CN103768191A - Traditional Chinese medicinal mixture for preventing fatty liver and preparation method and application thereof - Google Patents
Traditional Chinese medicinal mixture for preventing fatty liver and preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicinal mixture for preventing fatty liver and a preparation method and application thereof. The preparation method comprises the following steps of mixing 5-15 parts of salvia miltiorrhiza, 3-5 parts of garlicin and 3-5 parts of crataegus pinnatifida, soaking in 20-30 parts of water for 1 hour, decocting at 180-200DEG C for 30-60 minutes, filtering, adding 10-20 parts of water to filter residue, decocting at 180-200DEG C for 30-60 minutes, filtering, mixing decoctions, adding 10-13 parts of clinacanthus nutans powder of 20 meshes, reflux-extracting at 100DEG C twice (3 hours each time), concentrating the extractive solution under reduced pressure, adding anhydrous ethanol, precipitating overnight at 4-20 DEG C, collecting filtrate, and concentrating at 70-80DEG C to 1/3 to 1/4 of the original volume to obtain the traditional Chinese medicinal mixture for preventing fatty liver. The traditional Chinese medicinal mixture for preventing fatty liver can be administered as liquid, capsules, tablets and other dosage forms, or administered by water decoction with teal leaves to prevent fatty liver by virtue of everyday life habits of people. The traditional Chinese medicinal mixture is convenient and has a good effect.
Description
Technical field
The invention belongs to Chinese herb on the prevention disease technical field, relate in particular to a kind of herb mixture that prevents fatty liver and preparation method thereof and application.
Background technology
Along with the change of dietary structure and life style, the prevalence of hyperlipidemia and fatty liver constantly rises, and human health and social development are constituted a serious threat.Hyperlipidemia is the high risk factor of numerous disease, and fatty liver comprises alcoholic fatty liver and the large class of non-alcoholic fatty liver disease two, wherein, and take non-alcoholic fatty liver disease as main.Non-alcoholic fatty liver disease is a class without excessive drinking history (essence of drinking weekly amount is less than 40g), store up as clinical pathologic characteristic, and alcoholic fatty liver is attended by excessive drinking history take hepatic parenchymal cells steatosis and fat.In recent years, occurred frequently along with fat and diabetes, the sickness rate of NAFLD raises year by year, and is considered to the one of the main reasons of cryptogenic cirrhosis, and the dependency of alcoholic fatty liver and liver cirrhosis, hepatocarcinoma is tightr.Non-alcoholic fatty liver disease and alcoholic fatty liver comparison, prevent and treat non-smart alcoholic strength fatty liver and have more meaning, because the overwhelming majority is not alcohol user or once in a while alcohol user in crowd.So far the pathogenesis of NAFLD still imperfectly understands, Most scholars is thought, NAFLD is not an independently disease, but because a variety of causes makes liver metabolism generation obstacle as obesity, diabetes, malnutrition, infection, anoxia etc., cause the dynamic adjustments dysequilibrium of lipid material, thus a kind of pathological state that causes fat to accumulate in hepatocyte.Its spectrum of disease comprises that simple fatty liver, fat hepatitis (NASH), fatty liver fibrosis and four of fatty cirrhosis arrive the heavy pathology stage on the lenient side.Simple fatty liver is the clinical course that a pathological changes is lighter, fat hepatitis is the cause of disease of generally acknowledged hepatic fibrosis and liver cirrhosis, it is reported that 50%NASH can make progress as hepatic fibrosis, and 15% can develop into liver cirrhosis, 3% can develop into liver failure in latter stage at end, need to carry out liver transplantation.
Hepatic is of a great variety, but most medicine lacks and be difficult to assess its definite curative effect, and most drug is by liver metabolism, and concerning the patient of existing hepatic injury, medication should be prudent, and require rational use of drug, in order to avoid increase the weight of liver function injury.
Therefore, increasing people payes attention to preventing the importance of fatty liver, but, due to living habit difference, to personal health attention degree difference, different people also should have very big difference mutually to the attitude of prevention and health care, a very large people does not want prevention to do as an independent thing, and this has also caused the failure of preventive means.Therefore, a kind of a kind of preventive means that can be dissolved in people's daily life seems very necessary.
