CN103827114B - 作为pde10a抑制剂的三唑并吡啶化合物 - Google Patents

作为pde10a抑制剂的三唑并吡啶化合物 Download PDF

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Publication number
CN103827114B
CN103827114B CN201280045398.XA CN201280045398A CN103827114B CN 103827114 B CN103827114 B CN 103827114B CN 201280045398 A CN201280045398 A CN 201280045398A CN 103827114 B CN103827114 B CN 103827114B
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methyl
base
pyridine
pyrazoles
acid amides
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Expired - Fee Related
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Chinese (zh)
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CN103827114A (zh
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亚历山大·弗洛尔
卡特里·格勒布科茨宾登
马蒂亚斯·克尔纳
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201280045398.XA 2011-09-19 2012-09-17 作为pde10a抑制剂的三唑并吡啶化合物 Expired - Fee Related CN103827114B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11181752.4 2011-09-19
EP11181752 2011-09-19
PCT/EP2012/068203 WO2013041472A1 (en) 2011-09-19 2012-09-17 Triazolopyridine compounds as pde10a inhibitors

Publications (2)

Publication Number Publication Date
CN103827114A CN103827114A (zh) 2014-05-28
CN103827114B true CN103827114B (zh) 2016-08-24

Family

ID=46851999

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CN201280045398.XA Expired - Fee Related CN103827114B (zh) 2011-09-19 2012-09-17 作为pde10a抑制剂的三唑并吡啶化合物

