CN103751058A - 一种牡丹护肤品及其制备方法 - Google Patents
一种牡丹护肤品及其制备方法 Download PDFInfo
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- CN103751058A CN103751058A CN201410012591.4A CN201410012591A CN103751058A CN 103751058 A CN103751058 A CN 103751058A CN 201410012591 A CN201410012591 A CN 201410012591A CN 103751058 A CN103751058 A CN 103751058A
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- paeonia suffruticosa
- flos moutan
- peony
- skin care
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004016236A1 (ja) * | 2002-08-14 | 2004-02-26 | Fancl Corporation | 化粧料 |
CN1660342A (zh) * | 2005-01-10 | 2005-08-31 | 张凤娟 | 牡丹美白霜及其制备方法 |
CN101601639A (zh) * | 2009-07-01 | 2009-12-16 | 张果果 | 一种牡丹保湿精油的组配及制作方法 |
CN102731673A (zh) * | 2012-07-05 | 2012-10-17 | 东北林业大学 | 一种牡丹种子胶的制备工艺 |
-
2014
- 2014-01-10 CN CN201410012591.4A patent/CN103751058B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004016236A1 (ja) * | 2002-08-14 | 2004-02-26 | Fancl Corporation | 化粧料 |
CN1660342A (zh) * | 2005-01-10 | 2005-08-31 | 张凤娟 | 牡丹美白霜及其制备方法 |
CN101601639A (zh) * | 2009-07-01 | 2009-12-16 | 张果果 | 一种牡丹保湿精油的组配及制作方法 |
CN102731673A (zh) * | 2012-07-05 | 2012-10-17 | 东北林业大学 | 一种牡丹种子胶的制备工艺 |
Non-Patent Citations (1)
Title |
---|
刘普等: "凤丹籽饼粕单萜苷类成分的研究", 《中国药学杂志》 * |
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