CN103784521B - A kind ofly coordinate Chinese medicine composition of operative treatment peritoneal abscess and preparation method thereof - Google Patents
A kind ofly coordinate Chinese medicine composition of operative treatment peritoneal abscess and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition coordinating operative treatment peritoneal abscess, it is made up of the component of following weight portion: Radix Et Rhizoma Rhei 20-30 part, Natrii Sulfas 20-30 part, Radix Paeoniae Rubra 3-6 part, Flos Carthami 3-6 part, Endothelium Corneum Gigeriae Galli 2-4 part.Also disclose the preparation method of this Chinese medicine composition, this Chinese medicine composition is pure Chinese medicinal preparation, easy to use, without obvious toxic-side effects; Instant effect, determined curative effect, medicine source is extensive, with low cost; Effective percentage is up to 98%, and complication rate is little, treating both the principal and secondary aspects of a disease, and long-term effect is good.
Description
Technical field
The present invention relates to and a kind ofly coordinate Chinese medicine composition of operative treatment peritoneal abscess and preparation method thereof
Background technology
Peritoneal abscess refers to liquefy because of tissue necrosis in a certain gap of intraperitoneal or position, by parcels such as intestinal song, internal organs, stomach wall, nethike embrane or mesentery, forms limitation pus and gathers, cause the various diseases of secondary peritonitis; All peritoneal abscess can be caused after abdominal operation and wound, infection is the main cause causing peritoneal abscess, its clinical manifestation is mainly subphrenic abscess, pelvic abscess and interbowel abscess, and many employing abscess excisions, placing drainage carry out the thorough drain of pus, hemostasis, the application of effective antibiotics, nutrition supporting therapy at present.Abscess of appendix is a type of peritoneal abscess, there is certain representativeness, vermiform appendix has and oozes out, downright bad, during perforation, nethike embrane and neighbouring intestinal tube can tend to vermiform appendix and be formed and surround, swollen swollen be not the empyema of a lacuna, often nethike embrane and the small intestinal of an inflammatory masses, patient's much cold is fought, high heat, numeration of leukocyte raises, Right Lower Abdomen can touch an enclosed mass, obscure boundary, tenderness is obvious, with surrounding tissue adhesion, anatomy relationship is unclear, independent surgical resection therapy is usually difficult to reach the curative effect of thoroughly curing, and likely there is intestinal fistula, peritonitis, the complication such as intestinal obstruction.
Summary of the invention
The object of the invention is, for overcoming above-mentioned the deficiencies in the prior art, to provide a kind of Chinese medicine composition coordinating operative treatment peritoneal abscess, can promote that abscess is limited to, absorbing, shorten the course of disease, shorten the hospital stays, reduce medical expense.
Another object of the present invention is to provide the preparation method of this Chinese medicine composition.
For achieving the above object, the present invention adopts following technical proposals:
Technical solution of the present invention source and foundation: formula of the present invention is according to China's theory of TCM, in conjunction with inventor's clinical research for many years, the macroscopic syndrome of Chinese medicine opinion is controlled and the Empirical formula that draws in the refined diagnosis Technology application of modern medicine to clinical experimentation.China's Chinese medicine thinks that this disease is for the scorchingly hot gastrointestinal that blocks, stagnation of QI-blood, positive bright accumulation of heat ， Zhou flow of QI being obstructed, and the pain occurred, vomit, swollen, close, heat five large symptoms; Sick belong to excess syndrome of interior-heat, according to the theory of the six hollow viscera must keep its unobstructed, when by purgation for controlling; Treatment is with activating blood circulation to dissipate blood stasis, heat-clearing and toxic substances removing, dispersing cold for relieving pain, and loosening bowel to relieve constipation is main.Dredging intestines, heat reliving and toxin-eliminating, blood circulation promoting and blood stasis dispelling three method develop simultaneously, and reach and purge heat by heresy, and dredging Chang Zhou effaces the pernicious influence, promoting tissue regeneration by removing blood stasis, thus plays the effect of strengthening vital QI to eliminate pathogenic factors.Early postoperative period is applied, and can improve the recovery time of gastrointestinal function, reduces intestinal source property toxin absorption, becomes the main source of healthy intestinal absorption nutrition, produces humoral immunization and cellular immunization to antibacterial and toxin.Strengthen the oxidasic activity of superoxides, reduce or suppress the formation of oxygen-derived free radicals, reduce active oxygen to the infringement of cells of organs.Improve gastrointestinal tract blood flow, reduce inflammatory seep, promote that peritoneum absorbs, reduce inflammation adhesion and abscess formation.Application modern medical techniques carries out science location, qualitative, quantitative Diagnosis to the cause of disease of peritoneal abscess, the combination of Chinese and Western medicine, guarantees the integrity of clinical diagnosis and the comprehensive for the treatment of.
