CN103768577A - Anti-alopecia traditional Chinese medicinal composition extract and application of extract in cosmetics - Google Patents
Anti-alopecia traditional Chinese medicinal composition extract and application of extract in cosmetics Download PDFInfo
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Abstract
The invention discloses an anti-alopecia traditional Chinese medicinal composition extract and application of the extract in cosmetics. The traditional Chinese medicinal composition comprises the following components in percentage by weight: 2-50 percent of gastrodin, 1-35 percent of yam, 2-30 percent of dried ginger, 2-40 percent of saponin, 1-30 percent of Chinese ivy stem, and 1-30 percent of opuntia dillenii haw. The traditional Chinese medicinal composition extract is advantageous to follicle growth, activate scalp cells and strengthen scalp blood circulation, has the effects of activating blood to promote qi circulation, prevent hair loss and control oil, has a particularly remarkable curative effect to alopecia seborrhoeica, and can be applied to hair cosmetics.
Description
Technical field
The present invention relates to a kind of composite Chinese medicine composition, this Chinese medicine composition extract is conducive to hair follicle stimulating growth, activation scalp cells, and strengthen scalp blood circulation, there is blood-activating and qi-promoting, prevent alopecia and control oily effect, particularly seborrheic alopecia is had to significant curative effect, can be applied to hair cosmetic.
Background technology
Alopecia has become the large problem that many moderns face.Alopecia is mainly divided into two kinds: the alopecia of physiological alopecia and seborrhea.Thereby physiological alopecia is often due to the atrophy attenuation of scalp tissue Musclar layer, microfilament blood vessel network blood flow is reduced and cause, this situation with advancing age can be all the more obviously.The alopecia that some youngsters occur early stage physical involution form is often mainly due to due to scalp blood circulation difference., make head be in high-strung excited state, and occurred that blood flow slows down, and occur temporary alopecia in the face of computer as long-term.Seborrheic alopecia is because androgen impact in sebaceous gland receptor body occurs that the symptom of hypertrophy wraps root of hair, and root of hair cannot provide enough nutrition to dry, the dry cutout that there will be nutrition and alopecia.
Scientific research is found androgen, particularly dihydrotestosterone (be called for short DHT) this special androgen is too hyperfunction to be the principal element that causes seborrheic alopecia.And DHT building-up process needs 5α-reductase to participate in, so it is synthetic to suppress DHT by inhibition 5α-reductase activity, reach the object of Anti-hair loss.At present the inhibition of 5α-reductase activity is mainly adopted the western medicine compositions such as finasteride, epristeride, epristeride, dutasteride, as patent of invention CN200810110577.2 has announced the external preparation of a kind for the treatment of androgens psilosis that contains the 5α-reductase inhibitor such as finasteride and seborrheic dermatitis, acne.But western medicine composition zest is large, side effect is large, so developing natural Anti-hair loss active component comes into one's own day by day, patent of invention ZL201210325594.4 has announced and discloses a kind of compositions with Anti-hair loss, it is made up of the raw material of following parts by weight: 8～24 parts of Radix Polygoni Multiflori, 6～18 parts of Semen Sesamis, 4～16 parts of Rhizoma Zingberis Recens, 5～15 parts of Semen Juglandiss, 3～18 parts, Semen sojae atricolor, 4～16 parts of Fructus Lyciis.Patent of invention ZL201210209947.4 discloses a kind of Chinese medicine extract with anticreep control oil effect.This Chinese medicine extract, its active component is made up of the former medicine of following portions by weight ratio: Radix Salviae Miltiorrhizae 10～20 weight portions, Rhizoma Dioscoreae 5～10 weight portions, Radix Sophorae Flavescentis 10～15 weight portions, Rhizoma Chuanxiong 5～8 weight portions, Fructus Lycii 5～8 weight portions, Fructus Zanthoxyli 5～10 weight portions, Fructus Ligustri Lucidi 4～8 weight portions, Caulis Hederae Sinensis 10～15 weight portions, Fructus Aurantii Immaturus 5～8 weight portions, Radix Puerariae 6～10 weight portions.The present invention adopts the Chinese medicine composition low to human body zest, toxicity is low as 5α-reductase inhibitor, reaches the object of Anti-hair loss.
