CN103750540A - Inflammation diminishing antibiosis type tobacco oral cavity spray and preparation method thereof - Google Patents
Inflammation diminishing antibiosis type tobacco oral cavity spray and preparation method thereof Download PDFInfo
- Publication number
- CN103750540A CN103750540A CN201410027414.3A CN201410027414A CN103750540A CN 103750540 A CN103750540 A CN 103750540A CN 201410027414 A CN201410027414 A CN 201410027414A CN 103750540 A CN103750540 A CN 103750540A
- Authority
- CN
- China
- Prior art keywords
- tobacco
- extract
- acid
- mouth sprays
- mixed solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Manufacture Of Tobacco Products (AREA)
Abstract
The invention discloses inflammation diminishing antibiosis type tobacco oral cavity spray which comprises, by mass, 5%-30% of tobacco extracts, 0.12%-3.6% of Chinese herb extracts, 1%-10% of tobacco flavor and the balance auxiliary materials. The Chinese herb extracts comprise the extract of purslane, the extract of honeysuckle, the extract of cape jasmine, the extract of dandelions, the extract of schisandra chinensis and the extract of wild chrysanthemum flowers. The spray enables a user to have the satisfaction equal to that of smoking of a traditional cigarette and has the secondary effect of inflammation diminishing and antibiosis. The invention further discloses a method for preparing the inflammation diminishing antibiosis type tobacco oral cavity spray.
Description
Technical field
The present invention relates to Field of Tobacco, relate to particularly a kind of antiphlogistic antibacterial type tobacco mouth sprays and preparation method thereof.
Background technology
After the traditional cigarette of circulation burning in the market, can produce gas phase and the mutually two-part aerosol of grain.Gas phase partly accounts for 92% of whole flue gas quality, and grain mutually part accounts for 8%.Some compositions in this two parts aerosol pollute the environment, and in addition, the stub after smoking also exists the possibility of initiation fire.
Along with the step of international Tobacco Control campaign is more accelerated, national governments are especially further strict to the restriction of public place smoking to smoking, and formed gradually social consensus.Under increasingly strict Tobacco Control environment, Partial Tobacco consumer may select new non-traditional tobacco product, and this variation tendency is day by day clear.According to statistics in 2011, show, when worldwide cigarette volume of production and marketing declines to some extent, other types tobacco product presents rapid growth trend.It is estimated, within 2011, the world's non-traditional tobacco product market sale total value is about 60,000,000,000 dollars, and wherein smoke-free tobacco product is about 16,000,000,000 dollars, becomes one the rising forces on World tobacco market.Therefore, further research and develop Novel smokeless gas tobacco and seem particularly necessary.
In recent years, the incidence of disease of mouth disease is high, and along with the raising of people's living standard and health perception, the control of mouth disease and the protection of tooth are more and more important, and people also more and more pay attention to the clean and health in oral cavity.Aspect the antiphlogistic antibacterial in oral cavity, mouth sprays because of its volume little, easy to carry, wieldy advantage and there is very large development potentiality.
Summary of the invention
First technical problem that the present invention will solve is to provide a kind of antiphlogistic antibacterial type tobacco mouth sprays, comprises following material, counts: 5-30% tobacco extract by mass fraction; 0.12-3.6% Chinese herbal medicine extract; 1-10% flavouring essence for tobacco; All the other are auxiliary material; Wherein, described Chinese medical extract is the extract of purslane, honeysuckle, cape jasmine, dandelion, the fruit of Chinese magnoliavine and mother chrysanthemum; This spray can provide user to be equal to suck the satisfaction of traditional cigarette also to have the second effect of antiphlogistic antibacterial.
Second technical problem that the present invention will solve is to provide a kind of preparation method of antiphlogistic antibacterial type tobacco mouth sprays.
The present invention adopts following technical proposals:
An antiphlogistic antibacterial type tobacco mouth sprays, comprises following material, counts: 5-30% tobacco extract by mass fraction; 0.12-3.6% Chinese herbal medicine extract; 1-10% flavouring essence for tobacco; All the other are auxiliary material; Wherein, described Chinese medical extract is the extract of purslane, honeysuckle, cape jasmine, dandelion, the fruit of Chinese magnoliavine and mother chrysanthemum.