Traditional Chinese medicine composition of the present invention is made up of the crude drug of following weight portion:
Radix Et Rhizoma Rhei 20-30 part, Natrii Sulfas 20-30 part, Radix Paeoniae Rubra 3-6 part, Flos Carthami 3-6 part, Endothelium Corneum Gigeriae Galli 2-4 part.
Optimum weight part proportioning of pharmaceutical composition of the present invention is:
Radix Et Rhizoma Rhei 25 parts, 25 parts, Natrii Sulfas, Radix Paeoniae Rubra 4 parts, 6 parts, Flos Carthami, Endothelium Corneum Gigeriae Galli 3 parts.
Described Radix Et Rhizoma Rhei, Natrii Sulfas, Radix Paeoniae Rubra, Flos Carthami and Endothelium Corneum Gigeriae Galli 5 taste medical material be the kind that " Chinese Pharmacopoeia " 2010 version () records, every regulation that its quality is relevant under all meeting each kind item.
Wherein, Radix Et Rhizoma Rhei: bitter in the mouth, cold in nature.Return stomach, spleen, large intestine, liver, pericardium channel.Have purging heat to relax the bowels effect, constipation, abdominal part distension, pain with tenderness, even hyperpyrexia, unconsciousness and delirium stagnant for Gastrointestinal excess heat, purging heat to relax the bowels, cleanses the intestines and stomach, pushes away Chen Zhixin.Cure mainly the accumulation of food in the stomach and intes tine due to indigestion caused by gastrointestinal retention, constipation due to dry stool is obstructed, irritable feverish sensation of chest and heart, oliguria with reddish urine etc.Or damp-heat diarrhea is incessantly thirsty, gets ill from overeating and cut off the water.Or married woman's postponed menstruation, abdominal pain in menstruation, darkish complexion has block etc.
Natrii Sulfas: mineral is arduous salty, cold.Enter stomach, large intestine channel.Purgatives medicine, cathartic drug.Cure mainly under softening the hard mass rushes down, removing damp-heat, removing blood stasis stimulates the menstrual flow, and skin ulcer is treated in detumescence.Control excess-heat to stagnate, abdominal distention constipation, retention of phlegm gathers, and conjunctival congestion is hidden from view, erysipelas, carbuncle.
Radix Paeoniae Rubra: bitter is cool.Bitter in the mouth is flat.Enter liver, spleen channel.Effect: clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI.
Flos Carthami: property and flavor of peppery and warm, enters the heart, Liver Channel.There is effect of promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving.
Endothelium Corneum Gigeriae Galli: sweet, cold.Return spleen, stomach, small intestinal, urinary bladder channel.Energy promoting digestion and invigorating the stomach, arresting seminal emission.
Chinese medicine composition of the present invention can adopt following methods to prepare:
(1) after taking each Chinese medicinal components by parts by weight in prescription, dry porphyrize powder, crosses 300 mesh sieves, loads sealing in vial for subsequent use;
(2) Radix Et Rhizoma Rhei, Natrii Sulfas mixing are mixed well, then other Chinese medicines of each weight portion are added, comprise Radix Paeoniae Rubra, Flos Carthami, Endothelium Corneum Gigeriae Galli, spray vinegar dries and ground 300 mesh sieves into powder, and the vinegar adding 3 times amount Chinese medicine compositions (mL/g) is modulated into pasty state, and to load sealing in vial for subsequent use.
Usage and dosage: after Chinese medicine composition vinegar of the present invention is mixed well, loads in textile cloth bag, abdomen external application, twice daily, each 30 ~ 60 minutes, 7 ~ 10 days courses for the treatment of.While Chinese medicine composition abdomen external application treatment of the present invention, coordinate ZhouLin frequency spectrum instrument to irradiate at distance Chinese medicine cloth bag 30cm place, then effect is better.
Side effect and contraindication: through the clinical observation on the therapeutic effect in more than 10 years, patient occurs without obvious toxic-side effects; Anemia of pregnant woman and allergic constitution patient avoid use.
