CN103858008B - 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 - Google Patents

用于肾损伤和肾衰竭的诊断及预后的方法和组合物 Download PDF

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Publication number
CN103858008B
CN103858008B CN201280039959.5A CN201280039959A CN103858008B CN 103858008 B CN103858008 B CN 103858008B CN 201280039959 A CN201280039959 A CN 201280039959A CN 103858008 B CN103858008 B CN 103858008B
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hours
experimenter
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probability
renal
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Chinese (zh)
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CN103858008A (zh
Inventor
J·安德伯格
J·格雷
P·麦克弗森
K·中村
J·P·坎普夫
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Astute Medical Inc
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Astute Medical Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CN201280039959.5A 2011-07-09 2012-07-05 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 Expired - Fee Related CN103858008B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161506038P 2011-07-09 2011-07-09
US61/506,038 2011-07-09
PCT/US2012/045583 WO2013009573A1 (en) 2011-07-09 2012-07-05 Methods and compositions for diagnosis and prognosis of renal injury and renal failure

Publications (2)

Publication Number Publication Date
CN103858008A CN103858008A (zh) 2014-06-11
CN103858008B true CN103858008B (zh) 2017-03-01

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Family Applications (1)

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CN201280039959.5A Expired - Fee Related CN103858008B (zh) 2011-07-09 2012-07-05 用于肾损伤和肾衰竭的诊断及预后的方法和组合物

Country Status (9)

Country Link
US (2) US20140171522A1 (enExample)
EP (1) EP2729803A4 (enExample)
JP (1) JP2014521088A (enExample)
CN (1) CN103858008B (enExample)
AU (1) AU2012282918A1 (enExample)
CA (1) CA2841880A1 (enExample)
EA (1) EA201490105A1 (enExample)
MX (1) MX2014000283A (enExample)
WO (1) WO2013009573A1 (enExample)

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WO2014120569A1 (en) * 2013-01-25 2014-08-07 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for human epididymis protein-4 (he4)
US10130950B2 (en) 2013-11-27 2018-11-20 Bio-Rad Laboratories, Inc. Microfluidic droplet packing
CN104045453B (zh) * 2014-06-11 2016-08-24 句容市鑫诚果业家庭农场 一种石榴专用有机肥料及其制备方法
CN106536709A (zh) 2014-06-16 2017-03-22 基纽拜奥股份有限公司 尺寸交替的注入到液滴中以促进分选
CN104062294A (zh) * 2014-07-11 2014-09-24 青岛千士医疗科技有限公司 一种支气管/肺上皮细胞线粒体损伤的检测方法
CN104166003B (zh) * 2014-08-06 2016-06-08 中国人民解放军第二军医大学 人附睾蛋白4在制备系统性红斑狼疮性肾病诊断试剂或试剂盒中的应用
WO2016130802A1 (en) * 2015-02-11 2016-08-18 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
TW201827070A (zh) * 2016-12-19 2018-08-01 康鶴生醫科技股份有限公司 合成多肽、含該多肽的組合物、由其產生的抗體及其用途

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US20060057066A1 (en) * 2004-07-19 2006-03-16 Georges Natsoulis Reagent sets and gene signatures for renal tubule injury
CN1791797A (zh) * 2003-03-27 2006-06-21 儿童医院医疗中心 用于检测肾小管细胞损伤的早发的方法和试剂盒
US20070087387A1 (en) * 2005-04-21 2007-04-19 Prasad Devarajan Method for the Early Detection of Renal Disease Using Proteomics
CN101679525A (zh) * 2007-03-26 2010-03-24 诺瓦提斯公司 用于监测肾功能的预测性的肾安全性生物标志物和生物标志物标签
CN101960308A (zh) * 2008-02-29 2011-01-26 国立大学法人名古屋大学 急性肾损伤及预后推测用生物标记物以及其用途
CN102016552A (zh) * 2008-03-05 2011-04-13 神谷来克斯公司 用于分子的高灵敏性检测的方法和组合物
CN102089658A (zh) * 2008-06-04 2011-06-08 普罗迪奥塞斯股份公司 用于体外测试化学物质的发育毒性和胚胎毒性的蛋白生物标志物

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AU7347300A (en) * 1999-09-02 2001-03-26 Gene Logic, Inc. Modulation of he4 in inflammatory and renal diseases
EP2095107B1 (en) * 2006-11-14 2014-07-02 Alere San Diego, Inc. Methods for risk assignment
KR20100015438A (ko) * 2007-03-09 2010-02-12 트리패스 이미징, 인코포레이티드 Ｈｅ4 모노클로날 항체 및 이의 사용 방법
NZ610356A (en) * 2008-08-28 2015-03-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
ES2528799T3 (es) * 2008-11-22 2015-02-12 Astute Medical, Inc. Métodos para el pronóstico de insuficiencia renal aguda
JP5763098B2 (ja) * 2009-12-20 2015-08-12 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
US20120329071A1 (en) * 2010-03-05 2012-12-27 Mark Chance Protein biomarkers and therapeutic targets for renal disorders
EP2646822B1 (en) * 2010-11-29 2017-11-01 Alere San Diego, Inc. Methods for diagnosis and risk prediction in heart failure
WO2013006629A1 (en) * 2011-07-06 2013-01-10 Alere San Diego Inc. Methods and compositions for assigning likelihood of acute kidney injury progression

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CN1791797A (zh) * 2003-03-27 2006-06-21 儿童医院医疗中心 用于检测肾小管细胞损伤的早发的方法和试剂盒
US20060057066A1 (en) * 2004-07-19 2006-03-16 Georges Natsoulis Reagent sets and gene signatures for renal tubule injury
US20070087387A1 (en) * 2005-04-21 2007-04-19 Prasad Devarajan Method for the Early Detection of Renal Disease Using Proteomics
CN101679525A (zh) * 2007-03-26 2010-03-24 诺瓦提斯公司 用于监测肾功能的预测性的肾安全性生物标志物和生物标志物标签
CN101960308A (zh) * 2008-02-29 2011-01-26 国立大学法人名古屋大学 急性肾损伤及预后推测用生物标记物以及其用途
CN102016552A (zh) * 2008-03-05 2011-04-13 神谷来克斯公司 用于分子的高灵敏性检测的方法和组合物
CN102089658A (zh) * 2008-06-04 2011-06-08 普罗迪奥塞斯股份公司 用于体外测试化学物质的发育毒性和胚胎毒性的蛋白生物标志物

Also Published As

Publication number Publication date
WO2013009573A1 (en) 2013-01-17
JP2014521088A (ja) 2014-08-25
EP2729803A1 (en) 2014-05-14
AU2012282918A1 (en) 2014-02-06
US20140171522A1 (en) 2014-06-19
EP2729803A4 (en) 2015-08-05
US20160097779A1 (en) 2016-04-07
CN103858008A (zh) 2014-06-11
EA201490105A1 (ru) 2014-07-30
CA2841880A1 (en) 2013-01-17
MX2014000283A (es) 2014-05-01

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