Preferably, described Chinese herbal medicine extract is: 0.02-0.6% purslane extract, 0.02-0.6% Honegsukle flower P.E, 0.02-0.6% capejasmine extract, 0.02-0.6% dandelion extract, 0.02-0.6% Schisandra chinens P.E and 0.02-0.6% Flos Chrysanthemi Indici extract.
Preferably, the pH value of described tobacco mouth sprays is 7～9; More preferably, the pH value of described tobacco mouth sprays is 9.Nicotine is one of main active in tobacco extract, and nicotine enters from buccal absorption the acid-base balance that human circulation depends on pH and the nicotine of saliva, blood plasma.The acid-base balance of nicotine is that about pH is 7.8 at 37 ℃.The pH that supposes saliva is 6.8, and only approximately 10% nicotine will be uncharged alkali form.Therefore, in order to promote nicotine to take free alkali form (its as main by the form of mucosal absorption), absorb, must increase the pH of saliva.At pH, be 9.0 o'clock, the nicotine more than 90% will be the free alkali form easily absorbing.
Described tobacco extract is the tobacco effective active composition extracting from tobacco leaf, the take alcohol, aldehyde, ketone, ester, hydro carbons, heterocyclic that refer to contain in tobacco are main tobacco flavor material (phenmethylol, phytol, west uncle's three enediols, 3-methyl-2-butene aldehyde, benzaldehyde, solanone, Megastigmatrienone, dihydroactinidiolide, methyl hexadecanoate, ethyl palmitate, neophytadiene, pyridine etc.) and other bioactivator, as alkaloid, Salanesol, protein, amino acid and carbohydrate etc.
Preferably, described tobacco extract is one or more mixtures in flue-cured tobacco extract, air-curing of tobacco leaves extract, solarization tobacco extract; Described air-curing of tobacco leaves is burley tobaccos, Maryland, wrapper cigarette; Described suncured tabacco is Turkish tobaccos, shines red cigarette, shines tobacco, Nicotiniana rustica; In tobacco leaf, the content of nicotine is 2.2～2.3%.
Preferably, described tobacco extract obtains by following steps: the 1) preparation of tobacco extract: by composite raw material, guarantee in raw tobacco that nicotine content is 2.2～2.3%, accurately take tobacco leaf powder sample, add 75-80% alcohol reflux to extract, solid-to-liquid ratio is 1:10～15, filters and get its filtrate after refluxing extraction 1～2h, at 55～65 ℃, water-bath concentrated filtrate, obtains tobacco extract; 2) by countercurrent chromatography instrument, set different solvents system tobacco extract is carried out to separation; 3) determine cut appearance time; 4) Fractional Collections effective active composition, obtains tobacco extract.
High-speed counter-current chromatograph is the instrument that can be used for the separation and acquisition of alkaloid compound in tobacco, flavone compound, terpenoid, organic acid compound, lignin and coumarin kind compound, quinones.
Active component in Chinese herbal medicine extract, take purslane as example, and in purslane herb, the number of chemical material such as contained levarterenol, dihydroxy benzenes ethamine, dihydroxyphenylalanine and multiple sylvite, malic acid, citric acid, glutamic acid, aspartic acid, alanine and sucrose, glucose, fructose is its active component.
Described Chinese herbal medicine extract can directly be bought acquisition by market, also can extract voluntarily.While extracting voluntarily, but each Chinese medicine get indescribably, finally mix, also can once extract the mixture of each Chinese medicine.
The equal integration of drinking and medicinal herbs of Chinese herbal medicine relating in the present invention.
Preferably, described Chinese herbal medicine extract extracts according to following steps:
Each Chinese medicine material is mixed, in 70 ℃～75 ℃ pure water, flood, solid-to-liquid ratio is 1:10～15, and its filtrate is filtered and got to ultrasonic extraction after extracting 1～3h, filter residue adds the water of 7～9 multiple doses to continue ultrasonic extraction 1～3h to filter and get its filtrate, merge twice filtrate again; Filtrate is added and in Rotary Evaporators, is concentrated into 1/3 of filtrate volume～2/3 o'clock and stops concentrating, and cooling concentration liquid, obtains Chinese herbal medicine crude extract; Centrifugal Chinese herbal medicine crude extract, gets supernatant, obtains Chinese herbal medicine extract.
