CN103800642B - For preventing and treating the pharmaceutical preparation of cholera fowl - Google Patents
For preventing and treating the pharmaceutical preparation of cholera fowl Download PDFInfo
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- CN103800642B CN103800642B CN201410078758.7A CN201410078758A CN103800642B CN 103800642 B CN103800642 B CN 103800642B CN 201410078758 A CN201410078758 A CN 201410078758A CN 103800642 B CN103800642 B CN 103800642B
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Abstract
The invention provides a kind ofly for preventing and treating the Chinese medicinal composition preparation of cholera fowl, its bulk drug comprises the wind-weed, the bighead atractylodes rhizome, wilsonii, giant knotweed, suchow mosla herb, sargentodoxa cuneata, the seed of Chinese dodder, the seed of feather cockscomb, radix scrophulariae, purslane, great burdock achene, leaf of negundo chastetree, when medicine, hawthorn, rainbow conk, Chinese prickly ash, Radix Angelicae Sinensis, asafoetide, radix glehniae, the bark of official magnolia, hairy euphorbia, folium panacis japonici cum caule, wrinkled giant hyssop, selfheal, tarragon and moutan bark. This Chinese medicinal composition preparation have low toxicity, side effect little, without features such as the resistances to the action of a drug, and noresidue in animal products, can be used for preventing and treating cholera fowl, the fowl cholera especially being caused by resistance to chemical drug and antibiotic strain.
Description
Technical field
The present invention relates to traditional Chinese medicine technical field, relate in particular to a kind of for preventing and treating the pharmaceutical preparation of cholera fowl.
Background technology
Cholera fowl is the common acute infectious disease being caused by chicken pasteurella multocida, often presents septic symptom, and M & M is very high, therefore claims again chicken bovine pasteurellosis, is called for short chicken and goes out to lose. This disease mainly infects by alimentary canal, respiratory tract and skin trauma, and multiple being born under sultry, moist environmental condition, sees young chicken and laying hen, larger on egg laying performance impact. Feeding and management is improper, wet weather is moist, improper ventilation etc. easily causes morbidity and popular. Acute when popular, often eat food evening carefully, within the 2nd day, with regard to die by visitation of God, M & M is all very high.
This disease be often sporadic, or be popularity. On poultry, susceptible is chicken, duck etc., and within 16 weeks, the chicken below age generally has stronger resistance. The main infection sources is the poultry carrying disease germs owing to having introduced, contaminated chicken coop, feed trough, tank etc. all may become the infection sources, chicken group's feeding and management is not good at, improper ventilation and fracture in internal parasitic disease, nutritional deficiency, long-distance transport, change in weather, overcast and rainy moist, hen house, cut off the water supply or flip-flop feed, all can make chicken improve the neurological susceptibility of cholera fowl. This sick route of transmission is mainly secretion by ill chicken oral cavity, nasal cavity and eye conjunctiva through directly contacting or airborne, the death rate of infected chicken normally 0～20% or higher, and often there is egg drop reduction and continuation local infection in laying hen.
Heart hat fat, the visible point of stomach fat that this sick pathological change is specially disease chicken are hemorrhage. Lung has hyperemia or blutpunkte. The pathology of liver has characteristic, and liver is slightly swollen, and qualitative change is crisp, is brown or yellowish-brown. Liver surface is scattered with many canescence, downright bad point that syringe needle is large. The general variation of spleen is not obvious, has the enlargement a little of minority case, and quality is more soft. Muscular stomach is hemorrhage comparatively obvious, and enteron aisle especially duodenum is Catarrhal and hemorrhagic enteritis, and intestinal contents contains blood. There is the case of respiratory symptom, can see and in nose and paranasal sinuses, have volume sticky discharge. There is arthritic case, mainly see joint swelling deformation, have inflammatory exudate and caseous necrosis. The case of wattle oedema, has purulence caseous substance in wattle, or dry and hard, downright bad, come off. The ovary of hen is obviously hemorrhage, the congestion of blood vessel degree varies on ovarian follicle, and ovarian follicle distortion sometimes, like partly boiling sample.
Western medicine antibiotic, sulfa drugs, olaquindox etc. all have certain effect to the anti-disease of effecting a permanent cure, but also band is served problem, as not thorough in treatment, often recurrence after drug withdrawal; Abuse of antibiotics is developed immunity to drugs bacterium, cause scope of medication to dwindle, dosage increases, production cost increases, and heavy dose of medication produces certain side effect to body, and cause poultry product drug residue excessively high, finding the medicine of preventing and treating cholera fowl safer, efficient, that have no side effect becomes the emphasis of people's research.
Western medicine is focused on Eradicates except disease and evil, eliminates the cause of disease; Chinese medicine is emphasized entirety, focuses on the resistance against diseases that improves body, the various functions of adjustment, balance body, and application safety is reliable, adopts Chinese medicine to replace western medicine disease, can overcome the many disadvantages that Western medicine exists.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of for preventing and treating the Chinese medicinal composition preparation of cholera fowl, its have low toxicity, side effect little, without features such as the resistances to the action of a drug, and noresidue in animal products, can be used for preventing and treating cholera fowl, the fowl cholera especially being caused by resistance to chemical drug and antibiotic strain.
For solving the problems of the technologies described above, the invention provides a kind ofly for preventing and treating the Chinese medicinal composition preparation of cholera fowl, its bulk drug comprises: the wind-weed, the bighead atractylodes rhizome, wilsonii, giant knotweed, suchow mosla herb, sargentodoxa cuneata, the seed of Chinese dodder, the seed of feather cockscomb, radix scrophulariae, purslane, great burdock achene, leaf of negundo chastetree, when medicine, hawthorn, rainbow conk, Chinese prickly ash, Radix Angelicae Sinensis, asafoetide, radix glehniae, the bark of official magnolia, hairy euphorbia, folium panacis japonici cum caule, wrinkled giant hyssop, selfheal, tarragon and moutan bark.
Wherein, in described Chinese medicinal composition preparation, the weight portion of each bulk drug is respectively the wind-weed 45 weight portion～55 weight portions, the bighead atractylodes rhizome 30 weight portion～40 weight portions, wilsonii 40 weight portion～50 weight portions, giant knotweed 20 weight portion～30 weight portions, suchow mosla herb 15 weight portion～25 weight portions, sargentodoxa cuneata 20 weight portion～30 weight portions, the seed of Chinese dodder 25 weight portion～35 weight portions, the seed of feather cockscomb 20 weight portion～30 weight portions, radix scrophulariae 35 weight portion～45 weight portions, purslane 20 weight portion～30 weight portions, great burdock achene 20 weight portion～30 weight portions, leaf of negundo chastetree 25 weight portion～35 weight portions, when medicine 20 weight portion～30 weight portions, hawthorn 30 weight portion～40 weight portions, rainbow conk 15 weight portion～25 weight portions, Chinese prickly ash 25 weight portion～35 weight portions, Radix Angelicae Sinensis 30 weight portion～40 weight portions, asafoetide 25 weight portion～35 weight portions, radix glehniae 25 weight portion～35 weight portions, the bark of official magnolia 20 weight portion～30 weight portions, hairy euphorbia 30 weight portion～40 weight portions, folium panacis japonici cum caule's 45 weight portion～55 weight portions, wrinkled giant hyssop 30 weight portion～40 weight portions, selfheal 15 weight portion～25 weight portions, tarragon 20 weight portion～30 weight portions and moutan bark 25 weight portion～35 weight portions.
