CN102949661B - External pharmaceutical composition for conditioning breast and preparation method thereof - Google Patents
External pharmaceutical composition for conditioning breast and preparation method thereof Download PDFInfo
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- CN102949661B CN102949661B CN201210419132.9A CN201210419132A CN102949661B CN 102949661 B CN102949661 B CN 102949661B CN 201210419132 A CN201210419132 A CN 201210419132A CN 102949661 B CN102949661 B CN 102949661B
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Abstract
The invention provides an external pharmaceutical composition for conditioning breast and a preparation method thereof. The external pharmaceutical composition for conditioning breast consists of the following raw materials, by weight: 3-5 parts of frankincense, 3-5 parts of myrrh, 1-3 parts of rhizoma sparganii, 1-3 parts of curcuma zedoary, 3-5 parts of cinnamon, 1-3 parts of corydalis tuber, 2-4 parts of nidus vespae, 1-2 parts of clove, 2-4 parts of rheum officinale, 1-2 parts of leech and 2-6 parts of angelica. The external pharmaceutical composition provided by the invention has scientific compatibility and employs carefully selected medicines, has mild drug properties, and no toxic or side effect, and can be used for routine breast conditioning, prevention of breast diseases, treatment of mammary gland hyperplasia and mastitis with good curative effect.
Description
Technical field
A kind of external conditioning mammary gland pharmaceutical composition that the present invention proposes belongs to the external application Chinese medicine field of the new mammary gland of female, is applicable to female mammary gland system.
Background technology
Female mammary gland disease is one of principal disease of present stage harm women's health.According to World Health Organization (WHO) (WHO) global female mammary gland sickness survey data statistics, China approximately has 50% women to suffer from mastopathy in various degree.Common female mammary gland disease has: cyclomastopathy, mammitis, acute mastitis, breast carcinoma etc.Wherein cyclomastopathy is the modal cystic hyperplasia of breast of women, and seven sickness rate account for the first place of mastopathy, and this sick sickness rate is the trend rising year by year in recent years, and the age also more and more becomes younger.Mastitis are a kind of commonly encountered diseases of women breast-feeding their children, and general morbidity is anxious, painful large, are multiplely born in the postpartum breastfeeding phase, and primipara is particularly common, and clinical symptoms is mainly galactostasis, and breast color of the leather is red, heating, and mastalgia, has enclosed mass.In addition, approximately there are every year 200000 women to suffer from breast carcinoma, more than 40,000 women's death.Its mortality rate is with annual 3% amplitude rapid growth, becomes China's the fastest cancer of mortality rate speedup over nearly 10 years.Mastopathy has formed great threat to women's Health and Living.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition of external conditioning mammary gland.This pharmaceutical composition not only can be used for daily mammary gland conditioning, and the generation of prevention mastopathy, also can be used for the treatment of the mastopathy such as cyclomastopathy, mammitis, and curative effect is good.
A pharmaceutical composition for external conditioning mammary gland, is made up of the crude drug of following weight portion: Olibanum 3-5 part, Myrrha 3-5 part, Rhizoma Sparganii 1-3 part, Rhizoma Curcumae 1-3 part, Cortex Cinnamomi 3-5 part, Rhizoma Corydalis 1-3 part, Nidus Vespae 2-4 part, Flos Caryophylli 1-2 part, Radix Et Rhizoma Rhei 2-4 part, Hirudo 1-2 part, Radix Angelicae Sinensis 2-6 part.
Preferably, the compositions of above-mentioned external conditioning mammary gland, is made up of the crude drug of following weight portion: 4 parts of Olibanums, 5 parts of Myrrhas, 2 parts of Rhizoma Sparganii, 3 parts of Rhizoma Curcumae, 4 parts of Cortex Cinnamomis, 2 parts of Rhizoma Corydalis, 4 parts of Nidus Vespaes, 1 part of Flos Caryophylli, 3 parts of Radix Et Rhizoma Rhei, 2 parts of Hirudos, 4 parts of Radix Angelicae Sinensis.
