CN103768191B - A kind of herb mixture preventing fatty liver and preparation method thereof and application - Google Patents
A kind of herb mixture preventing fatty liver and preparation method thereof and application Download PDFInfo
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Abstract
The invention provides a kind of herb mixture preventing fatty liver and preparation method thereof and application, by by 5～15 parts of Radix Salviae Miltiorrhizaes, 3～5 parts of garlicins, with 20～30 parts of water soakings 1 hour after the mixing of 3～5 portions of Fructus Crataegis, 180～200 DEG C decoct 30～60min, leach decocting liquid, in filtering residue, adding 10 again～180～200 DEG C of the water of 20 parts decocts 30～60min, leach decocting liquid, merge twice decocting liquid, decocting liquid will add 10～13 parts of excellent grass meal ends of escaping that granularity is 20 orders, water reflux, extract, is used twice at 100 DEG C, each 3 hours, after extracting solution concentrating under reduced pressure, add dehydrated alcohol, overnight precipitation at 4 DEG C～20 DEG C, take filtrate, it is concentrated into the 1/3～1/4 of original volume at 70～80 DEG C of temperature, obtain the herb mixture of prevention fatty liver, this herb mixture can as liquid, capsule, the medicines such as tablet are taken, can also to boil water with Folium Camelliae sinensis after take, fully it is dissolved into the prevention carrying out fatty liver in people's daily life custom, convenient and respond well.
Description
Technical field
The invention belongs to Chinese herb on the prevention disease technical field, particularly relate to a kind of herb mixture preventing fatty liver and preparation method thereof and application.
Background technology
Along with the prevalence of dietary structure and living-pattern preservation, hyperlipidemia and fatty liver constantly rises, human health and social development are constituted a serious threat. Hyperlipidemia is the high risk factor of numerous disease, and fatty liver includes alcoholic fatty liver and the big class of non-alcoholic fatty liver disease two, wherein, based on non-alcoholic fatty liver disease. Non-alcoholic fatty liver disease is a class without excessive drinking history (drink alcohol amount is less than 40g weekly), stores up for clinical pathologic characteristic with hepatic parenchymal cells steatosis and fat, and alcoholic fatty liver is attended by excessive drinking history. In recent years, occurred frequently along with fat and diabetes, the sickness rate of NAFLD raises year by year, and is considered as the one of the main reasons of cryptogenic cirrhosis, and alcoholic fatty liver is tightr with the dependency of liver cirrhosis, hepatocarcinoma. Non-alcoholic fatty liver disease and alcoholic fatty liver compare, and prevent and treat non-essence alcoholic strength fatty liver more meaning, because the overwhelming majority is not alcohol user or once in a while alcohol user in crowd. So far the pathogenesis of NAFLD still imperfectly understands, Most scholars is thought, NAFLD is not an independent disease, but owing to a variety of causes makes liver metabolism generation obstacle such as obesity, diabetes, malnutrition, infection, anoxia etc., cause the dynamic adjustment imbalance of lipid material, thus causing fat a kind of pathological state of accumulation in hepatocyte. Its spectrum of disease includes simple fatty liver, fat hepatitis (NASH), fatty liver fibrosis and fatty cirrhosis four from light to the pathologic stage of weight.Simple fatty liver is the clinical course that a pathological changes is lighter, hepatic fibrosis that fat hepatitis is then well recognized as and the cause of disease of liver cirrhosis, it was reported that 50%NASH can be in progress as hepatic fibrosis, and 15% can develop into liver cirrhosis, 3% can develop into liver failure in latter stage at end, it is necessary to carry out liver transplantation.
Hepatic is of a great variety, but most medicine shortage is difficult to assess its definite curative effect, and most drug is by liver metabolism, and the patient for existing hepatic injury, medication should be prudent, and requires rational use of drug, in order to avoid increasing the weight of liver function injury.
Therefore, increasing people payes attention to the importance of prevention fatty liver, but, due to living habit difference, to personal health attention degree difference, the attitude of prevention and health care also should be had very big difference by different people mutually, a very big people is not desired to prevention to do as an independent thing at all, and this result also in the failure of preventive means. Therefore, a kind of a kind of preventive means can being dissolved in people's daily life seems very necessary.