Summary of the invention
The object of the invention is the defect in order to overcome chemical synthetic drug, a kind of Chinese medicine composition is provided, this Chinese medicine composition extract is conducive to hair follicle stimulating growth, can activate scalp cells, and strengthen scalp blood circulation, there is blood-activating and qi-promoting, prevent alopecia and control oily effect, particularly seborrheic alopecia is had to significant curative effect.
To achieve the object of the present invention, the present invention has adopted following technical scheme:
A Chinese medicine composition for Anti-hair loss, is characterized in that the component that comprises following percentage by weight: Rhizoma Gastrodiae 2-50%, Rhizoma Dioscoreae 1-35%, Rhizoma Zingiberis 2-30%, Fructus Gleditsia 2-40%, Caulis Hederae Sinensis 1-30%, Radix et Caulis Opuntiae Dillenii 1-30%.
For obtaining the extract of above-mentioned Chinese medicine composition, the present invention has adopted following technical scheme: by the Rhizoma Gastrodiae in above-mentioned Chinese medicine composition, Rhizoma Dioscoreae, Rhizoma Zingiberis, Fructus Gleditsia, Caulis Hederae Sinensis, Radix et Caulis Opuntiae Dillenii is pulverized, mix homogeneously after sieving, add extraction solvent, soak after 0.5 ~ 2h together with extracting solvent, under room temperature, extract with high pressure homogenize extractor, extracting solution is through centrifugalize, after concentrating under reduced pressure, go up again macroporous resin column purification, the ethanol elution part that collection mass fraction is 30%-80%, being evaporated to extracting solution is 1: 0.5 ~ 1: 5 with quality of medicinal material ratio, make Chinese medicine composition extract, extraction solvent is water, ethanol, alcohol-water mixed solution.
The second object of the present invention be by the extract of above-mentioned Chinese medicine composition for hair cosmetic, make stable in properties, respond well hair cosmetic.
For realizing the second object of the present invention, the present invention has adopted following technical scheme: the extract of above-mentioned Chinese medicine composition is used for preparing hair cosmetic, it is characterized in that the extract that contains above-mentioned Chinese medicine composition in hair cosmetic, its consumption is 0.1-50%, and preferable amount is 1-15%.Except containing above-mentioned Chinese medicine composition extract, can suitably add as required and be applicable to the common composition that hair cosmetic uses, as matrix components such as wetting agent, conditioner, water, surfactants.
The dosage form of hair cosmetic is not particularly limited, and can be solution, emulsion, cream frost, spray etc.
Beneficial effect of the present invention: theory of Chinese medical science, essence of the kidney being reflected on the hair.The growth of sending out with come off, moist and withered all depend on that essence in kidney is supplemented nutrition and blood moisten foster, title " hair is the sign of blood condition " again.Kidney storing essence, essence can be changed again blood, and blood is with hair care.Kidney essense abundance, essence can be changed blood, and the prosperous hair of blood must be supported, and hair is moist, growth is rapid; Deficiency of kidney-essence, changes insufficiency of blood, and hair loses supports, and hair is early white, or withered coming off.The present invention carries out the design of herbal mixture according to the theory of Chinese medical science of monarch, the Rhizoma Gastrodiae in Chinese medicine composition of the present invention, has wind-damp dispelling, and effect of pain relieving, promoting flow of QI and blood, the hair care that nourishes blood, as monarch drug; Rhizoma Dioscoreae and Rhizoma Zingiberis are ministerial drugs, and wherein Rhizoma Dioscoreae property is flat, have stomach reinforcing the kidney invigorating, effect of the benefit essence of reinforcing the kidney, Rhizoma Zingiberis has expelling wind and activating blood circulation effect, and the unobstructed meridians of energy, accelerate circulation, activate hair follicle, can promote the excretion of the absorption of skin histology nutrition and waste material, improve scalp ecology; Fructus Gleditsia and Caulis Hederae Sinensis are adjuvant drugs, can clearing away heat and eliminating dampness, dispel superabundant fats, unobstructed obstruction hair follicle, but also have draw out pus by applying a plaster to the affected part, detumescence, evacuation of pus, have certain effect for treatment scalp acne; Radix et Caulis Opuntiae Dillenii has effect of heat-clearing and toxic substances removing, scattered silt detumescence, toxin expelling granulation promoting, promoting flow of QI and blood, has extraordinary irritation function, as making medicine, coordinating the actions of various ingredients in a prescription simultaneously.Chinese medicine composition extract of the present invention is conducive to hair follicle stimulating growth, activation scalp cells, and strengthen scalp blood circulation, and there is blood-activating and qi-promoting, prevent alopecia and control oily effect, particularly seborrheic alopecia is had to significant curative effect.
