CN103767965A - Forsythia suspensa leaf hand sanitizer and preparation method thereof - Google Patents
Forsythia suspensa leaf hand sanitizer and preparation method thereof Download PDFInfo
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- CN103767965A CN103767965A CN201410002498.5A CN201410002498A CN103767965A CN 103767965 A CN103767965 A CN 103767965A CN 201410002498 A CN201410002498 A CN 201410002498A CN 103767965 A CN103767965 A CN 103767965A
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Abstract
The invention relates to the field of daily cosmetics, and particularly relates to a mild type Chinese medicinal herb hand sanitizer with bacteriostatic, antibacterial and skin moisturizing effects, including a Chinese medicinal herb composition and an extraction process thereof and a preparation method of the hand sanitizer. A Forsythia suspensa leaf hand sanitizer comprises a functional component, a surfactant, a thickener, a humectant, a pH regulator, an anti-hard water agent, an aromatic, a pigment, a pearling agent and deionized water, wherein the functional component is Forsythia suspensa leaf extract, traditional Chinese medicine mixed extract, and Dioscorea opposita powder, and the traditional Chinese medicine mixed extract is mixed extract of Scutellaria baicalensis, Astragalus membranaceus and Asparagus cochinchinensis. The hand sanitizer provided by the invention has cleaning and antibacterial, skin moisturizing and skin caring effects, and does not cause dry hand skin, skin injury and other adverse effects even after frequent hand cleaning.
Description
Technical field
The present invention relates to daily cosmetics field, particularly a kind of mild Chinese herbal medicine handwashing liquid with antibacterial, sterilization, skin-moisturizing, skin, the preparation technology of the combination that comprises the Chinese herbal medicine relating to and extraction process thereof and handwashing liquid.
Background technology
People are in life, and both hands are easy to touch antibacterial, dirt, and if can not be in time, clean hand effectively, may endanger healthy.Especially for the special occupation such as doctor, nurse crowd, it is particularly important that hand cleaning more seems.
Handwashing liquid is as a kind of novel hand cleaning product, there is evening compared with traditional cleaning supplies such as fancy soap, soap, but it is easy to use because having, the water-saving that saves time, avoid cross infection, be easy to deposit, reduce the features such as nature consumption, therefore be subject to liking of more and more consumers.Along with the raising that people required quality of life, the properties of product of handwashing liquid are required also to increase thereupon, not only to guarantee its cleannes, also to there is certain health-care effect, without skin irritation, very few chemical addition agent etc.
The function that more existing products have is less, and some antibacterial adopt chemical products, some interpolation antiseptic etc.Therefore,, along with the maturation of handwashing liquid consumption market, what consumer needed is multi-functional and the handwashing liquid of mild.
Summary of the invention
The present invention overcomes the deficiencies in the prior art, and technical problem to be solved is to provide a kind of mild Chinese medicine handwashing liquid with antibacterial, sterilization, skin-moisturizing, skin effect.Except cleaning spot, degerming, all right moisturizing, skin protection, even if clean hand is frequent, can not cause the adverse consequencess such as hand skin overdrying, injured skin yet.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is: a kind of Folium Forsythiae handwashing liquid, comprise functional components, surfactant, thickening agent, wetting agent, acid-base modifier, anti-hard water agent, aromatic, color element, pearling agent and deionized water composition, described functional components is Folium Forsythiae extract, Chinese medicine mixed extract and Rhizoma Dioscoreae powder, described Chinese medicine mixed extract is Radix Scutellariae, the mixed extract of the Radix Astragali and three kinds of Chinese medicines of Radix Asparagi, described Folium Forsythiae extract accounts for the 0.3-10% of handwashing liquid gross weight, described Chinese medicine mixed extract accounts for the 1-10% of handwashing liquid gross weight, described Rhizoma Dioscoreae powder accounts for the 1-5% of handwashing liquid gross weight.
Described functional components is that the preferable amount of Folium Forsythiae extract, Chinese medicine mixed extract and Rhizoma Dioscoreae powder is: described Folium Forsythiae extract accounts for the 3-5% of handwashing liquid gross weight, described Chinese medicine mixed extract accounts for the 3-5% of handwashing liquid gross weight, and described Rhizoma Dioscoreae powder accounts for the 2-3% of handwashing liquid gross weight.
The preparation method of described Folium Forsythiae extract is, supercritical CO
2extraction is prepared Folium Forsythiae extract: Folium Forsythiae was pulverized to 40 mesh sieves, pack extractor into; Be 32 ℃ in temperature, pressure is under 15-20MPa condition, makes CO
2gas becomes liquid vaporificization from gas, after to add weight percent concentration be 2.5% ethanol, time 2 h; Then material is flowed into separator and separate, medicinal residues are separated with extract; The mixed extract that separation is obtained adsorbs, and adsorption time is 4 hours, obtains Folium Forsythiae extract after absorption.