Wherein, in described Chinese medicinal composition preparation, the weight portion of each bulk drug is respectively the wind-weed 48 weight portion～52 weight portions, the bighead atractylodes rhizome 33 weight portion～37 weight portions, wilsonii 43 weight portion～47 weight portions, giant knotweed 23 weight portion～27 weight portions, suchow mosla herb 18 weight portion～22 weight portions, sargentodoxa cuneata 23 weight portion～27 weight portions, the seed of Chinese dodder 28 weight portion～32 weight portions, the seed of feather cockscomb 23 weight portion～27 weight portions, radix scrophulariae 38 weight portion～42 weight portions, purslane 23 weight portion～27 weight portions, great burdock achene 23 weight portion～27 weight portions, leaf of negundo chastetree 28 weight portion～32 weight portions, when medicine 23 weight portion～27 weight portions, hawthorn 33 weight portion～37 weight portions, rainbow conk 18 weight portion～22 weight portions, Chinese prickly ash 28 weight portion～32 weight portions, Radix Angelicae Sinensis 33 weight portion～37 weight portions, asafoetide 28 weight portion～32 weight portions, radix glehniae 28 weight portion～32 weight portions, the bark of official magnolia 23 weight portion～27 weight portions, hairy euphorbia 33 weight portion～37 weight portions, folium panacis japonici cum caule's 48 weight portion～52 weight portions, wrinkled giant hyssop 33 weight portion～37 weight portions, selfheal 18 weight portion～22 weight portions, tarragon 23 weight portion～27 weight portions and moutan bark 28 weight portion～32 weight portions.
Wherein, in described Chinese medicinal composition preparation, the weight portion of each bulk drug is respectively the wind-weed 50 weight portions, the bighead atractylodes rhizome 35 weight portions, wilsonii 45 weight portions, giant knotweed 25 weight portions, suchow mosla herb 20 weight portions, sargentodoxa cuneata 25 weight portions, the seed of Chinese dodder 30 weight portions, the seed of feather cockscomb 25 weight portions, radix scrophulariae 40 weight portions, purslane 25 weight portions, great burdock achene 25 weight portions, leaf of negundo chastetree 30 weight portions, when medicine 25 weight portions, hawthorn 35 weight portions, rainbow conk 20 weight portions, Chinese prickly ash 30 weight portions, Radix Angelicae Sinensis 35 weight portions, asafoetide 30 weight portions, radix glehniae 30 weight portions, the bark of official magnolia 25 weight portions, hairy euphorbia 35 weight portions, folium panacis japonici cum caule's 50 weight portions, wrinkled giant hyssop 35 weight portions, selfheal 20 weight portions, tarragon 25 weight portions and moutan bark 30 weight portions.
The present invention also provides the preparation method of above-mentioned Chinese medicinal composition preparation, be specially above-mentioned raw materials medicine is ground into respectively to powder, be uniformly mixed by weight, cross 20 mesh sieves, obtain mixture, adopt water boiling and extraction 1～2 time, for the mixture of every 1kg, water uses 6～8L, extracts 1～1.5 hour at every turn, suction filtration, remove filter residue, merging filtrate, the extract obtaining adopts Reduced Pressure Concentration Device at 70 DEG C～80 DEG C, vacuum is 0.09Mpa～0.095Mpa, and solution to be concentrated feed liquor flow velocity is 150～200mlmin-1Condition under concentrated, the concentrated extract obtaining carries out vacuum drying at 45 DEG C～55 DEG C, obtains extracting powder, is Chinese medicinal composition preparation.
The present invention also provides a kind of feed, and it comprises wheat, dregs of beans, the dish dregs of rice, medical stone, calcium monohydrogen phosphate, salt, amino acid premix, vitamin premix, composite trace element and above-mentioned Chinese medicinal composition preparation.
Wherein, in described feed, the weight portion of each raw material is respectively wheat 5.5kg～6.5kg, dregs of beans 1kg～2kg, dish dregs of rice 1kg～2kg, medical stone 750g～850g, calcium monohydrogen phosphate 350g～450g, salt 150g～250g, amino acid premix 350g～450g, vitamin premix 550g～650g, composite trace element 250g～350g and above-mentioned Chinese medicinal composition preparation 1kg～1.2kg.
Wherein, in described feed, the weight portion of each raw material is respectively wheat 6kg, dregs of beans 1.5kg, dish dregs of rice 1.5kg, medical stone 800g, calcium monohydrogen phosphate 400g, salt 200g, amino acid premix 400g, vitamin premix 600g, composite trace element 300g and above-mentioned Chinese medicinal composition preparation 1.1kg.
The present invention also provides the preparation method of above-mentioned feed, is specially:
The first step, is ground into respectively powder by the bulk drug of described Chinese medicinal composition preparation, is uniformly mixed by weight, cross 20 mesh sieves, obtain mixture, adopt water boiling and extraction 1～2 time, for the mixture of every 1kg, water uses 6～8L, extracts 1～1.5 hour at every turn, suction filtration, remove filter residue, merging filtrate, the extract obtaining adopts Reduced Pressure Concentration Device at 70 DEG C～80 DEG C, vacuum is 0.09Mpa～0.095Mpa, and solution to be concentrated feed liquor flow velocity is 150～200mlmin-1Condition under concentrated, the concentrated extract obtaining carries out vacuum drying at 45 DEG C～55 DEG C, obtains extracting powder, is Chinese medicinal composition preparation;
Second step, by wheat, dregs of beans, the dish dregs of rice, medical stone, calcium monohydrogen phosphate, salt is pulverized respectively, send in mixer and be uniformly mixed in proportion, obtain compound, compound is dried 2～3 minutes with the rotary drum dryer of 180 DEG C～220 DEG C of temperature, the water content that makes compound is 5%～10%, make semi-finished product, semi-finished product are sieved, the aperture of sieving is for the first time 1mm, obtain finished product, filtering out the granule that is greater than 1mm pulverizes again, the finished product filtering out is sent into and in mixing and blending machine, is added in proportion amino acid premix, vitamin premix, Chinese medicinal composition preparation prepared by composite trace element and the first step, stir 2 minutes, obtain feed.
Beneficial effect of the present invention:
Provided by the invention for prevent and treat the Chinese medicinal composition preparation of cholera fowl have low toxicity, side effect little, without features such as the resistances to the action of a drug, and noresidue in animal products, can be used for preventing and treating cholera fowl, the fowl cholera especially being caused by resistance to chemical drug and antibiotic strain.
Detailed description of the invention
Confirm its disease being located in the interior according to the Dialectics of traditional Chinese veterinary medicine, property belong to heat poison card, treatment is with clearing heat and detoxicating, purging intense heat eliminating dampness, coordinate taste yang-energy, strengthen transportation capabilities, realize prevention effect, it can promote and strengthen the immunologic function of body and the ability of kill bacteria, increase cytophagous quantity and ability, the specificity and the non-specific immune function etc. that improve body are relevant, the present invention is exactly taking theory of traditional Chinese medical science as basis, provide a kind of for preventing and treating the Chinese medicinal composition preparation of cholera fowl, its bulk drug comprises: the wind-weed, the bighead atractylodes rhizome, wilsonii, giant knotweed, suchow mosla herb, sargentodoxa cuneata, the seed of Chinese dodder, the seed of feather cockscomb, radix scrophulariae, purslane, great burdock achene, leaf of negundo chastetree, work as medicine, hawthorn, rainbow conk, Chinese prickly ash, Radix Angelicae Sinensis, asafoetide, radix glehniae, the bark of official magnolia, hairy euphorbia, folium panacis japonici cum caule, wrinkled giant hyssop, selfheal, tarragon and moutan bark.