Radix Et Rhizoma Rhei energy heat and toxic materials clearing away, clearing away heat-fire, hemostasis removing toxic substances, blood circulation promoting and blood stasis dispelling; Natrii Sulfas external has effect of heat-clearing and toxic substances removing, removing blood stasis promoting the circulation of blood, mass dissipating and swelling eliminating.Radix Et Rhizoma Rhei, the mirabilite external applying efficacy of a drug absorb by skin or play a role in infiltration human body, coordinate frequency spectrograph or TDP irradiation treatment, effect is better, can produce heat rapidly after the energising of TDP lamp, and give off can intelligent's body compared with the wave band infrared ray far away of position, deep, local vascular dilation can be made, strengthen blood circulation, improve tissue metabolism and nutritional status, strengthen immunologic function, strengthen phagocytic function and vascular permeability, be conducive to the absorption of inflammatory exudate, reach therapeutic purposes.The permeability of blood capillary when Radix Paeoniae Rubra can reduce acute inflammation, reduces oozing out of inflammation, improves the blood circulation of local, promotes the absorption of inflammation, and makes inflammation foci localization, the granulomatous formation of inflammation-inhibiting.Flos Carthami has blood circulation promoting and blood stasis dispelling, improves microcirculatory effect.Chinese herb rhubarb is cold in nature, sweet-bitter flavor heat and toxic materials clearing away, clearing away heat-fire, particularly external has effect of detoxicating and resolving stagnation of pathogens, detumescence, share generation synergism with Natrii Sulfas, utilize the high excessive moisture oozed in action draws tissue, the blood flow of local is accelerated, capillary open, improve microcirculation, penetration enhancement, reach the object of detumescence, pain relieving, antiinflammatory.Radix Paeoniae Rubra, Flos Carthami share stronger antiendotoxin and anti-endotoxin induces the monokaryon/endogenous inflammatory mediator of macrophage generation and the release of tumor necrosis factor and interleukin-6; increase platelet and fibrinogen content; increase hematoblastic coagulation; improve because of the disturbances of blood coagulation caused by disseminated inravascular coagulation; improve superoxide dismutase activity; regulate too high or too low immunoreation, protection and internal organs impaired under repairing stress state.Its pathological characters of acute diffuse peritonitis shows as the congestion and edema of peritoneal cavity and internal organs thereof, a large amount of inflammatory liquid oozes out, and in art, there is a large amount of dirty solution in visible abdominal cavity, and stomach, intestinal wall congestion and edema are more serious.Gastrointestinal edema caused by peritonitis adds operation technique, repeatedly, a large amount of peritoneal irrigations makes postoperative abdominal cavity edema increase the weight of, peritonitis and operation wound make body be in stress state simultaneously, renin angiotensin aldosterone system irritability increases, cause water-sodium retention, increase the weight of the tolerant edema of intraperitoneal further and intraperitoneal oozes out, be unfavorable for the recovery of gastrointestinal function recovery after operation, and the reason such as abdominal distention easily causes infection of incisional wound and splits.Natrii Sulfas, main component is sodium sulfate crystal, and can contain micro-sodium chloride, magnesium sulfate, calcium sulfate etc., be the refining crystallization of natural mirabilite, its nature and flavor are worked hard salty-cold, enter stomach, large intestine channel.Function purging heat to relax the bowels, moisturize, softening hardness and disperse swelling.The constipation cured mainly caused by Gastrointestinal excess heat for oral administration, the cards such as abdominal distention painful abdominal mass pain.During external application, Natrii Sulfas exists with sulfate ion form equally, becomes hyperosmotic state, and it, can also the Intraabdominal transudate of huge uptake except absorbing the moisture in portion of air.Thus accelerate the edema eliminating ascites and abdominal cavity, gastrointestinal wall, be conducive to the recovery that patient is postoperative.And its effect is only limitted to abdominal part, few to systemic effects.Share with Radix Et Rhizoma Rhei, produce mutual reinforcement between effect, can utilize and highly ooze moisture unnecessary in action draws tissue, reinforcement regional flow, makes capillary open increase, improves microcirculation, penetration enhancement, reach the object of detumescence, pain relieving, antiinflammatory.Endothelium Corneum Gigeriae Galli sweet in the mouth, property is put down.Enter spleen, stomach, small intestinal, bladder, can eat by removing food stagnancy, the inducing decomposition of calculi, arresting enursis.Chinese medicine has cold, hot, warm, cool four kinds, and in addition, some character is gentle, is referred to as the medicine of levelling.The medicine of levelling, because its effect relaxes, in general, no matter be cold or hot disease, all can fit applications.Endothelium Corneum Gigeriae Galli sweet in the mouth, property is put down, and makes up a prescription, can play good therapeutical effect as one is auxiliary.Natrii Sulfas joins Endothelium Corneum Gigeriae Galli, gets clean Endothelium Corneum Gigeriae Galli, fries to heaving, and spray vinegar takes out, and dry and grind external application or raw subsides into powder, can make hard masses softening and resolving, effect of heat clearing away fossil strengthens; Its mechanism is by producing stimulation to the reticuloendothelial system of spleen, its hypertrophy phenomenon and phagocytic activity are strengthened to some extent, enteric nervous is caused to reflect: abdomen external application Natrii Sulfas Endothelium Corneum Gigeriae Galli paste, local skin have heating, rubescent, play the irritation such as vesicle, small intestinal and vermiform appendix, bag-shaped Colon Movement strengthen; Therefore, drug effect is caused by neural reflex.Strengthen owing to wriggling, supply of blood flow enriches, and reticuloendothelial system phagocytic function is strengthened, thus has transferred the resistance against diseases of body inherence.
