CN103816262A - Medicine for treating neonatal gastrointestinal dysfunction - Google Patents
Medicine for treating neonatal gastrointestinal dysfunction Download PDFInfo
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Abstract
The invention relates to a medicine for treating neonatal gastrointestinal dysfunction, and belongs to the field of traditional Chinese medicines. The medicine is characterized in that effective components are prepared from rheum officinale, astragalus membranaceus, fried rhizoma atractylodis macrocephalae, white poria, fruits of immature citron, roots of common peony and capillary artemisia in a certain proportion. The medicine can remarkably improve the clinical symptoms of infants with gastrointestinal dysfunction, effectively improve the gastroenteric function and meanwhile, can motivate increase of IgA, IgG and IgM secretion of the own immune system of the infant, so that the humoral immunity function of the infant is improved. The traditional Chinese medicine preparation is free from toxic and side effects and any untoward effects in the medication process, can be clystered and orally taken, and is easy to accept.
Description
Technical field
The invention belongs to the field of Chinese medicines, particularly a kind of Chinese medicine preparation for the treatment of Neonatal gastrointestinal dysfunction.
Background technology
Gastrointestinal dysfunction is the commitment of gastrointestinal functional failure, and neonate, because gastrointestinal growth is immature, more easily occurs gastrointestinal dysfunction, and the state of an illness is dangerous, treatment difficulty.At present the pathogenesis of Neonatal gastrointestinal dysfunction is not set forth clearly completely, lacks unified perfect diagnosis and treatment standard, clinically mainly adopts Comprehensive Treatment also without specific treatment method, Cure the Primary Disease, but case fatality rate is still very high.Doctor trained in Western medicine treatment primary disease aspect without specific therapy, the main digestive tract power such as acid inhibitor and the motilium medicines such as cimetidine that adopt, as neonate is taken Medilac-Vita medicine, but curative effect is not outstanding, because microbial ecological agent is in neonate application experience deficiency, also can cause infection, larger to neonate toxic and side effects.The Chinese patent medicine of Chinese traditional treatment primary disease mainly contains YUNNAN BAIYAO, XUEBIJING etc., and YUNNAN BAIYAO main component is Radix Notoginseng (its effective ingredient is triterpenoid saponin, flavonoid glycoside, alkaloid), has blood circulation promoting and blood stasis dispelling, hemostasis, anti-inflammation detumescence, toxin expelling effect.XUEBIJING has the effect of potent anti-endotoxin, the effect that the endogenous inflammatory mediator property out of control that also has potent anti-endotoxin induction monocyte/macrophage to produce discharges, but cure rate, effective percentage are lower.
Summary of the invention
The object of the present invention is to provide a kind of medicine for the treatment of Neonatal gastrointestinal dysfunction, pure Chinese medicinal preparation, has no side effect, and cure rate is high.
The present invention is except possessing blood circulation promoting and blood stasis dispelling, hemostasis, anti-inflammation detumescence, toxin expelling effect, also emphasize " The spleen and stomach provide the material basis of the acquired ", by improving environment in digestive tract, promote congenital and adaptive immunity, curative effect more comprehensively, deficiency and excess is taken into account, and has embodied better " organic conception " and " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs " application in clinical.
The present invention is achieved in that
The medicine for the treatment of Neonatal gastrointestinal dysfunction, is characterized in that the raw material composition of making effective ingredient is by weight ratio: Radix Et Rhizoma Rhei 2-3, Radix Astragali 3-6, Rhizoma Atractylodis Macrocephalae (parched) 3-6, Poria 3-6, Fructus Aurantii Immaturus 3-6, Radix Paeoniae Rubra 3-6 and Herba Artemisiae Scopariae 3-6.
Medicine of the present invention can obviously improve gastrointestinal dysfunction infant clinical symptoms, effectively improves gastrointestinal function, also can excite infant autoimmune system IgA simultaneously, IgG, and IgM secretes increase, thereby improves children patient humoral immune function.And this Chinese medicine preparation, has no side effect, in medication process, have no any untoward reaction, can coloclysis also can be oral, be easy to accept.