Summary of the invention
It is an object of the invention to provide a kind of herb mixture preventing fatty liver and preparation method thereof and application, it is intended to solve the problem that fatty liver can not prevent in time or prevention process is cumbersome.
The present invention is achieved in that a kind of herb mixture preventing fatty liver, it is characterised in that this herb mixture is that raw material is prepared from by component in parts by mass:
Preferably, described herb mixture is that raw material is prepared from by component in parts by mass:
Invention further provides a kind of tea beverage preventing fatty liver, including each component in parts by mass:
Herb mixture 1～2 part;
Folium Camelliae sinensis 3～5 parts;
Fructus Gardeniae 2～4 parts.
Preferably, described Folium Camelliae sinensis is green tea.
The preparation method that invention further provides the herb mixture of above-mentioned prevention fatty liver, comprises the following steps:
(1) by after 5～15 parts of Radix Salviae Miltiorrhizaes, 3～5 parts of garlicins, 3～5 parts of Fructus Crataegis mixing with 20～30 parts of water soakings 1 hour, 180～200 DEG C decoct 30～60min, leach decocting liquid, then add 10 in filtering residue～and 180～200 DEG C of the water of 20 parts decocts 30～60min, leach decocting liquid, merge twice decocting liquid;
(2) the described decocting liquid after the merging obtained toward step (1) adds 10～13 parts of excellent grass meal ends of escaping that granularity is 20 orders, water reflux, extract, is used twice at 100 DEG C, each 3 hours, after extracting solution concentrating under reduced pressure, add dehydrated alcohol, overnight precipitation at 4 DEG C～20 DEG C, take filtrate, it is concentrated into the 1/3～1/4 of original volume at 70～80 DEG C of temperature, obtains the herb mixture of prevention fatty liver.
The preparation method that invention further provides the tea beverage of above-mentioned prevention fatty liver, comprise the following steps: after the herb mixture described in 1～2 part of claim 1 or 2,3～5 portions of Folium Camelliae sinensis and 2～4 parts of Fructus Gardeniae mixing, add 90～100 parts of water boil 5～10min, filter, go filtrate, obtain the tea beverage of prevention fatty liver.
Preferably, described dosage form is solution, capsule, granule and tablet.
The present invention overcomes the deficiencies in the prior art, a kind of herb mixture preventing fatty liver and preparation method thereof and application are provided, by by 5～15 parts of Radix Salviae Miltiorrhizaes, 3～5 parts of garlicins, with 20～30 parts of water soakings 1 hour after the mixing of 3～5 portions of Fructus Crataegis, 180～200 DEG C decoct 30～60min, leach decocting liquid, in filtering residue, adding 10 again～180～200 DEG C of the water of 20 parts decocts 30～60min, leach decocting liquid, merge twice decocting liquid, decocting liquid will add 10～13 parts of excellent grass meal ends of escaping that granularity is 20 orders, water reflux, extract, is used twice at 100 DEG C, each 3 hours, after extracting solution concentrating under reduced pressure, add dehydrated alcohol, overnight precipitation at 4 DEG C～20 DEG C, take filtrate, it is concentrated into the 1/3～1/4 of original volume at 70～80 DEG C of temperature, obtain the herb mixture of prevention fatty liver.
