CN103784521A - Traditional Chinese medicinal composition for treating abdominal absdcess in combination with operative treatment and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for treating abdominal absdcess in combination with operative treatment and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for treating abdominal absdcess in combination with operative treatment, and the traditional Chinese medicinal composition is prepared from the following components in parts by weight: Radix Et Rhizoma Rhei 20-30 parts, mirabilite 20-30 parts, Radix Paeoniae Rubra (Paeonia lactiflora and/or Paeonia veitchii) 3-6 parts, Carthamus tinctorius flower 3-6 parts, and gizzard membrane of Gallus gallus domesticus 2-4 parts. The invention also discloses a preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition disclosed by the invention is a pure traditional Chinese medicinal preparation with the advantages of convenience in administration, no obvious toxic and adverse effect, quick action, definite therapeutic effect, easily-available raw materials, low cost, high effective rate (up to 98%), low complication incidence, treatment of both symptoms and root causes, and good long-term effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition that coordinates operative treatment peritoneal abscess and preparation method thereof
Background technology
Peritoneal abscess refers to that a certain gap of intraperitoneal or position, because tissue necrosis liquefies, by parcels such as intestinal song, internal organs, stomach wall, nethike embrane or mesentery, form limitation pus and gather, and causes the various diseases of secondary peritonitis; After abdominal operation and wound, all can cause peritoneal abscess, infection is the main cause that causes peritoneal abscess, its clinical manifestation is mainly subphrenic abscess, pelvic abscess and interbowel abscess, and abscess excision, the placing drainages of adopting carry out the thorough drain of pus, hemostasis, the application of effective antibiotics, nutrition supporting therapy more at present.Abscess of appendix is a type of peritoneal abscess, there is certain representativeness, vermiform appendix has and oozes out, downright bad, when perforation, nethike embrane and near intestinal tube can tend to vermiform appendix and form encirclement, swollen swelling not is the empyema of a lacuna, often nethike embrane and the small intestinal of an inflammatory agglomerate, the war of patient's much cold, high heat, numeration of leukocyte raises, Right Lower Abdomen can touch an enclosed mass, obscure boundary, tenderness is obvious, with surrounding tissue adhesion, anatomy relationship is unclear, surgical resection therapy is usually difficult to reach the curative effect of thorough healing separately, and likely there is intestinal fistula, peritonitis, the complication such as intestinal obstruction.
Summary of the invention
The object of the invention is, for overcoming above-mentioned the deficiencies in the prior art, provides a kind of Chinese medicine composition that coordinates operative treatment peritoneal abscess, can promote abscess limitation, absorb, and shortens the course of disease, shortens the hospital stays, reduces medical expense.
Another object of the present invention is to provide the preparation method of this Chinese medicine composition.
For achieving the above object, the present invention adopts following technical proposals:
Technical solution of the present invention source and foundation: formula of the present invention is according to China's theory of TCM, in conjunction with inventor's clinical research for many years, the refined diagnosis technology of macroscopical determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of Chinese medicine and modern medicine apply in clinical experimentation, draw through proved recipe.China's Chinese medicine thinks that this disease is the scorchingly hot gastrointestinal that blocks, stagnation of QI-blood, positive bright accumulation of heat ， Zhou flow of QI being obstructed, and occur pain, vomit, swollen, close, heat five large symptoms; The sick excess syndrome of interior-heat that belongs to, according to the theory of the six hollow viscera must keep its unobstructed, when by purgation for controlling; Treatment is with activating blood circulation to dissipate blood stasis, heat-clearing and toxic substances removing, dispersing cold for relieving pain, and loosening bowel to relieve constipation is main.Tongli is captured, heat reliving and toxin-eliminating, blood circulation promoting and blood stasis dispelling three methods develop simultaneously, and reaches and purges heat by heresy, and dredging Chang Zhou effaces the pernicious influence, promoting tissue regeneration by removing blood stasis, thereby plays the effect of strengthening vital QI to eliminate pathogenic factors.Early postoperative period application, the recovery time that can improve gastrointestinal function, reduces intestinal source property toxin and absorbs, and becomes the main source of healthy intestinal absorption nutrition, and antibacterial and toxin are produced to humoral immunization and cellular immunization.Strengthen the oxidasic activity of superoxides, reduce or suppress the formation of oxygen-derived free radicals, reduce the infringement of active oxygen to cells of organs.Improve gastrointestinal tract blood flow, reduce inflammation and ooze out, promote peritoneum to absorb, reduce inflammation adhesion and abscess and form.Application modern medicine technology is carried out science location, qualitative, quantitative Diagnosis to the cause of disease of peritoneal abscess, and the comprehensive of the integrity of clinical diagnosis and treatment guaranteed in the combination of Chinese and Western medicine.