Summary of the invention
The object of the present invention is to provide a kind of herb mixture that prevents fatty liver and preparation method thereof and application, be intended to solve the problem that fatty liver can not prevent in time or prevention process is cumbersome.
The present invention is achieved in that a kind of herb mixture that prevents fatty liver, it is characterized in that, this herb mixture is by being that raw material is prepared from by mass parts component below:
Preferably, described herb mixture is by being that raw material is prepared from by mass parts component below:
The present invention further provides a kind of tea beverage that prevents fatty liver, comprised following by the each component of mass parts:
1～2 part of herb mixture;
3～5 parts of Folium Camelliae sinensis;
2～4 parts of Fructus Gardeniaes.
Preferably, described Folium Camelliae sinensis is green tea.
The preparation method that the present invention further provides the herb mixture of above-mentioned prevention fatty liver, comprises the following steps:
(1) 5～15 parts of Radix Salviae Miltiorrhizaes, 3～5 parts of garlicins, 3～5 portions of Fructus Crataegis are mixed after with 20～30 parts of water soakings 1 hour, 180～200 ℃ decoct 30～60min, leach decocting liquid, then add 180～200 ℃ of decoction 30～60min of water of 10～20 parts in filtering residue, leach decocting liquid, merge twice decocting liquid;
(2) in the described decocting liquid after the merging obtaining toward step (1), adding granularity is 10～13 parts of excellent grass meal ends of escaping of 20 object, twice of water reflux, extract, at 100 ℃, each 3 hours, after extracting solution concentrating under reduced pressure, add dehydrated alcohol, the precipitation of spending the night at 4 ℃～20 ℃, gets filtrate, at 70～80 ℃ of temperature, be concentrated into 1/3～1/4 of original volume, obtain preventing the herb mixture of fatty liver.
The present invention further provides the preparation method of the tea beverage of above-mentioned prevention fatty liver, comprise the following steps: after the herb mixture described in 1～2 part of claim 1 or 2,3～5 portions of Folium Camelliae sinensis and 2～4 portions of Fructus Gardeniaes are mixed, add 90～100 parts of water boil 5～10min, filter, go filtrate, obtain preventing the tea beverage of fatty liver.
Preferably, described dosage form is solution, capsule, granule and tablet.
The present invention overcomes the deficiencies in the prior art, a kind of herb mixture that prevents fatty liver and preparation method thereof and application are provided, by by 5～15 parts of Radix Salviae Miltiorrhizaes, 3～5 parts of garlicins, after 3～5 portions of Fructus Crataegis mix with 20～30 parts of water soakings 1 hour, 180～200 ℃ decoct 30～60min, leach decocting liquid, in filtering residue, add 180～200 ℃ of decoction 30～60min of water of 10～20 parts again, leach decocting liquid, merge decocting liquid twice, be 10～13 parts of excellent grass meal ends of escaping of 20 object by adding granularity in decocting liquid, twice of water reflux, extract, at 100 ℃, each 3 hours, after extracting solution concentrating under reduced pressure, add dehydrated alcohol, the precipitation of spending the night at 4 ℃～20 ℃, get filtrate, at 70～80 ℃ of temperature, be concentrated into 1/3～1/4 of original volume, obtain preventing the herb mixture of fatty liver.
In the present invention, Radix Salviae Miltiorrhizae to coronary heart disease, hypertension, hyperlipidemia, have extraordinary curative effect and preventive effect, garlicin can be by improving the level of liver cyclic adenosine monophosphate, regulating lipid metabolism film is transported and cell proliferation, and increases the activity of enzyme, and blood fat hydrolysis is increased, biosynthesis reduces, increase the excretion of lipid composition, maintain lipoprotein and triglyceride within normal range, reach the effect of prevention fatty liver; There is antioxidation and inflammation-inhibiting reaction simultaneously, play liver-protective function.The melancholy grass of escaping contains abundant flavonoid, can improve systemic blood flow state, reduces blood fat, in addition, also contains the mineral, vitamin, aminoacid of multiple needed by human etc., and especially vitamin C, crude protein, dietary fiber, mineral equal size are abundant.A kind of powerful antioxidant of vitamin C, has the effect of removing interior free yl, and itself is oxidized, and makes oxidized form of glutathione be reduced to reduced glutathion, thus performance antioxidation.As long as vitamin C abundance; vitamin C, glutathion, sulfydryl forms strong antioxidation combination freely; remove free radical; stop the toxic action of lipid peroxidation and some chemical substance; the homergy of liver-protective detoxification ability and cell; vitamin C can directly be removed free radical, can also transmit electronics to free radical, thereby reduces the lipid peroxidation that free radical causes.In addition, melancholy is escaped after the contained vitamin B12 of grass absorbs and is mainly housed in liver, and fat metabolism acid, makes fat, carbohydrate, protein suitably be used by health, present Research Patients with Fatty Liver vitamin B12 and folate content obviously reduce, and after supplementing, can reach preventive effect.Fructus Crataegi has stimulating central nervous system system, reduce blood pressure and the function of cholesterol.
