CN103772321A - 美克洛嗪的合成方法以及盐酸美克洛嗪的合成方法 - Google Patents
美克洛嗪的合成方法以及盐酸美克洛嗪的合成方法 Download PDFInfo
- Publication number
- CN103772321A CN103772321A CN201210411683.0A CN201210411683A CN103772321A CN 103772321 A CN103772321 A CN 103772321A CN 201210411683 A CN201210411683 A CN 201210411683A CN 103772321 A CN103772321 A CN 103772321A
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- CN
- China
- Prior art keywords
- meclozine
- reaction
- piperazine
- chemical equation
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (12)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210411683.0A CN103772321B (zh) | 2012-10-24 | 2012-10-24 | 美克洛嗪的合成方法以及盐酸美克洛嗪的合成方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201210411683.0A CN103772321B (zh) | 2012-10-24 | 2012-10-24 | 美克洛嗪的合成方法以及盐酸美克洛嗪的合成方法 |
Publications (2)
Publication Number | Publication Date |
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CN103772321A true CN103772321A (zh) | 2014-05-07 |
CN103772321B CN103772321B (zh) | 2015-09-02 |
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Application Number | Title | Priority Date | Filing Date |
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CN201210411683.0A Active CN103772321B (zh) | 2012-10-24 | 2012-10-24 | 美克洛嗪的合成方法以及盐酸美克洛嗪的合成方法 |
Country Status (1)
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CN (1) | CN103772321B (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010046908A2 (en) * | 2008-09-17 | 2010-04-29 | Calyx Chemicals And Pharmaceuticals Pvt. Ltd. | Novel water based process for the preparation of substituted diphenylmethyl piperazines |
WO2010132821A2 (en) * | 2009-05-14 | 2010-11-18 | The General Hospital Corporation | Methods and compositions for treating degenerative and ischemic disorders |
-
2012
- 2012-10-24 CN CN201210411683.0A patent/CN103772321B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010046908A2 (en) * | 2008-09-17 | 2010-04-29 | Calyx Chemicals And Pharmaceuticals Pvt. Ltd. | Novel water based process for the preparation of substituted diphenylmethyl piperazines |
WO2010132821A2 (en) * | 2009-05-14 | 2010-11-18 | The General Hospital Corporation | Methods and compositions for treating degenerative and ischemic disorders |
Non-Patent Citations (3)
Title |
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SABINO GOENECHEA ET AL.: "Synthese einiger Metaboliten des Meclozins", 《ARCHIV DER PHARMAZIE》 * |
王立升等: "二苯甲基哌嗪类化合物的合成及其抗变态反应活性", 《中国药物化学杂志》 * |
赵增任等: "盐酸美克洛嗪的合成", 《中国新药杂志》 * |
Also Published As
Publication number | Publication date |
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CN103772321B (zh) | 2015-09-02 |
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CP01 | Change in the name or title of a patent holder |
Address after: 100871, Beijing, Haidian District, Cheng Fu Road, No. 298, Zhongguancun Fangzheng building, 5 floor Patentee after: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee after: PKU HEALTHCARE Corp.,Ltd. Patentee after: PKU HEALTHCARE INDUSTRY Group Address before: 100871, Beijing, Haidian District, Cheng Fu Road, No. 298, Zhongguancun Fangzheng building, 5 floor Patentee before: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee before: SOUTHWEST SYNTHETIC PHARMACEUTICAL Corp.,Ltd. Patentee before: Pku Healthcare Industry Group Co.,Ltd. |
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Effective date of registration: 20221012 Address after: 3007, Hengqin international financial center building, No. 58, Huajin street, Hengqin new area, Zhuhai, Guangdong 519031 Patentee after: New founder holdings development Co.,Ltd. Patentee after: PKU HEALTHCARE Corp.,Ltd. Patentee after: Peking University Medical Management Co.,Ltd. Address before: 100871, Beijing, Haidian District, Cheng Fu Road, No. 298, Zhongguancun Fangzheng building, 5 floor Patentee before: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee before: PKU HEALTHCARE Corp.,Ltd. Patentee before: PKU HEALTHCARE INDUSTRY Group |