In the present invention, Radix Salviae Miltiorrhizae to coronary heart disease, hypertension, hyperlipidemia, have extraordinary curative effect and preventive effect, garlicin can pass through to improve the level of liver cyclic adenosine monophosphate, the transhipment of regulating lipid metabolism film and cell proliferation, and increase the activity of enzyme, make blood fat hydrolysis increase, biosynthesis reduces, increase the excretion of lipid composition, maintain lipoprotein and triglyceride within normal range, reach the effect of prevention fatty liver; There is antioxidation simultaneously and suppress inflammatory reaction, playing liver-protective function. Melancholy escapes grass containing abundant flavonoid, can improve systemic blood flow state, reduces blood fat, additionally, possibly together with the mineral of multiple needed by human, vitamin, aminoacid etc., especially vitamin C, crude protein, dietary fiber, mineral equal size enrich. Vitamin C one powerful antioxidant, has the effect removing interior free yl, and itself is oxidized, and makes oxidized form of glutathione be reduced to reduced glutathion, thus playing antioxidation. As long as vitamin C is sufficient; then vitamin C, glutathion, freely sulfydryl form the combination of strong antioxidation; scavenging free radicals; stop the toxic action of lipid peroxidation and some chemical substance; the homergy of liver-protective detoxification ability and cell; vitamin C energy directly scavenging free radicals, moreover it is possible to transmission electronics is to free radical, thus reducing the lipid peroxidation that free radical causes. In addition, melancholy is escaped after the vitamin B12 contained by grass absorbs and is mainly housed in liver, and fat metabolism acid makes fat, carbohydrate, protein suitably be used by health, present Research Patients with Fatty Liver vitamin B12 and folate content substantially reduce, and can reach preventive effect after supplementing. Fructus Crataegi has stimulating central nervous system system, reduce blood pressure and the function of cholesterol.
The herb mixture of the present invention can coordinate with Folium Camelliae sinensis etc. to boil water after drink, good mouthfeel, have prevention fatty liver effect, do not cover again delicate fragrance and the tea color and luster of tea, it is possible to be effectively dissolved in the middle of people's daily life, be present good merchantable brand of giving a present.
Accompanying drawing explanation
Fig. 1 be four groups of mices in effect example of the present invention hepatic tissue section dyeing after observed result figure under the microscope.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearly understand, below in conjunction with drawings and Examples, the present invention is further elaborated. Should be appreciated that specific embodiment described herein is only in order to explain the present invention, is not intended to limit the present invention.
Embodiment 1
A kind of herb mixture preventing fatty liver, is prepared by following steps:
(1) by the water soaking of use 200ml 1 hour after 50g Radix Salviae Miltiorrhizae, 50g garlicin, the dry Fructus Crataegi powder mixing of 30g, 180～200 DEG C decoct 30～60min, leach decocting liquid, then 180～200 DEG C of the water adding 100ml in filtering residue decocts 30～60min, leach decocting liquid, merge twice decocting liquid;
(2) the described decocting liquid after the merging obtained toward step (1) adds the excellent grass meal end of escaping of 100g that granularity is 20 orders, water reflux, extract, is used twice at 100 DEG C, each 3 hours, after extracting solution concentrating under reduced pressure, add dehydrated alcohol, overnight precipitation at 4 DEG C～20 DEG C, take filtrate, it is concentrated into the 1/3～1/4 of original volume at 70～80 DEG C of temperature, obtains the herb mixture 1 of prevention fatty liver.
Embodiment 2
A kind of herb mixture preventing fatty liver, is prepared by following steps:
(1) using 300ml water soaking 1 hour after 150g Radix Salviae Miltiorrhizae, 3g garlicin, the mixing of 5g Fructus Crataegi, 180～200 DEG C decoct 30～60min, leach decocting liquid, then add 180～200 DEG C of 200ml water decoction 30～60min in filtering residue, leach decocting liquid, merge twice decocting liquid;
(2) the described decocting liquid after the merging obtained toward step (1) adds the excellent grass meal end of escaping of 130g that granularity is 20 orders, water reflux, extract, is used twice at 100 DEG C, each 3 hours, after extracting solution concentrating under reduced pressure, add dehydrated alcohol, overnight precipitation at 4 DEG C～20 DEG C, take filtrate, it is concentrated into the 1/3～1/4 of original volume at 70～80 DEG C of temperature, obtains the herb mixture 2 of prevention fatty liver.