Traditional Chinese medicine composition of the present invention is to be made up of the crude drug of following weight portion:
Radix Et Rhizoma Rhei 20-30 part, Natrii Sulfas 20-30 part, Radix Paeoniae Rubra 3-6 part, Flos Carthami 3-6 part, Endothelium Corneum Gigeriae Galli 2-4 part.
Optimum weight part proportioning of pharmaceutical composition of the present invention is:
25 parts of Radix Et Rhizoma Rhei, 25 parts, Natrii Sulfas, 4 parts of Radix Paeoniae Rubra, 6 parts, Flos Carthami, 3 parts of Endothelium Corneum Gigeriae Galli.
Described Radix Et Rhizoma Rhei, Natrii Sulfas, Radix Paeoniae Rubra, Flos Carthami and Endothelium Corneum Gigeriae Galli 5 taste medical materials are the kind that " Chinese Pharmacopoeia " 2010 version () is recorded, and its quality all meets every regulation relevant under each kind item.
Wherein, Radix Et Rhizoma Rhei: bitter in the mouth, cold in nature.Return stomach, spleen, large intestine, liver, pericardium channel.There is purging heat to relax the bowels effect,, constipation stagnant for Gastrointestinal excess heat, abdominal part distension, pain with tenderness, even hyperpyrexia, unconsciousness and delirium, purging heat to relax the bowels, cleanses the intestines and stomach, pushes away Chen Zhixin.Cure mainly the accumulation of food in the stomach and intes tine due to indigestion due to gastrointestinal retention, constipation due to dry stool is obstructed, irritable feverish sensation of chest and heart, oliguria with reddish urine etc.Or damp-heat diarrhea is thirsty more than, gets ill from overeating and cuts off the water.Or married woman's postponed menstruation, abdominal pain in menstruation, darkish complexion has piece etc.
Natrii Sulfas: mineral are arduous salty, cold.Enter stomach, large intestine channel.Purgatives medicine, cathartic drug.Cure mainly under softening the hard mass rushes down, removing damp-heat, removing blood stasis stimulates the menstrual flow, and skin ulcer is treated in detumescence.Control excess-heat stagnant, abdominal distention constipation, retention of phlegm gathers, and conjunctival congestion is hidden from view, erysipelas, carbuncle.
Radix Paeoniae Rubra: bitter, cool.Bitter in the mouth is flat.Enter liver, spleen channel.Effect: clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI.
Flos Carthami: property and flavor of peppery and warm, enters the heart, Liver Channel.There is effect of promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving.
Endothelium Corneum Gigeriae Galli: sweet, cold.Return spleen, stomach, small intestinal, urinary bladder channel.Energy promoting digestion and invigorating the stomach, arresting seminal emission.
Chinese medicine composition of the present invention can adopt following methods preparation:
(1) take after each Chinese medicinal components by parts by weight in prescription, dry porphyrize powder, crosses 300 mesh sieves, packs the interior sealing of vial into for subsequent use;
(2) Radix Et Rhizoma Rhei, Natrii Sulfas are mixed and mixed well, then add other Chinese medicines of each weight portion, comprise Radix Paeoniae Rubra, Flos Carthami, Endothelium Corneum Gigeriae Galli, spray vinegar dries and ground 300 mesh sieves into powder, and adding the vinegar of 3 times of amount Chinese medicine compositions (mL/g) to be modulated into pasty state, to pack in vial sealing into for subsequent use.
Usage and dosage: after Chinese medicine composition of the present invention is mixed well with vinegar, pack in textile cloth bag abdomen external application, every day twice, each 30～60 minutes, 7～10 days courses for the treatment of into.With Chinese medicine composition abdomen external application treatment of the present invention time, coordinating ZhouLin frequency spectrum instrument to irradiate apart from Chinese medicine cloth bag 30cm place, effect is better.
Side effect and contraindication: through the clinical observation on the therapeutic effect of more than 10 years, patient occurred without obvious toxic-side effects; Anemia of pregnant woman and allergic constitution patient avoid use.