Further, described Chinese medicinal composition preparation is only made up of above-mentioned raw materials medicine.
Further, in described Chinese medicinal composition preparation, the weight portion of each bulk drug is respectively the wind-weed 45 weight portion～55 weight portions, the bighead atractylodes rhizome 30 weight portion～40 weight portions, wilsonii 40 weight portion～50 weight portions, giant knotweed 20 weight portion～30 weight portions, suchow mosla herb 15 weight portion～25 weight portions, sargentodoxa cuneata 20 weight portion～30 weight portions, the seed of Chinese dodder 25 weight portion～35 weight portions, the seed of feather cockscomb 20 weight portion～30 weight portions, radix scrophulariae 35 weight portion～45 weight portions, purslane 20 weight portion～30 weight portions, great burdock achene 20 weight portion～30 weight portions, leaf of negundo chastetree 25 weight portion～35 weight portions, when medicine 20 weight portion～30 weight portions, hawthorn 30 weight portion～40 weight portions, rainbow conk 15 weight portion～25 weight portions, Chinese prickly ash 25 weight portion～35 weight portions, Radix Angelicae Sinensis 30 weight portion～40 weight portions, asafoetide 25 weight portion～35 weight portions, radix glehniae 25 weight portion～35 weight portions, the bark of official magnolia 20 weight portion～30 weight portions, hairy euphorbia 30 weight portion～40 weight portions, folium panacis japonici cum caule's 45 weight portion～55 weight portions, wrinkled giant hyssop 30 weight portion～40 weight portions, selfheal 15 weight portion～25 weight portions, tarragon 20 weight portion～30 weight portions and moutan bark 25 weight portion～35 weight portions.
Further, in described Chinese medicinal composition preparation, the weight portion of each bulk drug is respectively the wind-weed 48 weight portion～52 weight portions, the bighead atractylodes rhizome 33 weight portion～37 weight portions, wilsonii 43 weight portion～47 weight portions, giant knotweed 23 weight portion～27 weight portions, suchow mosla herb 18 weight portion～22 weight portions, sargentodoxa cuneata 23 weight portion～27 weight portions, the seed of Chinese dodder 28 weight portion～32 weight portions, the seed of feather cockscomb 23 weight portion～27 weight portions, radix scrophulariae 38 weight portion～42 weight portions, purslane 23 weight portion～27 weight portions, great burdock achene 23 weight portion～27 weight portions, leaf of negundo chastetree 28 weight portion～32 weight portions, when medicine 23 weight portion～27 weight portions, hawthorn 33 weight portion～37 weight portions, rainbow conk 18 weight portion～22 weight portions, Chinese prickly ash 28 weight portion～32 weight portions, Radix Angelicae Sinensis 33 weight portion～37 weight portions, asafoetide 28 weight portion～32 weight portions, radix glehniae 28 weight portion～32 weight portions, the bark of official magnolia 23 weight portion～27 weight portions, hairy euphorbia 33 weight portion～37 weight portions, folium panacis japonici cum caule's 48 weight portion～52 weight portions, wrinkled giant hyssop 33 weight portion～37 weight portions, selfheal 18 weight portion～22 weight portions, tarragon 23 weight portion～27 weight portions and moutan bark 28 weight portion～32 weight portions.
Most preferably, in described Chinese medicinal composition preparation, the weight portion of each bulk drug is respectively the wind-weed 50 weight portions, the bighead atractylodes rhizome 35 weight portions, wilsonii 45 weight portions, giant knotweed 25 weight portions, suchow mosla herb 20 weight portions, sargentodoxa cuneata 25 weight portions, the seed of Chinese dodder 30 weight portions, the seed of feather cockscomb 25 weight portions, radix scrophulariae 40 weight portions, purslane 25 weight portions, great burdock achene 25 weight portions, leaf of negundo chastetree 30 weight portions, when medicine 25 weight portions, hawthorn 35 weight portions, rainbow conk 20 weight portions, Chinese prickly ash 30 weight portions, Radix Angelicae Sinensis 35 weight portions, asafoetide 30 weight portions, radix glehniae 30 weight portions, the bark of official magnolia 25 weight portions, hairy euphorbia 35 weight portions, folium panacis japonici cum caule's 50 weight portions, wrinkled giant hyssop 35 weight portions, selfheal 20 weight portions, tarragon 25 weight portions and moutan bark 30 weight portions.
The present invention also provides the preparation method of above-mentioned Chinese medicinal composition preparation, be specially above-mentioned raw materials medicine is ground into respectively to powder, be uniformly mixed by weight, cross 20 mesh sieves, obtain mixture, adopt water boiling and extraction 1～2 time, for the mixture of every 1kg, water uses 6～8L, extracts 1～1.5 hour at every turn, suction filtration, remove filter residue, merging filtrate, the extract obtaining adopts Reduced Pressure Concentration Device at 70 DEG C～80 DEG C, vacuum is 0.09Mpa～0.095Mpa, and solution to be concentrated feed liquor flow velocity is 150～200mlmin-1Condition under concentrated, the concentrated extract obtaining carries out vacuum drying at 45 DEG C～55 DEG C, obtains extracting powder, is Chinese medicinal composition preparation.
The present invention also provides a kind of feed, and it comprises wheat, dregs of beans, the dish dregs of rice, medical stone, calcium monohydrogen phosphate, salt, amino acid premix, vitamin premix, composite trace element and above-mentioned Chinese medicinal composition preparation.
Further, described feed is only made up of above-mentioned raw materials.
In described feed, the weight portion of each raw material is respectively wheat 5.5kg～6.5kg, dregs of beans 1kg～2kg, dish dregs of rice 1kg～2kg, medical stone 750g～850g, calcium monohydrogen phosphate 350g～450g, salt 150g～250g, amino acid premix 350g～450g, vitamin premix 550g～650g, composite trace element 250g～350g and above-mentioned Chinese medicinal composition preparation 1kg～1.2kg.
Further, in described feed, the weight portion of each raw material is respectively wheat 6kg, dregs of beans 1.5kg, dish dregs of rice 1.5kg, medical stone 800g, calcium monohydrogen phosphate 400g, salt 200g, amino acid premix 400g, vitamin premix 600g, composite trace element 300g and above-mentioned Chinese medicinal composition preparation 1.1kg.
