CN103845371A - Salvianic acid B-containing traditional Chinese medicine for treating and preventing haemorrhoid and preparation method thereof - Google Patents
Salvianic acid B-containing traditional Chinese medicine for treating and preventing haemorrhoid and preparation method thereof Download PDFInfo
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- CN103845371A CN103845371A CN201210496336.2A CN201210496336A CN103845371A CN 103845371 A CN103845371 A CN 103845371A CN 201210496336 A CN201210496336 A CN 201210496336A CN 103845371 A CN103845371 A CN 103845371A
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- lithospermic acid
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Abstract
The invention discloses a salvianic acid B-containing drug for treating hemorrhoid, which comprises the following components by weight part: 10-70 parts of salvianic acid B, 5-18 parts of sesame rapeseed oil, 20-35 parts of calcined plaster, 11-15 parts of hydrargyri oxydum rubrum and a proper amount of acidic additive. The salvianic acid B-containing traditional Chinese medicine has the beneficial effects of definite therapeutic effect, stabilization and low cost, and provides comfortable feeling to patients. A preparation method comprises the following steps: 1)taking salvianic acid B according to the weight part, adding a proper amount of acidic additive, uniformly grinding to obtain powder salvianic acid B for standby; 2)taking calcined plaster and hydrargyri oxydum rubrum according to weight part, crushing into fine powder, adding sesame rapeseed oil, and continuously and uniformly grinding; and 3)adding the powder salvianic acid B obtained in the step 1) to the step 2), and grinding to obtain the product drug.
Description
Technical field
The invention belongs to Chinese medicine preparation preparation field, especially relate to a kind of lithospermic acid B that contains and be used for the treatment of and prevent Chinese medicine of hemorrhoid and preparation method thereof.
Background technology
Hemorrhoid are a kind of chronic diseases of the vein group of the venous plexus generation varicose of anal orifice and rectal intestine bottom and anal mucosa and one or more softnesses of forming.Hemorrhoid are a kind of frequently-occurring diseases, in American-European countries, are to adopt operative treatment, and patient is more painful, and patients after surgery also will be taken antibiotic.And in East Asia and country in Southeast Asia, especially our country, is to adopt the mode of the traditional Chinese medical science to treat.
Although have various Therapeutic Method for hemorrhoid, up to the present, also do not find determined curative effect, stable, patient feels without uncomfortable medicine.
Lithospermic acid B is water soluble ingredient main in labiate Radix Salviae Miltiorrhizae, have anti-myocardial ischemina, improve the multiple pharmacologically actives such as hemorheological property, its chemical composition is the four poly-Caffeic acids compounds (as shown in Figure 1) that two molecule danshensus and the condensation of a part prolithospermic acid form.Lithospermic acid B chemical property is very unstable, finds that lithospermic acid B (<0.1mg/mL) ambient temperature overnight loss under low concentration in aqueous solution approaches 30% in experiment, and its catabolite is danshensu, protocatechualdehyde etc.
Summary of the invention
The technical problem that the present invention solves is, provides a kind of determined curative effect, stable, cost is low, the hemorrhoid Chinese medicine containing lithospermic acid B to patient without discomfort.
For solving the problems of the technologies described above, the technical solution used in the present invention is to contain the piles medicine of lithospermic acid B, one-tenth by following parts by weight proportioning is grouped into: 10 ~ 70 parts of lithospermic acid Bs, 5 ~ 18 parts of Semen Sesami Oleum Brassicae campestriss, 20 ~ 35 parts of Gypsum Fibrosum Preparatum, 11 ~ 15 parts, Hydrargyri Oxydum Rubrum, appropriate acidic additive.
Inventor is through repeatedly studying discovery, and lithospermic acid B has sterilization, blood circulation promoting and blood stasis dispelling, improves microcirculation, removes the functions such as free radical, contributes to especially to treat hemorrhoid; Semen Sesami Oleum Brassicae campestris pharmacologic action is in the present invention to fall lung qi, sharp edema caused by the lung disorder and antiinflammatory; That Gypsum Fibrosum Preparatum has is antipyretic, ease pain and have the effect of hemostasis, the outer used time, skin mucosa is there is to effect of convergence, and Gypsum Fibrosum Preparatum is added to 20 ~ 35 parts, also there is the effect of antiinflammatory, with auxiliary the coordinating of Semen Sesami Semen Allii Tuberosi oil phase; Hydrargyri Oxydum Rubrum has stronger inhibitory action and has sterilization for escherichia coli common in piles, removes corruption muscle, expedites the emergence of the effect of new muscle; Because lithospermic acid B chemical property is very unstable, the change of its pH environment that acidic additive is conducive to, has important function to the stability of salvianolic acid B.
As a further improvement on the present invention, can add Borneolum Syntheticum 1 ~ 5 weight portion, be conducive to the pain relieving of dispelling the heat.
