism prepared by the embodiment of the present invention 1 Recipe.Each gargarism to be contained in mouth 3 ~ 5 minutes, allow medicinal liquid fully contact disease damage place, then spue, rinsing the mouth is for 4 times seance amount so repeatedly.4 treatments of every natural gift, treat 7 days altogether.After treatment terminates, observe the situation of two groups of rear clinical symptom disappearance for the treatment of and the situation of disease damage district, oral cavity smear cultivation candidiasis, by following curative effect determinate standard statistical results:
Recovery from illness: the rubescent district of disease damage or white chorion disappear completely, the back nipple of atrophy recovers, and subjective symptoms disappears completely, and candidiasis checks negative.
Effective: the rubescent district of disease damage or white chorion major part disappear, and subjective symptoms obviously alleviates, and candidiasis inspection is turned out cloudy or probable positive.
Take a turn for the better: disease damage district reduces, and symptom alleviates, and candidiasis inspection is turned out cloudy or probable positive.
Invalid: disease damage and symptom unchanged, candidiasis checks positive.
Two groups of clinical efficacies in Table l, cure rate and total effective rate. test group is obviously better than matched group.
Table 1 liang group Clinical efficacy comparison [example]
Two groups of relapse rates compare: to the follow-up of patients 3 months of recovery from illness after drug withdrawal, and test group 16 example recovery from illness patient is 2 people's recurrences only, and relapse rate is 12.5%, and matched group 7 example recovery from illness patient has 5 people's recurrences, and relapse rate is 71.4%.
Claims (4)
1. treat the pharmaceutical composition of oral candidiasis for one kind, it is characterized in that: by weight, described pharmaceutical composition is prepared from through decocting by following traditional Chinese medicinal material raw materials: Herba Asari 13-18 part, Herba azollae imbricatae 42-60 part, Fructus Evodiae 7-10 part and Cortex Phellodendri 8-12 part.
2. treat the pharmaceutical composition of oral candidiasis as claimed in claim 1, it is characterized in that: by weight, described pharmaceutical composition is prepared from through decocting by following traditional Chinese medicinal material raw materials: Herba Asari 15 parts, Herba azollae imbricatae 50 parts, Fructus Evodiae 8 parts and Cortex Phellodendri 10 parts.
3. treat the pharmaceutical composition of oral candidiasis as claimed in claim 1 or 2, it is characterized in that: described pharmaceutical composition is gargarism.
4. the application of the pharmaceutical composition described in claim 1 or 2 in the medicine of the old oral candidiasis of preparation treatment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410073263.5A CN103877223B (en) | 2014-03-03 | 2014-03-03 | A kind of pharmaceutical composition and application thereof for the treatment of oral candidiasis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410073263.5A CN103877223B (en) | 2014-03-03 | 2014-03-03 | A kind of pharmaceutical composition and application thereof for the treatment of oral candidiasis |
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| Publication Number | Publication Date |
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| CN103877223A CN103877223A (en) | 2014-06-25 |
| CN103877223B true CN103877223B (en) | 2015-09-30 |
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| CN201410073263.5A Expired - Fee Related CN103877223B (en) | 2014-03-03 | 2014-03-03 | A kind of pharmaceutical composition and application thereof for the treatment of oral candidiasis |
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| CN106361951A (en) * | 2016-10-24 | 2017-02-01 | 严成 | Traditional Chinese medicine for treating chronic mucocutaneous candidiasis |
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| CN1078896A (en) * | 1992-12-31 | 1993-12-01 | 许中伟 | External application cream for mouth ulcer |
| CN1850200A (en) * | 2006-03-06 | 2006-10-25 | 浙江大学 | Formula of external-use Chinese medicine for treating ulcerative stomatitis |
| CN101422579B (en) * | 2008-12-09 | 2011-06-15 | 郭璟璟 | Traditional Chinese medicine preparation for treating oral ulcer |
| CN103520396B (en) * | 2013-10-30 | 2015-07-08 | 李绍辉 | Mouthwash used for preventing infection after oral implant rehabilitation |
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Granted publication date: 20150930 Termination date: 20170303 |