Wherein, the effect of Olibanum: regulating qi and activating blood, analgesic therapy, chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.
The effect of Myrrha: breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.There is the effect such as promoting blood circulation and stopping pain, detumescence and promoting granulation.
The effect of Rhizoma Sparganii: Rhizoma Sparganii energy relieving stagnant and resolving masses, therefore can control all diseases, to control married woman's blood vessels uncomfortable, cardiac and abdominal pain, the tire that falls, the stagnant blood that disappears, mends labor, logical menstruation, controls flatulence, disappear and flutter damage blood stasis, puerperal abdonimal pain, blood fortune stagnated blood not under, old addiction lump in the abdomen lumps.
The function of Rhizoma Curcumae cures mainly: circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.
The effect of Cortex Cinnamomi: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion collapse, stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.For sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation.
The effect of Rhizoma Corydalis: obstruction of qi in the chest and cardialgia, side of body rib, all pains of gastral cavity abdomen, headache, lumbago, colicky, bones and muscles pain, dysmenorrhea, amenorrhea, puerperal, the stasis of blood was suffered from abdominal pain, and traumatic injury, has promoting blood circulation to remove blood stasis, effect of promoting the circulation of QI to relieve pain.
The effect of Nidus Vespae: wind-expelling pain-stopping; The detumescence of rose poison; Killing parasites for relieving itching.Main air temperature arthralgia pain; Wind carious pain; Carbuncle malignant boil; Scrofula; Mouthpiece swells and ache; Anal fistula; Rubella pruritus; Skin stubborn dermatitis.
The effect of Flos Caryophylli: warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI.Cure mainly singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, ringworm.
The effect of Radix Et Rhizoma Rhei: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; The constipation of removing toxic substances excess-heat; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; Scald.
The effect of Hirudo: the diseases such as menstruation apolipsis, lump in the abdomen stomachache, blood-retention, traumatic blood stasis are had a pain, carbuncle erysipelas.
The effect of Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
The preparation method of the compositions of above-mentioned external conditioning mammary gland, is characterized in that, comprises the steps:
(1) take each crude drug by component proportion, grind respectively, sieve, obtain crude drug fine powder;
(2) first by crude drug fine powder mix homogeneously such as Rhizoma Sparganii, Rhizoma Curcumae, Cortex Cinnamomi, Rhizoma Corydalis, Nidus Vespae, Flos Caryophylli, Radix Et Rhizoma Rhei, Hirudo, Radix Angelicae Sinensis, add the alcoholic solution of 2-3 times of volume 70-80%, ultrasonic extraction, extracting solution reclaims ethanol extremely without alcohol taste, separate through secondary filter net filtration again, remove the impurity in medicinal liquid, obtain pure medicinal liquid;
(3) by Olibanum, Myrrha fine powder mix homogeneously, add the alcoholic solution of 2-3 times of volume 85-95%, dipping spends the night, and extracting solution reclaims ethanol extremely without alcohol taste, then separates through secondary filter net filtration, removes the impurity in medicinal liquid, obtains pure medicinal liquid;
(4) the medicinal liquid mix homogeneously that step (2) and step (3) obtain, obtains product.
Also can as required, adopt conventional method, compositions be made to the dosage forms such as cream, frost, emulsion.
Beneficial effect of the present invention is:
Externally-applied medicinal composition compatibility science of the present invention, selects YAOJING thin, and property of medicine gentleness, can not produce toxic and side effects, can be used for daily mammary gland conditioning, the generation of prevention mastopathy, also can be used for the treatment of the mastopathy such as cyclomastopathy, mammitis, evident in efficacy.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in further detail, but do not form any limitation of the invention, and the change of anyone limited number of time of doing within the scope of the claims in the present invention, still in claim protection domain of the present invention.
