CN103816400A - Capsule for treating primary tuberculosis in children and preparation method thereof - Google Patents
Capsule for treating primary tuberculosis in children and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a capsule for treating primary tuberculosis in children and a preparation method thereof in order to solve the problem of treatment of primary tuberculosis in cooperation with isoniazid. The preparation method is characterized by comprising the following steps: (1) distilling coarse powder of fragrant sarcococca herb, rice-paper plant, ipomoea pes-caprae, trikeraia hookeri, luculia intermedia hutch and ficus pumila respectively with water vapor to extract essential oil, collecting the essential oil, then mixing the essential oil for later use, and collecting the dregs for later use; (2) mixing catclaw buttercup root, Chinese ladiestresses root or herb, Chinese taxillus herb, rhizoma pleionis, ophicalcite and mulberries with the dregs in the step 1, carrying out water extraction and alcohol precipitation, and drying the supernatant to obtain a primary material; (3) spraying the essential oil into the primary material, sieving the material with a 60-mesh sieve, and filling the powder into the capsule, thus obtaining the capsule. Clinical experiments prove that the capsule for treating primary tuberculosis in cooperation with isoniazid has the characteristics of good curative effect and relatively high safety and is worthy of clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to capsule of a kind of child's for the treatment of primary pulmonary tuberculosis and preparation method thereof.
Background technology
Tuberculosis is the chronic infectious disease being caused by mycobacterium tuberculosis, can invade and many internal organs, with pulmonary get involved form pulmonary tuberculosis (pulrnonary tuberculosis) the most common, discharge of bacteria patient is its important source of infection.Not necessarily morbidity after human infection tulase, when resistance reduces or cell-mediated allergy while increasing, just may cause clinical onset.Primary pulmonary tuberculosis (primary tuberculosis) refers to the primary infection that the tulase spittle is inhaled in air, and sickness rate is only 10% left and right.If the infected's Abwehrkraft des Koepers is strong, may even in many decades, there is not clinical tuberculosis in the several years.This kind of pulmonary tuberculosis is more common in child, and adult and old people are rare.
Primary pulmonary tuberculosis, especially the cooperation isoniazid of child patient treatment choice drug is isoniazid (INH), and the oral rear absorption of INH is rapid, can in several days, kill 90% of tuberculosis flora in focus, the inside and outside tulase of cell is all had to killing action, belong to full bactericide.The problem of INH maximum is that dosage >10mg/ (kgd) or responsive body constitution are prone to hepatic injury, some patients were also can occur together peripheral neuritis, allergy, erythra.
The traditional Chinese medical science is " pulmonary tuberculosis ", " consumptive disease in childhood " with respect to the name of disease of primary pulmonary tuberculosis, after the evil poison of pathogenesis sense consumptive disease worm, and struggle between vital QI and pathogen before this, then with the passing of time impairment of YIN, hyperactivity of fire caused by deficiency of YIN, the very cloudy consumption wound of gas or deficiency of both YIN and YANG.But due to the intervention of doctor trained in Western medicine antituberculotics, serious interference nature process lungy, but the anti-consumptive disease of the current traditional Chinese medical science coordinates isoniazid Therapeutic Method also to fall aspect asthenic fire in the parasite killing nourishing YIN of being based on traditional pulmonary tuberculosis, cause the stack of effect deadness, and the side effect that can not resist doctor trained in Western medicine antitubercular agent deposits yields.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the capsule of the treatment child primary pulmonary tuberculosis that side effect is little and preparation method thereof.
The technical scheme that the present invention solves its technical problem is: a kind of pharmaceutical composition that coordinates isoniazid treatment primary pulmonary tuberculosis, is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts, delicate fragrance osmanthus, 6 ~ 12 parts of Radix seu Herba Spiranthis Lanceae, 3 ~ 10 parts of Herba Chlorophyti Laxis, 6 ~ 12 parts of Pseudobulbus Cremastrae Seu Pleioness, go back 3 ~ 10 parts, bobbin, 6 ~ 12 parts of Herba Ipomoeae Pes-Capraes, 6 ~ 12 parts of Radix Ranunculi Ternatis, 6 ~ 12 parts of Caulis fici pumilae (Fructus Fici Pumilae)s, 6 ~ 12 parts of Fructus cinnamomi immaturus, 1 ~ 5 part of Ophicalcitum, 3 ~ 10 parts of Fructus Mori, 10 ~ 25 parts of Herba Taxillis.