The specific embodiment
Come by specific embodiment below that the present invention is further illustrated, but these embodiment are just in order to illustrate, are not limitations of the present invention.
embodiment 1 Chinese medicine composition extract (I) and preparation method
Get Rhizoma Gastrodiae, Rhizoma Dioscoreae, Rhizoma Zingiberis, Fructus Gleditsia, Caulis Hederae Sinensis, the each 100g of Radix et Caulis Opuntiae Dillenii, pulverize, cross mix homogeneously after 60 mesh sieves, adding mass fraction is 70% ethanol water 6 kg, soak after 1h, under room temperature, extract with high pressure homogenize extractor, extracting solution is through centrifugalize, after concentrating under reduced pressure, go up again macroporous resin column purification, the ethanol elution part that collection mass fraction is 70%, being evaporated to extracting solution is 1: 1 with quality of medicinal material ratio, makes Chinese medicine composition extract
(I).
embodiment 2 Chinese medicine composition extract (II) and preparation methoies
get Rhizoma Gastrodiae 150g, Rhizoma Dioscoreae 120 g, Rhizoma Zingiberis 80g, Fructus Gleditsia 50g, Caulis Hederae Sinensis 120g, Radix et Caulis Opuntiae Dillenii 80g, pulverize, cross mix homogeneously after 40 mesh sieves, adding mass fraction is 50% ethanol water 7.2 kg, soak after 1.5h, under room temperature, extract with high pressure homogenize extractor, extracting solution is through centrifugalize, after concentrating under reduced pressure, go up again macroporous resin column purification, the ethanol elution part that collection mass fraction is 70%, being evaporated to extracting solution is 1: 1 with quality of medicinal material ratio, makes Chinese medicine composition extract
(II).
embodiment 3 Chinese medicine composition extract (III) and preparation methoies
Get Rhizoma Gastrodiae 100g, Rhizoma Dioscoreae 150 g, Rhizoma Zingiberis 100g, Fructus Gleditsia 90g, Caulis Hederae Sinensis 60g, Radix et Caulis Opuntiae Dillenii 100g, pulverize, cross mix homogeneously after 40 mesh sieves, adding mass fraction is 30% ethanol water 9 kg, soak after 1.5h, under room temperature, extract with high pressure homogenize extractor, extracting solution is through centrifugalize, after concentrating under reduced pressure, go up again macroporous resin column purification, the ethanol elution part that collection mass fraction is 60%, being evaporated to extracting solution is 1: 1 with quality of medicinal material ratio, makes Chinese medicine composition extract
(III).
embodiment 4 suppresses the active effect assessment test of 5α-reductase
By evaluating the inhibitory action of Chinese medicine composition extract to 5α-reductase activity, can determine that Chinese medicine extract is to the synthetic inhibition level of dihydrotestosterone (being called for short DHT), thereby determine the effect of its Anti-hair loss.Evaluation methodology is as follows:
Blank assay group (5α-reductase, dependency dihydrocoenzyme (NADPH), Tris buffer solution).
Blank group (testosterone of series concentration, 5α-reductase, dependency dihydrocoenzyme (NADPH), Tris buffer solution).