Beneficial effect of the present invention:
(1) pure Chinese medicinal preparation, easy to use, without obvious toxic-side effects;
(2) instant effect, determined curative effect, medicine source is extensive, with low cost;
(3) effective percentage is up to 98%, and complication rate is little, treating both the principal and secondary aspects of a disease, and long-term effect is good.
Detailed description of the invention
Below by instantiation, the present invention will be further elaborated, should be noted that following explanation is only to explain the present invention, not limits its content.
Embodiment 1 one kinds coordinates the Chinese medicine composition of operative treatment peritoneal abscess
[formula] Radix Et Rhizoma Rhei 250g, Natrii Sulfas 250g, Radix Paeoniae Rubra 40g, Flos Carthami 60g, Endothelium Corneum Gigeriae Galli 30g.
After [method for making] (1) takes each Chinese medicinal components by parts by weight in prescription, dry porphyrize powder, crosses 300 mesh sieves, loads sealing in vial for subsequent use;
(2) Radix Et Rhizoma Rhei, Natrii Sulfas mixing are mixed well, then other Chinese medicines of each weight portion are added, comprise Radix Paeoniae Rubra, Flos Carthami, Endothelium Corneum Gigeriae Galli, spray vinegar dries and ground 300 mesh sieves into powder, and the vinegar adding 3 times amount Chinese medicine compositions (mL/g) is modulated into pasty state, and to load sealing in vial for subsequent use.
Embodiment 2 one kinds coordinates the Chinese medicine composition of operative treatment peritoneal abscess
[formula] Radix Et Rhizoma Rhei 230g, Natrii Sulfas 230g, Radix Paeoniae Rubra 30g, Flos Carthami 40g, Endothelium Corneum Gigeriae Galli 20g.
After [method for making] (1) takes each Chinese medicinal components by parts by weight in prescription, dry porphyrize powder, crosses 300 mesh sieves, loads sealing in vial for subsequent use;
(2) Radix Et Rhizoma Rhei, Natrii Sulfas mixing are mixed well, then other Chinese medicines of each weight portion are added, comprise Radix Paeoniae Rubra, Flos Carthami, Endothelium Corneum Gigeriae Galli, spray vinegar dries and ground 300 mesh sieves into powder, and the vinegar adding 3 times amount Chinese medicine compositions (mL/g) is modulated into pasty state, and to load sealing in vial for subsequent use.Obtain.
Embodiment 3 one kinds coordinates the Chinese medicine composition of operative treatment peritoneal abscess
[formula] Radix Et Rhizoma Rhei 260g, Natrii Sulfas 260g, Radix Paeoniae Rubra 50g, Flos Carthami 30g, Endothelium Corneum Gigeriae Galli 40g.
After [method for making] (1) takes each Chinese medicinal components by parts by weight in prescription, dry porphyrize powder, crosses 300 mesh sieves, loads sealing in vial for subsequent use;
(2) Radix Et Rhizoma Rhei, Natrii Sulfas mixing are mixed well, then other Chinese medicines of each weight portion are added, comprise Radix Paeoniae Rubra, Flos Carthami, Endothelium Corneum Gigeriae Galli, spray vinegar dries and ground 300 mesh sieves into powder, and the vinegar adding 3 times amount Chinese medicine compositions (mL/g) is modulated into pasty state, and to load sealing in vial for subsequent use.Obtain.