The present invention has following clinical effectiveness:
One, prescription medical material high quality materials, meet and according to Chinese Pharmacopoeia and pharmacology compatibility, concoct, compatibility is proper, coordinates scientific and reasonable;
Two, pure Chinese medicinal preparation, has no side effect, taking convenience, and price material benefit;
Three, cure rate is high.Empirical tests, total effective rate 90% of the present invention.
Modern medicine is thought neonate gastrointestinal function developmental immaturity, especially premature infant, gastric mucosa rich blood vessel, but goblet cell and body of gland are all less than adult, hydrochloric acid and the various enzyme of secretion are all less than adult, gastric acidity is low, be unfavorable for killing pathogen, the in the situation that of anoxia-induced apoptosis and infection, gastrointestinal mucosa produces a large amount of reactive oxygen free radical while perfusion again, infringement mucosa cells causes the mucosa necrosis that comes off, there is toxical paralytic ileus, enterokinesia is slowed down, antibacterial and endotoxin directly or indirectly cause intestinal mucosal lesion simultaneously, Mucosa Barrier destroys, permeability increases, further increase the weight of gastrointestinal function damage, cause abdominal distention, vomiting or the symptom such as hemorrhage occur.The cause of disease that causes Neonatal gastrointestinal dysfunction mainly contains that middle severe hypoxia suffocates, severe infections, premature infant and low weight, septicemia, necrotizing enterocolitis, intracranial hemorrhage, severe are firmly swollen etc., wherein causes that with newborn with heavy asphyxia Hypoxia and ischemia gastrointestinal dysfunction is the most common.Chinese medicine is thought, neonate natural endowment deficiency, and, easily there is Jiao in improper feeding damaging the stomach, exopathogen criminal stomach, retardance, disturbance mechanism of qi, the performances such as stagnation of QI causing retention of food in " the young sun of young the moon ".Belong to " deficiency in origin and excess in superficiality " more.Purge heat, remove remaining evil therefore the treatment of Neonatal gastrointestinal dysfunction is mainly intended to QI and blood regulating, invigorating spleen and reinforcing stomach, Tongli.
The invaluable experience of the present invention understanding to the Neonatal gastrointestinal dysfunction cause of disease and pathogenesis and treatment with reference to motherland's medical science, consult existing reasonable formula, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, according to motherland's pharmacopeia and pharmacology compatibility, weed out the old and bring forth the new, be for the successful medicine of traditional medicine treatment Neonatal gastrointestinal dysfunction, can effectively treat Neonatal gastrointestinal dysfunction.
Modern pharmacological research proves:
1, Radix Et Rhizoma Rhei
Property hardship, cold, there is heat and toxic materials clearing away, clearing away heat-fire, removing toxic substances, blood circulation promoting and blood stasis dispelling, effect of hemostasis, can be used for treating tire just to discharge delay, tire is just discharged not smooth.The main component in Radix Et Rhizoma Rhei with catharsis effect is anthraquinone glycoside and dianthracene ketone glycoside, contains again rheotannic acid (Rheum tannic acids) and related substances thereof, and as gallic acid, cachou extract, tetrarin, this type of material has anti-diarrhea effect.In addition, Radix Et Rhizoma Rhei still contains fatty acid, calcium oxalate, glucose, fruit sugar and starch.
2, Fructus Aurantii Immaturus
Nature and flavor bitter, acrid, cold, have and regulate the flow of vital energy except painful abdominal mass, effect of circulation of qi promoting intestinal stasis relieving, can be used for controlling feeling of fullness, lead stagnant.Modern pharmacology finds that this Chinese medicine can excited gastrointestinal, makes it shrink rhythm and pace of moving things strong, and its extract shrinks and has obvious antagonism intestinal tube due to acetylcholine and histamine.
