CN103877223A - Medicine composition for treating oral candidiasis and application thereof - Google Patents
Medicine composition for treating oral candidiasis and application thereof Download PDFInfo
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- CN103877223A CN103877223A CN201410073263.5A CN201410073263A CN103877223A CN 103877223 A CN103877223 A CN 103877223A CN 201410073263 A CN201410073263 A CN 201410073263A CN 103877223 A CN103877223 A CN 103877223A
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Abstract
The invention discloses a medicine composition for treating oral candidiasis. The medicine composition is prepared from the following traditional Chinese raw materials in parts by weight: 13-18 parts of asarum, 42-60 parts of azolla imbricate, 7-10 parts of fructus evodiae and 8-12 parts of golden cypress by boiling in water. The medicine composition disclosed by the invention has the effects of clearing away heat and toxic materials and inhibiting fungus, and moreover the medicine liquid can directly act on infectious parts, and is good in absorption and allows fast effect.
Description
Technical field
The invention belongs to Chinese medicine technical field, be specifically related to a kind of pharmaceutical composition and application thereof for the treatment of oral candidiasis.
Background technology
Candidiasis is a kind of condition pathomycete, in oral cavity, exists, and can show as without the health carrier of clinical symptoms or have the oral candidiasis of clinical sign.There is scholar to isolate yeast-like fungus from aphtha patient's lesion, think this kind of Pseudomonas candidiasis, candida pseudotropicalis in the candidiasis of Cryptococcaeceae, height.Wherein Candida albicans is topmost pathogen.When body dysbacteriosis, immunologic function degression or immunity are lost, and its infection rate and sickness rate can raise.Long-term chronic oral cavity monilial infection, particularly proliferous type candidiasis stomatitis has the possibility cancerating, therefore it is very important thoroughly to treat early oral candidiasis.Especially gerontal patient, because its body's immunity goes down, once use for a long time antibiotic, hormone and chemotherapy etc., very easily concurrent oral cavity monilial infection.It shows as that oral mucosa hyperemia is rubescent, erythema or white chorion or speckle, the atrophy of back nipple, and has xerostomia, mucosa burning sensation and pain, parageusia or forfeiture etc., and Relapse rate, is difficult for thoroughly curing, and brings misery to patient, jeopardizes patient's health.
At present, treat clinically this sick common drug and mainly contain nystatin, ketoconazole, fluconazol.Nystatin is the common medicine for the treatment of clinically oral candidiasis, but its mouthfeel is poor, has the side effect such as nauseating, vomiting, makes patient be difficult to accept.The health azole drugs such as ketoconazole can Antifungi cell membrane ergosterol biosynthesis, affects the permeability of cell membrane, thereby suppress its growth, but health azole drug has headache, gastrointestinal upset, skin pruritus, long-term taking has the side effect such as hepatic injury.
Summary of the invention
In view of the deficiencies in the prior art, the object of the present invention is to provide pharmaceutical composition and the application thereof of the low treatment oral candidiasis of a kind of side effect.
The object of the present invention is achieved like this:
Treat a pharmaceutical composition for oral candidiasis, by weight, described pharmaceutical composition is prepared from through decocting by following traditional Chinese medicinal material raw materials: Herba Asari 13-18 part, Herba azollae imbricatae 42-60 part, Fructus Evodiae 7-10 part and Cortex Phellodendri 8-12 part.
Preferably, treat as mentioned above the pharmaceutical composition of oral candidiasis, wherein by weight, described pharmaceutical composition is prepared from through decocting by following traditional Chinese medicinal material raw materials: 10 parts of 15 parts of Herba Asaris, 50 parts of Herba azollae imbricataes, 8 parts of Fructus Evodiaes and Cortex Phellodendris.
Further preferably, treat as mentioned above the pharmaceutical composition of oral candidiasis, wherein said pharmaceutical composition is gargarism.
Find by a large amount of clinical practices, pharmaceutical composition of the present invention treat by rinsing the mouth after curative effect highly significant to old oral Candida patient.Therefore, second object of the present invention is to provide a kind of pharmaceutical applications, i.e. the application of aforementioned pharmaceutical compositions in the medicine of the old oral candidiasis of preparation treatment.
The preparation method of the gargarism the present invention relates to comprises the steps: to take Herba Asari, Herba azollae imbricatae, Fructus Evodiae and Cortex Phellodendri, clean roguing, dry, with bundle it, put in people's marmite, soak post-heating to boiling, continue to decoct 20-40 minute, filter, filtrate is concentrated into every milliliter containing 2.5-3.5g crude drug, obtains gargarism.