Radix Et Rhizoma Rhei energy heat and toxic materials clearing away, clearing away heat-fire, hemostasis removing toxic substances, blood circulation promoting and blood stasis dispelling; Natrii Sulfas external has effect of heat-clearing and toxic substances removing, removing blood stasis promoting the circulation of blood, mass dissipating and swelling eliminating.Radix Et Rhizoma Rhei, the mirabilite external applying efficacy of a drug can be absorbed or be permeated in human body by skin and play a role, coordinate frequency spectrograph or TDP irradiation treatment, effect is better, after TDP lamp energising, can produce rapidly heat, and give off can intelligent's body compared with the wave band infrared ray far away of position, deep, can make local vascular dilation, strengthen blood circulation, improve tissue metabolism and nutritional status, strengthen immunologic function, strengthen phagocytic function and vascular permeability, be conducive to the absorption of inflammatory exudate, reach therapeutic purposes.The permeability of blood capillary when Radix Paeoniae Rubra can reduce acute inflammation, reduces oozing out of inflammation, improves local blood circulation, promotes the absorption of inflammation, and makes inflammation focus localization, the granulomatous formation of inflammation-inhibiting.Flos Carthami has blood circulation promoting and blood stasis dispelling, improves microcirculatory effect.Chinese herb rhubarb is cold in nature, sweet-bitter flavor heat and toxic materials clearing away, clearing away heat-fire, particularly external has effect of detoxicating and resolving stagnation of pathogens, detumescence, share generation synergism with Natrii Sulfas, utilize the high effect of oozing to draw the excessive moisture in tissue, local blood flow is accelerated, blood capillary is open, improve microcirculation, promote to absorb, reach the object of detumescence, pain relieving, antiinflammatory.Radix Paeoniae Rubra, Flos Carthami share stronger antiendotoxin and the endogenous inflammatory mediator of anti-endotoxin induction monokaryon/macrophage generation and the release of tumor necrosis factor and interleukin-6; increase platelet and fibrinogen content; increase hematoblastic coagulation; improve because of the caused disturbances of blood coagulation of disseminated inravascular coagulation; improve superoxide dismutase activity; regulate too high or too low immunoreation, impaired internal organs under protection and reparation stress state.Its pathological characters of acute diffuse peritonitis shows as the congestion and edema of peritoneal cavity and internal organs thereof, a large amount of inflammatory liquid oozes out, and in art, there are a large amount of dirty solutions in visible abdominal cavity, and stomach, intestinal wall congestion and edema are more serious.Gastrointestinal edema due to peritonitis adds operation technique, repeatedly, a large amount of peritoneal irrigations increases the weight of postoperative abdominal cavity edema, peritonitis and operation wound make body in stress state simultaneously, renin angiotensin aldosterone system irritability increases, cause water-sodium retention, further increase the weight of the tolerant edema of intraperitoneal and intraperitoneal and ooze out, be unfavorable for the recovery of gastrointestinal function recovery after operation, and the reason such as abdominal distention easily causes infection of incisional wound and splits.Natrii Sulfas, main component is sodium sulfate crystal, can contain micro-sodium chloride, magnesium sulfate, calcium sulfate etc., is the refining crystallization of natural Natrii Sulfas, its nature and flavor are arduous salty-cold, enter stomach, large intestine channel.Function purging heat to relax the bowels, moisturize, softening hardness and disperse swelling.The for oral administration constipation curing mainly due to Gastrointestinal excess heat, the cards such as abdominal distention painful abdominal mass pain.When external application, Natrii Sulfas exists with sulfate ion form equally, becomes hyperosmotic state, and it, can also the Intraabdominal transudate of huge uptake except absorbing the moisture in portion of air.Thereby the edema of accelerating elimination ascites and abdominal cavity, gastrointestinal wall, is conducive to the postoperative recovery of patient.And its effect only limits to abdominal part, few to systemic effects.Share with Radix Et Rhizoma Rhei, produce mutual reinforcement between effect, can utilize the high effect of oozing to draw unnecessary moisture in tissue, strengthen regional flow, blood capillary opening is increased, improve microcirculation, promote to absorb, reach the object of detumescence, pain relieving, antiinflammatory.Endothelium Corneum Gigeriae Galli sweet in the mouth, property is flat.Enter spleen, stomach, small intestinal, bladder, can eat by removing food stagnancy the inducing decomposition of calculi, arresting enursis.Chinese medicine has cold, hot, warm, cool four kinds, in addition, some character is gentle, is referred to as the medicine of levelling.The medicine of levelling, because its effect relaxes, in general, and no matter be cold or hot disease, all can fit applications.Endothelium Corneum Gigeriae Galli sweet in the mouth, property is flat, makes up a prescription as one is auxiliary, can bring into play good therapeutical effect.Natrii Sulfas is joined Endothelium Corneum Gigeriae Galli, gets clean Endothelium Corneum Gigeriae Galli, fries to heaving, and spray vinegar takes out, and dries and grinds external application or raw subsides into powder, can make hard masses softening and resolving, and effect of heat clearing away fossil strengthens; Its mechanism is to produce stimulation by the reticuloendothelial system to spleen, its hypertrophy phenomenon and phagocytic activity are strengthened to some extent, cause intestinal neural reflex: abdomen external application Natrii Sulfas Endothelium Corneum Gigeriae Galli paste, local skin have heating, rubescent, play the irritation such as vesicle, small intestinal and vermiform appendix, bag-shaped Colon Movement strengthen; Therefore, drug effect causes by neural reflex.Strengthen owing to wriggling, supply of blood flow is abundant, and reticuloendothelial system phagocytic function is strengthened, thereby has transferred the resistance against diseases of body inherence.