3, Radix Paeoniae Rubra
Property acid, hardship, cool, point excess-heat that purifies the blood, the effect that dissipating blood stasis blood is detained.Contain paeoniflorin, oxypaeoniflorin, benzoylpaeoniflorin, albiflorin, paeoniflorin without ketone, Galla Turcica (Galla Helepensis) acyl paeoniflorin, containing dextrorotation cachou extract and volatilization wet goods, have the modern pharmacology effect of antithrombotic formation, antiplatelet aggregation again.
4, Poria
Sweet in the mouth, light flat.There is effect of promoting diuresis to eliminate damp pathogen, spleen invigorating.Containing β-pachyman, multiple tetracyclic triterpenoid, ergosterol, choline, adenine etc.There are the immunity of adjusting, strengthening the spleen and stomach, anti-infective effect, clinical in the strong treatment that waits card of insufficiency of the spleen transporting mistake.
5, the Rhizoma Atractylodis Macrocephalae
Property hardship, sweet, temperature.There is the function such as air making-up and spleen enlivening, dampness diuretic.Main chemical compositions is volatile oil, lactone compound and polysaccharide.Can strengthen the activity of small intestinal Spontaneous Contraction, and Rhizoma Atractylodis Macrocephalae oil can suppress the autonomic movement of intestinal tube, suppress stress ulcer and occur.
6, the Radix Astragali
Nature and flavor, sweet, tepor, effect is gentle, and main pharmacological is the feature of benefiting QI for strengthening the superficies.The Radix Astragali contains the Multiple components such as polysaccharide, glycoside, flavone and trace element, and cellular metabolism, nucleic acid metabolism, antibacterial and viral infection etc. are had to remarkable effect, and immune system, hormonal system etc. are all had to wide influence.
7, Herba Artemisiae Scopariae
Bitter in the mouth, has the effect of clearing away heat-damp and promoting diuresis, jaundice eliminating, and containing volatile oil, capillarisin, 6,7-dimethoxy coumarin, arcapillin A, B etc., have antipyretic, anti-inflammation, excited intestinal smooth, and immunity-regulating.
Theory of Chinese medical science thinks, Neonatal Congenital is reported QI-insufficiency, easily occurs in improper feeding damaging the stomach, retardance burntly, and exopathogen is violated stomach, enteral has bacterium, disturbance mechanism of qi, the performances such as stagnation of QI causing retention of food.Belong to " deficiency in origin and excess in superficiality ".Therefore the treatment of Neonatal gastrointestinal dysfunction is mainly intended to regulate QI and blood, clearing heat and expelling damp, Tongli purge heat, invigorating spleen and reinforcing stomach, removing are remaining evil.Research discovery by experiment, originally can pass through antiinflammatory, antipathogen, and effectively preventing common cold stimulates the inhibition that causes macrophage phagocytic and sterilizing function, and the lymphocytic immunologic function of prevention inhibition, has good immunoregulation effect.In addition, theory of Chinese medical science is emphasized " The spleen and stomach provide the material basis of the acquired ", and we, by improving gastrointestinal function, improve digestive tract internal environment, resist the transplanting of other bacterial strain, regulates mucomembranous immune system, regulates respiratory mucosa, promotes innate immunity and adaptive immunity.Said preparation is made up of Radix Et Rhizoma Rhei, Fructus Aurantii Immaturus, Radix Paeoniae Rubra, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Poria, Herba Artemisiae Scopariae seven flavor medicine.Radix Et Rhizoma Rhei heat and toxic materials clearing away, clearing away heat-fire, removing toxic substances, blood circulation promoting and blood stasis dispelling, hemostasis; Poria promoting diuresis to eliminate damp pathogen, spleen invigorating; Fructus Aurantii Immaturus, dispelling the stagnated QI is except painful abdominal mass, removing food stagnancy; The Rhizoma Atractylodis Macrocephalae, air making-up and spleen enlivening, dampness diuretic; The Radix Astragali, tonifying Qi and lifting yang, benefit is defended consolidating