The present invention also provides the preparation method of above-mentioned feed, is specially:
The first step, is ground into respectively powder by the bulk drug of described Chinese medicinal composition preparation, is uniformly mixed by weight, cross 20 mesh sieves, obtain mixture, adopt water boiling and extraction 1～2 time, for the mixture of every 1kg, water uses 6～8L, extracts 1～1.5 hour at every turn, suction filtration, remove filter residue, merging filtrate, the extract obtaining adopts Reduced Pressure Concentration Device at 70 DEG C～80 DEG C, vacuum is 0.09Mpa～0.095Mpa, and solution to be concentrated feed liquor flow velocity is 150～200mlmin-1Condition under concentrated, the concentrated extract obtaining carries out vacuum drying at 45 DEG C～55 DEG C, obtains extracting powder, is Chinese medicinal composition preparation;
Second step, by wheat, dregs of beans, the dish dregs of rice, medical stone, calcium monohydrogen phosphate, salt is pulverized respectively, send in mixer and be uniformly mixed in proportion, obtain compound, compound is dried 2～3 minutes with the rotary drum dryer of 180 DEG C～220 DEG C of temperature, the water content that makes compound is 5%～10%, make semi-finished product, semi-finished product are sieved, the aperture of sieving is for the first time 1mm, obtain finished product, filtering out the granule that is greater than 1mm pulverizes again, the finished product filtering out is sent into and in mixing and blending machine, is added in proportion amino acid premix, vitamin premix, Chinese medicinal composition preparation prepared by composite trace element and the first step, stir 2 minutes, obtain feed.
The pharmacology of each bulk drug is as follows:
The wind-weed: bitter, sweet, cold in nature, enter lung, stomach, kidney channel, there is the relieving restlessness of purging heat, the effect of nourshing Yin and drynsessmoistening prescription, removing heat from the lung to relieve cough, cures mainly fever caused by exogenous pathogenic factors, and high heat is irritated, lung-heat type cough, the interior heat symptom such as quench one's thirst; Its bitter cold matter profit, property sedimentation, can heat-clearing, can promote the production of body fluid again, kindly controls warm disease and evil and enters gas and divide, and heat is contained and is hindered Tianjin; Also be used for the treatment of diabetes; Phlegm-heat obstructing lung and breathing heavily, xeropulmonary cough, phlegm is few unfavorable; Fire excess from yin deficiency, the symptoms such as flaring up of deficient fire, the wind-weed has inhibitory action to various bacteria such as shigella dysenteriae, typhoid bacillus, Escherichia coli, proteus, staphylococcus, streptococcus.
The bighead atractylodes rhizome: taste is sweet, bitter, warm in nature, enters spleen, stomach warp, has tonifying spleen profit gas, eliminating dampness Li Shui, and strengthening exterior and reducing sweat, the effect that fortune spleen is moisturized, is mainly used in ruffian due to the dysfunction of the spleen in transport, QI failing to transform into body fluid and has one's mind filled with and rush down, phlegm and retained fluid oedema; The vexed lazy speech of the deficiency of qi in middle-jiao, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, abnormal sweating spontaneous perspiration.
Wilsonii: taste is pungent, bitter, micro-sweet, warm in nature, enters spleen, kidney, the heart channel of Hang-Shaoyin, have and replenish qi to invigorate the spleen, tonify the kidney to relieve mental strain, the effect of dispelling rheumatism, soft for wind-cold-dampness arthralgia, lumbocrural pain, muscles and bones impotence, be slow in action, the card such as body void is thin and weak, traumatic injury, fracture, oedema, beriberi, uncontrolled urination are itched.
Giant knotweed: micro-hardship, is slightly cold. Return liver, courage, lung channel, have clearing heat and detoxicating, normalizing gallbladder to cure jaundice, expelling wind and removing dampness, loose stasis of blood analgesic therapy, relieving cough and reducing sputum effect, for joint pain, jaundice with damp-heat pathogen, through Bi ， wei lump in the abdomen, coughing with a lot of sputum, scald, injury from falling down, the cards such as carbuncle sore tumefacting virus.
Suchow mosla herb: warm in nature, taste is pungent, has dispelling summer-heat to relieve superficies syndrome, effect of regulating qi-flowing for relieving pain, cures mainly flu, heatstroke, eruptive disease, peratodynia, the cards such as abscess of throat.
Sargentodoxa cuneata: bitter, property is flat, returns liver, large intestine channel, has the carbuncle that disappears that relieves internal heat, and promoting blood circulation and removing obstruction in channels, the effect of wind dispelling insecticide, cures mainly acute and chronic appendicitis, arthralgia due to wind-dampness, dysentery characterized by blood in the stool, blood drenches, irregular menstruation, infantile malnutrition due to digestive disturbances or intestinalparasites, worm pain, the cards such as injury from falling down.
The seed of Chinese dodder: taste is sweet, pungent, property is flat, enters liver,kidney,spleen warp, has tonifying kidney and benefiting sperm, and the effect of nourishing the liver to improve visual acuity is mainly used in the impotence of the insufficiency of the kidney yang, seminal emission premature ejaculation, frequent urination, dizziness and tinnitus; The Low Back Pain of suffering from a deficiency of the kidney, married woman is with down, and nausea is solid; The binocular of both liver and kidney deficiency, deficiency of liver-blood is dim-sighted, blurring of vision; The loose stool stomachache of speen-kidney dificiency, the cards such as diarrhea with undigested food.
The seed of feather cockscomb: bitter, cold nature, returns Liver Channel, has clearing liver-fire, and effect of removing nebula cures mainly the hot hot eyes of liver, the raw screen film of order, blurring of vision, the cards such as hepatopyretic vertigo.
Radix scrophulariae: taste is sweet, bitter, salty, cold nature, returns lung, stomach, kidney channel, there is clearing heat and cooling blood, purging intense heat and detonicating, effect of kidney is supported in enriching yin, curing mainly warm heresy joins the army, the pericardium that caves in, febrile virulent maculae, the cards such as constipation, hectic fever due to yin labor are coughed, hot eyes, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus are hindered in consumption of YIN caused by febrile disease, the deep red polydipsia of tongue, Tianjin.
Purslane: taste acid, cold in nature, return large intestine, Liver Channel, has clearing heat and detoxicatingly, and Li Shui dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, effect of the cool blood that stops blooding, cures mainly dysentery, enteritis, ephritis, postpartum, uterine hemorrhage, had blood in stool, the illnesss such as mastitis.
Great burdock achene: taste is pungent, hardship; Cold in nature, return lung, stomach warp, has dispelling wind and heat from the body, clearing heat and detoxicating promoting eruption, the loose swollen effect of a surname's lung relieve sore throat, cure mainly anemopyretic cold, warm disease from the beginning of; Wind-heat or cough with lung heat, cough up phlegm not smooth; Abscess of throat; Macula is not saturating; At the measles initial stage, rash goes out not smooth and rubella itch; The card such as sore swollen toxin and mumps.
Leaf of negundo chastetree: taste is pungent; Bitter; Property is put down, and returns lung channel, has the dampness elimination of inducing sweat, eliminating phlegm and relieving asthma; Removing toxic substances, expels pathogenic wind from the body surface, dehumidifying, and desinsection, effect of pain relieving, cures mainly cold, cough, asthma; Stomachache; Stomachache; Summer-heat and damp is rushed down dysentery; Beriberi swelling; Rubella itch; The ringworm of the foot; Acute mastitis swells and ache; The cards such as snake bite and insect sting.
Work as medicine: bitter, cold in nature, return liver, stomach, large intestine channel, there is clearing away damp-heat, effect of stomach invigorating, cures mainly jaundice with damp-heat pathogen, hypochondriac pain, dysentery stomachache, the cards such as poor appetite.
Hawthorn: taste acid, sweet, slightly warm in nature, returns spleen, stomach, Liver Channel, has food digesting stomach fortifying, effect of the loose stasis of blood of promoting the circulation of qi, is mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, has loose bowels, and dysentery, hawthorn is the staple for the treatment of indigestion, and hawthorn can increase the secretion of peptic digest enzyme, promotes the cards such as digestion.