The preparation method of described Chinese medicine mixed extract is: be that Radix Scutellariae 3-6 part, Radix Astragali 2-5 part and Radix Asparagi 5-8 part proportioning are mixed by Radix Scutellariae, the Radix Astragali and Radix Asparagi according to weight portion, add water and soak half an hour at 60 ℃, it is 1:8 that described Radix Scutellariae, the Radix Astragali and Radix Asparagi mix with the weight part ratio of water, twice of rear decoction, 1.5 hours for the first time, 1 hour for the second time, merge and boil liquid, filter; Filtrate decompression is concentrated into the extractum of relative density 1.25-1.4, cooling after, add the ethanol precipitation of concentration of volume percent 60%, leave standstill 12 hours, after leaching supernatant, reclaim ethanol, at 60 ℃, be concentrated into the extractum of relative density 1.05-1.1, the dry Chinese medicine mixed extract that obtains.
The preparation method of described Rhizoma Dioscoreae powder is: by new fresh Rhizoma dioscoreae pulverizer defibrination; After add clear water filter repeatedly limpid to powder water; Precipitate rinsing, 3-4 time; Through precipitation; Last 60 ℃ of drying under reduced pressure of temperature control obtain Rhizoma Dioscoreae powder.
A kind of Folium Forsythiae handwashing liquid preparation method, comprises the steps: to add deionized water in container, heating, and in the time that temperature is heated to 40-50 ℃, limit adds wetting agent limit to stir, and stirs evenly; Be cooled to 20-30 ℃, add successively in proportion while stirring surfactant, functional components, anti-hard water agent, aromatic, pigment and pearling agent, after stirring evenly, add thickening agent, be adjusted to suitable viscosity; To neutrality or subacidity, make finished product with acid-base modifier adjusting product P H; Finished product is at room temperature still aging; After degassed froth breaking, obtain Folium Forsythiae handwashing liquid.
The major function composition containing in Folium Forsythiae extract has phillyrin and Fructus Forsythiae ester glycoside etc.Modern pharmacological research shows, Folium Forsythiae extract has good anti-inflammation, bacteriostasis and sterilization, removing free radical, antioxidative effect.Wherein the various bacteria such as staphylococcus aureus, escherichia coli and Candida albicans are had to very strong antibacterial action.
Radix Scutellariae is heat clearing and damp drying class Chinese medicine, containing baicalin and baicalin, nature and flavor hardship, cold.Research shows that it has antibacterial action to the multiple gram negative bacilli such as escherichia coli, dysentery bacterium, Bacillus typhi, bacillus pyocyaneus, bordetella pertussis and staphylococcus aureus, to dermatophytes and A type influenza virus PR
8there is inhibitory action.
The Radix Astragali has antibacterial action to dysentery bacterium and multiple gram-positive cocci, the effect that have expelling pus and promoting granulation, enhances metabolism.
Radix Asparagi is cold in nature, sweet in the mouth, and micro-hardship, containing agedoite and phlegmatic temperament etc.Its effect is shown in that ancient book records, as " road book eight Supreme Beings through ": want not fear of cold, get Radix Asparagi, Poria is that end takes it.Every day decoction being taken at a draught, sweating when Great Cold, unlined garment." the Master of Preserving Simplicity " cloud: Du's purple Radix Asparagi in incognito,, there are son 140 people in imperial 80 outer families, 300 li of day row." row fairy maiden " cloud: Pinus densiflora food Radix Asparagi, dedentition is more raw, fine appearing again." angle's biography ": sweet beginning person, people from Taiyuan.Take Radix Asparagi, in the human world 300 years." repairing very secret purport ": angle takes Radix Asparagi, happy calm and peaceful face after one hundred days, thin the inferior is strong.Three one hundred days, body is light.3 years, body was walked like flying.Therefore tool promotes the effect of body fluid metabolism, moist skin and hair.Anthrax bacillus, A type and beta hemolytic streptococcus, diphtheria corynebacterium, diphtheroid, Diplococcus pneumoniae, staphylococcus aureus, Staphylococcus citreus, Staphylococcus albus and bacillus subtilis are all had to inhibitory action in various degree.
Rhizoma Dioscoreae nature and flavor are sweet, flat.There is skin care, moisturize, the effect of skin care skin Caring.The plurality of active ingredients such as mucous albumen, allantoin, arginine.
Several extract compatibilities use, and have synergistic function, have effect antibacterial, antibacterial, that moisturize moisturizing, skin moistening granulation promoting, skin Caring.
Handwashing liquid batching of the present invention comprises surfactant, thickening agent, wetting agent, acid-base modifier, anti-hard water agent, aromatic, pigment, pearling agent, water.
1, surfactant is divided into first type surface activating agent and cosurfactant.
