CN1078896A

CN1078896A - External application cream for mouth ulcer

Info

Publication number: CN1078896A
Application number: CN 92115056
Authority: CN
Inventors: 许中伟; 韩启德
Original assignee: Individual
Current assignee: Individual
Priority date: 1992-12-31
Filing date: 1992-12-31
Publication date: 1993-12-01

Abstract

The invention discloses the acupuncture points external application medicine of a kind of treatment recurrent aphtha (being commonly called as oral ulcer)---external application cream for mouth ulcer I number, it is made of crude drug (Fructus Evodiae, processed with wine Cortex Phellodendri) and medicinal substrate.External application biped or monopodia Yongquan acupoint.It is easy to use, has no side effect, and effective percentage 90-95% is suitable for being difficult for oral or the oral local administration person especially.

Description

External application cream for mouth ulcer

The medicament composing prescription, manufacture method and the point-application that the present invention relates to the recurrent aphtha external application for curing are used.

Recurrent aphtha (claims recurrent aphthous ulcer again, be commonly called as oral ulcer) be common disease in the oral mucosa, can be because of infecting, malnutrition, factor such as endocrine regulation and spiritual nerve and bringing out, the sickness rate height, cause of disease complexity, definite pathogenesis is unclear, primary disease intermittence, and causalgia is unbearably, influence feed and speech, traditional treatment is oral vitamin class and amcinonide, but does not all have specially good effect, and certain side effect is arranged, oral local administration is (as the skin ulcer mask, medicated powder sprays or mouth is gargled) though certain pain relieving is arranged, the promoting healing effect, but it is short that disadvantage is the medicine Local Residence Time, easily dissolves and come off by saliva dilution, so be difficult to bring into play lastingly drug effect, and mouthfeel is poor (as hardship, peppery, sensations such as pain), the infant application difficult often makes the patient can not adhere to medication thus, affects the treatment.

Task of the present invention provide a kind of simple, effectively, use convenience, no pain, acceptant treatment this sick medicine and method.

Rationale of the present invention is: the traditional Chinese medical science is thought " flaming up of heart-fire; taste heat is stopped up and caused aphtha of the mouth and tongue ", " aphtha of the mouth and tongue; due to all part of the body cavity above the diaphragm housing the heart and lungs heat is stopped up ", " contain on the dificiency in lower-JIAO, cause aphtha of the mouth and tongue ", and internal organs such as its morbidity and the heart, liver, gallbladder, spleen, stomach, lung, kidney all are related.The present invention adopts Fructus Evodiae, wine Cortex Phellodendri (processed) compound recipe to form.Though Fructus Evodiae is warm, the hot hardship of loosing is fallen, and it is descending to draw heat, and Shugan Zhitong; The Cortex Phellodendri hardship, heavy, heat clearing and damp drying, the kind kidney channel fire mutually that rushes down, wine is processed then the fire of the part of the body cavity above the diaphragm housing the heart and lungs clearly, and skin ulcer is treated in detoxifcation, reach the thought on " inner disease outer treat ", " treating disease in the upper by managing the lower " according to traditional Chinese medical science internal organs theory of channels and collaterals, the well cave Yongquan acupoint of the few the moon of choosing foot applies with medicine-feeding, and the meridian dredging relaxes, draw the fire of the part of the body cavity above the diaphragm housing the heart and lungs and descending, clear interior-heat and dampness, thus equilibrium between yin and yang regulated, and pain relieving helps more.We's two medicines supplement and complement each other, dosage is suitable, promptly there is Drug therapy that the dual function of acupoint stimulation is arranged again, and is equipped with medicinal short oozing property substrate (glycerol, mixing-in fat acid glyceride, lanoline, azone), moulding to rise, preserve moisture, promote the drug osmotic stimulation.

This medicine is through clinical prolonged application, and effective percentage 90-95% is easy to use, has no side effect, and is suitable for being difficult for oral especially or the oral local administration person, as infant, facial paralysis patient etc.Processing technology is simple, and cost is low, can be mass-produced.

The present invention finishes as follows: 1. medicament composing prescription: Fructus Evodiae+wine Cortex Phellodendri (processed)+substrate, and wherein crude drug content is 40-60%; 2. Fructus Evodiae content is 40-80% in the crude drug, and the wine Cortex Phellodendri (processed) then is 20-60%; 3. substrate is glycerol, mixing-in fat acid glyceride (fusing point 34-38 ℃), lanoline, vaseline, azone or the mixture between them; 4. crude drug preparation method: the composition medicine is ground into Powdered respectively through cracker for medicine, sieves through 100 mesh sieves, mix by percentage composition described in 2., and through the abundant mix homogeneously of mixer; 5. crude drug and substrate mixed method: crude drug powder and liquid matrix mixed or rub in blender or in other container to press mixes, moistening to whole medicines, the color and luster unanimity, tack-free and instrument, can be arbitrarily moulding and not cracked, to pinch and do not pulverize with hand rubbing, soft durometer is suitable.As being substrate with 60-85% glycerine water solution and mixing-in fat acid glyceride (fusion temperature＜60 ℃), the two separately percentage composition be 50-80% and 20-50%, with the mixing-in fat acid glyceride of liquefaction and after glycerite fully mixes, promptly rapidly and the crude drug powder even in stirrer for mixing, also can earlier glycerite fully be mixed under above-mentioned conditional request with the crude drug powder, the mixing-in fat acid glyceride that adds liquefaction again, stirring and evenly mixing while hot; 6. get mixed medicine and stick together, make circular ointment, it is the 0.3-0.9 gram that its diameter 1-2cm, thick 0.3-0.7cm, every obedient ointment contain the crude drug amount; 7. ointment is put in the suitable sponge ring of a size, outer pad one sizable plastic sheeting, in case moisture oozes out in the medicine, its external application one film, with fixedly sponge ring, plastic sheeting and ointment, another side applies skim waterproof, air-locked thin plastic or its succedaneum, cover ointment and with film card fixing (similar corn plaster) mutually, airtight preservation; When 8. using, ointment is aimed at biped (but also monopodia) Yongquan acupoint, be fixed on the foot, changed dressings once in 12 hours or 24 hours by adhesive tape, or bedtime medication every night, take off after rising morning.

Embodiment 1

Get evodiae powder 6g and processed with wine Cortex Phellodendri powder 4g, mix homogeneously, with 3g mixing-in fat acid glyceride heat fused, be cooled to 40 ℃, mix with the glycerine water solution of 7g 80%, add while hot in the crude drug powder behind the 10g mixing, mix through stirring, rub to press, getting it filled sticks together makes the ointment of 20 diameter 1.5cm, thick 0.5cm.

Embodiment 2

Get evodiae powder 5.5g and processed with wine Cortex Phellodendri powder 4.5g mix homogeneously, 3g mixing-in fat acid glyceride is pressed the fusing of embodiment 1 condition, with glycerine water solution and the 0.5g azone mix homogeneously of 6.5g 80%, add in the 10g crude drug powder, make ointment by embodiment 1 same procedure.

Claims

1, a kind of liniment of acupuncture point for the treatment of recurrent aphtha, it is characterized in that being made of crude drug and medicinal substrate, wherein crude drug accounts for 40-60%, and crude drug is made up of Fructus Evodiae, processed with wine Cortex Phellodendri, wherein Fructus Evodiae accounts for the 40-80% of crude drug content, and the processed with wine Cortex Phellodendri accounts for 20-60%.

2, according to right 1 described substrate, can by glycerol, mixing-in fat acid glyceride, lanoline, azone, vaseline wherein two or more mixture constitute.