Embodiment 1
A pharmaceutical composition for external conditioning mammary gland, is made up of the crude drug of following weight portion: 4 parts of Olibanums, 5 parts of Myrrhas, 2 parts of Rhizoma Sparganii, 3 parts of Rhizoma Curcumae, 4 parts of Cortex Cinnamomis, 2 parts of Rhizoma Corydalis, 4 parts of Nidus Vespaes, 1 part of Flos Caryophylli, 3 parts of Radix Et Rhizoma Rhei, 2 parts of Hirudos, 4 parts of Radix Angelicae Sinensis.
Embodiment 2
A pharmaceutical composition for external conditioning mammary gland, is made up of the crude drug of following weight portion: 3 parts of Olibanums, 3 parts of Myrrhas, 1 part of Rhizoma Sparganii, 1 part of Rhizoma Curcumae, 4 parts of Cortex Cinnamomis, 1 part of Rhizoma Corydalis, 2 parts of Nidus Vespaes, 1 part of Flos Caryophylli, 2 parts of Radix Et Rhizoma Rhei, 1 part of Hirudo, 2 parts of Radix Angelicae Sinensis.
Embodiment 3
A pharmaceutical composition for external conditioning mammary gland, is made up of the crude drug of following weight portion: 5 parts of Olibanums, 5 parts of Myrrhas, 3 parts of Rhizoma Sparganii, 3 parts of Rhizoma Curcumae, 3 parts of Cortex Cinnamomis, 3 parts of Rhizoma Corydalis, 4 parts of Nidus Vespaes, 2 parts of Flos Caryophyllis, 4 parts of Radix Et Rhizoma Rhei, 2 parts of Hirudos, 6 parts of Radix Angelicae Sinensis.
Embodiment 4
A pharmaceutical composition for external conditioning mammary gland, is made up of the crude drug of following weight portion: 5 parts of Olibanums, 3 parts of Myrrhas, 2 parts of Rhizoma Sparganii, 3 parts of Rhizoma Curcumae, 5 parts of Cortex Cinnamomis, 2 parts of Rhizoma Corydalis, 3 parts of Nidus Vespaes, 2 parts of Flos Caryophyllis, 2 parts of Radix Et Rhizoma Rhei, 2 parts of Hirudos, 2 parts of Radix Angelicae Sinensis.
The preparation method of embodiment 1-4 pharmaceutical composition, comprises the steps:
(1) take each crude drug by component proportion, grind respectively, sieve, obtain crude drug fine powder;
(2) first by Rhizoma Sparganii, Rhizoma Curcumae, Cortex Cinnamomi, Rhizoma Corydalis, Nidus Vespae, Flos Caryophylli, Radix Et Rhizoma Rhei, Hirudo,
The crude drug fine powder mix homogeneously such as Radix Angelicae Sinensis, add the alcoholic solution of 2 times of volumes 75%, ultrasonic extraction, and 40-80kHZ, temperature is 60-65 DEG C, extracts 30min; Extracting solution reclaims ethanol to without alcohol taste through Rotary Evaporators, then via hole diameter is that the hollow fiber microfiltration membrane of 10 μ m and the hollow fiber ultrafiltration membrane of 0.02 μ m are filtered, and directly removes the starch in medicinal liquid, natural gum, pectin, lymphatic temperament, protein, antibacterial, virus waits macromole impurity, obtains pure medicinal liquid;
(3) by Olibanum, Myrrha fine powder mix homogeneously, add the alcoholic solution of 2 times of volumes 95%, dipping spends the night, extracting solution reclaims ethanol extremely without alcohol taste through Rotary Evaporators, via hole diameter is that the hollow fiber microfiltration membrane of 10 μ m and the hollow fiber ultrafiltration membrane of 0.02 μ m are filtered again, directly removes the starch in medicinal liquid, natural gum, pectin, lymphatic temperament, protein, antibacterial, virus waits macromole impurity, obtains pure medicinal liquid;
(4) the medicinal liquid mix homogeneously that step (2) and step (3) obtain, obtains product.