Embodiment 3
A kind of herb mixture preventing fatty liver, is prepared by following steps:
(1) using 250ml water soaking 1 hour after 100g Radix Salviae Miltiorrhizae, 40g garlicin, the mixing of 40g Fructus Crataegi, 180～200 DEG C decoct 30～60min, leach decocting liquid, then add 180～200 DEG C of 180ml water decoction 30～60min in filtering residue, leach decocting liquid, merge twice decocting liquid;
(2) the described decocting liquid after the merging obtained toward step (1) adds the excellent grass meal end of escaping of 110g part that granularity is 20 orders, water reflux, extract, is used twice at 100 DEG C, each 3 hours, after extracting solution concentrating under reduced pressure, add dehydrated alcohol, overnight precipitation at 4 DEG C～20 DEG C, take filtrate, it is concentrated into the 1/3～1/4 of original volume at 70～80 DEG C of temperature, obtains the herb mixture 3 of prevention fatty liver.
Embodiment 4
A kind of tea beverage preventing fatty liver, is prepared by following steps:
After 10g herb mixture 1,30g black tea and 20g Fructus Gardeniae being mixed, add 900ml water boil 5～10min, filter, go filtrate, obtain the tea beverage 1 of prevention fatty liver.
Embodiment 5
A kind of tea beverage preventing fatty liver, is prepared by following steps:
After 20 herb mixtures 1,50g green tea and 40g Fructus Gardeniae being mixed, add 1000ml water boil 5～10min, filter, go filtrate, obtain the tea beverage 2 of prevention fatty liver.
Embodiment 6
A kind of tea beverage preventing fatty liver, is prepared by following steps:
After 10g herb mixture 1,40g green tea and 30g Fructus Gardeniae being mixed, add 100ml water boil 5～10min, filter, go filtrate, obtain the tea beverage 3 of prevention fatty liver.
Embodiment 7
The preparation of the granular preparation of the herb mixture of prevention fatty liver, detailed process is as follows:
In 4.8kg herb mixture 1, add 0.36kg dextrin, 6.07kg lactose, and with the ethanol that volumetric concentration is 60～70% as binding agent, in CH-300 type trough type mixing machine, be mixed and made into soft material.
YK-160 type oscillating granulator is adopted to granulate; by granule with RXH-B-II type hot air circulation drying oven at 60～75 DEG C of temperature dried; with ZS-350 type shaking screen (three outlets) granulate, through the automatic particle packaging machine subpackage of DXDK40II type, obtain 5.3kg granular preparation.
Embodiment 8
The preparation of the capsule preparations of the herb mixture of prevention fatty liver, detailed process is as follows:
Hydroxypropyl methylcellulose solution is sprayed in 4.0kg herb mixture 1, the GHL150 type high-speed mixing granulating machine produced with Changzhou Yu Tong drying equipment company limited successively is granulated, the GFG150 type HighefficientFluidbeddrier produced with Changzhou Yu Tong drying equipment company limited dries, after ZS-350 type shaking screen (three outlets) granulate of Nanjing Qun Bang drying equipment company limited production, and add 0.02kg micropowder silica gel, the JP2000A hard capsule filling machine capsule charge produced with Beijing Jia Furui Science and Technology Ltd. after the SH600 mixer mix homogeneously of Nanjing Qun Bang drying equipment company limited production, obtain capsule preparations, capsule preparations content is 4.0kg.
Wherein, hydroxypropyl methylcellulose solution refers to that the ethanol that hydroxypropyl methylcellulose and volumetric concentration are 40% is configured to mass volume ratio (kg/ml) is the solution of 3%, and hydroxypropyl methylcellulose is 0.04kg.
Embodiment 9
The preparation of the tablet of the herb mixture 1 of prevention fatty liver, detailed process is as follows:
0.12kg dextrin is added in 4.0kg herb mixture 1, 0.12kg starch, it is binding agent with the ethanol that volumetric concentration is 60～70% after mix homogeneously, the GHL150 type high-speed mixing granulating machine produced with Changzhou Yu Tong drying equipment company limited successively is granulated, the GFG150 type HighefficientFluidbeddrier produced with Changzhou Yu Tong drying equipment company limited dries, ZS-350 type shaking screen (three outlets) granulate produced with Nanjing Qun Bang drying equipment company limited, and add 0.004kg Pulvis Talci, the SH600 mixer mix homogeneously produced with Nanjing Qun Bang drying equipment company limited, the ZP-35 type tabletting machine produced by Shanghai Tianxiang, obtain 4.0kg tablet.