First type surface activating agent can be selected anion surfactant, comprise fatty alcohol polyoxyethylene ether sulfate, α olefin sulfonate, SAS, methyl sodiosul foaliphatate and their combination, consumption is the 0.05-25% of handwashing liquid weight, preferred fat polyoxyethylenated alcohol sulfate.
Cosurfactant is divided into amphoteric surfactant and non-ionic surface active agent.Wherein amphoteric surfactant can be selected cocamidopropyl betaine, lauroylamidopropyl betaine, dodecyldimethylammonium hydroxide inner salt, myristyl dimethyl betaine, hexadecyldimethyl benzyl ammonium betanin, octodecyl betaine, dodecanamide propyl amine oxide, cocamidopropyl propyl amide amine oxide, CH3-(CH2)13N(CH3)2-O, octadecyl dimethyl amine oxide, dodecyl sulfobetaine, dodecanamide propyl hydroxy sulfo lycine, cocoamido propyl hydroxy sulfobetaine, amide groups aminoacid, non-ionic surface active agent can be selected alkyl polyglucoside, coconut oil fatty acid monoethanolamide, cocoanut fatty acid diethanolamide, fatty alcohol-polyoxyethylene ether.Select wherein a kind of or their combination, consumption is the 1-20% of handwashing liquid weight.Be preferably cocamidopropyl betaine, dodecyldimethylammonium hydroxide inner salt, amide groups aminoacid, alkyl polyglucoside and their combination.
2, thickening agent can be selected sodium chloride (NaCl), ammonium chloride (NH
4cl), potassium chloride (KCl), polyvidone (PVP), alkanolamide, carboxymethyl hydroxyethyl cellulose, hydroxyethyl-cellulose, spermaceti hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, hydroxy methocel and their combination, consumption is the 0.05-6% of handwashing liquid weight.
3, wetting agent can be selected liquid paraffin, glycerol, ethylene glycol, sorbitol, propylene glycol, 1, ammediol, butanediol, alkyl polyglucoside, hydrophilic lanoline, amino acid humectant, pantothenylol, hydroxyethyl urea, citric acid glyceride and their combination, consumption is the 1-20% of handwashing liquid weight.
4, acid-base modifier can be selected food stage citric acid or sodium hydroxide, and consumption is the 0.01-1.5% of handwashing liquid weight.
5, anti-hard water agent can be selected disodium EDTA or tetrasodium salt (EDTA-2Na or EDTA-4Na), food stage citric acid and their combination, and consumption is the 0.01-1% of handwashing liquid weight.
6, aromatic can be selected citronellol, linalool, α-daphnone and various essence and quintessence oil, and as Flos Rosae Rugosae quintessence oil, Herba Menthae wet goods, consumption is the 0-1% of handwashing liquid weight.
7, red, the sodium copper chlorophllin of the optional garden beet of pigment, caramel color, light blue, indigo, lemon yellow etc., consumption is the 0-1.5% of handwashing liquid weight.
8, the optional spent glycol monostearate of pearling agent or Ethylene Glycol Distearate, consumption is the 0-5% of handwashing liquid weight.
The preparation process of handwashing liquid of the present invention comprises: in container, add appropriate deionized water, and heating, in the time that temperature is heated to 40-50 ℃, limit adds wetting agent limit to stir, and stirs evenly; Be cooled to 20-30 ℃, add successively in proportion while stirring surfactant, functional components, anti-hard water agent, aromatic, pigment and pearling agent, after stirring evenly, add thickening agent, be adjusted to suitable viscosity; To neutrality or subacidity, make finished product with acid-base modifier adjusting product P H; Finished product is at room temperature still aging; After degassed froth breaking, obtain Folium Forsythiae handwashing liquid.
Compared with prior art the present invention has following beneficial effect.
1, one of functional component in the present invention's formula Folium Forsythiae extract, its raw material sources are to be selected from aboundresources, the Folium Forsythiae of wide material sources, but not the Fructus Forsythiae of Chinese medicine medication.Carry out the extraction of effective ingredient by Folium Forsythiae, have and draw materials extensively, make full use of resource, low cost and other advantages.Show active constituent content contained in Folium Forsythiae and be not less than Fructus Forsythiae according to modern pharmacological research and science detection simultaneously, and some active constituent contents are also better than Fructus Forsythiae.The present invention is applied to Folium Forsythiae extract in handwashing liquid first.
2, the extracting method advanced person who adopts in the present invention, tool effective component extraction rate is high, save time, safety, standardization and industrialized level be compared with high, is conducive to form Standardization System industry.
3, the present invention is added in handwashing liquid formula by plurality of Chinese compatibility, and tool is antibacterial, sterilization, skin-moisturizing, skin effect.Avoid because of the repeatedly clean or excessively clean problem appearance that causes the skin discomforts such as skin overdrying.