Embodiment 4 one kinds coordinates the Chinese medicine composition of operative treatment peritoneal abscess
[formula] Radix Et Rhizoma Rhei 240g, Natrii Sulfas 240g, Radix Paeoniae Rubra 40g, Flos Carthami 50g, Endothelium Corneum Gigeriae Galli 30g.
After [method for making] (1) takes each Chinese medicinal components by parts by weight in prescription, dry porphyrize powder, crosses 300 mesh sieves, loads sealing in vial for subsequent use;
(2) Radix Et Rhizoma Rhei, Natrii Sulfas mixing are mixed well, then other Chinese medicines of each weight portion are added, comprise Radix Paeoniae Rubra, Flos Carthami, Endothelium Corneum Gigeriae Galli, spray vinegar dries and ground 300 mesh sieves into powder, and the vinegar adding 3 times amount Chinese medicine compositions (mL/g) is modulated into pasty state, and to load sealing in vial for subsequent use.Obtain.
Clinical data
One, physical data:
Case-data is selected from inpatient 1416 example in October ,-2013 in November, 2008, is divided into treatment group 472 example at random, contrast A group 472 example, contrast B group 472 example.Treatment group and matched group age, the ratio of men and women and coincident with severity degree of condition had comparability through X 2 test no significant difference (P > 0.05) at 45 ~ 80 years old.
Table 1 gender situation compares
Note: gender comparison between group, through X
2inspection, X
2=1.34, P>0.05, there was no significant difference, has comparability.
Table 2 respectively group patient age compares
Note: between group, patient age distribution is compared, through rank test, P>0.05; There was no significant difference, has comparability.
The table 3 respectively group abdominal cavity infection state of an illness compares by stages
Note: before treatment, between group, conditions of patients compares, through X by stages
2inspection, X
2=0.10, P>0.05, there was no significant difference, has comparability.
Two, diagnostic criteria, case selection and criterion of therapeutical effect:
(1) diagnostic criteria: according to Clinical symptom and sign, abdominal cavity infection was divided into for three phases by laboratory examination results and iconography report:
(1) low-grade infection: the abdominal cavity infection time in 12 hours,
1), after abdominal operation and wound, heating, abdominal part can touch enclosed mass, obscure boundary, and tenderness is obvious;
2), there are percussion pain, tenderness under diaphragm and hypochondriac region, if this place's skin has pitting edema when abscess table is shallow, liver dullness circle raises;
3), numeration of leukocyte raises and the increase of neutrophilic granulocyte ratio;
4), under X-ray or B ultrasonic orientation direction puncture, can pus be extracted out;
5), through CT capable qualitative positioning diagnostic result positive.
(2) grade and moderate infection: the abdominal cavity infection time, above-mentioned symptom continued to increase the weight of in 12-48 hour, had infection poisoning symptom, increase through X-ray or ultrasound diagnosis abscess, abdominal paracentesis can extract more than pus 1000mL out.
(3) severe infection: diffusivity abdominal cavity infection occurs, disease time >=48 hour, has serious Sepsis shape to merge organ function obstacle.
(2) case inclusive criteria
Case-data is selected from inpatient 1416 example in October ,-2013 in November, 2008, and all patient admits diagnosis all meets the diagnostic criteria that surgical infection societies of the U.S. in 2010 and the U.S. infect the second edition complexity abdominal cavity infection diagnosis and treatment guide that disease is learned to issue.
(3) curative effect determinate standard
(1) cure: in 5 days, body temperature is down to 37 DEG C, stomachache and local tenderness disappear, and palpation is not and enclosed mass; B ultrasonic prompting enclosed mass dissipates; Numeration of leukocyte, neutrophilic granulocyte percentage ratio obviously decline.
(2) effective: in 5 ~ 10 days, body temperature is down to 37 DEG C, stomachache and local tenderness disappearance or slight, palpation and ultrasound diagnosis enclosed mass reduce more than 2/3; Numeration of leukocyte, neutrophilic granulocyte percentage ratio obviously decline.
(3) invalid: after 10 days, body temperature is still more than 37 DEG C.Stomachache and local tenderness are without improvement or increase the weight of on the contrary, touch obvious enclosed mass; Numeration of leukocyte, neutrophilic granulocyte percentage ratio decline slowly or are not improved.