Effect example
1, laboratory animal
SD rat 60, cleaning grade, male, body weight 180～200g is purchased from Shanghai Slac Experimental Animal Co., Ltd., the quality certification number: SCXK(Shanghai) No. 2002-0010.
2, experimental technique
(1) prepare non-ethanol fatty liver and stimulate food, including high lipid food cholesterol 2%, sodium cholate 0.5%, propylthiouracil 0.2%, sucrose 5%, Adeps Sus domestica 10%, normal feedstuff 82.3%.
(2) 60 SD rats being divided into first to fourth group, often group is 20. Wherein, first group is normal group, continuous 8 weeks feeding normal diet; Second group is stimulation group, and within continuous 8 weeks, feeding stimulates food; 3rd group is prevention group 1, pressed 0.3ml/100g body weight gavage every day with herb mixture 1 respectively, persistently fed 8 weeks before each feeding stimulates food; 4th group is prevention group 2, pressed 2ml/100g body weight gavage every day with the tea beverage 1 of prevention fatty liver respectively, persistently fed 8 weeks before each feeding stimulates food.
3, experiment analytical method and result
(1) putting to death each group of rat, before putting to death, water 12h is prohibited in fasting, after giving 3% pentobarbital sodium anesthesia, and abdominal aortic blood, separate serum, put-20 DEG C of Refrigerator stores to be measured; Often group takes same position hepatic tissue two pieces, and one piece of immersion 4% paraformaldehyde solution is fixed, gradient alcohol dehydration, paraffin embedding, section, conventional H E dyes, and puts optical microphotograph Microscopic observation, as it is shown in figure 1, wherein, A is normal group, and B is stimulation group, and C is prevention group 1, D is prevention group 2. From figure 1 it appears that the mouse liver oil red dyeing after high fat diet of stimulation group, in hepatocyte, fat is in red dye, shows obvious fatty liver, and prevention group 1,2 obvious alleviation compared with stimulation group, and be close with normal group fatty liver.
Another block takes 500mg hepatic tissue and fully mixes with chloroform-methanol mixed liquor (1:1) by 1:9, stand overnight, 3000 turns/min is centrifuged 15min, take supernatant in full automatic biochemical apparatus detect ALT(alanine aminotransferase), AST(aspartate amino transferase). By the quantitative data data mean of detectionStandard deviation represents, uses one factor analysis of variance and SNK-q inspection to carry out statistical analysis, and the use of group data data is lost and inspection carries out statistical analysis. P < 0.05 represents that difference is statistically significant.
| Packet | ALT(U/L) | AST(U/L) | FFA(μm of ol/ml) |
| Normal group | 29.32±7.13 | 45.35±3.10 | 197.11±5.545 |
| Stimulation group | 44.03±5.29 | 101.16±3.15 | 3.81±31.232 |
| Prevention group 1 | 32.01±6.83 | 42.68±4.56 | 2.74±12.45 |
| Prevention group 2 | 30.01±5.83 | 41.68±3.56 | 2.44±11.45 |
Table 1 Serum ALT, AST, FFA comparative result
Stimulation group Serum ALT, AST are apparently higher than normal group and prevention group 1,2(p < 0.05); Normal group and prevention group 1,2 Serum ALT, AST level are similar, not statistically significant (p respectively 0.311 and 0.454).Stimulation group serum FFA expresses higher than prevention group 1,2 and normal group (p respectively 0.046 and 0.030), and prevention group simultaneously 1,2 serum FFA expresses lower than normal group, statistically significant (p=0.002).
It can be seen that the herb mixture 1 of the present invention and tea beverage 1 can effectively prevent the rising of liver organization triglyceride, total cholesterol level, transaminase level from Fig. 1 and table 1, it is prevented that liver fat lesion.
Compare the shortcoming and defect with prior art, the method have the advantages that
(1) herb mixture of the present invention adopted raw material valency is low is easy to get, and prevention fatty liver is respond well.
(2) preparation method of the herb mixture of the present invention is simple, and cost is low, is suitable to industrialization and produces.