Rainbow conk: taste is sweet, light, cold nature, returns liver; Spleen; Lung channel, has invigorating spleen to remove dampness; Relieving cough and asthma; Clearing heat and detoxicating; Antineoplastic effect, cures mainly CAH; Cirrhosis; Chronic bronchitis; Infantile spasm bronchitis; Abscess of throat; Kinds of tumors; Rheumatoid arthritis; The cards such as leukaemia.
Chinese prickly ash: taste is pungent, warm in nature, return spleen, stomach, kidney channel, there is warming middle energizer to relieve pain, effect of killing parasites to relieve itshing. For coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to enterositosis, ascariasis, the cards such as eczema itch.
Radix Angelicae Sinensis: taste is sweet, pungent, bitter, warm in nature, returns liver, the heart, the spleen channel, and having enriches blood invigorates blood circulation, and menstruation regulating relieves the pain, the effect relaxing bowel, and the head who cures mainly deficiency of heart-blood is giddy, lassitude hypodynamia, palpitation, and other syndrome of blood deficiency.
Asafoetide: bitter, pungent, warm in nature, return kidney, stomach warp, have disappear long-pending, loose ruffian, effect of desinsection, stagnant for meat, hemostasis abdominal mass, mass in abdomen, the cards such as abdominal pain due to enterositosis.
Radix glehniae: cold nature, sweet, the micro-hardship of taste, has nourishiing yin to clear away the lung-heat, and effect of reinforcing stomach reg fluid cures mainly the cough cards such as phlegm blood, pyreticosis Tianjin wound is thirsty of lung-heat type cough, labor.
The bark of official magnolia: bitter, pungent, warm in nature, return the spleen channel; Stomach warp; Large intestine channel, has promoting the circulation of qi and disappears long-pending; Eliminating dampness is except full; Effect of relieving asthma, cures mainly stagnation of QI due to dyspepsia; Abdominal distention constipation; Damp retention in middle-jiao, gastral cavity ruffian is vomited and diarrhoea; Phlegm is stopped up the circulation of vital energy in the wrong direction; The fullness sensation in chest card such as breath with cough.
Hairy euphorbia: mildly bitter flavor, micro-acid, cool in nature, have clearing heat and detoxicating, effect that dampness removing is antipruritic, for bacillary dysentery, amoebic dysentery, enteritis, enteron aisle trichomonad, indigestion, bronchitis, pyelonephritis; The cards such as eczema, dermatitis, pruitus are controlled in external application.
Folium panacis japonici cum caule: bitter, sweet, cold in nature, attach to the lung and stomach meridians, there is tonifying Qi, beneficial lung, drives away summer heat, and the effect of promoting the production of body fluid, cures mainly qi-asthenia cough, hot summer weather agitation, Tianjin wound is thirsty, and the head is unclear, the tired weary card that waits of four limbs.
Wrinkled giant hyssop: taste is pungent, slightly warm in nature, returns lung, spleen, stomach warp, has dispelling summer-heat to relieve superficies syndrome, effect of removing dampness to restore normal functioning of the stomach. For summertime flu, fever and chills headache, chest gastral cavity ruffian is vexed, and vomiting is had loose bowels, the vomiting of pregnancy, nasosinusitis, the cards such as hand, tinea pedis.
Selfheal: bitter, pungent, cold in nature, enter liver, gallbladder channel, have and relieve inflammation or internal heat, improving eyesight, dissipating bind, effect of detumescence, cures mainly red eye, swell pain, and order pearl nyctalgia, has a headache dizzy, scrofula, goiter and tumor, swells and ache; Thyroid gland enlargement, scrofula, the proliferation of mammary gland, the card such as hypertension, hyperglycaemia, high fat of blood and high blood are sticky.
Tarragon: taste is pungent, bitter, warm in nature, returns liver,spleen,kidney warp, cures mainly haematemesis; Bleeding from five sense organs or subcutaneous tissue; Painstaking blood; Have blood in stool; Uterine bleeding; Gestation hemorrhage; Irregular menstruation; Dysmenorrhoea; Fetal irritability; Trusted subordinate's crymodynia; The protracted dysentery of having loose bowels; Choleraic myospasm; Under band; Eczema; Mange; Hemorrhoid; The cards such as large carbuncle.
Moutan bark: bitter, pungent, cold nature, enter the heart, liver, kidney channel, there is the effect of clearing heat and cooling blood, promoting blood circulation to remove blood stasis, be mainly used in treating warm heat disease heat invading xuefen, send out spot, tell nosebleed, hot Fu Yin of pyreticosis later stage divides heating, deficiency of Yin osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhoea, carbuncle sore tumefacting virus, falls and flutter the card such as the pain of injury, rheumatic fever numbness.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine composition 1
By wind-weed 50g, bighead atractylodes rhizome 35g, wilsonii 45g, giant knotweed 25g, suchow mosla herb 20g, sargentodoxa cuneata 25g, seed of Chinese dodder 30g, seed of feather cockscomb 25g, radix scrophulariae 40g, purslane 25g, great burdock achene 25g, leaf of negundo chastetree 30g, as medicine 25g, hawthorn 35g, rainbow conk 20g, Chinese prickly ash 30g, Radix Angelicae Sinensis 35g, asafoetide 30g, radix glehniae 30g, bark of official magnolia 25g, hairy euphorbia 35g, folium panacis japonici cum caule 50g, wrinkled giant hyssop 35g, selfheal 20g, tarragon 25g and moutan bark 30g are ground into respectively powder, be uniformly mixed, cross 20 mesh sieves, obtain mixture, adopt water boiling and extraction 2 times, for the mixture of every 1kg, water uses 7L, each extraction 1.5 hours, suction filtration, remove filter residue, merging filtrate, the extract obtaining adopts Reduced Pressure Concentration Device at 80 DEG C, vacuum is 0.095Mpa, solution to be concentrated feed liquor flow velocity is 200mlmin-1Condition under concentrated, the concentrated extract obtaining carries out vacuum drying at 50 DEG C, obtains extracting powder, is Chinese medicinal composition preparation 1.
Embodiment 2 Chinese medicine compositions 2
By wind-weed 48g, bighead atractylodes rhizome 33g, wilsonii 43g, giant knotweed 23g, suchow mosla herb 18g, sargentodoxa cuneata 23g, seed of Chinese dodder 28g, seed of feather cockscomb 23g, radix scrophulariae 38g, purslane 23g, great burdock achene 23g, leaf of negundo chastetree 28g, as medicine 23g, hawthorn 33g, rainbow conk 18g, Chinese prickly ash 28g, Radix Angelicae Sinensis 33g, asafoetide 28g, radix glehniae 28g, bark of official magnolia 23g, hairy euphorbia 33g, folium panacis japonici cum caule 48g, wrinkled giant hyssop 33g, selfheal 18g, tarragon 23g and moutan bark 28g are ground into respectively powder, be uniformly mixed, cross 20 mesh sieves, obtain mixture, adopt water boiling and extraction 2 times, for the mixture of every 1kg, water uses 7L, each extraction 1.5 hours, suction filtration, remove filter residue, merging filtrate, the extract obtaining adopts Reduced Pressure Concentration Device at 80 DEG C, vacuum is 0.095Mpa, solution to be concentrated feed liquor flow velocity is 200mlmin-1Condition under concentrated, the concentrated extract obtaining carries out vacuum drying at 50 DEG C, obtains extracting powder, is Chinese medicinal composition preparation 2.