That described Chinese herbal medicine is selected is dry, free from insect pests, without going rotten, the Chinese herbal medicine of free from extraneous odour, after pulverizer is pulverized, extract.
Those skilled in the art can select applicable flavouring essence for tobacco as required.Specifically, first by distill-GC/MS of head space, the fragrance matter of dissimilar tobacco is carried out qualitative and quantitative analysis or collects flue-cured tobacco total particulate matter in mainstream smoke with cambridge filter, adopt GC/MS to carry out qualitative and quantitative analysis to the fragrance matter of main flume, and then tentatively draft the kind of the flavouring essence for tobacco with tobacco note, adjust the adding proportion of different material, through cigarette, fragrant Shi Fanfu debates perfume (or spice), determines kind and the adding proportion of the flavouring essence for tobacco with tobacco note.Preferably; described flavouring essence for tobacco is dorinone, β-damascone, 2; 6; 6-trimethyl-2-cyclohexene-1; 4-diketone, 2-hydroxyl-3; 5; 5-trimethyl-2-cyclonene, geranyl acetone, alpha, beta-lonone, furfural, 5 methyl furfural, benzaldehyde, phenylacetaldehyde, phenmethylol, palmitic acid, isovaleric acid, 2 methyl valeric acid, acetic acid, phenylacetic acid, dihydroactinidiolide, dimethyl succinate, indoles, pyridine, 3-acetylpyridine, 3-ethylpyridine, 2-methylpyrazine, 2; one or more mixtures in 3,5-trimethylpyrazine.
Those skilled in the art can select applicable auxiliary material as required.Preferably, described auxiliary material comprise anticorrisive agent, pH adjusting agent, sweetener, solvent.Amount ratio between various auxiliary material need not limit, and those skilled in the art can select according to actual needs.
More preferably, described anticorrisive agent is benzoic acid and sodium benzoate, propionic acid and sodium salt thereof or calcium salt, parabens and sodium salt thereof (Sodium Methyl Hydroxybenzoate, ethyl-para-hydroxybenzoate and sodium salt thereof), sorbic acid and sylvite, potassium metabisulfite, sodium pyrosulfite, sodium sulfite, sodium hydrogensulfite or Hydros.The consumption of anticorrisive agent according to GB2760-2011≤food additives use standard >=regulation.
Described pH adjusting agent is citric acid, sorbic acid, malic acid, sodium acid carbonate or sodium hydrogen phosphate.
Described sweetener is one or more synthetic sugar or natural sugar, is suitable as any type of carbohydrate of sweetener.
Described solvent is the mixture of pure water or pure water and edible glycerol.
Add edible glycerol and be for dissolve some not/be insoluble in the flavouring essence for tobacco of water, for example dorinone, β-damascone, 2,6,6-trimethyl-2-cyclohexene-Isosorbide-5-Nitrae-diketone, geranyl acetone, benzaldehyde, phenylacetaldehyde, palmitic acid, dihydroactinidiolide.The amount of edible glycerol meets dissolves flavouring essence for tobacco.
Spray of the present invention can adopt the various dosage specification packings of 20g, 50g, 100g etc.
A preparation method for antiphlogistic antibacterial type tobacco mouth sprays, comprises the following steps:
1) purslane extract, Honegsukle flower P.E, capejasmine extract, dandelion extract, Schisandra chinens P.E and Flos Chrysanthemi Indici extract are dissolved, obtain mixed solution A, standby;
2) flavouring essence for tobacco is dissolved, obtain mixed solution B, standby;
3) mixed solution A and mixed solution B are merged, add wherein tobacco extract, auxiliary material, stir, regulate pH to appropriate pH value, then filling in spraying bottle, make finished product.
