CN103781354A - 用拉喹莫德与醋酸格拉替雷的组合治疗多发性硬化症 - Google Patents

用拉喹莫德与醋酸格拉替雷的组合治疗多发性硬化症 Download PDF

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Publication number
CN103781354A
CN103781354A CN201280043755.9A CN201280043755A CN103781354A CN 103781354 A CN103781354 A CN 103781354A CN 201280043755 A CN201280043755 A CN 201280043755A CN 103781354 A CN103781354 A CN 103781354A
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laquinimod
thunder
acetic acid
methods
amount
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CN201280043755.9A
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Chinese (zh)
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约西·吉尔甘
诺拉·塔克斯克
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Teva Pharmaceutical Industries Ltd
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Teva Pharmaceutical Industries Ltd
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Priority to CN201610302142.2A priority Critical patent/CN105944081A/zh
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CN201280043755.9A 2011-07-28 2012-07-27 用拉喹莫德与醋酸格拉替雷的组合治疗多发性硬化症 Pending CN103781354A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610302142.2A CN105944081A (zh) 2011-07-28 2012-07-27 用拉喹莫德与醋酸格拉替雷的组合治疗多发性硬化症

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161512808P 2011-07-28 2011-07-28
US61/512,808 2011-07-28
PCT/US2012/048684 WO2013016684A1 (en) 2011-07-28 2012-07-27 Treatment of multiple sclerosis with combination of laquinimod and glatiramer acetate

Related Child Applications (1)

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CN201610302142.2A Division CN105944081A (zh) 2011-07-28 2012-07-27 用拉喹莫德与醋酸格拉替雷的组合治疗多发性硬化症

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CN103781354A true CN103781354A (zh) 2014-05-07

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CN201280043755.9A Pending CN103781354A (zh) 2011-07-28 2012-07-27 用拉喹莫德与醋酸格拉替雷的组合治疗多发性硬化症
CN201610302142.2A Pending CN105944081A (zh) 2011-07-28 2012-07-27 用拉喹莫德与醋酸格拉替雷的组合治疗多发性硬化症

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CN201610302142.2A Pending CN105944081A (zh) 2011-07-28 2012-07-27 用拉喹莫德与醋酸格拉替雷的组合治疗多发性硬化症

Country Status (19)