As a further improvement on the present invention, preferably technical scheme is, 50 parts of lithospermic acid Bs, 5 parts of Semen Sesami Oleum Brassicae campestriss, 20 parts of Gypsum Fibrosum Preparatum, 12 parts, Hydrargyri Oxydum Rubrum, appropriate acidic additive.
As a further improvement on the present invention, this piles medicine is emulsifiable paste shape, and the beneficial effect of its generation is to facilitate patient's external.
Another problem that the present invention will solve is to provide a kind of method of preparing containing the piles medicine of lithospermic acid B, comprises the following steps: (1) gets salvianolic acid B by weight ratio, adds appropriate acidic additive, grinds evenly, obtains powder salvianolic acid B for subsequent use; (2) get by weight ratio Gypsum Fibrosum Preparatum, Hydrargyri Oxydum Rubrum, after pulverization, adds Semen Sesami Oleum Brassicae campestris, continues to grind evenly; (3) the powder salvianolic acid B of gained in step (1) is added in step (2), grinds, get final product to obtain piles medicine; (4) can continue the piles medicine obtaining in (3) to make emulsifiable paste shape, facilitate patient to use.
Step (4), makes emulsifiable paste shape by the piles medicine in step (3), adopts the preparation method of those skilled in the art's routine; In step (2), when adding Semen Sesami Oleum Brassicae campestris, can also add Borneolum Syntheticum.
Accompanying drawing explanation
Accompanying drawing 1 is the chemical structural formula of lithospermic acid B.
concrete enforcement is mode
Extract the method for lithospermic acid B, can adopt following steps: red rooted salvia is pulverized, and puts in extraction pot, after adding 8 times of amount 0.01mol/L soak with hydrochloric acid and spending the night, with 14 times of water gaging percolation.The solution that percolation extracts is crossed AB-8 type macroporous resin column and is carried out purification, first remove with 0.01mol/L hydrochloric acid eluting the impurity not being adsorbed, remove the larger impurity of depolarization with 25% ethanol elution again, finally lyophilizing after 40% ethanol elution concentrating under reduced pressure recovery ethanol is obtained to the lithospermic acid B that purity is greater than 80%.Get the sample 1g that said method obtains, porphyrize, adds ethanol 5mL, fully stir, filter, get filtrate number and drip, point, on filter paper bar, after doing, is put under ultra-violet lamp (365nm) and is observed, aobvious pewter fluorescence, filter paper is suspended in liquor ammoniae fortis bottle and (does not contact liquid level), after 20min, take out, put under uviol lamp (365nm) and observe, highlight aeruginous fluorescence, show to contain in product lithospermic acid B.
The lithospermic acid B that in the present invention, embodiment adopts comes as for natural drug Engineering Technical Research Centre modern Chinese medicine chamber, Shandong Province.
Comparative example 1: by existing ointment for treating hemorrhoid medicine on market, contain 1 part of Sanguis Draxonis (weight portion), 0.5 part, Cinnabaris, 0.5 part of Olibanum, 0.5 part of Myrrha, 0.5 part of Cortex Phellodendri, 1 part of Calamina, forges 0.5 part of Radix Sanguisorbae, 0.5 part of Borneolum Syntheticum.
Use the patient of above-mentioned haemorrhoids ointment, 15 days wound healings, but in the process that uses ointment, there is pruritus in affected part, feeling has the discomforts such as foreign body.
Comparative example 2: also sell and have a kind of Chinese medicine for the treatment of hemorrhoid on market, formed 6 ~ 10 parts, Hydrargyri Oxydum Rubrum, 12 ~ 18 parts of Gypsum Fibrosum Preparatum, 4 ~ 8 parts of Borneolum Syntheticums, 20 ~ 30 parts of Semen Sesami Oleum Brassicae campestriss by following Chinese crude drug.
Use the Chinese medicine of the treatment hemorrhoid of technique scheme to need 15 talentes to fully recover.
The embodiment of the present invention 1: should be grouped into by the one-tenth of following parts by weight proportioning containing the piles medicine of lithospermic acid B: 20 parts of lithospermic acid Bs, 10 parts of Semen Sesami Oleum Brassicae campestriss, 20 parts of Gypsum Fibrosum Preparatum, 11 parts, Hydrargyri Oxydum Rubrum, appropriate acidic additive.
Its preparation method is: comprise the following steps:
(1) get by weight ratio 20 parts of lithospermic acid Bs, add appropriate acidic additive, grind evenly, obtain powder lithospermic acid B for subsequent use;
(2) get by weight ratio 20 parts of Gypsum Fibrosum Preparatum, 11 parts, Hydrargyri Oxydum Rubrum, after pulverization, adds 10 parts of Semen Sesami Oleum Brassicae campestriss, continues to grind evenly;
(3) the powder lithospermic acid B of gained in step (1) is added in step (2), grinds, get final product to obtain piles medicine, and then make emulsifiable paste shape.