4, be widely used, be applicable to numerous crowds, especially, concerning the crowd of the special industries such as medical personnel, repair of machine industry, the present invention is that a kind of safety is selected again efficiently, has health-care effect, good for health.And be the safe mild handwashing liquid that a kind of suitable child uses, be applicable to all kinds of crowds and use.
The specific embodiment
Below in conjunction with specific embodiment, the invention will be further described.
Embodiment 1
A kind of Folium Forsythiae handwashing liquid, every 100g handwashing liquid by weight, comprise that Folium Forsythiae extract 5g, Chinese medicine mixed extract 3g, Rhizoma Dioscoreae powder 1g, AESA 12g, cocamidopropyl betaine 10g, sodium chloride 4g, glycerol 8g, propylene glycol 2g, hydrophilic lanoline 3g, food stage citric acid are appropriate, citronellol 0.05g, light blue 0.1g, all the other are deionized water.
Preparation technology:
(1) Folium Forsythiae was pulverized to 40 mesh sieves, packed into extractor; Be 32 ℃ in temperature, pressure is under 15MPa condition, makes CO
2gas becomes liquid vaporificization from gas, after to add weight percent concentration be 2.5% ethanol, time 2 h; Then material is flowed into separator and separate, medicinal residues are separated with extract; The mixed extract that separation is obtained adsorbs, and adsorption time is 4 hours, obtains Folium Forsythiae extract after absorption;
(2) Radix Scutellariae, the Radix Astragali and Radix Asparagi are that 6 parts of Radix Scutellariaes, 5 parts of the Radixs Astragali and 5 parts of proportionings of Radix Asparagi are mixed according to weight portion, add water and soak half an hour at 60 ℃, it is 1:8 that described Radix Scutellariae, the Radix Astragali and Radix Asparagi mix with the weight part ratio of water, twice of rear decoction, 1.5 hours for the first time, 1 hour for the second time, merge and boil liquid, filter; Filtrate decompression is concentrated into the extractum of relative density 1.25, cooling after, add the ethanol precipitation of concentration of volume percent 60%, leave standstill 12 hours, after leaching supernatant, reclaim ethanol, at 60 ℃, be concentrated into the extractum of relative density 1.1, the dry Chinese medicine mixed extract that obtains;
(3) by new fresh Rhizoma dioscoreae pulverizer defibrination; After add clear water filter repeatedly limpid to powder water; Precipitate rinsing, 3-4 time; Through precipitation; Last 60 ℃ of drying under reduced pressure of temperature control obtain Rhizoma Dioscoreae powder;
(4) in container, add appropriate deionized water, heating, in the time that temperature is heated to 40 ℃, limit adds glycerol, propylene glycol and hydrophilic lanoline limit to stir, and stirs evenly; Be cooled to 24 ℃, add successively in proportion while stirring AESA, cocamidopropyl betaine, Folium Forsythiae extract, Chinese medicine mixed extract, Rhizoma Dioscoreae powder, food stage citric acid, citronellol and light blue, after stirring evenly, add sodium chloride, stir evenly; Add food stage citric acid to regulate PH to neutrality or subacidity; Still aging under room temperature; After degassed froth breaking, obtain Folium Forsythiae handwashing liquid.
Embodiment 2
A kind of Folium Forsythiae handwashing liquid, every 100g handwashing liquid by weight, comprise that Folium Forsythiae extract 3g, Chinese medicine mixed extract 3g, Rhizoma Dioscoreae powder 3g, AESA 10g, cocamidopropyl betaine 10g, sodium chloride 4g, glycerol 8g, propylene glycol 2g, hydrophilic lanoline 3g, alkyl polyglucoside 2g, food stage citric acid are appropriate, lemon yellow 0.1g, all the other are deionized water.
Preparation technology:
(1) Folium Forsythiae was pulverized to 40 mesh sieves, packed into extractor; Be 32 ℃ in temperature, pressure is under 16MPa condition, makes CO
2gas becomes liquid vaporificization from gas, after to add weight percent concentration be 2.5% ethanol, time 2 h; Then material is flowed into separator and separate, medicinal residues are separated with extract; The mixed extract that separation is obtained adsorbs, and adsorption time is 4 hours, obtains Folium Forsythiae extract after absorption;
(2) Radix Scutellariae, the Radix Astragali and Radix Asparagi are that 3 parts of Radix Scutellariaes, 5 parts of the Radixs Astragali and 8 parts of proportionings of Radix Asparagi are mixed according to weight portion, add water and soak half an hour at 60 ℃, it is 1:8 that described Radix Scutellariae, the Radix Astragali and Radix Asparagi mix with the weight part ratio of water, twice of rear decoction, 1.5 hours for the first time, 1 hour for the second time, merge and boil liquid, filter; Filtrate decompression is concentrated into the extractum of relative density 1.3, cooling after, add the ethanol precipitation of concentration of volume percent 60%, leave standstill 12 hours, after leaching supernatant, reclaim ethanol, at 60 ℃, be concentrated into the extractum of relative density 1.05, the dry Chinese medicine mixed extract that obtains;
(3) by new fresh Rhizoma dioscoreae pulverizer defibrination; After add clear water filter repeatedly limpid to powder water; Precipitate rinsing, 3-4 time; Through precipitation; Last 60 ℃ of drying under reduced pressure of temperature control obtain Rhizoma Dioscoreae powder;
(4) in container, add appropriate deionized water, heating, in the time that temperature is heated to 45 ℃, adds respectively glycerol, propylene glycol, hydrophilic lanoline and alkyl polyglucoside, and limit edged stirs, and stirs evenly; Be cooled to 28 ℃, add successively in proportion while stirring AESA, cocamidopropyl betaine, Folium Forsythiae extract, Chinese medicine mixed extract, Rhizoma Dioscoreae powder, food stage citric acid and lemon yellow, after stirring evenly, add sodium chloride, stir evenly; Add food stage citric acid to regulate PH to neutrality or subacidity; Still aging under room temperature; After degassed froth breaking, obtain Folium Forsythiae handwashing liquid.