(3), while the tea beverage of the present invention has effect of prevention fatty liver, do not cover again delicate fragrance and the tea color and luster of tea, it is possible to be effectively dissolved in the middle of people's daily life, be present good merchantable brand of giving a present.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all any amendment, equivalent replacement and improvement etc. made within the spirit and principles in the present invention, should be included within protection scope of the present invention.
Claims (7)
1. the herb mixture preventing fatty liver, it is characterised in that this herb mixture is that raw material is prepared from by component in parts by mass:
2. the herb mixture preventing fatty liver as claimed in claim 1, it is characterised in that described herb mixture is that raw material is prepared from by component in parts by mass:
3. the tea beverage preventing fatty liver, it is characterised in that the raw material components of described tea beverage is calculated as by mass parts:
Herb mixture described in claim 1 or 2 1～2 part;
Folium Camelliae sinensis 3～5 parts;
Fructus Gardeniae 2～4 parts.
4. the tea beverage preventing fatty liver as claimed in claim 3, it is characterised in that described Folium Camelliae sinensis is green tea.
5. the preparation method of the herb mixture preventing fatty liver, it is characterised in that comprise the following steps:
(1) by after 5～15 parts of Radix Salviae Miltiorrhizaes, 3～5 parts of garlicins, 3～5 parts of Fructus Crataegis mixing with 20～30 parts of water soakings 1 hour, 180～200 DEG C decoct 30～60min, leach decocting liquid, in filtering residue, adding 10 again～180～200 DEG C of the water of 20 parts decocts 30～60min, leach decocting liquid, merge twice decocting liquid;
(2) the described decocting liquid after the merging obtained toward step (1) adds 10～13 parts of excellent grass meal ends of escaping that granularity is 20 orders, water reflux, extract, is used twice at 100 DEG C, each 3 hours, after extracting solution concentrating under reduced pressure, add dehydrated alcohol, overnight precipitation at 4 DEG C～20 DEG C, take filtrate, it is concentrated into the 1/3～1/4 of original volume at 70～80 DEG C of temperature, obtains the herb mixture of prevention fatty liver.
6. the preparation method of the tea beverage preventing fatty liver, it is characterized in that comprising the following steps: after the herb mixture described in 1～2 part of claim 1 or 2,3～5 portions of Folium Camelliae sinensis and 2～4 parts of Fructus Gardeniae mixing, add 90～100 parts of water boil 5～10min, filter, take filtrate, obtain the tea beverage of prevention fatty liver.
7. the application in the conventional Chinese medicine preparation dosage form of preparation of the herb mixture described in claim 1 or 2, it is characterised in that described dosage form is solution, capsule, granule and tablet.
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| CN104905065A (en) * | 2015-06-18 | 2015-09-16 | 江苏农牧科技职业学院 | Feed for improving immunity of black muscovy duck and preparation method thereof |
| CN104982716A (en) * | 2015-06-18 | 2015-10-21 | 江苏农牧科技职业学院 | Fodder capable of improving egg laying capacity of black muscovy ducks and preparing method of fodder |
| CN105341570B (en) * | 2015-10-14 | 2018-03-16 | 哈尔滨工业大学 | Serial sorrow is escaped careless functional beverage and preparation method thereof |
| CN106070794A (en) * | 2016-06-08 | 2016-11-09 | 郭良来 | One purifies the blood health protection tea and preparation method thereof |
| CN107242376A (en) * | 2017-05-31 | 2017-10-13 | 江苏农牧科技职业学院 | It is a kind of to prevent and treat the fat feed of pet and preparation method |
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Inventor after: Wang Ping Inventor after: Zhang Yingjian Inventor after: Xue Juan Inventor after: Luo Dongping Inventor after: Wang Youchun Inventor before: Wang Ping Inventor before: Zhang Yingjian Inventor before: Gao Lei Inventor before: Luo Dongping Inventor before: Wang Youchun |
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Free format text: CORRECT: INVENTOR; FROM: WANG PING ZHANG YINGJIAN GAO LEI LUO DONGPING WANG YOUCHUN TO: WANG PING ZHANG YINGJIAN XUE JUAN LUO DONGPING WANG YOUCHUN |
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Granted publication date: 20160615 Termination date: 20180124 |
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