Three, clinical testing procedure:
(1) case grouping
Selected 1416 examples are observed case and are all met this research diagnostic criteria.Be divided into treatment group 472 example at random, contrast A group 472 example, contrast B group 472 example.
(2) dosage regimen
1. therapeutic equipments and medicine
(1) instrument: ZhouLin frequency spectrum instrument, model ws-311, Beijing Zhou Lin frequency spectrum Science and Technology Ltd. manufactures.
(2) medicine:
Coordinate the external application Chinese medicine prescription of operative treatment Abdominal cyst, be prepared from by embodiments of the invention 1;
Aztreonam: Shenzhen City Haibin Pharmaceutical Co., Ltd, authentication code: the accurate word H20058581 of traditional Chinese medicines;
Ciprofloxacin: Guangzhou Nan Xin pharmaceutical Co. Ltd, authentication code: the accurate word H44020106 of traditional Chinese medicines;
Levofloxacin: Zhejiang Medicine Co, authentication code: the accurate word H20033965 of traditional Chinese medicines;
Clindamycin: Zhuhai Ebang Pharmaceutical Co., Ltd., authentication code: the accurate word H20067876 of traditional Chinese medicines;
Piperacillin Tazobactam Sodium: Shangdong Ruiyang Pharmaceutical Co., Ltd, authentication code: the accurate word H20073602 of traditional Chinese medicines;
Meropenem: Haizheng Medicine Stock Co., Ltd., Zhejiang Prov, authentication code: the accurate word H20030331 of traditional Chinese medicines.
2. Therapeutic Method: all patients carry out abscess excision or abscess drain, strengthen nutritional support, with carry out antibacterial drug therapy, antibiotic selection: one is the drug sensitive test according to antibacterial, two is for abdominal cavity infection situation and empirical antibacterial drug therapy, and time, the order of severity, antibacterial and the present epidemiology of susceptibility state and the pharmacodynamics of anti-infectives that mainly abdominal cavity infection occurs are selected.Treatment group uses Chinese prescription of the present invention on this basis, mixes well the textile cloth bag of rear loading, abdomen external application with vinegar, twice daily, and each 30-60 minute, 7 ~ 10 days courses for the treatment of.Contrast A group uses ZhouLin frequency spectrum instrument on this basis, and every day carries out twice irradiation, each 30-60 minute.Contrast B group, except operative drainage, effective antibiotics treatment, nutritional support, does not carry out other treatment.
(3) observation index
1, curative effect observation
Mainly clinical symptoms, sign (tension of abdominal muscle, tenderness rebound tenderness pressure, tabulate venter, abdominal mass etc.).
2, lab testing
Numeration of leukocyte, neutrophilic granulocyte percentage ratio, blood bio-chemistry checking refer to, ultrasound diagnosis, CT examination.
3, untoward reaction
Main monitoring index:
(1) anaphylaxis; (2) safety indexes: routine blood test, routine urinalysis, stool routine examination add occult blood, Liver and kidney merit, electrocardiogram.
Four, clinical treatment outcome and analysis
(1) clinical efficacy: treatment group and matched group, according to the forward and backward clinical symptoms for the treatment of and lab test results, carry out statistical disposition, make an appraisal by the comprehensive therapeutic effect of clinical efficacy criterion to medicine.Result shows, and the clinical cure rate for the treatment of group is 88.9%, obvious effective rate 8.9%, total effective rate 98.0%, is better than matched group (P ﹤ 0.01).Show Chinese medicine composition determined curative effect of the present invention, in table 4.
Situation synopsis is treated between table 4. group
Note: P<0.01.
(2) laboratory checking index testing result: to treatment group, contrast A group and contrast B group, according to the lab test results that treatment is forward and backward, respectively statistical disposition is carried out to the change of leukocyte, neutrophilic granulocyte.
1, treat forward and backward leukocytic change: to before three groups of each 472 routine patient treatments and treatment 5,10 days after numeration of leukocyte, carry out statistical disposition respectively, result shows: all have obvious minimizing (p ﹤ 0.01) before adopting the numeration of leukocyte of Chinese medicine composition partner treatment of the present invention after 5 days and 10 days comparatively to treat.Treat the numeration of leukocyte after 5 days in one-tenth human leukocyte range of normal value (4.0 ~ 10.0 × 10
9/ L), it is more remarkable to treat effect after 10 days, is better than contrast A group and contrast B group (p ﹤ 0.05), shows that Chinese medicine composition of the present invention increases symptom to the leukocyte occurred after peritoneal abscess operative treatment and has significant curative effect.