Chinese medicine of the present invention can be prepared from by following method:
(1) by delicate fragrance osmanthus, go back bobbin, Herba Ipomoeae Pes-Capraes, Herba Chlorophyti Laxi, Fructus cinnamomi immaturus, Caulis fici pumilae (Fructus Fici Pumilae) coarse powder respectively with vapor distillation extract volatile oil, and collect after mixing for standby use, medicinal residues are for subsequent use;
(2) medicinal residues in Radix Ranunculi Ternati, Radix seu Herba Spiranthis Lanceae, Herba Taxilli, Pseudobulbus Cremastrae Seu Pleiones, Ophicalcitum, Fructus Mori and step 1 are mixed and add 5 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, left standstill; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, leave standstill 15 minutes, then with 3000rpm/min centrifugal 20 minutes, get supernatant, spraying is dry, draws just material;
(3) gained volatile oil in step 1 is sprayed in the first material of step 2 gained, mix, cross 60 mesh sieves, encapsulated forming.
Wherein said: delicate fragrance osmanthus is Buxaceae Sarcococca plant delicate fragrance osmanthus Sarcococca ruscifolia Stapf root.Nature and flavor are pungent, bitter, flat.Merit can regulating QI to relieve pain, dispelling, collateral-activating.
Radix seu Herba Spiranthis Lanceae, for the orchid family Spiranthes plant Radix seu Herba Spiranthis Lanceae Spiranthes australis (R. Brown.) Lindl., with root, all herbal medicine.Nature and flavor are sweet, light, flat.Merit can enriching yin boost qi, removing pathogenic heat from blood and toxic substance from the body.
Herba Chlorophyti Laxi is herb or the root of feverfew Prenanthes henryi Dunn Prenanthes henryi Dunn.Bitter in the mouth; Cold in nature.Merit can heat-clearing and toxic substances removing; Dissipating blood stasis hemostasis.
Pseudobulbus Cremastrae Seu Pleiones is orchid Cremastra appendiculata Cremastra appendiculata (D.Don) Makino, pleione bulbocodioides Pleione bulbocodioides(Franch.) the dry pseudobulb of Rolfe or Pleione yunnanensis Pleione yunnanensis Rolfe.Nature and flavor are sweet, micro-pungent, cold.Enter liver, stomach warp.Merit can heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.
Also bobbin is the fruit of orchid Rhizoma Gastrodiae Gastrodia elata Bl..Sweet in the mouth; Cold in nature.Merit can tonify deficiency subduing the wind syndrome.
Herba Ipomoeae Pes-Capraes is the herb of Convolvulaceae morning glory two leaf Radix Ipomoeae Ipomoea pescarpae (L.) Sweet.Pungent, the micro-hardship of nature and flavor, wet.Merit can expelling wind and removing dampness, the detumescence of drawing out pus by applying a plaster to the affected part.
Radix Ranunculi Ternati is the dried root of the little Herba Ranunculi Japonici Ranunculus of ranunculaceae plant ternatus Thunb..Nature and flavor sweet, acrid, warm.Return liver, lung meridian.Merit can eliminating stagnation, detumescence.
Caulis fici pumilae (Fructus Fici Pumilae) is stem, the leaf of moraceae plants Caulis fici pumilae (Fructus Fici Pumilae) Ficus pumila L..Sour in the mouth, cool in nature.Merit can expelling wind and removing dampness; Promoting blood circulation to remove obstruction in the collateral; Removing toxic substances and promoting subsidence of swelling.
Fructus cinnamomi immaturus is the tender fruit of children of canella Cortex Cinnamomi.Gas fragrance, taste is micro-sweet.Nature and flavor Wen Xingan, returns stomach warp.Merit can warming spleen and stomach for dispelling cold.
Ophicalcitum is metamorphic rock rocks ophicalcite Serpentine.Nature and flavor acid, puckery, flat.Return Liver Channel.Merit can removing stasis to stop bleeding, sore.
Fructus Mori is the dry fruit ear of moraceae plants Mulberry Morus alba L..Nature and flavor are sweet, sour, cold.GUIXIN, liver, kidney channel.The merit YIN nourishing of can enriching blood, promotes the production of body fluid and moisturizes.
Herba Taxilli is the dry stem and branch with leaf of Loranthaceae plant Herba Taxilli Taxillus chinensis (DC.) Danser.Nature and flavor bitter, sweet, flat.Return liver, kidney channel.Merit can invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.