Beneficial effect of the present invention:
(1) pure Chinese medicinal preparation, easy to use, without obvious toxic-side effects;
(2) instant effect, determined curative effect, medicine source is extensive, with low cost;
(3) effective percentage is up to 98%, and complication rate is little, treating both the principal and secondary aspects of a disease, and long-term effect is good.
The specific embodiment
Below by instantiation, the present invention will be further elaborated, should be noted that following explanation is only in order to explain the present invention, not limits its content.
1 one kinds of embodiment coordinate the Chinese medicine composition of operative treatment peritoneal abscess
[formula] Radix Et Rhizoma Rhei 250g, Natrii Sulfas 250g, Radix Paeoniae Rubra 40g, Flos Carthami 60g, Endothelium Corneum Gigeriae Galli 30g.
[method for making] (1) takes after each Chinese medicinal components by parts by weight in prescription, and dry porphyrize powder is crossed 300 mesh sieves, packs the interior sealing of vial into for subsequent use;
(2) Radix Et Rhizoma Rhei, Natrii Sulfas are mixed and mixed well, then add other Chinese medicines of each weight portion, comprise Radix Paeoniae Rubra, Flos Carthami, Endothelium Corneum Gigeriae Galli, spray vinegar dries and ground 300 mesh sieves into powder, and adding the vinegar of 3 times of amount Chinese medicine compositions (mL/g) to be modulated into pasty state, to pack in vial sealing into for subsequent use.
2 one kinds of embodiment coordinate the Chinese medicine composition of operative treatment peritoneal abscess
[formula] Radix Et Rhizoma Rhei 230g, Natrii Sulfas 230g, Radix Paeoniae Rubra 30g, Flos Carthami 40g, Endothelium Corneum Gigeriae Galli 20g.
[method for making] (1) takes after each Chinese medicinal components by parts by weight in prescription, and dry porphyrize powder is crossed 300 mesh sieves, packs the interior sealing of vial into for subsequent use;
(2) Radix Et Rhizoma Rhei, Natrii Sulfas are mixed and mixed well, then add other Chinese medicines of each weight portion, comprise Radix Paeoniae Rubra, Flos Carthami, Endothelium Corneum Gigeriae Galli, spray vinegar dries and ground 300 mesh sieves into powder, and the vinegar that adds 3 times of amount Chinese medicine compositions (mL/g) is modulated into pasty state, and to pack in vial sealing into for subsequent use.Obtain.
3 one kinds of embodiment coordinate the Chinese medicine composition of operative treatment peritoneal abscess
[formula] Radix Et Rhizoma Rhei 260g, Natrii Sulfas 260g, Radix Paeoniae Rubra 50g, Flos Carthami 30g, Endothelium Corneum Gigeriae Galli 40g.
[method for making] (1) takes after each Chinese medicinal components by parts by weight in prescription, and dry porphyrize powder is crossed 300 mesh sieves, packs the interior sealing of vial into for subsequent use;
(2) Radix Et Rhizoma Rhei, Natrii Sulfas are mixed and mixed well, then add other Chinese medicines of each weight portion, comprise Radix Paeoniae Rubra, Flos Carthami, Endothelium Corneum Gigeriae Galli, spray vinegar dries and ground 300 mesh sieves into powder, and the vinegar that adds 3 times of amount Chinese medicine compositions (mL/g) is modulated into pasty state, and to pack in vial sealing into for subsequent use.Obtain.