Table 5 is treated front and back leukocyte and is compared
Note: treat and compare with matched group respectively for latter 10 days with treatment for latter 5 days, through t inspection, p < 0.05.
2, treat the change of forward and backward neutrophilic granulocyte percentage ratio: to before three groups of each 472 routine patient treatments and treatment 5,10 days after neutrophil count, carry out statistical disposition respectively, result shows: all have obvious minimizing (p ﹤ 0.01) before adopting the neutrophilic granulocyte percentage comparison therapy of Chinese medicine composition partner treatment of the present invention after 5 days and 10 days.Treat effect after 10 days more remarkable, be better than contrast A group and contrast B group (p ﹤ 0.05), show that Chinese medicine composition of the present invention has significant curative effect to the symptom that the neutrophilic granulocyte occurred after peritoneal abscess operative treatment increases.
Table 6 is treated front and back neutrophilic granulocyte percentage ratio and is compared
Note: treat and compare with matched group respectively for latter 10 days with treatment for latter 5 days, through t inspection, p ﹤ 0.05.
(3) safety observations:
Routine blood test, routine urinalysis, stool routine examination, Liver and kidney function and electrocardiogram etc. before and after 472 routine patient treatments for the treatment of group are checked, before and after result treatment, above-mentioned indices has no significant change, shows that prescription all has no adverse effects to liver function, kidney merit, electrocardiogram etc.Patient has no obvious adverse reaction at clinical application viewing duration.Yin Ben research is medicine for external use, and small number of patients has local skin anaphylaxis, but does not affect therapeutic effect.
Routine blood test, routine urinalysis, stool routine examination, Liver and kidney function and Electrocardioscopy result before and after the treatment of table 7 treatment group
Note: compare before and after the treatment of blood biochemistry leading indicator, p>0.05.
(4) model case:
Case 1, Zhang, female, 25 years old, after acute appendicitis piercing operation, heating, full abdomen pain, tenderness rebound tenderness, total white blood cells raised, and neutrophilic granulocyte percentage ratio obviously raises, and acute peritonitis sign is obvious.Give the drain of operation Abscess incision, effective antibiotics infection control, hemostasis, supporting treatment.Coordinate this prescription abdominal part hot-wet compress, coordinate ZhouLin frequency spectrum instrument to irradiate at distance Chinese medicine cloth bag 30cm place, treat body temperature after 3 days and decline gradually, symptom is controlled, and treats a course for the treatment of, and healing in 12 days is left hospital simultaneously.
Case 2, Lee so-and-so, female, 31 years old, after acute appendicitis piercing operation, heating, full abdomen pain, tenderness rebound tenderness, total white blood cells raise, neutrophilic granulocyte percentage ratio obviously raises, and acute peritonitis sign is obvious.Give the drain of operation Abscess incision, effective antibiotics infection control, supporting treatment.Coordinate this prescription abdominal part hot-wet compress, treat body temperature after 4 days and decline gradually, symptom is controlled, and treats a course for the treatment of, and healing in 15 days is left hospital.
Case 3, Chen, man, 33 years old, after acute appendicitis piercing operation, heating, full abdomen pain, tenderness rebound tenderness, total white blood cells raised, and neutrophilic granulocyte percentage ratio obviously raises, and acute peritonitis sign is obvious.Give the drain of operation Abscess incision, effective antibiotics infection control, supporting treatment.Coordinate this prescription abdominal part hot-wet compress, coordinate ZhouLin frequency spectrum instrument to irradiate at distance Chinese medicine cloth bag 30cm place, treat body temperature after 4 days and decline gradually, symptom is controlled, and treats a course for the treatment of, and healing in 14 days is left hospital simultaneously.
Case 4, Wang, man, 40 years old, after the capable kposthesis of Alimentary Tract Perforation, body temperature continued to raise, and has obvious peritoneal irritation sign, and total white blood cells raises, and neutrophilic granulocyte percentage ratio obviously raises, and was that subphrenic abscess is formed through CT examination.Surgical incision abscess, placing drainage continues peritoneal abscess drain, effective antibiotics infection control, hemostasis, nutritional support, coordinate this prescription abdominal part hot-wet compress simultaneously, treat body temperature after 6 days and decline gradually, symptom is controlled, and treats two courses for the treatment of, and healing in 28 days is left hospital.