Herb mixture of the present invention can coordinate with Folium Camelliae sinensis etc. after to boil water to be drunk, and good mouthfeel has effect of prevention fatty liver, does not cover again delicate fragrance and the tea color and luster of tea, can effectively be dissolved in the middle of people's daily life, and be the present good merchantable brand of giving a present.
Accompanying drawing explanation
Fig. 1 is observed result figure under the microscope after the hepatic tissue section dyeing of four groups of mices in effect embodiment of the present invention.
The specific embodiment
In order to make object of the present invention, technical scheme and advantage clearer, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
Embodiment 1
Prevent a herb mixture for fatty liver, prepare by following steps:
(1) dry to 50g Radix Salviae Miltiorrhizae, 50g garlicin, 30g Fructus Crataegi powder is mixed after with the water soaking of 200ml 1 hour, 180～200 ℃ decoct 30～60min, leach decocting liquid, then toward 180～200 ℃ of decoction 30～60min of water that add 100ml in filtering residue, leach decocting liquid, merge twice decocting liquid;
(2) in the described decocting liquid after the merging obtaining toward step (1), adding granularity is the excellent grass meal ends of escaping of 20 object 100g, twice of water reflux, extract, at 100 ℃, each 3 hours, after extracting solution concentrating under reduced pressure, add dehydrated alcohol, the precipitation of spending the night at 4 ℃～20 ℃, gets filtrate, at 70～80 ℃ of temperature, be concentrated into 1/3～1/4 of original volume, obtain preventing the herb mixture 1 of fatty liver.
Embodiment 2
Prevent a herb mixture for fatty liver, prepare by following steps:
(1) 150g Radix Salviae Miltiorrhizae, 3g garlicin, 5g Fructus Crataegi are mixed to the rear 300ml of using water soaking 1 hour, 180～200 ℃ decoct 30～60min, leach decocting liquid, then add 180～200 ℃ of decoction 30～60min of 200ml water in filtering residue, leach decocting liquid, merge twice decocting liquid;
(2) in the described decocting liquid after the merging obtaining toward step (1), adding granularity is the excellent grass meal ends of escaping of 20 object 130g, twice of water reflux, extract, at 100 ℃, each 3 hours, after extracting solution concentrating under reduced pressure, add dehydrated alcohol, the precipitation of spending the night at 4 ℃～20 ℃, gets filtrate, at 70～80 ℃ of temperature, be concentrated into 1/3～1/4 of original volume, obtain preventing the herb mixture 2 of fatty liver.
Embodiment 3
Prevent a herb mixture for fatty liver, prepare by following steps:
(1) 100g Radix Salviae Miltiorrhizae, 40g garlicin, 40g Fructus Crataegi are mixed to the rear 250ml of using water soaking 1 hour, 180～200 ℃ decoct 30～60min, leach decocting liquid, then add 180～200 ℃ of decoction 30～60min of 180ml water in filtering residue, leach decocting liquid, merge twice decocting liquid;
(2) in the described decocting liquid after the merging obtaining toward step (1), adding granularity is the 20 excellent grass meal ends of escaping of object 110g part, twice of water reflux, extract, at 100 ℃, each 3 hours, after extracting solution concentrating under reduced pressure, add dehydrated alcohol, the precipitation of spending the night at 4 ℃～20 ℃, gets filtrate, at 70～80 ℃ of temperature, be concentrated into 1/3～1/4 of original volume, obtain preventing the herb mixture 3 of fatty liver.