Embodiment 3 Chinese medicine compositions 3
By wind-weed 52g, bighead atractylodes rhizome 37g, wilsonii 47g, giant knotweed 27g, suchow mosla herb 22g, sargentodoxa cuneata 27g, seed of Chinese dodder 32g, seed of feather cockscomb 27g, radix scrophulariae 42g, purslane 27g, great burdock achene 27g, leaf of negundo chastetree 32g, as medicine 27g, hawthorn 37g, rainbow conk 22g, Chinese prickly ash 32g, Radix Angelicae Sinensis 37g, asafoetide 32g, radix glehniae 32g, bark of official magnolia 27g, hairy euphorbia 37g, folium panacis japonici cum caule 52g, wrinkled giant hyssop 37g, selfheal 22g, tarragon 27g and moutan bark 32g are ground into respectively powder, be uniformly mixed, cross 20 mesh sieves, obtain mixture, adopt water boiling and extraction 2 times, for the mixture of every 1kg, water uses 7L, each extraction 1.5 hours, suction filtration, remove filter residue, merging filtrate, the extract obtaining adopts Reduced Pressure Concentration Device at 80 DEG C, vacuum is 0.095Mpa, solution to be concentrated feed liquor flow velocity is 200mlmin-1Condition under concentrated, the concentrated extract obtaining carries out vacuum drying at 50 DEG C, obtains extracting powder, is Chinese medicinal composition preparation 3.
Embodiment 4 feeds
By wheat 6kg, dregs of beans 1.5kg, dish dregs of rice 1.5kg, medical stone 800g, calcium monohydrogen phosphate 400g, salt 200g pulverizes respectively, send in mixer and be uniformly mixed, obtain compound, compound is dried 3 minutes with the rotary drum dryer of 200 DEG C of temperature, the water content that makes compound is 5%, make semi-finished product, semi-finished product are sieved, the aperture of sieving is for the first time 1mm, obtain finished product, filtering out the granule that is greater than 1mm pulverizes again, the finished product filtering out is sent into and in mixing and blending machine, is added amino acid premix 400g, vitamin premix 600g, Chinese medicinal composition preparation 1.1kg prepared by composite trace element 300g and embodiment 1, stir 2 minutes, obtain feed.
Embodiment 5 acute toxicity testings and long term toxicity test
Acute toxicity testing
Require to carry out prerun according to acute toxicity test, find that tested medicine cannot measure LD50. Therefore carry out maximum dosage-feeding test in a day. Get 40 of above-mentioned mouse, fasting be can't help water after 12 hours, be divided at random administration group and water control group by body weight, every group 20, administration group is given the liquid 0.4ml/10g of the crude drug amount 2.6g/ml concentration of the Chinese medicinal composition preparation of preparing containing embodiment 1, gavage one day 2 times, water control group is to the water of equal volume. After each treated animal administration, 5, every box, normal raising, close observation, all Continuous Observations seven days, the toxic reaction that record may occur and death condition, after administration, mouse outward appearance hair color light, behavioral activity is normal, occur without abnormal pathologic neural reflex, in seven days, well, other Novel presentation is seen at end in feed, and changes of weight is no significant difference and none animal dead compared with water control group, visually observe the main organs such as the heart, liver, spleen, lung, kidney, without general pathology changes such as significantly hemorrhage, tissue degeneratiaon, necrosis.
Long term toxicity test
Experiment is established 2 groups altogether: Chinese medicinal composition preparation group (dosage is respectively 53.1g crude drug/kg) and blank group prepared by the embodiment of the present invention 1, to 9 week age big white mouse within continuous 180 days, gavage, administration 90 days, 180 days and drug withdrawal are after 30 days, put to death respectively rat, check each treated animal hematological indices [red blood cell (RBC), mean corpuscular volume (MCV) (MCV), hematid specific volume (HCT), blood platelet (PLT), mean platelet volume (MPV), leucocyte (WBC), hemoglobin (HGB), mean corpusular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) (MCHC), lymphocyte percentage (LPR), neutrophil percentage (GPR), intermediate value cell percentage (MPR), RDW (RDWR), RDW number (RDWA), Reticulocyte percentage (RET), blood zymogen time (PT) agglutinates], blood biochemical is learned index [glutamic-pyruvic transaminase (ALT), total protein (TP), albumin (ALB), total bilirubin (TBIL), glutamic-oxalacetic transaminease (AST), creatine kinase (CK), creatinine (CREA), urea nitrogen (BUN), blood sugar (GLU), T-CHOL (CHOL), triglyceride (TG), glutamine aminopherase (GGT), alkaline phosphatase (ALP), serum potassium ion (K+), serum sodium ion (Na+), serum chloride ion (Cl-)]. All animal hearts, liver, spleen, lung, kidney, brain, uterus, ovary, thymus gland, adrenal gland are visually observed, and the calculating organ index of weighing; Blank group and the Chinese medicine immune formulation treated animal heart, liver, spleen, lung, kidney, brain (brain, cerebellum, brain stem), hypophysis, optic nerve, sciatic nerve, spinal cord (cervical part of esophagus, chest section, waist section), uterus, ovary, mammary gland, thyroid gland, thymus gland, pancreas, adrenal gland, salivary gland (salivary gland), esophagus, Stomach duodenum, bladder, lymph node (submandibular lymph nodes, lymphonodi mesenterici), tracheae, sustainer are carried out to Pathomorphology inspection simultaneously.
Result shows: administration treated animal is in the different dosing cycle, above index and control group comparison, and all without anomaly, hematology and biochemical index are all in range of normal value.
Result shows that it is safe that Chinese medicine composition long-term, high-dose of the present invention uses.
Embodiment 6 control experiments
Experimental animal: at healthy 20 Day-old Broiler Chickens of certain chicken house, select close 180 of body weight, cut open inspection and bacteriology checking and be diagnosed as the sick chicken of fowl cholera by clinical symptoms, pathology, separately select 900 in the broiler chicken group of 20 ages in days of morbidity not and test.
Chinese medicinal composition preparation 1 prepared by medicine: embodiment 1, feed prepared by embodiment 4, terramycin.
Bacterial classification: avian pasteurella multocida C48-1Bacterial strain is provided by China Veterinary Drugs Supervisory Inst..
Attack poison liquid: test is front by C48-1Pasteurella velogen strain moves into brain heart soup nutrient solution and cultivates 24 hours, is inoculated in suitable culture medium after healthy chicken goes down to posterity rejuvenation, 18 hours results bacterium liquid of 37 DEG C of water-baths, counting viable bacteria. Increase progressively dilution bacterium liquid with 10 times with the sterile saline of PH7.0, recording the minimum lethal dose of chicken is 4 viable bacterias, is prepared into every ml and attacks toadstool liquid containing 4 viable bacterias.
Method
Treatment experiment: sick 180 fowl cholera chicken is divided into 3 groups, 60 every group at random. Treatment by Chinese herbs group, the Chinese medicinal composition preparation 1 of preparing by the embodiment of the present invention 1 is treated, and every day, 50g, was dissolved in the solution that is prepared into 1g/ml in distilled water, at twice gastric infusion; Terramycin treatment group, with 0.3% terramycin treatment; Control group, need not any medicine. Experimental period is 7d, each group of feeding common wheat feed during treating.