superficial resistance, inducing diuresis to remove edema; Herba Artemisiae Scopariae, eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice; Radix Paeoniae Rubra, clearing away heat and cooling blood, eliminating stasis to stop pain.We are take Radix Et Rhizoma Rhei as principal agent, and it rushes down exerts oneself by force, and assistant is with Poria spleen invigorating, and the two one falls He, in case under rushing down too, firm middle gas; Fructus Aurantii Immaturus, Radix Paeoniae Rubra are ministerial drug, are intended to strengthen the stagnant blood stasis dispelling effect that disappears; Neonate is tender and lovely because of its internal organs, and shape gas does not fill, dysfunction of the spleen, and experiencing damp and hot heresy can not defeatedization, and pent-up is in inner, functional activity of QI being not smooth, hot and suffocating liver and gall, so that bile leaks, and overflows in skin appearance, yellowing of the skin, and this side adds with Herba Artemisiae Scopariae, is intended to eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice; Neonatal immune system developmental immaturity, has a low resistance, and this side gets the Radix Astragali, Rhizoma Atractylodis Macrocephalae replenishing QI to invigorate the spleen, and the effect of tonifying Qi and lifting yang, is intended to righting.Full side is eliminating evil is main, and righting is auxiliary, and one dispels one holds up, and complements each other, and righting is for eliminating evil, by strengthening the method for healthy energy, gets rid of evils and goes out, be i.e. so-called " just containing evil in dispelling ".Eliminating evil is for righting, eliminate the infringement of paathogenic factor and reach protection healthy energy, restorative object is so-called: " heresy is gone just from peace ".
The specific embodiment
Below in conjunction with embodiment, the present invention is elaborated.
Embodiment 1
1, the side's of getting Chinese medicine Radix Et Rhizoma Rhei 2g, Radix Astragali 3g, Rhizoma Atractylodis Macrocephalae (parched) 3g, Poria 3g, Fructus Aurantii Immaturus 3g, Radix Paeoniae Rubra 3g and Herba Artemisiae Scopariae 3g.Soak half an hour, hot digestion 1.5 hours, gets filtrate stand-by.
2, the residue steaming and decocting 1 hour that adds water again after steaming and decocting, obtains filtrate.
3, merge 2 times to obtain filtrate, obtain medicine of the present invention.Oral: every day 3 times, every day 2-10ml.
Using method: the present invention can be prepared into oral liquid formulation, can also be prepared into powder, pill, electuary, capsule and unguentum according to a conventional method, also can get above-mentioned raw materials medicine and make important decoct by proportioning and take.
Embodiment 2
Divide and get Radix Et Rhizoma Rhei 3g, Radix Astragali 4g, Rhizoma Atractylodis Macrocephalae (parched) 4g, Poria 4g, Fructus Aurantii Immaturus 4g, Radix Paeoniae Rubra 4g and Herba Artemisiae Scopariae 4g.Manufacture method and instructions of taking, with embodiment 1, can effectively be treated stool thin, complete not change of Gu person.
Embodiment 3
Divide and get Radix Et Rhizoma Rhei 2g, Radix Astragali 6g, Rhizoma Atractylodis Macrocephalae (parched) 6g, Poria 6g, Fructus Aurantii Immaturus 6g, Radix Paeoniae Rubra 6g and Herba Artemisiae Scopariae 6g.Manufacture method and instructions of taking, with embodiment 1, can effectively be treated intestinal bleeding, and stool alteration of form person holds concurrently.
Clinical trial
For the curative effect of checking medicine of the present invention, applicant carries out following clinical trial in 2010-2013 in Liaocheng of Shandong Province the People's Hospital department of pediatrics:
One, clinical data
1, test altogether the birth less than neonatal patient of 28 days 230 examples of gastrointestinal function obstacle, wherein female's 93 examples, male 137 examples.
2, above-mentioned patient is divided into two groups at random:
First group is treatment group, totally 117 examples, wherein female's 55 examples, male 62 examples;
Second group is matched group, totally 113 examples, wherein female's 38 examples, male 75 examples.