Also can as required, adopt conventional method, compositions be made to the dosage forms such as cream, frost, emulsion.
The using method of externally-applied medicinal composition of the present invention:
1,, for daily conditioning, 2-3 time weekly, medicine of the present invention is evenly applied to two breast surface, massage 5-10min.
2, for the treatment of mastopathy, every day 1-2 time, within 7 days, be a course for the treatment of,, medicine of the present invention is evenly applied to two breast surface, massage 5-10min.
Clinical case:
Case 1: patient Han Nvshi, 40 years old, be diagnosed as two newborn cyclomastopathy through certain hospital, after treatment, patient's subjective effect is not obvious.Look into breast and can touch streak lump, have tenderness.Use every day the pharmaceutical composition of the embodiment of the present invention 1 to be applied in breast surface, after 2 courses for the treatment of, patient's readme is uncomfortable to be alleviated.Continue to use after 3 courses for the treatment of, patient is again through examination in hospital, and two breasts are normal.After recovery from illness, Mrs Han continues to use medicine of the present invention and carries out daily conditioning, existing more than 1 year, does not have mastopathy to occur.
Case 2: patient Ms Zhang, is in the postpartum breastfeeding phase.Clinical symptoms is galactostasis, and breast color of the leather is red, heating, and mastalgia, has enclosed mass.Be diagnosed as mastitis through hospital.After using 1 course for the treatment of of medicine of the embodiment of the present invention 1, symptom takes a turn for the better to some extent: enclosed mass dwindles, though milk is not enough a little, and can suckling.Continue to use after 2 courses for the treatment of, enclosed mass disappears, without pain, and milk abundance, suckling is normal.Make a definite diagnosis through hospital, mastitis is cured.
Case 3: patient Lin Nvshi, is in the postpartum breastfeeding phase.Clinical symptoms is for stopping breast, and breast color of the leather is white, heating, and enclosed mass is hard to suppurate.Be diagnosed as mastitis through hospital.After using 2 courses for the treatment of of medicine of the embodiment of the present invention 3, symptom takes a turn for the better to some extent: enclosed mass dwindles, and tenderness slows down to some extent, though milk is not enough a little, and can suckling.Continue to use after 2 courses for the treatment of, enclosed mass disappears, without pain, and milk abundance, suckling is normal.Make a definite diagnosis through hospital, mastitis is cured.Rear its continues to use medicine of the present invention and carries out daily conditioning, follows up a case by regular visits to 1 year without recurrence.
Case 4: patient Qi Nvshi, 45 years old, suffers from cyclomastopathy more than 3 years, nodosity in breast, breast falling inflation discomfort, pain.Use after 2 courses for the treatment of of medicine of the embodiment of the present invention 2, pain slows down, continue to use 4 courses for the treatment of after pain sense disappear, breast checks normal thoroughly.Rear its continues to use medicine of the present invention and carries out daily conditioning, follows up a case by regular visits to 1 year without recurrence.
Claims (4)
1. the pharmaceutical composition of an external conditioning mammary gland, it is characterized in that, formed by the crude drug of following weight portion: 4 parts of Olibanums, 5 parts of Myrrhas, 2 parts of Rhizoma Sparganii, 3 parts of Rhizoma Curcumae, 4 parts of Cortex Cinnamomis, 2 parts of Rhizoma Corydalis, 4 parts of Nidus Vespaes, 1 part of Flos Caryophylli, 3 parts of Radix Et Rhizoma Rhei, 2 parts of Hirudos, 4 parts of Radix Angelicae Sinensis.
2. the pharmaceutical composition of external conditioning mammary gland according to claim 1, is characterized in that, described pharmaceutical composition can be cream, frost, emulsion, water preparation dosage form.