4 one kinds of embodiment coordinate the Chinese medicine composition of operative treatment peritoneal abscess
[formula] Radix Et Rhizoma Rhei 240g, Natrii Sulfas 240g, Radix Paeoniae Rubra 40g, Flos Carthami 50g, Endothelium Corneum Gigeriae Galli 30g.
[method for making] (1) takes after each Chinese medicinal components by parts by weight in prescription, and dry porphyrize powder is crossed 300 mesh sieves, packs the interior sealing of vial into for subsequent use;
(2) Radix Et Rhizoma Rhei, Natrii Sulfas are mixed and mixed well, then add other Chinese medicines of each weight portion, comprise Radix Paeoniae Rubra, Flos Carthami, Endothelium Corneum Gigeriae Galli, spray vinegar dries and ground 300 mesh sieves into powder, and the vinegar that adds 3 times of amount Chinese medicine compositions (mL/g) is modulated into pasty state, and to pack in vial sealing into for subsequent use.Obtain.
Clinical data
One, physical data:
Case-data is selected from November, 2008-2013 inpatient 1416 examples in year October, is divided at random treatment group 472 examples, and contrast A organizes 472 examples, and contrast B organizes 472 examples.Treatment group and matched group age, men and women's ratio and coincident with severity degree of condition had comparability through X 2 test no significant difference (P > 0.05) at 45～80 years old.
The comparison of table 1 gender situation
Note: sex comparison between group, through X
2check, X
2=1.34, P>0.05, there was no significant difference, has comparability.
The comparison of the each group of table 2 patient age
Note: between group, patient age distributes relatively, through rank test, P>0.05; There was no significant difference, has comparability.
The each group of the table 3 abdominal cavity infection state of an illness compares by stages
Note: before treatment, between group, conditions of patients compares by stages, through X
2check, X
2=0.10, P>0.05, there was no significant difference, has comparability.
Two, diagnostic criteria, case selection and criterion of therapeutical effect:
(1) diagnostic criteria: according to clinical symptoms sign, abdominal cavity infection was divided into for three phases by laboratory examination results and iconography report:
(1) low-grade infection: the abdominal cavity infection time in 12 hours,
1), after abdominal operation and wound, heating, abdominal part can touch enclosed mass, obscure boundary, tenderness is obvious;
2), there are percussion pain, tenderness under diaphragm and hypochondriac region, if this place's skin has pitting edema when abscess table is shallow, liver dullness circle raises;
3), numeration of leukocyte raises and the increase of neutrophilic granulocyte ratio;
4), under X ray or B ultrasonic orientation direction, puncture, can extract pus out;
5), through the capable qualitative level diagnosis result positive of CT.
(2) grade and moderate infection: the abdominal cavity infection time, above-mentioned symptom continued to increase the weight of in 12-48 hour, had infection poisoning symptom, increases through X ray or ultrasound diagnosis abscess, more than abdominal paracentesis can be extracted pus 1000mL out.
(3) severe infection: diffusivity abdominal cavity infection occurs, and disease time >=48 hour, have serious Sepsis shape to merge organ function obstacle.
(2) case inclusive criteria
Case-data is selected from November, 2008-2013 inpatient 1416 examples in year October, and all patient's ADs all meet surgical infection society of the U.S. in 2010 and the U.S. infects the diagnostic criteria of the complicated abdominal cavity infection diagnosis and treatment of the second edition guide that sick association issues.
(3) curative effect determinate standard
(1) cure: in 5 days, body temperature is down to 37 ℃, stomachache and local tenderness disappear, and palpation is not and enclosed mass; B ultrasonic prompting enclosed mass dissipates; Numeration of leukocyte, neutrophilic granulocyte percentage ratio obviously decline.
(2) effective: in 5～10 days, body temperature is down to 37 ℃, stomachache and local tenderness disappear or are slight, and palpation and ultrasound diagnosis enclosed mass dwindle more than 2/3; Numeration of leukocyte, neutrophilic granulocyte percentage ratio obviously decline.
(3) invalid: after 10 days, body temperature still exceedes 37 ℃.Stomachache and local tenderness, without improving or increasing the weight of on the contrary, are touched obvious enclosed mass; Numeration of leukocyte, neutrophilic granulocyte percentage ratio decline slowly or are not improved.