Two, diagnostic criteria
In conjunction with the Neonatal gastrointestinal dysfunction guide of AAP's proposition in 2003, formulate Neonatal gastrointestinal dysfunction standard:
Slight performance: the 25%-50% of Wei Zhu Liu≤feeding volume, occurs 2,3 times; Gastroesophageal reflux or vomiting, or slight hematemesis; Light moderate abdominal distention or hypoactive bowel sounds; Defecation postpones or tire is just discharged not smooth; Laxativeness or have blood in stool.
Severe performance: serious abdominal distention or skin of abdomen variable color, or borborygmus disappears; Intestinal obstruction or intestinal perforation sign; Severe diarrhea or obvious courageous and upright feces; Serious asphyxia or bradycardia; The serious heart, pulmonary insufficiency; Gastrointestinal tract congenital malformation, intestinal obstruction etc. all.
In above-mentioned treatment group, patients with mild 57 examples, severe patient's 60 examples; Matched group mild or moderate patient 55 examples, severe patient's 58 examples.
Three, Therapeutic Method
Treatment group: oral medicine water decoction of the present invention, every day potion, 1ml/Kg, 2 times/day.
Matched group: oral 0.5/ time of Medilac-Vita, 3 times/day.
Four, the standard of curative effect evaluation
Neonatal gastrointestinal dysfunction recovery from illness and the diagnostic criteria taking a turn for the better:
(1) infant is fed rear without vomiting abdominal distention;
(2) the residual milk amount of the each stomach of the infant <2mL/kg that stomach feeding tube is fed;
(3) infant is without having blood in stool or the occult blood positive;
(4) have a medical check-up abdominal part without obvious visible peristalsis visible intestinal peristalsis, borborygmus is normal;
(5) the vertical position of abdominal part plain film is without dilatation of intestine or pneumatosis etc.
Haemostatic effect criterion:
After medication 24 hours Occult blood of gastric fluids continue strong positive or+it is invalid number not become; By ++++to ++ or by +++ to+for stopping blooding effectively.
Borborygmus recovers criterion:
After medication, 24 ~ 48 hours absent bowel soundses recover or 3 beats/min of < are invalid; If borborygmus returns to >3 beat/min for effective.
Five, curative effect
Statistical method: use SPSS17.0 statistical software statistical data, to the statistics of continuous data, represent with mean, standard deviation, add if desired and represent with median or percentile, minima, maximum, variable is distributed and carries out normal state check, when Normal Distribution, check with t, heterogeneity of variance person, with t ' check; Nonnormal distribution, with rank test etc.; To enumeration data, adopt the accurate probabilistic method of fisher or X
2check; Before and after self of level data, relatively use Wilcoxon signed rank sum test; Relatively analyzing with Ridit of two groups of level data, or corresponding rank test.All statistical computations are all carried out with statistical software, using P≤0.5 as there being significance statistical significance, using P≤0.01 as there being very significant statistical significance.
Efficacy result sees the following form:
| Group | Effectively (example) | Invalid (example) | Effective percentage |
| Treatment group (117 example) | 96 | 21 | 82% |
| Matched group (113 example) | 74 | 39 | 65% |
Two groups of total effective rate comparisons, P < 0.05, significant difference.
Six, conclusion
Treatment group effective percentage 82%, matched group effective percentage 65%.Treatment level effective percentage is apparently higher than matched group.
Seven, concrete case
Case 1, man, 3 days.
Because of few being admitted to hospital for 3 days of taking food.Infant anoxia after birth history, gives to alleviate after clearing pneogaster, chafe and oxygen uptake after life, and feed is few, vomiting, and row's green stool, urine amount is few, and psychoreaction is poor, drowsiness.Have a medical check-up: psychoreaction is poor, breathe steadily, the visible xanthochromia of skin, poor flexibility, cardiopulmonary are without extremely, and abdominal part is distension slightly, a little less than borborygmus, a little less than Primitive reflex.Plain abdominal radiograph shows intestinal tympanites.Be diagnosed as hypoxic ischemic encephalopathy of newborn, Neonatal gastrointestinal dysfunction.Except treatment protopathy, give medicine of the present invention, the use that is decocted in water for oral dose, took medicine after 3 days, and just, feed increases row's yellow, and vomiting disappears, and psychoreaction is clearly better, and intestinal tympanites disappears, and abdominal part is soft, and borborygmus is normal.Treat to cure for 2 weeks and leave hospital.