Composition principle: the traditional Chinese medical science is " pulmonary tuberculosis ", " consumptive disease in childhood " with respect to the name of disease of primary pulmonary tuberculosis, after the evil poison of pathogenesis sense consumptive disease worm, struggle between vital QI and pathogen before this, then with the passing of time impairment of YIN, hyperactivity of fire caused by deficiency of YIN, the very cloudy consumption wound of gas or deficiency of both YIN and YANG.But due to the intervention of doctor trained in Western medicine antituberculotics, serious interference nature process lungy, but the anti-consumptive disease of the current traditional Chinese medical science coordinates isoniazid Therapeutic Method also to fall aspect asthenic fire in the parasite killing nourishing YIN of being based on traditional pulmonary tuberculosis, cause the stack of effect deadness, and the side effect that can not resist doctor trained in Western medicine antitubercular agent deposits yields.
Compared with prior art, the present invention has following characteristics.
1, prescription uniqueness: get delicate fragrance osmanthus, Radix seu Herba Spiranthis Lanceae in side for monarch, described delicate fragrance osmanthus and the two combination of Radix seu Herba Spiranthis Lanceae can lung heat clearing networks, sharp blood vessels, regulating menstruation is regulated the flow of vital energy, and its feature is that Papillary can remove pathogenic wind in lung network.Inventor's laboratory pharmacological research shows: heavy dose of delicate fragrance osmanthus decoct rat oral gavage (1000mg/kg), can resist the rat liver homogenate lipid peroxidation of FeC12-vitamin C-ADP mixture induction, and malonaldehyde (MDA) content is declined; The rats'liver infringement that isoniazid is caused has inhibitory action.So the two coordinates except can effectively removing pathogenic wind in lung network, alleviate outside respiratory symptom, also have and the effect of nourishing liver.
2, in side, get Herba Chlorophyti Laxi, Pseudobulbus Cremastrae Seu Pleiones, go back bobbin, Herba Ipomoeae Pes-Capraes is minister: the reciprocal causation of the primary pulmonary tuberculosis expectorant stasis of blood, therefore choose Herba Chlorophyti Laxi removing toxic substances dissipating blood stasis; Monarch drug dredging collateral power is strong, and the turbid effect deficiency of eliminating the phlegm, therefore get Pseudobulbus Cremastrae Seu Pleiones expectorant powder junction; The basis of expectorant is that water is turbid, therefore get Herba Ipomoeae Pes-Capraes dehumidifying; Also among bobbin and we, there is the merit of open-minded deficiency-phlegm.
3, supplementary drug thing: Radix Ranunculi Ternati eliminating stagnation, contributes to reduce the later stage to tie empty formation; Caulis fici pumilae (Fructus Fici Pumilae) helps Herba Chlorophyti Laxi removing toxic substances dissipating blood stasis; Fructus Mori, Herba Taxilli help goes back bobbin invigorating the liver and kidney, vital base and primordial QI consolidating; Fructus cinnamomi immaturus warming middle-JIAO, one sideization cold-phlegm, also has the balanced property of medicine on the other hand, prevents cold and cool meaning too.
4, get Ophicalcitum using corrigent, get the meaning of its convergence.
5, medicine material consumption of the present invention is to grope in a large number to sum up through inventor to draw: delicate fragrance osmanthus dosage is heavier, and there is the merit of replenishing blood and nourishing liver this dosage below; Ophicalcitum dosage is less, gets the meaning of its convergence using corrigent, and can not affect the overall property of medicine of our row lung network.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: 20 parts, delicate fragrance osmanthus, 10 parts of Radix seu Herba Spiranthis Lanceae, 6 parts of Herba Chlorophyti Laxis, 10 parts of Pseudobulbus Cremastrae Seu Pleioness, go back 6 parts, bobbin, 10 parts of Herba Ipomoeae Pes-Capraes, 10 parts of Radix Ranunculi Ternatis, 10 parts of Caulis fici pumilae (Fructus Fici Pumilae)s, 10 parts of Fructus cinnamomi immaturus, 2 parts of Ophicalcitums, 6 parts of Fructus Mori, 20 parts of Herba Taxillis.
The preparation method of embodiment 1 is: by delicate fragrance osmanthus, Radix seu Herba Spiranthis Lanceae, Herba Chlorophyti Laxi, Pseudobulbus Cremastrae Seu Pleiones, go back bobbin, Herba Ipomoeae Pes-Capraes, Radix Ranunculi Ternati, Caulis fici pumilae (Fructus Fici Pumilae), Fructus cinnamomi immaturus, Ophicalcitum, Fructus Mori, Herba Taxilli mixing and water adding and decoct, after 30 minutes, get filtrate, medicinal residues add water to continue to decoct after 20 minutes and get filtrate, twice filtrate merges, and is divided into two parts of morning and evenings to take.