A preparation method for antiphlogistic antibacterial type tobacco mouth sprays, comprises the following steps:
1) extract of purslane, honeysuckle, cape jasmine, dandelion, the fruit of Chinese magnoliavine and mother chrysanthemum Six-element Chinese herbal medicine is mixed, add dissolved in purified water, obtain mixed solution A, standby;
2) by flavouring essence for tobacco, add proper amount of edible glycerine to dissolve, obtain mixed solution B, standby;
3) the mixed solution B of mixed solution A and exact mass is merged, add wherein tobacco extract, other auxiliary material, pure water is quantitative, stirs, and goods are adjusted to appropriate pH value by pH adjusting agent, then filling in spraying bottle, makes finished product.
Beneficial effect of the present invention is as follows:
1, spray environmental protection of the present invention, smokeless, second effect also the satisfaction of traditional cigarette with antiphlogistic antibacterial is provided except providing user to be equal to.
2, tobacco consumption person often uses that the present invention is this not take treatment disease and be object antiphlogistic antibacterial mouth sprays can play a role in health care, and user adopts and do not have medicine association but the means relevant to life just can be enjoyed the antiphlogistic antibacterial effect of medicinal herb components in goods; The report that there is not yet at present this type of antiphlogistic antibacterial type tobacco mouth sprays formula both at home and abroad, the present invention has broad application prospects.
3, preparation of the present invention can make user obtain being equal to the satisfaction of sucking traditional cigarette, can enjoy again the antiphlogistic antibacterial effect of Chinese herbal medicine active component, can also avoid traditional cigarette burning harm to non-smokers and tobacco consumption person self on the impact of environment and second-hand-cigarette, its research and development and Study on manufacturing technology have important practical significance to accelerating tobacco scientific and technological progress, lifting cigarette brand value and tackling new Tobacco Control situation.
4, the present invention had both been applicable to the male sex, had also been applicable to women, and user's employing does not have medicine association but the means relevant to life just can be enjoyed the antiphlogistic antibacterial effect of medicinal herb components in formula.
5, add flavouring essence for tobacco can provide cigarette consumption person's sense of smell, sense of taste satisfaction.
6, compatibility of the present invention is reasonable, be easy to manufacture, the goods of spray-type are easy to carry, use health, spray goods of the present invention both can be used as the interim substitute of ban on opium-smoking and the opium trade place traditional cigarette, also can become a kind of desirable novel environment friendly functional form smoke-free tobacco product in smoker's daily life.
The specific embodiment
In order to be illustrated more clearly in the present invention, below in conjunction with preferred embodiment, the present invention is described further.
Purslane: cold in nature, the sweet acid of taste; Enter the heart, liver, spleen, large intestine channel.Purslane complete stool be used as medicine there is removing toxic substances, the drug effect such as that inhibiting bacteria and diminishing inflammation, diuresis stop dysentery, ease constipation disappears is stagnant, debug, improving eyesight; External application can be controlled the diseases such as erysipelas, venomous snake bite.Shigella dysenteriae, typhoid bacillus and Escherichia coli are had to stronger inhibitory action, can be used for the auxiliary curing of various inflammation, have the title of " natural antibiotics ".
Honeysuckle: the sweet cold air of property fragrance, clear heat with drugs of sweet flavour and cold nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.There is clearing heat and detoxicating, anti-inflammatory, qi-restoratives and treat the effect of wind, can also suppress and the pathogen of killing bottleneck throat, human body is had to anti-infective effect.
Cape jasmine: heat-clearing, purging intense heat, cool blood.Liver, antalgic and inflammation relieving, choleresis, gastric secretion, pancreatic secretion, central nervous system, cardiovascular and cerebrovascular are had to positive role, cape jasmine decoction has inhibitory action to corynebacterium diphtheriae, staphylococcus aureus, typhoid bacillus, and various skin fungi is also had to inhibitory action in various degree.
Dandelion: cold in nature, sweet-bitter flavor, has the effect of clearing heat and detoxicating, dispersing swelling and dissipating binds, dampness removing removing jaundice.Pharmacological evaluation finds that dandelion decoction has stronger inhibitory action to staphylococcus aureus, also has inhibitory action to pathogenic dermatophyte.