Three, clinical trial method:
(1) case grouping
Selected 1416 examples are observed case and are all met this research diagnostic criteria.Be divided at random treatment group 472 examples, contrast A organizes 472 examples, and contrast B organizes 472 examples.
(2) dosage regimen
1. therapeutic equipments and medicine
(1) instrument: ZhouLin frequency spectrum instrument, model ws-311, Beijing Zhou Lin frequency spectrum Science and Technology Ltd. manufactures.
(2) medicine:
The external application Chinese medicine prescription that coordinates operative treatment Abdominal cyst, is prepared from by embodiments of the invention 1;
Aztreonam: Shenzhen City Haibin Pharmaceutical Co., Ltd, authentication code: the accurate word H20058581 of traditional Chinese medicines;
Ciprofloxacin: Guangzhou Nan Xin pharmaceutical Co. Ltd, authentication code: the accurate word H44020106 of traditional Chinese medicines;
Levofloxacin: Zhejiang Medicine Co, authentication code: the accurate word H20033965 of traditional Chinese medicines;
Clindamycin: Zhuhai Ebang Pharmaceutical Co., Ltd., authentication code: the accurate word H20067876 of traditional Chinese medicines;
Piperacillin Tazobactam Sodium: Shangdong Ruiyang Pharmaceutical Co., Ltd, authentication code: the accurate word H20073602 of traditional Chinese medicines;
Meropenem: Haizheng Medicine Stock Co., Ltd., Zhejiang Prov, authentication code: the accurate word H20030331 of traditional Chinese medicines.
2. Therapeutic Method: all patients carry out abscess excision or abscess drain, strengthen nutritional support, with carry out antibacterial drug therapy, antibiotic selection: the one, according to the drug sensitive test of antibacterial, the 2nd, for abdominal cavity infection situation and empirical antibacterial drug therapy, be mainly that time, the order of severity, antibacterial and the present epidemiology of susceptibility state and the pharmacodynamics of anti-infectives that abdominal cavity infection occurs selected.Treatment group is used Chinese prescription of the present invention on this basis, after mixing well, packs textile cloth bag into vinegar, abdomen external application, every day twice, each 30-60 minute, 7～10 days courses for the treatment of.Contrast A group uses ZhouLin frequency spectrum instrument, every day to carry out twice irradiation on this basis, each 30-60 minute.Contrast B group, except operative drainage, effective antibiotics treatment, nutritional support, is not carried out other treatment.
(3) observation index
1, curative effect observation
Mainly clinical symptoms, sign (tension of abdominal muscle, tenderness rebound tenderness pressure, tabulate venter, abdominal mass etc.).
2, lab testing
Numeration of leukocyte, neutrophilic granulocyte percentage ratio, blood biochemical analysis refer to, ultrasound diagnosis, CT examination.
3, untoward reaction
Main monitoring index:
(1) anaphylaxis; (2) safety indexes: routine blood test, routine urinalysis, stool routine examination add occult blood, Liver and kidney merit, electrocardiogram.
Four, clinical treatment results and analysis
(1) clinical efficacy: treatment group and matched group, according to treatment forward and backward clinical symptoms and lab test results, carry out statistical disposition, by clinical efficacy criterion, the comprehensive therapeutic effect of medicine are made an appraisal.Result demonstration, the clinical cure rate for the treatment of group is 88.9%, obvious effective rate 8.9%, total effective rate 98.0%, is better than matched group (P ﹤ 0.01).Show Chinese medicine composition determined curative effect of the present invention, in table 4.
Between table 4. group, treat situation synopsis
Note: P<0.01.
(2) laboratory checking index testing result: to treatment group, contrast A group and contrast B group, according to the forward and backward lab test results for the treatment of, respectively the variation of leukocyte, neutrophilic granulocyte is carried out to statistical disposition.
1, treat forward and backward leukocytic variation: to before three groups of each 472 routine patient treatments and the numeration of leukocyte for the treatment of after 5,10 days, carry out respectively statistical disposition, result shows: before adopting the numeration of leukocyte of Chinese medicine composition partner treatment of the present invention after 5 days and 10 days to treat, all have obvious minimizing (p ﹤ 0.01).Treat numeration of leukocyte after 5 days becoming in human leukocyte range of normal value (4.0～10.0 × 10
9/ L), treat after 10 days effect more remarkable, be better than contrasting A group and contrast B group (p ﹤ 0.05), show that the leukocyte occurring after Chinese medicine composition of the present invention is to peritoneal abscess operative treatment increases symptom and has significant curative effect.