3. the preparation method of the pharmaceutical composition of external conditioning mammary gland described in claim 1, is characterized in that, comprises the steps:
(1) take each crude drug by component proportion, grind respectively, sieve, obtain crude drug fine powder;
(2) first by the fine powder mix homogeneously of Rhizoma Sparganii, Rhizoma Curcumae, Cortex Cinnamomi, Rhizoma Corydalis, Nidus Vespae, Flos Caryophylli, Radix Et Rhizoma Rhei, Hirudo, Radix Angelicae Sinensis, add the alcoholic solution of 2-3 times of volume 70-80%, ultrasonic extraction, extracting solution reclaims ethanol extremely without alcohol taste, separate through secondary filter net filtration again, remove the impurity in medicinal liquid, obtain pure medicinal liquid;
(3) by Olibanum, Myrrha fine powder mix homogeneously, add the alcoholic solution of 2-3 times of volume 85-95%, dipping spends the night, and extracting solution reclaims ethanol extremely without alcohol taste, then separates through secondary filter net filtration, removes the impurity in medicinal liquid, obtains pure medicinal liquid;
(4) the medicinal liquid mix homogeneously that step (2) and step (3) obtain, obtains product.
4. the preparation method of the pharmaceutical composition of external according to claim 3 conditioning mammary gland, is characterized in that, sieving described in step (1) referred to 400 mesh sieves.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210419132.9A CN102949661B (en) | 2012-10-29 | 2012-10-29 | External pharmaceutical composition for conditioning breast and preparation method thereof |
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| CN201210419132.9A CN102949661B (en) | 2012-10-29 | 2012-10-29 | External pharmaceutical composition for conditioning breast and preparation method thereof |
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| CN102949661A CN102949661A (en) | 2013-03-06 |
| CN102949661B true CN102949661B (en) | 2014-07-23 |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104586716A (en) * | 2013-10-31 | 2015-05-06 | 广州熹美生物科技有限公司 | Breast nursing cream |
| CN104586668A (en) * | 2013-10-31 | 2015-05-06 | 广州市纳爱生物科技有限公司 | Breast therapeutic massage cream |
| CN104162095A (en) * | 2014-06-27 | 2014-11-26 | 郑尧基 | Paste capable of clearing abdominal dropsy and relieving pain |
| CN106974994A (en) * | 2016-01-15 | 2017-07-25 | 菏泽中原民俗文化研究院 | One kind treats mastitis externally applied drug |
| CN108452125A (en) * | 2018-06-12 | 2018-08-28 | 王红全 | A kind of Chinese herbal medicine formula and preparation method |
| CN109010702A (en) * | 2018-10-19 | 2018-12-18 | 烟台了神医疗器械有限公司 | A kind of External-applicationtraditional traditional Chinese medicinal and its drug paste preparation method for treating mazoitis |
| CN111450224A (en) * | 2020-05-21 | 2020-07-28 | 极臣生物科技(深圳)有限公司 | Traditional Chinese medicine composition for treating hyperplasia of mammary glands and preparation method and application thereof |
| CN112494624A (en) * | 2020-12-16 | 2021-03-16 | 宋鸿威 | Plaster formula for treating gynecological diseases and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1129122A (en) * | 1995-02-13 | 1996-08-21 | 张驰 | Ruan decoction for treatment of heperplasia of mamary glands and mamary ache |
| CN101361805A (en) * | 2008-07-31 | 2009-02-11 | 西安三八妇乐健康产业有限公司 | Traditional Chinese medicine for treating mammary gland diseases |
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2012
- 2012-10-29 CN CN201210419132.9A patent/CN102949661B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1129122A (en) * | 1995-02-13 | 1996-08-21 | 张驰 | Ruan decoction for treatment of heperplasia of mamary glands and mamary ache |
| CN101361805A (en) * | 2008-07-31 | 2009-02-11 | 西安三八妇乐健康产业有限公司 | Traditional Chinese medicine for treating mammary gland diseases |
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