Case 5, Zhang, female, 55 years old, Radical Operation of Gastric Carcinoma postoperative 3 days Intraperitoneal lymphs leak and peritoneal abscess formation, and body temperature continues to raise, intraperitoneal drainage liquid showed increased, peak after 1 week (1500ml/d) give parenteral nutrition, supplement fresh blood, blood plasma, albumen improve the immunologic function of patient.The antibiotic of hemostasis, application wide spectrum, and make antibacterial culturing, drug sensitive test, select antibiotic according to drug sensitive test, coordinate this prescription abdominal part hot-wet compress, treat body temperature after 6 days and decline gradually, symptom is controlled, and treats two courses for the treatment of, and healing in 25 days is left hospital simultaneously.
Claims (3)
1. coordinate a Chinese medicine composition for operative treatment peritoneal abscess, it is characterized in that, be made up of the crude drug of following weight portion: Radix Et Rhizoma Rhei 20-30 part, Natrii Sulfas 20-30 part, Radix Paeoniae Rubra 3-6 part, Flos Carthami 3-6 part, Endothelium Corneum Gigeriae Galli 2-4 part.
2. the Chinese medicine composition coordinating operative treatment peritoneal abscess as claimed in claim 1, is characterized in that, be made up of the crude drug of following weight portion: Radix Et Rhizoma Rhei 25 parts, 25 parts, Natrii Sulfas, Radix Paeoniae Rubra 4 parts, 6 parts, Flos Carthami, Endothelium Corneum Gigeriae Galli 3 parts.
3. the preparation method of the Chinese medicine composition of the cooperation operative treatment peritoneal abscess described in claim 1 or 2, is characterized in that, comprise the following steps:
(1) after taking each component by weight, dry porphyrize powder, for subsequent use;
(2) Radix Et Rhizoma Rhei, Natrii Sulfas mixing are mixed well, then add other Chinese medicines of each weight portion, comprise Radix Paeoniae Rubra, Flos Carthami, Endothelium Corneum Gigeriae Galli, spray vinegar dries, and the vinegar adding 3 times amount Chinese medicine compositions is modulated into pasty state, to obtain final product.
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| CN105106776A (en) * | 2015-09-15 | 2015-12-02 | 温福海 | Medicine used for treating intraperitoneal abscesses in cooperation with operations and preparation method |
| CN105687972A (en) * | 2016-04-20 | 2016-06-22 | 张延社 | Traditional Chinese medicine formula for treating peritoneal abscess |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1985905A (en) * | 2006-12-19 | 2007-06-27 | 南京中医药大学 | Chinese medicine preparation for preventing and treating intestinal adhesion after abdominal cavity operation and its preparing process and application |
| EP2172207A1 (en) * | 2007-08-02 | 2010-04-07 | Tianjin Tasly Pharmaceutical Co. Ltd. | A pharmaceutical composition for treating diabetes and its process for preparation |
| US20120164249A1 (en) * | 2009-09-01 | 2012-06-28 | Uni-President Biotech Co., Ltd. | Chinese herbal medicine composition used for antiinflammation, detumescence and acesodyne, and preparation method and use thereof |
| CN102579609A (en) * | 2012-03-09 | 2012-07-18 | 张睿 | Blood-clearing dropping pills and preparation method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1985905A (en) * | 2006-12-19 | 2007-06-27 | 南京中医药大学 | Chinese medicine preparation for preventing and treating intestinal adhesion after abdominal cavity operation and its preparing process and application |
| EP2172207A1 (en) * | 2007-08-02 | 2010-04-07 | Tianjin Tasly Pharmaceutical Co. Ltd. | A pharmaceutical composition for treating diabetes and its process for preparation |
| US20120164249A1 (en) * | 2009-09-01 | 2012-06-28 | Uni-President Biotech Co., Ltd. | Chinese herbal medicine composition used for antiinflammation, detumescence and acesodyne, and preparation method and use thereof |
| CN102579609A (en) * | 2012-03-09 | 2012-07-18 | 张睿 | Blood-clearing dropping pills and preparation method thereof |
Non-Patent Citations (2)
| Title |
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| Ｂ超引导穿刺及中药外敷联合抗生素治疗阑尾周围脓肿95例;孙子伟，等;《中国中医药》;20130831;第11卷(第15期);第50-51页 * |
| 中西医结合治疗阑尾周围脓肿32例临床体会;赵谦知，等;《中国现代医生》;20081031;第46卷(第28期);第70、75页 * |
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