Embodiment 2, crude drug weight proportion: 10 parts, delicate fragrance osmanthus, 6 parts of Radix seu Herba Spiranthis Lanceae, 3 parts of Herba Chlorophyti Laxis, 6 parts of Pseudobulbus Cremastrae Seu Pleioness, go back 3 parts, bobbin, 6 parts of Herba Ipomoeae Pes-Capraes, 6 parts of Radix Ranunculi Ternatis, 6 parts of Caulis fici pumilae (Fructus Fici Pumilae)s, 6 parts of Fructus cinnamomi immaturus, 1 part of Ophicalcitum, 3 parts of Fructus Mori, 10 parts of Herba Taxillis.
Embodiment 3, crude drug weight proportion: 20 parts, delicate fragrance osmanthus, 10 parts of Radix seu Herba Spiranthis Lanceae, 6 parts of Herba Chlorophyti Laxis, 10 parts of Pseudobulbus Cremastrae Seu Pleioness, go back 6 parts, bobbin, 10 parts of Herba Ipomoeae Pes-Capraes, 10 parts of Radix Ranunculi Ternatis, 10 parts of Caulis fici pumilae (Fructus Fici Pumilae)s, 10 parts of Fructus cinnamomi immaturus, 2 parts of Ophicalcitums, 6 parts of Fructus Mori, 20 parts of Herba Taxillis.
Embodiment 4, crude drug weight proportion: 30 parts, delicate fragrance osmanthus, 12 parts of Radix seu Herba Spiranthis Lanceae, 10 parts of Herba Chlorophyti Laxis, 12 parts of Pseudobulbus Cremastrae Seu Pleioness, go back 10 parts, bobbin, 12 parts of Herba Ipomoeae Pes-Capraes, 12 parts of Radix Ranunculi Ternatis, 12 parts of Caulis fici pumilae (Fructus Fici Pumilae)s, 12 parts of Fructus cinnamomi immaturus, 5 parts of Ophicalcitums, 10 parts of Fructus Mori, 25 parts of Herba Taxillis.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) by delicate fragrance osmanthus, go back bobbin, Herba Ipomoeae Pes-Capraes, Herba Chlorophyti Laxi, Fructus cinnamomi immaturus, Caulis fici pumilae (Fructus Fici Pumilae) coarse powder respectively with vapor distillation extract volatile oil, and collect after mixing for standby use, medicinal residues are for subsequent use;
(2) medicinal residues in Radix Ranunculi Ternati, Radix seu Herba Spiranthis Lanceae, Herba Taxilli, Pseudobulbus Cremastrae Seu Pleiones, Ophicalcitum, Fructus Mori and step 1 are mixed and add 5 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, left standstill; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, leave standstill 15 minutes, then with 3000rpm/min centrifugal 20 minutes, get supernatant, spraying is dry, draws just material;
(3) gained volatile oil in step 1 is sprayed in the first material of step 2 gained, mix, cross 60 mesh sieves, encapsulated forming.
Can set every capsules is 0.5g.
Effective combination of said medicine, coordinates mutually, effectively reach the object that coordinates isoniazid treatment primary pulmonary tuberculosis, and side effect is less.The above results is that clinical data fully proves, interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: in June, 2011 ~ 2013 are diagnosed as primary pulmonary tuberculosis 89 examples year June, 4 ~ 11 years old age, male 54 examples, female's 35 examples.89 routine patients are divided into matched group 30 examples, decoction group 29 examples and Capsules group 30 examples, before three groups of patient treatments, in sex, age, the course of disease, compare, and difference not statistically significant (P>0.05), has comparability.
1.1.2 diagnosis basis: foundation " clinical criteria of Child Pulmonary Tuberculosis and therapeutic scheme (trying) " 1. clinical manifestation in 2006: heating, cough continue more than 2 weeks, or pant etc.; 2. chest X-ray: performance is formed " bipolar picture " or claimed " dumbbell picture " by the lymph node of primary tumor, lymphangitis and intrathoracic enlargement in lung; 3. sputum, gastric juice or bronchoalveolar lavage fluid tubercule bacillus smear or cultivation are positive; 4. pathologic inspection meets pulmonary tuberculosis feature.Have the 1. with the 2., and the 3. or 4. item person.
1.2 method.