Prophylactic tria: 900 healthy chickens are divided into 3 groups at random, 300 every group. Feed prepared by the Chinese herb on the prevention group feeding embodiment of the present invention 4; Western medicine prevention group 0.1% terramycin; Control group need not any medicine, simultaneously, the feed of Western medicine prevention group and control group feeding is to remove the remaining composition of Chinese medicinal composition preparation 1 in the feed prepared of embodiment 4, the feed that adopts the same procedure of preparing with embodiment 4 to be prepared from, feed after 20d, three groups of chickens are all used the C of 1 minimum lethal dose48-1Cholera fowl living bacterial liquid is attacked poison, observes 7d.
Extracorporeal bacteria inhibitor test: Chinese medicinal composition preparation prepared by embodiment 1 adds in nutrient agar with 0.5%, in water-bath, boil after 30min and leave standstill and within several minutes, make insoluble Chinese medicine slag sink, getting supernatant adds agar and makes agar plate, and use same method to make the agar plate that does not add Chinese medicine, respectively at adding 0.1ml Pasteurella bacterium liquid (4.6 × 10 in two kinds of plates9/ ml), cultivate 24h for 37 DEG C, observe bacterial growth situation.
Result
Clinical symptoms
Sick chicken in each group all shows as: spirit is depressed, and tail fin is sagging, closes one's eyes slow-witted vertical, and feather is fluffy and disorderly unglazed; Poor appetite or absolutely useless, drink wish increases; 42 ~ 43 DEG C of body temperature; Mouth and nose flow out mucus, and mouth breathing, shakes the head; Violent diarrhea, row's green or white loose stool; Cockscomb and wattle are blue. The sick chicken death time of Chinese herb on the prevention and treatment group slightly postpones compared with blank group.
Cuing open inspection changes
The chicken that dies of illness is cutd open to inspection to be found: chicken peritonaeum, hypodermis and stomach fat have petechial hemorrhage, and the external membrane of heart, the heart are preced with fatty hemorrhage particularly evident; Hepatomegaly, the many canescence of surface distribution, the necrosis region that syringe needle is large, matter is crisp; Enteron aisle is with small intestine leading portion and colorectal mucosa hyperemia, hemorrhage serious; Pulmonary edema, extravasated blood. Chinese drug-treated group lesion degree is obviously light than terramycin group and blank group.
Laboratory examination: do contact with the heart, blood, liver and the spleen of sick chicken, Wright's staining microscopy, is shown in the Pasteurella of bipolar staining.
Extracorporeal bacteria inhibitor test: cultivate after 24h, blank group leader goes out 460 bacterium colonies, adds the plate of Chinese medicine without colony growth, has effectively suppressed Pasteurella C48-1The growth of strain.
Therapeutic test, the results are shown in Table 1.
Table 1 treatment experiment
| Group | Sick chicken number (only) | Cure number (only) | Cure rate (%) | The death rate (%) |
| Treatment by Chinese herbs group | 60 | 56 | 93.3 | 6.7 |
| Terramycin group | 60 | 49 | 81.6 | 18.4 |
| Control group | 60 | 5 | 8.3 | 91.7 |
As can be seen from Table 1, the survival number of the sick chicken of employing Chinese medicinal composition preparation and terramycin, apparently higher than control group, adopts the sick chicken survival number of Chinese medicinal composition preparation to be significantly higher than terramycin.
Prophylactic tria, the results are shown in Table 2.
Table 2 prophylactic tria
| Group | Test chicken (only) | Morbidity number (only) | Protective rate (%) |
| Chinese herb on the prevention group | 300 | 5 | 98.3 |
| Terramycin group | 300 | 19 | 93.7 |
| Control group | 300 | 43 | 85.7 |
3 groups of the duration of test all fowl cholera that has in various degree occur, but each group difference is obvious, the highest with Chinese medicinal composition preparation protection.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method. Those skilled in the art will utilize this important information, and foregoing amendment, to realize similar implementation status. But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the restriction of the present invention being made to other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations. But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (7)
1. a feed, is characterized in that: comprise wheat, dregs of beans, the dish dregs of rice, medical stone, calcium monohydrogen phosphate, salt, amino acid premix, vitamin premix, composite trace element and for preventing and treating the Chinese medicinal composition preparation of cholera fowl;
The weight portion of each raw material is respectively wheat 5.5kg～6.5kg, dregs of beans 1kg～2kg, dish dregs of rice 1kg～2kg, medical stone 750g～850g, calcium monohydrogen phosphate 350g～450g, salt 150g～250g, amino acid premix 350g～450g, vitamin premix 550g～650g, composite trace element 250g～350g and described Chinese medicinal composition preparation 1kg～1.2kg;
The bulk drug of described Chinese medicinal composition preparation forms by the wind-weed, the bighead atractylodes rhizome, wilsonii, giant knotweed, suchow mosla herb, sargentodoxa cuneata, the seed of Chinese dodder, the seed of feather cockscomb, radix scrophulariae, purslane, great burdock achene, leaf of negundo chastetree, when medicine, hawthorn, rainbow conk, Chinese prickly ash, Radix Angelicae Sinensis, asafoetide, radix glehniae, the bark of official magnolia, hairy euphorbia, folium panacis japonici cum caule, wrinkled giant hyssop, selfheal, tarragon and moutan bark;
The weight portion of each bulk drug is respectively the wind-weed 45 weight portion～55 weight portions, the bighead atractylodes rhizome 30 weight portion～40 weight portions, wilsonii 40 weight portion～50 weight portions, giant knotweed 20 weight portion～30 weight portions, suchow mosla herb 15 weight portion～25 weight portions, sargentodoxa cuneata 20 weight portion～30 weight portions, the seed of Chinese dodder 25 weight portion～35 weight portions, the seed of feather cockscomb 20 weight portion～30 weight portions, radix scrophulariae 35 weight portion～45 weight portions, purslane 20 weight portion～30 weight portions, great burdock achene 20 weight portion～30 weight portions, leaf of negundo chastetree 25 weight portion～35 weight portions, when medicine 20 weight portion～30 weight portions, hawthorn 30 weight portion～40 weight portions, rainbow conk 15 weight portion～25 weight portions, Chinese prickly ash 25 weight portion～35 weight portions, Radix Angelicae Sinensis 30 weight portion～40 weight portions, asafoetide 25 weight portion～35 weight portions, radix glehniae 25 weight portion～35 weight portions, the bark of official magnolia 20 weight portion～30 weight portions, hairy euphorbia 30 weight portion～40 weight portions, folium panacis japonici cum caule's 45 weight portion～55 weight portions, wrinkled giant hyssop 30 weight portion～40 weight portions, selfheal 15 weight portion～25 weight portions, tarragon 20 weight portion～30 weight portions and moutan bark 25 weight portion～35 weight portions.
2. feed as claimed in claim 1, is characterized in that: the weight portion of each raw material is respectively wheat 6kg, dregs of beans 1.5kg, dish dregs of rice 1.5kg, medical stone 800g, calcium monohydrogen phosphate 400g, salt 200g, amino acid premix 400g, vitamin premix 600g, composite trace element 300g and described Chinese medicinal composition preparation 1.1kg.