Embodiment 3
A kind of Folium Forsythiae handwashing liquid, every 100g handwashing liquid by weight, comprise that Folium Forsythiae extract 8g, Chinese medicine mixed extract 5g, Rhizoma Dioscoreae powder 5g, AESA 12g, cocamidopropyl betaine 8g, sodium chloride 5g, glycerol 8g, propylene glycol 1g, hydrophilic lanoline 4g, alkyl polyglucoside 2g, food stage citric acid are appropriate, lemon yellow 0.1g, all the other are deionized water.
Preparation technology:
(1) Folium Forsythiae was pulverized to 40 mesh sieves, packed into extractor; Be 32 ℃ in temperature, pressure is under 20MPa condition, makes CO
2gas becomes liquid vaporificization from gas, after to add weight percent concentration be 2.5% ethanol, time 2 h; Then material is flowed into separator and separate, medicinal residues are separated with extract; The mixed extract that separation is obtained adsorbs, and adsorption time is 4 hours, obtains Folium Forsythiae extract after absorption;
(2) Radix Scutellariae, the Radix Astragali and Radix Asparagi are that 4 parts of Radix Scutellariaes, 4 parts of the Radixs Astragali and 6 parts of proportionings of Radix Asparagi are mixed according to weight portion, add water and soak half an hour at 60 ℃, it is 1:8 that described Radix Scutellariae, the Radix Astragali and Radix Asparagi mix with the weight part ratio of water, twice of rear decoction, 1.5 hours for the first time, 1 hour for the second time, merge and boil liquid, filter; Filtrate decompression is concentrated into the extractum of relative density 1.35, cooling after, add the ethanol precipitation of concentration of volume percent 60%, leave standstill 12 hours, after leaching supernatant, reclaim ethanol, at 60 ℃, be concentrated into the extractum of relative density 1.06, the dry Chinese medicine mixed extract that obtains;
(3) by new fresh Rhizoma dioscoreae pulverizer defibrination; After add clear water filter repeatedly limpid to powder water; Precipitate rinsing, 3-4 time; Through precipitation; Last 60 ℃ of drying under reduced pressure of temperature control obtain Rhizoma Dioscoreae powder;
(4) in container, add appropriate deionized water, heating, in the time that temperature is heated to 48 ℃, adds respectively glycerol, propylene glycol, hydrophilic lanoline and alkyl polyglucoside, and limit edged stirs, and stirs evenly; Be cooled to 30 ℃, add successively in proportion while stirring AESA, cocamidopropyl betaine, Folium Forsythiae extract, Chinese medicine mixed extract, Rhizoma Dioscoreae powder, food stage citric acid and lemon yellow, after stirring evenly, add sodium chloride, stir evenly; Add food stage citric acid to regulate PH to neutrality or subacidity; Still aging under room temperature; After degassed froth breaking, obtain Folium Forsythiae handwashing liquid.
Embodiment 4
A kind of Folium Forsythiae handwashing liquid, every 100g handwashing liquid by weight, comprise that Folium Forsythiae extract 10g, Chinese medicine mixed extract 1g, Rhizoma Dioscoreae powder 2g, α olefin sulfonate 15g, dodecanamide propyl amine oxide 15g, polyvidone 2g, glycerol 8g, propylene glycol 2g, amino acid humectant 2g, food stage citric acid are appropriate, lemon yellow 0.1g, all the other are deionized water.