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Country Link
US (2) US8946427B2 (enExample)
EP (1) EP2758396B1 (enExample)
JP (1) JP2014526533A (enExample)
KR (1) KR101584925B1 (enExample)
CN (1) CN103827114B (enExample)
AU (1) AU2012311713A1 (enExample)
BR (1) BR112014006248A2 (enExample)
CA (1) CA2846758C (enExample)
CL (1) CL2014000641A1 (enExample)
CO (1) CO6900144A2 (enExample)
EA (1) EA201490599A1 (enExample)
ES (1) ES2626801T3 (enExample)
IL (1) IL231403A0 (enExample)
MX (1) MX2014003025A (enExample)
PE (1) PE20141553A1 (enExample)
PH (1) PH12014500499A1 (enExample)
SG (1) SG11201400759RA (enExample)
UA (1) UA108711C2 (enExample)
WO (1) WO2013041472A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2757882B1 (en) 2011-09-22 2020-11-04 Merck Sharp & Dohme Corp. Imidazopyridyl compounds as aldosterone synthase inhibitors
EP2757883B1 (en) 2011-09-22 2021-01-13 Merck Sharp & Dohme Corp. Triazolopyridyl compounds as aldosterone synthase inhibitors
DK2991984T3 (en) 2013-04-30 2017-05-08 Hoffmann La Roche PALLADIUM-CATALYST COUPLING OF PYRAZOLAMIDES
TWI652014B (zh) 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
CA2956268A1 (en) * 2014-07-30 2016-02-04 Mochida Pharmaceutical Co., Ltd. Pyrazole derivative manufacturing method
CA2956262A1 (en) * 2014-07-30 2016-02-04 Mochida Pharmaceutical Co., Ltd. Pyrazole derivative manufacturing method
CN112679467B (zh) 2015-03-11 2024-11-01 Fmc公司 杂环取代的二环唑杀有害生物剂
BR112017019326B1 (pt) 2015-03-12 2022-04-26 Fmc Corporation Composto, composição e método para controlar uma praga invertebrada
EP3359545B1 (en) 2015-10-08 2024-03-20 FMC Corporation Heterocycle-substituted bicyclic azole pesticides
ES2932627T3 (es) * 2017-08-22 2023-01-23 Bayer Ag Derivados heterocíclicos como pesticidas
EP3978077B1 (en) 2019-05-27 2023-11-29 Nihon Nohyaku Co., Ltd. Condensed heterocyclic compound having a bridgehead nitrogen atom or salt thereof, agricultural or horticultural insecticide comprising the compound, and method for using the insecticide
AR119140A1 (es) 2019-06-13 2021-11-24 Pi Industries Ltd Compuestos heterocíclicos fusionados y su uso como agentes de control de plagas
CN110396157B (zh) * 2019-08-07 2021-07-30 广州市建筑科学研究院有限公司 缓释型聚羧酸纳米减水剂及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1379777A (zh) * 1999-09-06 2002-11-13 弗·哈夫曼-拉罗切有限公司 氨基－三唑并吡啶衍生物
WO2010117926A1 (en) * 2009-04-07 2010-10-14 Schering Corporation Substituted triazolopyridines and analogs thereof
WO2011072694A1 (en) * 2009-12-17 2011-06-23 H. Lundbeck A/S Heteroaromatic phenylimidazole derivatives as pde10a enzyme inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012485A2 (en) 2003-07-31 2005-02-10 Bayer Pharmaceuticals Corporation Methods for treating diabetes and related disorders using pde10a inhibitors
NL2000397C2 (nl) * 2006-01-05 2007-10-30 Pfizer Prod Inc Bicyclische heteroarylverbindingen als PDE10 inhibitoren.
WO2010035745A1 (ja) * 2008-09-25 2010-04-01 杏林製薬株式会社 ヘテロ環ビアリール誘導体及びそれらを有効成分とするｐｄｅ阻害剤
WO2010059836A1 (en) * 2008-11-20 2010-05-27 Decode Genetics Ehf Substituted aza-bridged bicyclics for cardiovascular and cns disease
HRP20150345T1 (hr) * 2009-09-24 2015-05-08 F. Hoffmann-La Roche Ag Derivati imidazopiridina ili imidazopirimidina kao inhibitori fosfodiesteraze 10a
WO2011063830A1 (en) 2009-11-24 2011-06-03 Nokia Corporation An apparatus
TWI487705B (zh) * 2009-12-17 2015-06-11 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基三唑衍生物
TW201200516A (en) * 2009-12-17 2012-01-01 Lundbeck & Co As H Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1379777A (zh) * 1999-09-06 2002-11-13 弗·哈夫曼-拉罗切有限公司 氨基－三唑并吡啶衍生物
WO2010117926A1 (en) * 2009-04-07 2010-10-14 Schering Corporation Substituted triazolopyridines and analogs thereof
WO2011072694A1 (en) * 2009-12-17 2011-06-23 H. Lundbeck A/S Heteroaromatic phenylimidazole derivatives as pde10a enzyme inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia;Patrick R. Verhoest et al;《J. Med. Chem.》;20090724;第52卷;第5188页化合物28 *

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Publication number Publication date
IL231403A0 (en) 2014-04-30
UA108711C2 (uk) 2015-05-25
US20140303141A1 (en) 2014-10-09
US9227970B2 (en) 2016-01-05
PH12014500499A1 (en) 2014-04-14
KR20140075716A (ko) 2014-06-19
CL2014000641A1 (es) 2014-11-14
CN103827114A (zh) 2014-05-28
CA2846758C (en) 2017-09-12
EP2758396A1 (en) 2014-07-30
SG11201400759RA (en) 2014-07-30
US8946427B2 (en) 2015-02-03
EP2758396B1 (en) 2017-03-29
WO2013041472A1 (en) 2013-03-28
BR112014006248A2 (pt) 2017-04-11
CA2846758A1 (en) 2013-03-28
ES2626801T3 (es) 2017-07-26
CO6900144A2 (es) 2014-03-20
NZ621597A (en) 2015-04-24
EA201490599A1 (ru) 2014-07-30
KR101584925B1 (ko) 2016-01-12
AU2012311713A1 (en) 2014-03-13
PE20141553A1 (es) 2014-10-30
JP2014526533A (ja) 2014-10-06
MX2014003025A (es) 2014-05-28
US20150099735A1 (en) 2015-04-09

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