Finasteride group (testosterone of Finasteride solution, series concentration, 5α-reductase, dependency dihydrocoenzyme (NADPH), Tris buffer solution).
Chinese medicine composition group (testosterone of Chinese medicine composition extract, series concentration, 5α-reductase, dependency dihydrocoenzyme (NADPH), Tris buffer solution).
Above each group reaction system is hatched continuously at 37 ℃, time changing curve with ultraviolet grating spectrophotometer in the characteristic absorption wavelength OD value of the METHOD FOR CONTINUOUS DETERMINATION NADPH of 340nm place, convert out as the lowering of concentration speed in zymetology reaction substrate NADPH 10min according to NADPH standard curve, the fall off rate of deduction blank assay pipe, is enzymatic activity.Measurement result is shown in Table 1.
Table 1 5α-reductase activity
Table 1 result shows, Chinese medicine composition extract of the present invention has obvious inhibitory action to 5α-reductase activity, shows that it has good inhibitory action to dihydrotestosterone (being called for short DHT) is synthetic, has good Anti-hair loss effect.
embodiment 5 treats the test of seborrheic alopecia effect assessment
Prepare Chinese medicine composition extract (I) by embodiment 3, be dissolved in mass fraction and be in 10% alcoholic solution, be made into mass fraction and be 5% Chinese medicine composition extract solution, sample on probation.
Select 20-45 year seborrheic alopecia patient 40 examples, wherein male 32 people, women 8 people, on probation crowd.
Therapeutic Method: patient will try out sample absorbent cotton and embrocate gently affected part, with finger at coating place knocking 5min gently, every day is sooner or later each 30th is a course for the treatment of with 1 time, treats continuously 4 courses for the treatment of.Before and after all patient treatments, follow up a case by regular visits to and record result, drug withdrawal post-evaluation curative effect.
Curative effect determinate standard: recovery from illness (it is normal that alopecia recovers, without scratchiness); Effective (alopecia obviously reduces or recovers normal, and dandruff, pruritus disappear, and affected part has obvious new growth or former fine, soft fur sample to send out chap, black, hard, long, and outward appearance is obviously improved); Effectively (alopecia, dandruff reduce, and pruritus alleviates, and there is new growth in affected part, and outward appearance makes moderate progress); Invalid (alopecia, dandruff slightly reduce or are unchanged, and pruritus is slightly clear or the same, and without new growth, outward appearance is improved not obvious).Efficacy result is shown in Table 2.
Table 2 therapeutic evaluation result
Table 2 result shows, Chinese medicine composition of the present invention has comparatively significantly effect to treatment seborrheic alopecia, and effective above ratio reaches 52.5%, and effective above ratio reaches 87.5%.
embodiment 6 Anti-hair loss shampoos and preparation method thereof
Table 3 provides the anticreep shampoo formula that contains Chinese medicine extraction compositions, and the consumption of each material represents with mass fraction.
Table 3 Anti-hair loss shampoo formula
Preparation method: deionized water is heated to 80 ℃, adds cationic cellulose, after insulation is uniformly dissolved, add disodiumedetate, citric acid, sodium chloride, stirring and dissolving.Then, add Dodecyl Polyoxyethylene Ether sodium sulfovinate, stirring and dissolving.Add pearlescent flake, cetostearyl alcohol, olive oil, stirring and dissolving.Add Coconut Fatty Acid Monoethanolamide, cocamido propyl betaine and Chinese medicine extraction compositions, stir, pass into water quench to 50 ℃, add KF88 antiseptic, emulsified silicone oil and essence, while continuing to be cooled to 40 ℃, be Anti-hair loss shampoo.
embodiment 7 anticreep hair conditioner
Table 4 provides the Anti-hair loss hair conditioner formula that contains Chinese medicine extraction compositions, and the consumption of each material represents with mass fraction.