Preparation technology:
(1) Folium Forsythiae was pulverized to 40 mesh sieves, packed into extractor; Be 32 ℃ in temperature, pressure is under 18MPa condition, makes CO
2gas becomes liquid vaporificization from gas, after to add weight percent concentration be 2.5% ethanol, time 2 h; Then material is flowed into separator and separate, medicinal residues are separated with extract; The mixed extract that separation is obtained adsorbs, and adsorption time is 4 hours, obtains Folium Forsythiae extract after absorption;
(2) Radix Scutellariae, the Radix Astragali and Radix Asparagi are that 5 parts of Radix Scutellariaes, 2 parts of the Radixs Astragali and 5 parts of proportionings of Radix Asparagi are mixed according to weight portion, add water and soak half an hour at 60 ℃, it is 1:8 that described Radix Scutellariae, the Radix Astragali and Radix Asparagi mix with the weight part ratio of water, twice of rear decoction, 1.5 hours for the first time, 1 hour for the second time, merge and boil liquid, filter; Filtrate decompression is concentrated into the extractum of relative density 1.4, cooling after, add the ethanol precipitation of concentration of volume percent 60%, leave standstill 12 hours, after leaching supernatant, reclaim ethanol, at 60 ℃, be concentrated into the extractum of relative density 1.08, the dry Chinese medicine mixed extract that obtains;
(3) by new fresh Rhizoma dioscoreae pulverizer defibrination; After add clear water filter repeatedly limpid to powder water; Precipitate rinsing, 3-4 time; Through precipitation; Last 60 ℃ of drying under reduced pressure of temperature control obtain Rhizoma Dioscoreae powder;
(4) in container, add appropriate deionized water, heating, in the time that temperature is heated to 50 ℃, adds respectively glycerol, propylene glycol and amino acid humectant, and limit edged stirs, and stirs evenly; Be cooled to 25 ℃, add successively in proportion while stirring α olefin sulfonate, dodecanamide propyl amine oxide, Folium Forsythiae extract, Chinese medicine mixed extract, Rhizoma Dioscoreae powder, food stage citric acid and lemon yellow, after stirring evenly, add polyvidone, stir evenly; Add food stage citric acid to regulate PH to neutrality or subacidity; Still aging under room temperature; After degassed froth breaking, obtain Folium Forsythiae handwashing liquid.
Embodiment 5
A kind of Folium Forsythiae handwashing liquid, every 100g handwashing liquid by weight, comprise that Folium Forsythiae extract 0.3g, Chinese medicine mixed extract 4g, Rhizoma Dioscoreae powder 5g, methyl sodiosul foaliphatate 25g, lauroylamidopropyl betaine 20g, potassium chloride 6g, glycerol 6g, butanediol 3g, hydrophilic lanoline 5g, food stage citric acid are appropriate, Ethylene Glycol Distearate 3g, all the other are deionized water.
Preparation technology:
(1) Folium Forsythiae was pulverized to 40 mesh sieves, packed into extractor; Be 32 ℃ in temperature, pressure is under 16MPa condition, makes CO
2gas becomes liquid vaporificization from gas, after to add weight percent concentration be 2.5% ethanol, time 2 h; Then material is flowed into separator and separate, medicinal residues are separated with extract; The mixed extract that separation is obtained adsorbs, and adsorption time is 4 hours, obtains Folium Forsythiae extract after absorption;
(2) Radix Scutellariae, the Radix Astragali and Radix Asparagi are that 4 parts of Radix Scutellariaes, 4 parts of the Radixs Astragali and 6 parts of proportionings of Radix Asparagi are mixed according to weight portion, add water and soak half an hour at 60 ℃, it is 1:8 that described Radix Scutellariae, the Radix Astragali and Radix Asparagi mix with the weight part ratio of water, twice of rear decoction, 1.5 hours for the first time, 1 hour for the second time, merge and boil liquid, filter; Filtrate decompression is concentrated into the extractum of relative density 1.25, cooling after, add the ethanol precipitation of concentration of volume percent 60%, leave standstill 12 hours, after leaching supernatant, reclaim ethanol, at 60 ℃, be concentrated into the extractum of relative density 1.05, the dry Chinese medicine mixed extract that obtains;
(3) by new fresh Rhizoma dioscoreae pulverizer defibrination; After add clear water filter repeatedly limpid to powder water; Precipitate rinsing, 3-4 time; Through precipitation; Last 60 ℃ of drying under reduced pressure of temperature control obtain Rhizoma Dioscoreae powder;
(4) in container, add appropriate deionized water, heating, in the time that temperature is heated to 40 ℃, adds respectively glycerol, butanediol and hydrophilic lanoline, and limit edged stirs, and stirs evenly; Be cooled to 20 ℃, add successively in proportion while stirring methyl sodiosul foaliphatate, lauroylamidopropyl betaine, Folium Forsythiae extract, Chinese medicine mixed extract, Rhizoma Dioscoreae powder, food stage citric acid and Ethylene Glycol Distearate, after stirring evenly, add potassium chloride, stir evenly; Add food stage citric acid to regulate PH to subacidity; Still aging under room temperature; After degassed froth breaking, obtain Folium Forsythiae handwashing liquid.