Embodiment 4
Prevent a tea beverage for fatty liver, prepare by following steps:
After 10g herb mixture 1,30g black tea and 20g Fructus Gardeniae are mixed, add 900ml water boil 5～10min, filter, go filtrate, obtain preventing the tea beverage 1 of fatty liver.
Embodiment 5
Prevent a tea beverage for fatty liver, prepare by following steps:
After 20 herb mixtures 1,50g green tea and 40g Fructus Gardeniae are mixed, add 1000ml water boil 5～10min, filter, go filtrate, obtain preventing the tea beverage 2 of fatty liver.
Embodiment 6
Prevent a tea beverage for fatty liver, prepare by following steps:
After 10g herb mixture 1,40g green tea and 30g Fructus Gardeniae are mixed, add 100ml water boil 5～10min, filter, go filtrate, obtain preventing the tea beverage 3 of fatty liver.
Embodiment 7
The preparation of the granular preparation of the herb mixture of prevention fatty liver, detailed process is as follows:
In 4.8kg herb mixture 1, add 0.36kg dextrin, 6.07kg lactose, and the ethanol that is 60～70% by volumetric concentration is as binding agent, in CH-300 type trough type mixing machine, is mixed and made into soft material.
Adopt YK-160 type oscillating granulator to granulate; after granule is dry at 60～75 ℃ of temperature with RXH-B-II type hot air circulation drying oven; with ZS-350 type shaking screen (three outlets) granulate, through the automatic particle packaging machine subpackage of DXDK40II type, obtain 5.3kg granular preparation.
Embodiment 8
The preparation of the capsule preparations of the herb mixture of prevention fatty liver, detailed process is as follows:
In 4.0kg herb mixture 1, spray into hydroxypropyl methylcellulose solution, the GHL150 type high-speed mixing granulating machine of producing with Changzhou Yu Tong drying equipment company limited is successively granulated, the GFG150 type HighefficientFluidbeddrier of producing with Changzhou Yu Tong drying equipment company limited is dry, after ZS-350 type shaking screen (three outlets) granulate of producing with Nanjing Qun Bang drying equipment company limited, and add 0.02kg micropowder silica gel, the JP2000A hard capsule filling machine capsule charge that after the SH600 mixer mix homogeneously of producing with Nanjing Qun Bang drying equipment company limited, Beijing Jia Furui Science and Technology Ltd. produces, obtain capsule preparations, capsule preparations content is 4.0kg.
Wherein, the ethanol that it is 40% that hydroxypropyl methylcellulose solution refers to hydroxypropyl methylcellulose and volumetric concentration is mixed with the solution that mass volume ratio (kg/ml) is 3%, and hydroxypropyl methylcellulose is 0.04kg.
Embodiment 9
The preparation of the tablet of the herb mixture 1 of prevention fatty liver, detailed process is as follows:
In 4.0kg herb mixture 1, add 0.12kg dextrin, 0.12kg starch, the ethanol that is 60～70% by volumetric concentration after mix homogeneously is binding agent, the GHL150 type high-speed mixing granulating machine of producing with Changzhou Yu Tong drying equipment company limited is successively granulated, the GFG150 type HighefficientFluidbeddrier of producing with Changzhou Yu Tong drying equipment company limited is dry, ZS-350 type shaking screen (three outlets) granulate of producing with Nanjing Qun Bang drying equipment company limited, and add 0.004kg Pulvis Talci, the SH600 mixer mix homogeneously of producing with Nanjing Qun Bang drying equipment company limited, the ZP-35 type tablet machine tabletting of producing by Shanghai Tianxiang, obtain 4.0kg tablet.
Effect embodiment
1, laboratory animal
60 of SD rats, clean level, male, body weight 180～200g is purchased from Shanghai Slac Experimental Animal Co., Ltd., the quality certification number: SCXK(Shanghai) No. 2002-0010.
2, experimental technique
(1) preparing non-ethanol fatty liver stimulates food, comprises high lipid food cholesterol 2%, sodium cholate 0.5%, propylthiouracil 0.2%, sucrose 5%, Adeps Sus domestica 10%, normal feedstuff 82.3%.