Table 4 Anti-hair loss hair conditioner formula
Preparation method: INCROQUAT TMC-80 ECONOL TM22, disodiumedetate being added in deionized water, being heated to 80 ℃, is water.Glyceryl monostearate, cetostearyl alcohol, polydimethylsiloxane being mixed, be heated to 80 ℃, is oil phase.Oil phase and water are added in emulsifying pot, stir, emulsifying homogeneous, after 5 minutes, stirs while being cooled to 50 ℃, adds essence, KF88 antiseptic and Chinese medicine extraction compositions, stirs, and is cooled to 38 ℃, is Anti-hair loss hair conditioner.
Claims (2)
1. a Chinese medicine composition for Anti-hair loss, is characterized in that the component that comprises following percentage by weight: Rhizoma Gastrodiae 2-50%, Rhizoma Dioscoreae 1-35%, Rhizoma Zingiberis 2-30%, Fructus Gleditsia 2-40%, Caulis Hederae Sinensis 1-30%, Radix et Caulis Opuntiae Dillenii 1-30%; The extract of this Chinese medicine composition is adopted preparation with the following method: Rhizoma Gastrodiae, Rhizoma Dioscoreae, Rhizoma Zingiberis, Fructus Gleditsia, Caulis Hederae Sinensis, Radix et Caulis Opuntiae Dillenii are pulverized, mix homogeneously after sieving, add extraction solvent, soak after 0.5 ~ 2h together with extracting solvent, under room temperature, extract with high pressure homogenize extractor, extracting solution is through centrifugalize, after concentrating under reduced pressure, go up again macroporous resin column purification, the ethanol elution part that collection mass fraction is 30%-80%, being evaporated to extracting solution is 1: 0.5 ~ 1: 5 with quality of medicinal material ratio, makes Chinese medicine composition extract; Extraction solvent is water, ethanol, alcohol-water mixed solution.
2. contain the hair cosmetic of the extract of Chinese medicine composition claimed in claim 1, it is characterized in that the extract that contains Chinese medicine composition claimed in claim 1 in hair cosmetic, its consumption is 0.1-50%, and preferable amount is 1-15%.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109330960A (en) * | 2018-11-30 | 2019-02-15 | 江苏贝塔仕生物科技有限公司 | A kind of cosmetics can treat alopecia areata |
| CN111388390A (en) * | 2020-04-17 | 2020-07-10 | 广州章王化妆品有限公司 | Chinese herbal medicine shampoo with alopecia preventing and hair nourishing effects and preparation method thereof |
| CN115252485A (en) * | 2022-08-08 | 2022-11-01 | 澳宝化妆品（惠州）有限公司 | Preparation method of pichia pastoris extract and scalp care composition containing pichia pastoris extract |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1446531A (en) * | 2002-03-22 | 2003-10-08 | 董景平 | Disinfection attendance liquid prepared from Chinese herbal medicine and its production methods |
| CN103386111A (en) * | 2013-08-05 | 2013-11-13 | 谢明臣 | Special prescription for seborrhoeic alopecia |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109330960A (en) * | 2018-11-30 | 2019-02-15 | 江苏贝塔仕生物科技有限公司 | A kind of cosmetics can treat alopecia areata |
| CN111388390A (en) * | 2020-04-17 | 2020-07-10 | 广州章王化妆品有限公司 | Chinese herbal medicine shampoo with alopecia preventing and hair nourishing effects and preparation method thereof |
| CN115252485A (en) * | 2022-08-08 | 2022-11-01 | 澳宝化妆品（惠州）有限公司 | Preparation method of pichia pastoris extract and scalp care composition containing pichia pastoris extract |
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Inventor after: Gong Shengzhao Inventor after: Huang Cairong Inventor before: Gong Shengzhao |
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Effective date of registration: 20160316 Address after: 510300 Xingang West Road, Guangdong, Guangzhou, No. 152, No. Patentee after: Guangdong Industry Technical College Patentee after: GUANGDONG GADETIN DAILY NECESSITIES CO., LTD. Address before: 510300 Xingang West Road, Guangdong, Guangzhou, No. 152, No. Patentee before: Guangdong Industry Technical College |