Embodiment 6
A kind of Folium Forsythiae handwashing liquid, every 100g handwashing liquid by weight, comprise that Folium Forsythiae extract 6g, Chinese medicine mixed extract 5g, Rhizoma Dioscoreae powder 2g, SAS 5g, octodecyl betaine 3g, ammonium chloride 0.05g, ethylene glycol 18g, propylene glycol 2g, food stage citric acid are appropriate, lemon yellow 0.1g, ethylene glycol monostearate 5g, all the other are deionized water.
Preparation technology:
(1) Folium Forsythiae was pulverized to 40 mesh sieves, packed into extractor; Be 32 ℃ in temperature, pressure is under 17MPa condition, makes CO
2gas becomes liquid vaporificization from gas, after to add weight percent concentration be 2.5% ethanol, time 2 h; Then material is flowed into separator and separate, medicinal residues are separated with extract; The mixed extract that separation is obtained adsorbs, and adsorption time is 4 hours, obtains Folium Forsythiae extract after absorption;
(2) Radix Scutellariae, the Radix Astragali and Radix Asparagi are that 5 parts of Radix Scutellariaes, 2 parts of the Radixs Astragali and 5 parts of proportionings of Radix Asparagi are mixed according to weight portion, add water and soak half an hour at 60 ℃, it is 1:8 that described Radix Scutellariae, the Radix Astragali and Radix Asparagi mix with the weight part ratio of water, twice of rear decoction, 1.5 hours for the first time, 1 hour for the second time, merge and boil liquid, filter; Filtrate decompression is concentrated into the extractum of relative density 1.4, cooling after, add the ethanol precipitation of concentration of volume percent 60%, leave standstill 12 hours, after leaching supernatant, reclaim ethanol, at 60 ℃, be concentrated into the extractum of relative density 1.1, the dry Chinese medicine mixed extract that obtains;
(3) by new fresh Rhizoma dioscoreae pulverizer defibrination; After add clear water filter repeatedly limpid to powder water; Precipitate rinsing, 3-4 time; Through precipitation; Last 60 ℃ of drying under reduced pressure of temperature control obtain Rhizoma Dioscoreae powder;
(4) in container, add appropriate deionized water, heating, in the time that temperature is heated to 42 ℃, adds respectively ethylene glycol, propylene glycol, and limit edged stirs, and stirs evenly; Be cooled to 22 ℃, add successively in proportion while stirring SAS, octodecyl betaine, Folium Forsythiae extract, Chinese medicine mixed extract, Rhizoma Dioscoreae powder, food stage citric acid, lemon yellow and ethylene glycol monostearate, after stirring evenly, add ammonium chloride, stir evenly; Add food stage citric acid to regulate PH to neutral; Still aging under room temperature; After degassed froth breaking, obtain Folium Forsythiae handwashing liquid.
The antibacterial ring test of handwashing liquid
The Folium Forsythiae extract of interpolation various dose is prepared handwashing liquid and is carried out bacteriostatic test.
1. the circular filter paper sheet that is 7mm by aseptic dry diameter immerses containing 30min in the handwashing liquid of various dose Folium Forsythiae extract, dry for standby.
2. strains tested is staphylococcus aureus, escherichia coli, bacillus subtilis, Bacillus proteus.After cultivating, being mixed with respectively bacteria containing amount is 10
6-10
7the bacteria suspension of CFU/ml is for subsequent use.
3. get respectively appropriate bacteria suspension and be applied in potato dextrose agar surface, after filter paper is affixed on and is coated with on bacterium flat board.37 ℃ of constant temperature culture 24h, observe colony growth situation, and measure antibacterial ring size.Result is as shown in table 1.
Note: "-" represents not have obvious inhibition zone
Inhibition zone diameter is greater than 7mm for having fungistatic effect, and diameter is less than or equal to 7mm, for without fungistatic effect.Folium Forsythiae extract (0.1%) handwashing liquid has bacteriostasis to part bacterium, and Folium Forsythiae extract (0.3%) handwashing liquid, Folium Forsythiae extract (0.5%) handwashing liquid and Folium Forsythiae extract (1%) handwashing liquid are to all having fungistatic effect for examination bacterium.Can draw from experimental result, the minimum Folium Forsythiae extract concentration of fungistatic effect is 0.3%.
Product sense index
Not stratified, the even product of no suspended substance or precipitation; The odor type that conforms with the regulations, free from extraneous odour; In the refrigerator of (5 ± 2) ℃, place 24 hours, take out while returning to room temperature and observe, without precipitation and metachromatism; In the couveuse of (40 ± 1) ℃, place 24 hours, take out while returning to room temperature and observe, free from extraneous odour, without layering and metachromatism.