Usage: by this emulsifiable paste shape be applied in hemorrhoid place containing the piles medicine of lithospermic acid B, after 10 days, can take effect, affected part is as before smooth, feels that affected part is refrigerant in use procedure, the pruritus of can not generating heat, in more complete latter 1 year and lose recurrence.
Pharmacology: there is sterilization, blood circulation promoting and blood stasis dispelling, improve microcirculation, remove effect of free radical containing lithospermic acid B, and have Semen Sesami Oleum Brassicae campestris, Gypsum Fibrosum Preparatum, Hydrargyri Oxydum Rubrum, appropriate acidic additive, these composition combinations, collaborative mutually, so that produced the medicinal effects out of the treatment of expecting and prevention hemorrhoid.
Embodiment 2: remainder is identical with embodiment 1, different: 50 parts of lithospermic acid Bs, 5 parts of Semen Sesami Oleum Brassicae campestriss, 20 parts of Gypsum Fibrosum Preparatum, 12 parts, Hydrargyri Oxydum Rubrum, appropriate acidic additive.
After patient uses, within 8 days, take effect, medicinal effects is obviously better than embodiment 1.
Claims (5)
1. containing a piles medicine for lithospermic acid B, it is characterized in that, this piles medicine is grouped into by the one-tenth of following parts by weight proportioning: 10 ~ 70 parts of lithospermic acid Bs, 5 ~ 18 parts of Semen Sesami Oleum Brassicae campestriss, 20 ~ 35 parts of Gypsum Fibrosum Preparatum, 11 ~ 15 parts, Hydrargyri Oxydum Rubrum, appropriate acidic additive.
2. the piles medicine containing lithospermic acid B as claimed in claim 1, is characterized in that, 50 parts of described lithospermic acid Bs, 5 parts of Semen Sesami Oleum Brassicae campestriss, 20 parts of Gypsum Fibrosum Preparatum, 12 parts, Hydrargyri Oxydum Rubrum, appropriate acidic additive.
3. the piles medicine containing lithospermic acid B as claimed in claim 1 or 2, is characterized in that, this piles medicine is emulsifiable paste shape.
4. a method of preparing the piles medicine containing lithospermic acid B as claimed in claim 1 or 2, comprises the following steps:
(1) get by weight ratio lithospermic acid B, add appropriate acidic additive, grind evenly, obtain powder lithospermic acid B for subsequent use;
(2) get by weight ratio Gypsum Fibrosum Preparatum, Hydrargyri Oxydum Rubrum, after pulverization, adds Semen Sesami Oleum Brassicae campestris, continues to grind evenly;
(3) the powder lithospermic acid B of gained in step (1) is added in step (2), grinds, get final product to obtain piles medicine.
5. preparation as claimed in claim 4, containing the method for the piles medicine of lithospermic acid B, is characterized in that, can continue the piles medicine obtaining in step (3) to make newborn paste medicament.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210496336.2A CN103845371A (en) | 2012-11-29 | 2012-11-29 | Salvianic acid B-containing traditional Chinese medicine for treating and preventing haemorrhoid and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210496336.2A CN103845371A (en) | 2012-11-29 | 2012-11-29 | Salvianic acid B-containing traditional Chinese medicine for treating and preventing haemorrhoid and preparation method thereof |
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| CN103845371A true CN103845371A (en) | 2014-06-11 |
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| CN201210496336.2A Pending CN103845371A (en) | 2012-11-29 | 2012-11-29 | Salvianic acid B-containing traditional Chinese medicine for treating and preventing haemorrhoid and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040037792A1 (en) * | 2000-08-11 | 2004-02-26 | Takasago International Corp. | Deodorizing composition and method of using same |
| CN1868493A (en) * | 2005-05-27 | 2006-11-29 | 王洪艳 | Traditional Chinese medicine for treating haemorrhoids |
-
2012
- 2012-11-29 CN CN201210496336.2A patent/CN103845371A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040037792A1 (en) * | 2000-08-11 | 2004-02-26 | Takasago International Corp. | Deodorizing composition and method of using same |
| CN1868493A (en) * | 2005-05-27 | 2006-11-29 | 王洪艳 | Traditional Chinese medicine for treating haemorrhoids |
Non-Patent Citations (4)
| Title |
|---|
| 台南市道德中西药局: "男人有痔大不幸", 《HTTPS://WWW.FACEBOOK.COM/PERMALINK.PHP?STORY_FBID=442416205794500&ID=141718962530894》 * |
| 张金浩: "《痔和便秘防与治》", 31 January 2010, 西安交通大学出版社 * |
| 朱金墙等: "丹酚酸B的稳定性及其降解机理研究进展", 《中国中医药信息杂志》 * |
| 陈志雄等: "《常见病症家庭简易疗法》", 31 August 2009, 科学技术文献出版社 * |
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Application publication date: 20140611 |
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