Country Link
US (3) US20130029916A1 (https=)
EP (1) EP2736335A4 (https=)
JP (2) JP2014521658A (https=)
KR (1) KR20140054166A (https=)
CN (2) CN103781354A (https=)
AU (2) AU2012286699A1 (https=)
BR (1) BR112014002095A2 (https=)
CA (1) CA2843433A1 (https=)
CL (2) CL2014000209A1 (https=)
EA (1) EA201490377A1 (https=)
HK (2) HK1198279A1 (https=)
IL (1) IL251397A0 (https=)
IN (1) IN2014MN00333A (https=)
MX (1) MX2014001050A (https=)
PE (1) PE20142319A1 (https=)
SG (1) SG10201606191PA (https=)
UY (1) UY34358A (https=)
WO (1) WO2013016684A1 (https=)
ZA (1) ZA201401371B (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2234485B1 (en) 2007-12-20 2013-11-13 Teva Pharmaceutical Industries, Ltd. Stable laquinimod preparations
DK2542079T3 (da) 2010-03-03 2014-08-25 Teva Pharma Behandling af reumatoid artritis med en kombination af laquinimod og methotrexat
SG183512A1 (en) * 2010-03-03 2012-09-27 Teva Pharma Treatment of lupus nephritis using laquinimod
CA2851525A1 (en) 2011-10-12 2013-04-18 Teva Pharmaceutical Industries Ltd. Treatment of multiple sclerosis with combination of laquinimod and fingolimod
CN104093310A (zh) 2012-02-03 2014-10-08 泰华制药工业有限公司 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途
JP6215238B2 (ja) 2012-02-16 2017-10-18 テバ ファーマシューティカル インダストリーズ リミティド Ｎ−エチル−ｎ−フェニル−１，２−ジヒドロ−４，５−ジ−ヒドロキシ−１−メチル−２−オキソ−３−キノリンカルボキサミド、その製剤、および使用
TW201350467A (zh) 2012-05-08 2013-12-16 Teva Pharma Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺
TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
TW201410244A (zh) 2012-08-13 2014-03-16 Teva Pharma 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）
EP2916915A4 (en) 2012-11-07 2016-06-22 Teva Pharma LAQUINIMOD AMINE SALTS
US20160046582A1 (en) 2013-03-14 2016-02-18 Teva Pharmaceutical Industries Ltd. Crystals of laquinimod sodium and improved process for the manufacture thereof
EP3043647A4 (en) * 2013-09-12 2017-05-10 Teva Pharmaceutical Industries Ltd. Gene expression biomarkers of laquinimod responsiveness
US20150094332A1 (en) * 2013-09-27 2015-04-02 Teva Pharmaceutical Industries, Ltd. Laquinimod Combination Therapy For Treatment Of Multiple Sclerosis
EP3068395A4 (en) * 2013-11-15 2017-07-12 Teva Pharmaceutical Industries Ltd. Treatment of glaucoma using laquinimod
HK1225969A1 (zh) * 2014-01-17 2017-09-22 Teva Pharmaceutical Industries Ltd 利用低剂量的拉喹莫德治疗克隆氏病
WO2015168103A1 (en) 2014-04-29 2015-11-05 Teva Pharmaceutical Industries Ltd. Laquinimod for the treatment of relapsing-remitting multiple sclerosis (rrms) patients with a high disability status
US20150361757A1 (en) * 2014-06-17 2015-12-17 Baker Hughes Incoporated Borehole shut-in system with pressure interrogation for non-penetrated borehole barriers
EP3193870A4 (en) * 2014-09-16 2018-04-25 Teva Pharmaceutical Industries Ltd. Treatment of neurodegenerative diseases with combination of laquinimod and fingolimod
US20170028013A1 (en) * 2015-07-30 2017-02-02 Teva Pharmaceutical Industries, Ltd. Combination formulation of laquinimod and glatiramer acetate with amino acids
KR20200143716A (ko) * 2018-04-13 2020-12-24 모데차이 체비온 탈수초 치료용 조성물 및 방법
KR20220118419A (ko) 2019-12-19 2022-08-25 액티브 바이오테크 에이비 과도한 혈관신생과 관련된 안구 질병의 치료를 위한 화합물
KR102350943B1 (ko) * 2021-07-12 2022-01-14 주식회사 바움디자인시스템즈 집적 회로에 대한 소비 전력을 예측하는 방법 및 이를 수행하는 소비 전력 예측 시스템

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100322900A1 (en) * 2009-06-19 2010-12-23 Teva Pharmaceutical Industries, Ltd. Treatment of multiple sclerosis with laquinimod
WO2011086470A1 (en) * 2010-01-13 2011-07-21 Ramot At Tel-Aviv University Ltd Treatment of multiple sclerosis

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002076503A1 (en) * 2000-06-20 2002-10-03 Mayo Foundation For Medical Education And Research Treatment of central nervous system diseases by antibodies against glatiramer acetate
EP1778286A4 (en) * 2004-03-03 2009-04-08 Teva Pharma COMBINATION THERAPY WITH ACETATE OF GLATIRAMER AND RILUZOLE
KR20150065951A (ko) * 2006-06-12 2015-06-15 테바 파마슈티컬 인더스트리즈 리미티드 안정한 라퀴니모드 제제
ES2329327B1 (es) * 2008-03-19 2010-09-17 Proyecto De Biomedicina Cima, S.L. Combinaciones sinergicas de 5'-metiltioadenosina.
KR20110048571A (ko) * 2008-09-03 2011-05-11 테바 파마슈티컬 인더스트리즈 리미티드 면역 기능을 지닌 ２―옥소―１,２―다이하이드로―퀴놀린 조절제
AR073295A1 (es) * 2008-09-16 2010-10-28 Genentech Inc Metodos para tratar la esclerosis multiple progresiva. articulo de fabricacion.
WO2010070449A2 (en) * 2008-12-17 2010-06-24 Actavis Group Ptc Ehf Highly pure laquinimod or a pharmaceutically acceptable salt thereof
WO2011019375A1 (en) * 2009-08-10 2011-02-17 Teva Pharmaceutical Industries Ltd. Treatment of bdnf-related disorders using laquinimod
EP2493477B1 (en) * 2009-10-27 2013-10-16 Wyeth LLC Bazedoxifene formulations with antioxidants

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100322900A1 (en) * 2009-06-19 2010-12-23 Teva Pharmaceutical Industries, Ltd. Treatment of multiple sclerosis with laquinimod
WO2011086470A1 (en) * 2010-01-13 2011-07-21 Ramot At Tel-Aviv University Ltd Treatment of multiple sclerosis

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