Leukocyte comparison before and after table 5 treatment
Note: treat latter 5 days with latter 10 days for the treatment of respectively with matched group comparison, through t check, p < 0.05.
2, treat the variation of forward and backward neutrophilic granulocyte percentage ratio: to before three groups of each 472 routine patient treatments and the neutrophil count for the treatment of after 5,10 days, carry out respectively statistical disposition, result shows: before adopting the neutrophilic granulocyte percentage ratio of Chinese medicine composition partner treatment of the present invention after 5 days and 10 days to treat, all have obvious minimizing (p ﹤ 0.01).Treat after 10 days effect more remarkable, be better than contrasting A group and contrast B group (p ﹤ 0.05), the symptom that the neutrophilic granulocyte that shows to occur after Chinese medicine composition of the present invention is to peritoneal abscess operative treatment increases has significant curative effect.
Neutrophilic granulocyte percentage ratio comparison before and after table 6 treatment
Note: treat latter 5 days with latter 10 days for the treatment of respectively with matched group comparison, through t check, p ﹤ 0.05.
(3) safety is observed:
Routine blood test, routine urinalysis, stool routine examination, liver, renal function and electrocardiogram etc. before and after 472 for the treatment of group routine patient treatments are checked, before and after result treatment, above-mentioned indices has no significant change, shows that prescription all has no adverse effects to liver function, kidney merit, electrocardiogram etc.Patient has no obvious adverse reaction at clinical application viewing duration.Yin Ben research is medicine for external use, and small number of patients has local skin anaphylaxis, but does not affect therapeutic effect.
Routine blood test, routine urinalysis, stool routine examination, liver, renal function and Electrocardioscopy result before and after the treatment of table 7 treatment group
Note: compare p>0.05 before and after the biochemical leading indicator treatment of blood.
(4) model case:
Case 1, Zhang, female, 25 years old, after acute appendicitis piercing operation, heating, full abdomen pain, tenderness rebound tenderness, total white blood cells raises, and neutrophilic granulocyte percentage ratio obviously raises, and acute peritonitis sign is obvious.The Abscess incision drain of performing the operation, effective antibiotics infection control, hemostasis, supporting treatment.Coordinate this prescription abdominal part hot-wet compress, coordinating ZhouLin frequency spectrum instrument to irradiate apart from Chinese medicine cloth bag 30cm place, treat body temperature after 3 days and decline gradually simultaneously, symptom is controlled, treats a course for the treatment of, and healing in 12 days is left hospital.
Case 2, Lee so-and-so, female, 31 years old, after acute appendicitis piercing operation, heating, full abdomen pain, tenderness rebound tenderness, total white blood cells raises, neutrophilic granulocyte percentage ratio obviously raises, acute peritonitis sign is obvious.The Abscess incision drain of performing the operation, effective antibiotics infection control, supporting treatment.Coordinate this prescription abdominal part hot-wet compress, treat body temperature after 4 days and decline gradually, symptom is controlled, treats a course for the treatment of, and healing in 15 days is left hospital.
Case 3, Chen, man, 33 years old, after acute appendicitis piercing operation, heating, full abdomen pain, tenderness rebound tenderness, total white blood cells raises, and neutrophilic granulocyte percentage ratio obviously raises, and acute peritonitis sign is obvious.The Abscess incision drain of performing the operation, effective antibiotics infection control, supporting treatment.Coordinate this prescription abdominal part hot-wet compress, coordinating ZhouLin frequency spectrum instrument to irradiate apart from Chinese medicine cloth bag 30cm place, treat body temperature after 4 days and decline gradually simultaneously, symptom is controlled, treats a course for the treatment of, and healing in 14 days is left hospital.
Case 4, Wang, man, 40 years old, after the capable kposthesis of Alimentary Tract Perforation, body temperature continued to raise, and has obvious peritoneal irritation sign, and total white blood cells raises, and neutrophilic granulocyte percentage ratio obviously raises, and is that subphrenic abscess forms through CT examination.Surgical incision abscess, placing drainage continues peritoneal abscess drain, effective antibiotics infection control, hemostasis, nutritional support coordinate this prescription abdominal part hot-wet compress simultaneously, treat body temperature after 6 days and decline gradually, symptom is controlled, treats two courses for the treatment of, and healing in 28 days is left hospital.