(2) 60 SD rats are divided into first to fourth group, every group is 20.Wherein, first group is normal group, within continuous 8 weeks, gives and feeds normal diet; Second group is stimulating group, and within continuous 8 weeks, giving to feed stimulates food; The 3rd group is prevention group 1, before giving hello stimulation food, presses 0.3ml/100g body weight gavage every day respectively with herb mixture 1 at every turn, continues nursing 8 weeks; The 4th group is prevention group 2, presses 2ml/100g body weight gavage every day each to the tea beverage 1 of using respectively prevention fatty liver before feeding stimulation food, continues nursing 8 weeks.
3, experiment analytical method and result
(1) put to death each group of rat, before putting to death, water 12h is prohibited in fasting, give after 3% pentobarbital sodium anesthesia, and abdominal aortic blood, separation of serum, puts-20 ℃ of Refrigerator stores to be measured; Get two of same position hepatic tissues for every group, immersion 4% paraformaldehyde solution is fixed, gradient alcohol dehydration, paraffin embedding, section, conventional H E dyeing, puts optical microphotograph Microscopic observation, as shown in Figure 1, and wherein, A is normal group, and B is stimulating group, and C is prevention group 1, and D is prevention group 2.As can be seen from Figure 1, stimulating group mouse liver oil red dyeing after high fat diet, in hepatocyte, fat is red and dyes, and shows obvious fatty liver, and prevention group 1,2 obvious alleviation compared with stimulating group, and be close with normal group fatty liver.
Another piece is got 500mg hepatic tissue and is fully mixed by 1:9 and chloroform-methanol mixed liquor (1:1), hold over night, the centrifugal 15min of 3000 turn/min, gets supernatant and detects ALT(alanine aminotransferase in full automatic biochemical apparatus), AST(aspartate amino transferase).By the quantitative data data mean of detection
standard deviation represents, uses one factor analysis of variance and SNK-q check to carry out statistical analysis, and the use of group data data is lost and statistical analysis is carried out in check.P < 0.05 represents that difference has statistical significance.
| Grouping | ALT（U/L） | AST（U/L） | FFA（μmol/ml） |
| Normal group | 29.32±7.13 | 45.35±3.10 | 197.11±5.545 |
| Stimulating group | 44.03±5.29 | 101.16±3.15 | 3.81±31.232 |
| Prevention group 1 | 32.01±6.83 | 42.68±4.56 | 2.74±12.45 |
| Prevention group 2 | 30.01±5.83 | 41.68±3.56 | 2.44±11.45 |
Table 1 Serum ALT, AST, FFA comparative result
Stimulating group Serum ALT, AST are apparently higher than normal group and prevention group 1,2(p < 0.05); Normal group and prevention group 1,2 Serum ALT, AST level are similar, not statistically significant (p is respectively 0.311 and 0.454).Stimulating group serum FFA expresses higher than prevention group 1,2 and normal group (p is respectively 0.046 and 0.030), and 1, the 2 serum FFA of prevention group simultaneously express lower than normal group, have statistical significance (p=0.002).
From Fig. 1 and table 1, can find out, herb mixture 1 of the present invention and tea beverage 1 can effectively prevent the rising of liver organization triglyceride, total cholesterol level, transaminase level, prevent liver fat lesion.
Compare and the shortcoming and defect of prior art, the present invention has following beneficial effect:
(1) herb mixture of the present invention adopts that raw material valency is low to be easy to get, and prevention fatty liver is respond well.
(2) preparation method of herb mixture of the present invention is simple, and cost is low, is suitable for industrialization and produces.
(3) when tea beverage of the present invention has effect of prevention fatty liver, not covering again delicate fragrance and the tea color and luster of tea, can effectively be dissolved in the middle of people's daily life, is the present good merchantable brand of giving a present.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any modifications of doing within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.
Claims (7)
1. a herb mixture that prevents fatty liver, is characterized in that, this herb mixture is by being that raw material is prepared from by mass parts component below:
2. the herb mixture of prevention fatty liver as claimed in claim 1, is characterized in that, described herb mixture is by being that raw material is prepared from by mass parts component below:
3. a tea beverage that prevents fatty liver, is characterized in that, comprises following by the each component of mass parts:
1～2 part of herb mixture described in claim 1 or 2;
3～5 parts of Folium Camelliae sinensis;
2～4 parts of Fructus Gardeniaes.