The present invention can summarize with other the concrete form without prejudice to spirit of the present invention or principal character.Therefore, no matter from which point, above-mentioned embodiment of the present invention all can only think explanation of the present invention can not limit invention, claims have been pointed out scope of the present invention, and scope of the present invention is not pointed out in above-mentioned explanation, therefore, any variation in implication and the scope suitable with claims of the present invention, all should think to be included in the scope of claims.
Claims (6)
1. a Folium Forsythiae handwashing liquid, comprise functional components, surfactant, thickening agent, wetting agent, acid-base modifier, anti-hard water agent, aromatic, color element, pearling agent and deionized water composition, it is characterized in that: described functional components is Folium Forsythiae extract, Chinese medicine mixed extract and Rhizoma Dioscoreae powder, described Chinese medicine mixed extract is Radix Scutellariae, the mixed extract of the Radix Astragali and three kinds of Chinese medicines of Radix Asparagi, described Folium Forsythiae extract accounts for the 0.3-10% of handwashing liquid gross weight, described Chinese medicine mixed extract accounts for the 1-10% of handwashing liquid gross weight, described Rhizoma Dioscoreae powder accounts for the 1-5% of handwashing liquid gross weight.
2. a kind of Folium Forsythiae handwashing liquid according to claim 1, is characterized in that: described Folium Forsythiae extract accounts for the 3-5% of handwashing liquid gross weight, and described Chinese medicine mixed extract accounts for the 3-5% of handwashing liquid gross weight, and described Rhizoma Dioscoreae powder accounts for the 2-3% of handwashing liquid gross weight.
3. a kind of Folium Forsythiae handwashing liquid according to claim 1 and 2, the preparation method that it is characterized in that described Folium Forsythiae extract is supercritical CO
2extraction is prepared Folium Forsythiae extract: Folium Forsythiae was pulverized to 40 mesh sieves, pack extractor into; Be 32 ℃ in temperature, pressure is under 15-20MPa condition, makes CO
2gas becomes liquid vaporificization from gas, after to add weight percent concentration be 2.5% ethanol, time 2 h; Then material is flowed into separator and separate, medicinal residues are separated with extract; The mixed extract that separation is obtained adsorbs, and adsorption time is 4 hours, obtains Folium Forsythiae extract after absorption.
4. a kind of Folium Forsythiae handwashing liquid according to claim 1 and 2, is characterized in that the preparation method of described Chinese medicine mixed extract is:
Be that Radix Scutellariae 3-6 part, Radix Astragali 2-5 part and Radix Asparagi 5-8 part proportioning are mixed by Radix Scutellariae, the Radix Astragali and Radix Asparagi according to weight portion, add water and soak half an hour at 60 ℃, it is 1:8 that described Radix Scutellariae, the Radix Astragali and Radix Asparagi mix with the weight part ratio of water, twice of rear decoction, 1.5 hours for the first time, 1 hour for the second time, merge and boil liquid, filter; Filtrate decompression is concentrated into the extractum of relative density 1.25-1.4, cooling after, add the ethanol precipitation of concentration of volume percent 60%, leave standstill 12 hours, after leaching supernatant, reclaim ethanol, at 60 ℃, be concentrated into the extractum of relative density 1.05-1.1, the dry Chinese medicine mixed extract that obtains.
5. a kind of Folium Forsythiae handwashing liquid according to claim 1 and 2, is characterized in that the preparation method of described Rhizoma Dioscoreae powder is: by new fresh Rhizoma dioscoreae pulverizer defibrination; After add clear water filter repeatedly limpid to powder water; Precipitate rinsing, 3-4 time; Through precipitation; Last 60 ℃ of drying under reduced pressure of temperature control obtain Rhizoma Dioscoreae powder.
6. a kind of Folium Forsythiae handwashing liquid preparation method according to claim 1 and 2, is characterized in that comprising the steps: adding in container deionized water, heating, and in the time that temperature is heated to 40-50 ℃, limit adds wetting agent limit to stir, and stirs evenly; Be cooled to 20-30 ℃, add successively in proportion while stirring surfactant, functional components, anti-hard water agent, aromatic, pigment and pearling agent, after stirring evenly, add thickening agent, be adjusted to suitable viscosity; To neutrality or subacidity, make finished product with acid-base modifier adjusting product P H; Finished product is at room temperature still aging; After degassed froth breaking, obtain Folium Forsythiae handwashing liquid.
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| CN108078815A (en) * | 2017-12-01 | 2018-05-29 | 吴义峰 | A kind of disposable hand cleanser of natural bacteriostatic and preparation method thereof |
| CN107998043A (en) * | 2017-12-11 | 2018-05-08 | 成都顺发消洗科技有限公司 | A kind of antiphlogistic antibacterial hand cleanser |
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| CN108514533A (en) * | 2018-05-14 | 2018-09-11 | 成都金开生物工程有限公司 | Kojic acid bacteriostatic hand sanitizer and preparation method thereof |
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