Using method: after patient adopts 2% sodium bicarbonate to gargle solution to gargle, gargarism is contained in mouth to 3～5 minutes, allows medicinal liquid fully contact disease damage place, then spue, rinsing the mouth is for 4-5 time seance amount so repeatedly.
Pharmaceutical composition of the present invention has effect of heat-clearing and toxic substances removing, Antifungi, and medicinal liquid directly acts on the position of monilial infection, and good absorbing is rapid-action, the preparation of medicinal liquid of the present invention is simultaneously simple, draws materials conveniently, and price is excellent honest and clean, easy to use, effective, have no side effect, relapse rate is low.
Detailed description of the invention
It should be noted that, the traditional Chinese medicinal material raw materials that various embodiments of the present invention adopt has following source: Herba Asari is selected aristolochiaceae plant Herba Asari Asarum heterotropoides Fr.Schmidt var.mandshuricum(Maxim.) the dry herb of Kitag..Herba azollae imbricatae is selected the azolla plant Herba azollae imbricatae Azolla imbricata(Roxb. of fern Herba azollae imbricatae section) the dry herb of Nakai.Fructus Evodiae is selected rutaceae Fructus Evodiae Evodia rutaecarpa(Juss.) the dry immature fruit of Benth..Cortex Phellodendri is selected the dry bark of rutaceae wampee Phellodendron chinense Schneid. or Cortex Phellodendri Phellodendron amurense Rupr..
Be below specific embodiments of the invention, technical scheme of the present invention is done to further description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
Embodiment 1
Take Herba Asari 15g, Herba azollae imbricatae 50g, Fructus Evodiae 8g and Cortex Phellodendri 10g, clean roguing, dry, with bundle it, put in people's marmite, add 0.8L water, soak 30 minutes post-heating to boiling, continue to decoct 30 minutes, filter, filtrate is concentrated into every milliliter containing 3g crude drug, obtains gargarism.
Embodiment 2
Take Herba Asari 18g, Herba azollae imbricatae 42g, Fructus Evodiae 8g and Cortex Phellodendri 12g, clean roguing, dry, with bundle it, put in people's marmite, add 1L water, soak 30 minutes post-heating to boiling, continue to decoct 30 minutes, filter, filtrate is concentrated into every milliliter containing 3g crude drug, obtains gargarism.
Embodiment 3
Take Herba Asari 13g, Herba azollae imbricatae 60g, Fructus Evodiae 8g and Cortex Phellodendri 8g, clean roguing, dry, with bundle it, put in people's marmite, add 1L water, soak 30 minutes post-heating to boiling, continue to decoct 30 minutes, filter, filtrate is concentrated into every milliliter containing 3g crude drug, obtains gargarism.
Embodiment 4
Take Herba Asari 16g, Herba azollae imbricatae 55g, Fructus Evodiae 10g, Cortex Phellodendri 10g, clean roguing, dry, with bundle it, put in people's marmite, add 0.8L water, soak 30 minutes post-heating to boiling, continue to decoct 30 minutes, filter, filtrate is concentrated into every milliliter containing 3g crude drug, obtains gargarism.
Clinical practice example
52 routine gerontal patients, all have the clinical manifestation of oral candidiasis in various degree, and disease damage district smear cultivation results is the candidiasis positive.Male 35 examples in all patients, female's 17 examples, the oldest 80 years old, minimum 62 years old, 69.2 ± 2.5 years old mean age.52 routine patients are divided into test group and matched group at random, test group 26 examples, matched group 26 examples, two groups at aspect there was no significant differences such as sex, age, the state of an illness, has comparability.
Matched group patient gargles to 2% sodium bicarbonate solution, every day three times, meanwhile, gives ketoconazole capsules in Chinese l00mg, and once a day, decoction being taken at a draught after lunch, treats 7 days altogether.After test group patient gargles solution and gargle to 2% sodium bicarbonate, gargle with gargarism prepared by the embodiment of the present invention 1 Recipe.Gargarism is contained in mouth to 3～5 minutes at every turn, allows medicinal liquid fully contact disease damage place, then spue, rinsing the mouth is for 4 times seance amount so repeatedly.4 treatments of every natural gift, treat 7 days altogether.After treatment finishes, observe the situation of the situation of clinical symptom disappearance after two groups of treatments and disease damage district, oral cavity smear cultivation candidiasis, by following curative effect determinate standard statistical results:
Recovery from illness: the rubescent district of disease damage or white chorion disappear completely, the back nipple of atrophy recovers, and subjective symptoms disappears completely, and candidiasis checks negative.