Case 2, man, 8 days
Because of vomiting, companion's abdominal distention is admitted to hospital for 5 days.Infant is gestational age premature labor in 34 weeks, tire premature rupture of fetal membrane history, birth weight 2400g, after life, live local hospital department of pediatrics and give the Supporting Therapy of suiting the medicine to the illness such as warming, fluid infusion, infection control, within 4-6 hour, opens milk after raw, because of breast milk deficiency, feeding formula breast, feed is few, the green stool of row, within raw latter 3 days, occur vomiting, vomitus contains coffee-like thing, day vomiting 2-3 time, engender abdominal distention, stool and hypourocrinia, psychoreaction is poor, heating, body temperature is the highest 37.9 ℃, transfers my institute.Have a medical check-up: psychoreaction is poor, rapid breathing, the visible xanthochromia of skin, poor flexibility, two pulmonary respiration sounds are coarse, abdominal part distension, stomach wall edema, a little less than borborygmus, a little less than Primitive reflex.The visible occult blood positive of defecating, plain abdominal radiograph shows that intestinal tympanites, intestinal wall thicken.Be diagnosed as pneumonia of newborn, neonatal necrotizing enterocolitis, Neonatal Sepsis.Except treatment protopathy, give medicine of the present invention, the use that is decocted in water for oral dose, took medicine after 5 days, and just, feed increases row's yellow, and vomiting disappears, and psychoreaction is clearly better, and intestinal tympanites disappears, and abdominal part is soft, and borborygmus is normal.Check fecal occult blood disappears.Treat to cure for 3 weeks and leave hospital.
Claims (2)
1. the medicine for the treatment of Neonatal gastrointestinal dysfunction, is characterized in that the raw material composition of making effective ingredient is by weight ratio: Radix Et Rhizoma Rhei 2-3, Radix Astragali 3-6, Rhizoma Atractylodis Macrocephalae (parched) 3-6, Poria 3-6, Fructus Aurantii Immaturus 3-6, Radix Paeoniae Rubra 3-6 and Herba Artemisiae Scopariae 3-6.
2. the medicine for the treatment of Neonatal gastrointestinal dysfunction according to claim 1, is characterized in that raw material composition and the weight proportion of wherein making effective ingredient are: Radix Et Rhizoma Rhei 2, the Radix Astragali 3, Rhizoma Atractylodis Macrocephalae (parched) 3, Poria 3, Fructus Aurantii Immaturus 3, Radix Paeoniae Rubra 3 and Herba Artemisiae Scopariae 3.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311541A (en) * | 2015-11-28 | 2016-02-10 | 尹玲苓 | Traditional Chinese medicine composition for treating gastrointestinal dysfunction of patients suffering from intra-abdominal hypertension |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1602915A (en) * | 2004-07-28 | 2005-04-06 | 昆明市中医医院 | Stomach motility promoting medicine for treating stomach and intestine function failure and its preparation |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1602915A (en) * | 2004-07-28 | 2005-04-06 | 昆明市中医医院 | Stomach motility promoting medicine for treating stomach and intestine function failure and its preparation |
Non-Patent Citations (2)
| Title |
|---|
| 徐学芹、张丽丽: "新生儿胃肠功能障碍48例临床分析", 《社区医学杂志》, vol. 3, no. 8, 31 December 2005 (2005-12-31), pages 73 - 74 * |
| 杨彤、王琳琳: "新生儿胃肠功能障碍的研究进展", 《医学综述》, vol. 12, no. 21, 30 November 2006 (2006-11-30), pages 1314 - 1316 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311541A (en) * | 2015-11-28 | 2016-02-10 | 尹玲苓 | Traditional Chinese medicine composition for treating gastrointestinal dysfunction of patients suffering from intra-abdominal hypertension |
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