1.2.1 Therapeutic Method: matched group is take " clinical criteria of Child Pulmonary Tuberculosis and therapeutic scheme (trying) " therapeutic scheme as foundation, application isoniazid 10mg/ kg, rifampicin 10mg/ kg are oral, and it is oral that what after 15 days, symptom can not get controlling use isoniazid 10mg/ kg, ethambutol 25mg/ kg instead.Decoction group and Capsules group are on the treatment basis of matched group, and decoction group adds with gained decoction oral in the embodiment of the present invention 1,2 times/d, after one month, use gained capsule oral in embodiment 3 instead, Capsules group adds with gained capsule oral in the embodiment of the present invention 3,2g/ time, 2 times/d.It within 3 months, is a course for the treatment of.Treat and carry out efficacy evaluation in 3 months later, as do not reach clinical cure and carry out the treatment of second course for the treatment of.
1.2.2 criterion of therapeutical effect: 1. symptom disappears completely; 2. chest X-ray primary complex performance disappears; 3. smear or cultivation are negative.Three groups were carried out respectively efficacy evaluation at 3 months and 6 months.
1.2.3 statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data is checked with t, enumeration data χ
2check.
2 results.
Rear 3 months three groups of Comprehensive Clinical curative effects of 2.1 treatment comparison: matched group cure rate is 67.67%(20/30), decoction group is 93.10%(26/29), Capsules group is 93.33%(28/30).Three groups of comparisons, decoction group and Capsules group are apparently higher than matched group (decoction group χ
2=4.54, P<0.05; Capsules group χ
2=6.67, P<0.05).
Rear 6 months three groups of Comprehensive Clinical curative effects of 2.2 treatment comparison: after 6 months, three groups of cure rates are 100%.
2.3 3 groups of adverse reactions of patients incidence rates comparison: after treatment, matched group has 33.33% patient to occur untoward reaction, wherein abnormal liver function 9 examples, peripheral neuritis 2 examples, nausea and vomiting 1 example; Decoction group has 10.34% patient to occur untoward reaction, wherein abnormal liver function 2 examples, nausea and vomiting 2 examples; Capsules group has 10.00% patient to occur untoward reaction, wherein abnormal liver function 2 examples.Three groups of comparisons, decoction group and Capsules group are starkly lower than matched group (decoction group χ
2=4.54, P<0.05; Capsules group χ
2=4.81, P<0.05).
3. conclusion.
This result of study shows, take decoction group of the present invention and Capsules group total effective rate apparently higher than matched group, and without obvious adverse reaction, illustrate that pharmaceutical composition prepared by the inventive method has that effect is clear and definite, untoward reaction is light, the higher advantage of safety aspect isoniazid treatment primary pulmonary tuberculosis coordinating.
Claims (1)
1. treat capsule of child's primary pulmonary tuberculosis and preparation method thereof for one kind, it is characterized in that, its crude drug is delicate fragrance osmanthus, Radix seu Herba Spiranthis Lanceae, Herba Chlorophyti Laxi, Pseudobulbus Cremastrae Seu Pleiones, goes back bobbin, Herba Ipomoeae Pes-Capraes, Radix Ranunculi Ternati, Caulis fici pumilae (Fructus Fici Pumilae), Fructus cinnamomi immaturus, Ophicalcitum, Fructus Mori, Herba Taxilli, and preparation method is made up of following steps:
(1) by delicate fragrance osmanthus, go back bobbin, Herba Ipomoeae Pes-Capraes, Herba Chlorophyti Laxi, Fructus cinnamomi immaturus, Caulis fici pumilae (Fructus Fici Pumilae) coarse powder respectively with vapor distillation extract volatile oil, and collect after mixing for standby use, medicinal residues are for subsequent use;
(2) medicinal residues in Radix Ranunculi Ternati, Radix seu Herba Spiranthis Lanceae, Herba Taxilli, Pseudobulbus Cremastrae Seu Pleiones, Ophicalcitum, Fructus Mori and step 1 are mixed and add 5 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, left standstill; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, leave standstill 15 minutes, then with 3000rpm/min centrifugal 20 minutes, get supernatant, spraying is dry, draws just material;
(3) gained volatile oil in step 1 is sprayed in the first material of step 2 gained, mix, cross 60 mesh sieves, encapsulated forming.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104888035A (en) * | 2015-05-28 | 2015-09-09 | 史风 | Chinese medicinal granules for treating primary pulmonary tuberculosis and preparation method thereof |
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| CN102188615A (en) * | 2011-04-19 | 2011-09-21 | 张海英 | Method for treating scrofula |
| CN102727779A (en) * | 2012-07-04 | 2012-10-17 | 王海霞 | Pharmaceutical composition for treating ovarian cysts and preparation method thereof |
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