Effective: the rubescent district of disease damage or white chorion are most of to disappear, and subjective symptoms obviously alleviates, and candidiasis inspection is turned out cloudy or probable positive.
Take a turn for the better: disease damage district dwindles, and symptom alleviates, and candidiasis inspection is turned out cloudy or probable positive.
Invalid: disease damage and symptom are unchanged, candidiasis checks positive.
Two groups of clinical efficacies are in Table l, cure rate and total effective rate. and test group is obviously better than matched group.
Table 1 liang group Clinical efficacy comparison [example]
Two groups of relapse rate comparisons: after drug withdrawal, the patient of recovery from illness is followed up a case by regular visits to 3 months, only 2 people's recurrences of test group 16 example recovery from illness patients, relapse rate is 12.5%, and matched group 7 example recovery from illness patients have 5 people's recurrences, and relapse rate is 71.4%.
Claims (4)
1. treat the pharmaceutical composition of oral candidiasis for one kind, it is characterized in that: by weight, described pharmaceutical composition is prepared from through decocting by following traditional Chinese medicinal material raw materials: Herba Asari 13-18 part, Herba azollae imbricatae 42-60 part, Fructus Evodiae 7-10 part and Cortex Phellodendri 8-12 part.
2. treat as claimed in claim 1 the pharmaceutical composition of oral candidiasis, it is characterized in that: by weight, described pharmaceutical composition is prepared from through decocting by following traditional Chinese medicinal material raw materials: 10 parts of 15 parts of Herba Asaris, 50 parts of Herba azollae imbricataes, 8 parts of Fructus Evodiaes and Cortex Phellodendris.
3. the pharmaceutical composition for the treatment of as claimed in claim 1 or 2 oral candidiasis, is characterized in that: described pharmaceutical composition is gargarism.
4. the application of the pharmaceutical composition described in claim 1 or 2 in the medicine of the old oral candidiasis of preparation treatment.
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| CN201410073263.5A CN103877223B (en) | 2014-03-03 | 2014-03-03 | A kind of pharmaceutical composition and application thereof for the treatment of oral candidiasis |
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| CN201410073263.5A CN103877223B (en) | 2014-03-03 | 2014-03-03 | A kind of pharmaceutical composition and application thereof for the treatment of oral candidiasis |
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| CN103877223A true CN103877223A (en) | 2014-06-25 |
| CN103877223B CN103877223B (en) | 2015-09-30 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106361951A (en) * | 2016-10-24 | 2017-02-01 | 严成 | Traditional Chinese medicine for treating chronic mucocutaneous candidiasis |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078896A (en) * | 1992-12-31 | 1993-12-01 | 许中伟 | External application cream for mouth ulcer |
| CN1850200A (en) * | 2006-03-06 | 2006-10-25 | 浙江大学 | Formula of external-use Chinese medicine for treating ulcerative stomatitis |
| CN101422579A (en) * | 2008-12-09 | 2009-05-06 | 郭璟璟 | Traditional Chinese medicine preparation for treating oral ulcer |
| CN103520396A (en) * | 2013-10-30 | 2014-01-22 | 李绍辉 | Mouthwash used for preventing infection after oral implant rehabilitation |
-
2014
- 2014-03-03 CN CN201410073263.5A patent/CN103877223B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078896A (en) * | 1992-12-31 | 1993-12-01 | 许中伟 | External application cream for mouth ulcer |
| CN1850200A (en) * | 2006-03-06 | 2006-10-25 | 浙江大学 | Formula of external-use Chinese medicine for treating ulcerative stomatitis |
| CN101422579A (en) * | 2008-12-09 | 2009-05-06 | 郭璟璟 | Traditional Chinese medicine preparation for treating oral ulcer |
| CN103520396A (en) * | 2013-10-30 | 2014-01-22 | 李绍辉 | Mouthwash used for preventing infection after oral implant rehabilitation |
Non-Patent Citations (1)
| Title |
|---|
| 毕云: "中药治疗念珠菌性口腔炎_肠炎及肺念珠菌病临床观察", 《实用中医药杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106361951A (en) * | 2016-10-24 | 2017-02-01 | 严成 | Traditional Chinese medicine for treating chronic mucocutaneous candidiasis |
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