3. the preparation method of feed described in claim 1 or 2, is characterized in that:
The first step, is ground into respectively powder by the bulk drug of described Chinese medicinal composition preparation, is uniformly mixed by weight, cross 20 mesh sieves, obtain mixture, adopt water boiling and extraction 1～2 time, for the mixture of every 1kg, water uses 6～8L, extracts 1～1.5 hour at every turn, suction filtration, remove filter residue, merging filtrate, the extract obtaining adopts Reduced Pressure Concentration Device at 70 DEG C～80 DEG C, vacuum is 0.09MPa～0.095MPa, and solution to be concentrated feed liquor flow velocity is 150～200mlmin-1Condition under concentrated, the concentrated extract obtaining carries out vacuum drying at 45 DEG C～55 DEG C, obtains extracting powder, is Chinese medicinal composition preparation;
Second step, by wheat, dregs of beans, the dish dregs of rice, medical stone, calcium monohydrogen phosphate, salt is pulverized respectively, send in mixer and be uniformly mixed in proportion, obtain compound, compound is dried 2～3 minutes with the rotary drum dryer of 180 DEG C～220 DEG C of temperature, the water content that makes compound is 5%～10%, make semi-finished product, semi-finished product are sieved, the aperture of sieving is for the first time 1mm, obtain finished product, filtering out the granule that is greater than 1mm pulverizes again, the finished product filtering out is sent into and in mixing and blending machine, is added in proportion amino acid premix, vitamin premix, Chinese medicinal composition preparation prepared by composite trace element and the first step, stir 2 minutes, obtain feed.
4. for preventing and treating a Chinese medicinal composition preparation for cholera fowl, it is characterized in that: bulk drug forms by the wind-weed, the bighead atractylodes rhizome, wilsonii, giant knotweed, suchow mosla herb, sargentodoxa cuneata, the seed of Chinese dodder, the seed of feather cockscomb, radix scrophulariae, purslane, great burdock achene, leaf of negundo chastetree, when medicine, hawthorn, rainbow conk, Chinese prickly ash, Radix Angelicae Sinensis, asafoetide, radix glehniae, the bark of official magnolia, hairy euphorbia, folium panacis japonici cum caule, wrinkled giant hyssop, selfheal, tarragon and moutan bark;
The weight portion of each bulk drug is respectively the wind-weed 45 weight portion～55 weight portions, the bighead atractylodes rhizome 30 weight portion～40 weight portions, wilsonii 40 weight portion～50 weight portions, giant knotweed 20 weight portion～30 weight portions, suchow mosla herb 15 weight portion～25 weight portions, sargentodoxa cuneata 20 weight portion～30 weight portions, the seed of Chinese dodder 25 weight portion～35 weight portions, the seed of feather cockscomb 20 weight portion～30 weight portions, radix scrophulariae 35 weight portion～45 weight portions, purslane 20 weight portion～30 weight portions, great burdock achene 20 weight portion～30 weight portions, leaf of negundo chastetree 25 weight portion～35 weight portions, when medicine 20 weight portion～30 weight portions, hawthorn 30 weight portion～40 weight portions, rainbow conk 15 weight portion～25 weight portions, Chinese prickly ash 25 weight portion～35 weight portions, Radix Angelicae Sinensis 30 weight portion～40 weight portions, asafoetide 25 weight portion～35 weight portions, radix glehniae 25 weight portion～35 weight portions, the bark of official magnolia 20 weight portion～30 weight portions, hairy euphorbia 30 weight portion～40 weight portions, folium panacis japonici cum caule's 45 weight portion～55 weight portions, wrinkled giant hyssop 30 weight portion～40 weight portions, selfheal 15 weight portion～25 weight portions, tarragon 20 weight portion～30 weight portions and moutan bark 25 weight portion～35 weight portions.
5. Chinese medicinal composition preparation as claimed in claim 4, is characterized in that: the weight portion of each bulk drug is respectively the wind-weed 48 weight portion～52 weight portions, the bighead atractylodes rhizome 33 weight portion～37 weight portions, wilsonii 43 weight portion～47 weight portions, giant knotweed 23 weight portion～27 weight portions, suchow mosla herb 18 weight portion～22 weight portions, sargentodoxa cuneata 23 weight portion～27 weight portions, the seed of Chinese dodder 28 weight portion～32 weight portions, the seed of feather cockscomb 23 weight portion～27 weight portions, radix scrophulariae 38 weight portion～42 weight portions, purslane 23 weight portion～27 weight portions, great burdock achene 23 weight portion～27 weight portions, leaf of negundo chastetree 28 weight portion～32 weight portions, when medicine 23 weight portion～27 weight portions, hawthorn 33 weight portion～37 weight portions, rainbow conk 18 weight portion～22 weight portions, Chinese prickly ash 28 weight portion～32 weight portions, Radix Angelicae Sinensis 33 weight portion～37 weight portions, asafoetide 28 weight portion～32 weight portions, radix glehniae 28 weight portion～32 weight portions, the bark of official magnolia 23 weight portion～27 weight portions, hairy euphorbia 33 weight portion～37 weight portions, folium panacis japonici cum caule's 48 weight portion～52 weight portions, wrinkled giant hyssop 33 weight portion～37 weight portions, selfheal 18 weight portion～22 weight portions, tarragon 23 weight portion～27 weight portions and moutan bark 28 weight portion～32 weight portions.
6. the Chinese medicinal composition preparation as described in claim 4 or 5, it is characterized in that: the weight portion of each bulk drug is respectively the wind-weed 50 weight portions, the bighead atractylodes rhizome 35 weight portions, wilsonii 45 weight portions, giant knotweed 25 weight portions, suchow mosla herb 20 weight portions, sargentodoxa cuneata 25 weight portions, the seed of Chinese dodder 30 weight portions, the seed of feather cockscomb 25 weight portions, radix scrophulariae 40 weight portions, purslane 25 weight portions, great burdock achene 25 weight portions, leaf of negundo chastetree 30 weight portions, when medicine 25 weight portions, hawthorn 35 weight portions, rainbow conk 20 weight portions, Chinese prickly ash 30 weight portions, Radix Angelicae Sinensis 35 weight portions, asafoetide 30 weight portions, radix glehniae 30 weight portions, the bark of official magnolia 25 weight portions, hairy euphorbia 35 weight portions, folium panacis japonici cum caule's 50 weight portions, wrinkled giant hyssop 35 weight portions, selfheal 20 weight portions, tarragon 25 weight portions and moutan bark 30 weight portions.
7. the preparation method of Chinese medicinal composition preparation described in claim 5 or 6, it is characterized in that: above-mentioned raw materials medicine is ground into respectively to powder, be uniformly mixed by weight, cross 20 mesh sieves, obtain mixture, adopt water boiling and extraction 1～2 time, for the mixture of every 1kg, water uses 6～8L, extracts 1～1.5 hour at every turn, suction filtration, remove filter residue, merging filtrate, the extract obtaining adopts Reduced Pressure Concentration Device at 70 DEG C～80 DEG C, vacuum is 0.09MPa～0.095MPa, and solution to be concentrated feed liquor flow velocity is 150～200mlmin-1Condition under concentrated, the concentrated extract obtaining carries out vacuum drying at 45 DEG C～55 DEG C, obtains extracting powder, is Chinese medicinal composition preparation.
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| CN201410078758.7A CN103800642B (en) | 2014-03-06 | 2014-03-06 | For preventing and treating the pharmaceutical preparation of cholera fowl |
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| CN106421343A (en) * | 2016-10-24 | 2017-02-22 | 石家庄市九洲兽药有限公司 | Traditional Chinese veterinary medicine for preventing and treating poultry flu |
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