4. the tea beverage of prevention fatty liver as claimed in claim 3, is characterized in that, described Folium Camelliae sinensis is green tea.
5. prevent a preparation method for the herb mixture of fatty liver, it is characterized in that comprising the following steps:
(1) 5～15 parts of Radix Salviae Miltiorrhizaes, 3～5 parts of garlicins, 3～5 portions of Fructus Crataegis are mixed after with 20～30 parts of water soakings 1 hour, 180～200 ℃ decoct 30～60min, leach decocting liquid, then add 180～200 ℃ of decoction 30～60min of water of 10～20 parts in filtering residue, leach decocting liquid, merge twice decocting liquid;
(2) in the described decocting liquid after the merging obtaining toward step (1), adding granularity is 10～13 parts of excellent grass meal ends of escaping of 20 object, twice of water reflux, extract, at 100 ℃, each 3 hours, after extracting solution concentrating under reduced pressure, add dehydrated alcohol, the precipitation of spending the night at 4 ℃～20 ℃, gets filtrate, at 70～80 ℃ of temperature, be concentrated into 1/3～1/4 of original volume, obtain preventing the herb mixture of fatty liver.
6. one kind is prevented the preparation method of the tea beverage of fatty liver, it is characterized in that comprising the following steps: after the herb mixture described in 1～2 part of claim 1 or 2,3～5 portions of Folium Camelliae sinensis and 2～4 portions of Fructus Gardeniaes are mixed, add 90～100 parts of water boil 5～10min, filter, go filtrate, obtain preventing the tea beverage of fatty liver.
7. the application of the herb mixture described in claim 1 or 2 in the conventional Chinese medicine preparation dosage form of preparation, is characterized in that, described dosage form is solution, capsule, granule and tablet.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104905065A (en) * | 2015-06-18 | 2015-09-16 | 江苏农牧科技职业学院 | Feed for improving immunity of black muscovy duck and preparation method thereof |
| CN104982716A (en) * | 2015-06-18 | 2015-10-21 | 江苏农牧科技职业学院 | Fodder capable of improving egg laying capacity of black muscovy ducks and preparing method of fodder |
| CN105341570A (en) * | 2015-10-14 | 2016-02-24 | 哈尔滨工业大学 | Series Clinacanthus nutans functional beverage and preparation method thereof |
| CN106070794A (en) * | 2016-06-08 | 2016-11-09 | 郭良来 | One purifies the blood health protection tea and preparation method thereof |
| CN107242376A (en) * | 2017-05-31 | 2017-10-13 | 江苏农牧科技职业学院 | It is a kind of to prevent and treat the fat feed of pet and preparation method |
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| RO86649A2 (en) * | 1983-05-27 | 1985-04-17 | Intreprinderea De Medicamente "Biofarm",Ro | ANTITERRAMATIC ACTION DRUG |
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| RO86649A2 (en) * | 1983-05-27 | 1985-04-17 | Intreprinderea De Medicamente "Biofarm",Ro | ANTITERRAMATIC ACTION DRUG |
| CN1943702A (en) * | 2005-10-08 | 2007-04-11 | 周小明 | A Chinese traditional medicinal composition for treatment of hyperlipemia and its preparation method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104905065A (en) * | 2015-06-18 | 2015-09-16 | 江苏农牧科技职业学院 | Feed for improving immunity of black muscovy duck and preparation method thereof |
| CN104982716A (en) * | 2015-06-18 | 2015-10-21 | 江苏农牧科技职业学院 | Fodder capable of improving egg laying capacity of black muscovy ducks and preparing method of fodder |
| CN105341570A (en) * | 2015-10-14 | 2016-02-24 | 哈尔滨工业大学 | Series Clinacanthus nutans functional beverage and preparation method thereof |
| CN106070794A (en) * | 2016-06-08 | 2016-11-09 | 郭良来 | One purifies the blood health protection tea and preparation method thereof |
| CN107242376A (en) * | 2017-05-31 | 2017-10-13 | 江苏农牧科技职业学院 | It is a kind of to prevent and treat the fat feed of pet and preparation method |
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| CN103768191B (en) | 2016-06-15 |
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