Case 5, Zhang, female, 55 years old, postoperative 3 days Intraperitoneal lymphs of Radical Operation of Gastric Carcinoma leak and peritoneal abscess formation, and body temperature continues to raise, intraperitoneal drainage liquid showed increased, after 1 week, peak (1500ml/d) give parenteral nutrition, supplement fresh blood, blood plasma, albumen and improve patient's immunologic function.The antibiotic of hemostasis, application wide spectrum, and make antibacterial culturing, drug sensitive test, selects antibiotic according to drug sensitive test, coordinates this prescription abdominal part hot-wet compress simultaneously, treats body temperature after 6 days and declines gradually, and symptom is controlled, treats two courses for the treatment of, and healing in 25 days is left hospital.
Claims (3)
1. a Chinese medicine composition that coordinates operative treatment peritoneal abscess, is characterized in that, is made up of the crude drug of following weight portion:
Radix Et Rhizoma Rhei 20-30 part, Natrii Sulfas 20-30 part, Radix Paeoniae Rubra 3-6 part, Flos Carthami 3-6 part, Endothelium Corneum Gigeriae Galli 2-4 part.
2. the Chinese medicine composition of cooperation operative treatment peritoneal abscess as claimed in claim 1, is characterized in that, is made up of the crude drug of following weight portion:
25 parts of Radix Et Rhizoma Rhei, 25 parts, Natrii Sulfas, 4 parts of Radix Paeoniae Rubra, 6 parts, Flos Carthami, 3 parts of Endothelium Corneum Gigeriae Galli.
3. the preparation method of the Chinese medicine composition of the cooperation operative treatment peritoneal abscess described in claim 1 or 2, is characterized in that, comprises the following steps:
(1) take by weight after each component, dry porphyrize powder, for subsequent use;
(2) Radix Et Rhizoma Rhei, Natrii Sulfas are mixed and mixed well, then add other Chinese medicines of each weight portion, comprise Radix Paeoniae Rubra, Flos Carthami, Endothelium Corneum Gigeriae Galli, spray vinegar dries, and the vinegar that adds 3 times of amount Chinese medicine compositions (mL/g) is modulated into pasty state, to obtain final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106776A (en) * | 2015-09-15 | 2015-12-02 | 温福海 | Medicine used for treating intraperitoneal abscesses in cooperation with operations and preparation method |
| CN105687972A (en) * | 2016-04-20 | 2016-06-22 | 张延社 | Traditional Chinese medicine formula for treating peritoneal abscess |
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| CN1985905A (en) * | 2006-12-19 | 2007-06-27 | 南京中医药大学 | Chinese medicine preparation for preventing and treating intestinal adhesion after abdominal cavity operation and its preparing process and application |
| EP2172207A1 (en) * | 2007-08-02 | 2010-04-07 | Tianjin Tasly Pharmaceutical Co. Ltd. | A pharmaceutical composition for treating diabetes and its process for preparation |
| US20120164249A1 (en) * | 2009-09-01 | 2012-06-28 | Uni-President Biotech Co., Ltd. | Chinese herbal medicine composition used for antiinflammation, detumescence and acesodyne, and preparation method and use thereof |
| CN102579609A (en) * | 2012-03-09 | 2012-07-18 | 张睿 | Blood-clearing dropping pills and preparation method thereof |
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2014
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1985905A (en) * | 2006-12-19 | 2007-06-27 | 南京中医药大学 | Chinese medicine preparation for preventing and treating intestinal adhesion after abdominal cavity operation and its preparing process and application |
| EP2172207A1 (en) * | 2007-08-02 | 2010-04-07 | Tianjin Tasly Pharmaceutical Co. Ltd. | A pharmaceutical composition for treating diabetes and its process for preparation |
| US20120164249A1 (en) * | 2009-09-01 | 2012-06-28 | Uni-President Biotech Co., Ltd. | Chinese herbal medicine composition used for antiinflammation, detumescence and acesodyne, and preparation method and use thereof |
| CN102579609A (en) * | 2012-03-09 | 2012-07-18 | 张睿 | Blood-clearing dropping pills and preparation method thereof |
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| 孙子伟，等: "Ｂ超引导穿刺及中药外敷联合抗生素治疗阑尾周围脓肿95例", 《中国中医药》 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106776A (en) * | 2015-09-15 | 2015-12-02 | 温福海 | Medicine used for treating intraperitoneal abscesses in cooperation with operations and preparation method |
| CN105687972A (en) * | 2016-04-20 | 2016-06-22 | 张延社 | Traditional Chinese medicine formula for treating peritoneal abscess |
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| CN103784521B (en) | 2015-12-09 |
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