The fruit of Chinese magnoliavine: astringe the lung, nourshing kidney, promotes the production of body fluid, receives sweat.Have maincenter widely to suppress and cardiotonic, can strengthen the defence capability of body to nonspecific stimulation, its ethanol immersion liquid all has inhibitory action to bacillus anthracis, staphylococcus aureus, staphylococcus albus, typhoid bacillus, comma bacillus etc. in vitro.
Mother chrysanthemum: clearing heat and detoxicating, detumescence, to staphylococcus aureus, corynebacterium diphtheriae, streptococcus, Pseudomonas aeruginosa, puncture Shigella, influenza virus, all has inhibitory action.Can be widely used in that treatment furunculosis carbuncle is swollen, abscess of throat, wind fire cute conjunctivitis, the illness such as dizzy of having a headache.
Embodiment 1
Preparation 20g spray goods:
(1) add 10g dissolved in purified water after purslane, honeysuckle, cape jasmine, dandelion, the fruit of Chinese magnoliavine and mother chrysanthemum Six-element Chinese herbal medicine extract are mixed, obtain mixed solution A, standby;
(2) flavouring essence for tobacco in ratio takes in upper table is mixed, add proper amount of edible glycerine to dissolve, obtain mixed solution B, standby (during use, taking as requested again exact mass);
(3) the mixed solution B of mixed solution A and exact mass is merged, add wherein tobacco extract, Nepal's ethyl ester, sucrose, pure water quantitatively arrives 20g, stir, by pH adjusting agent, goods are adjusted to appropriate pH value, then filling in spraying bottle, make finished product.
Result of use is evaluated: organize three these spray goods of tobacco evaluation and analysis librarian use, experimental result shows, when the personnel that smoke panel test produce smoking cigarette desire, disposable spray sucks these goods of 0.4g, after average 2min, smoking cigarette desire disappears, and can on average continue 70min without smoking cigarette desire.
Embodiment 2
Preparation 50g spray goods:
(1) add 30g dissolved in purified water after purslane, honeysuckle, cape jasmine, dandelion, the fruit of Chinese magnoliavine and mother chrysanthemum Six-element Chinese herbal medicine extract are mixed, obtain mixed solution A, standby;
(2) flavouring essence for tobacco in ratio takes in upper table is mixed, add proper amount of edible glycerine to dissolve, obtain mixed solution B, standby (during use, taking as requested again exact mass);
(3) the mixed solution B of mixed solution A and exact mass is merged, add wherein tobacco extract, sorbic acid, sucrose, pure water quantitatively arrives 50g, stir, by pH adjusting agent, goods are adjusted to appropriate pH value, then filling in spraying bottle, make finished product.
Result of use is evaluated: organize three these spray goods of tobacco evaluation and analysis librarian use, experimental result shows, when the personnel that smoke panel test produce smoking cigarette desire, disposable spray sucks these goods of 0.4g, after average 2min, smoking cigarette desire disappears, and can on average continue 62min without smoking cigarette desire.
Embodiment 3
Preparation 100g spray goods:
(1) add 65g dissolved in purified water after purslane, honeysuckle, cape jasmine, dandelion, the fruit of Chinese magnoliavine and mother chrysanthemum Six-element Chinese herbal medicine extract are mixed, obtain mixed solution A, standby;
(2) flavouring essence for tobacco in ratio takes in upper table is mixed, add proper amount of edible glycerine to dissolve, obtain mixed solution B, standby (during use, taking as requested again exact mass);
(3) the mixed solution B of mixed solution A and exact mass is merged, add wherein tobacco extract, Nepal's ethyl ester, sucrose, pure water quantitatively arrives 100g, stir, by pH adjusting agent, goods are adjusted to appropriate pH value, then filling in spraying bottle, make finished product.
Result of use is evaluated: organize three these spray goods of tobacco evaluation and analysis librarian use, experimental result shows, when the personnel that smoke panel test produce smoking cigarette desire, disposable spray sucks these goods of 0.4g, after average 2min, smoking cigarette desire disappears, and can on average continue 46min without smoking cigarette desire.
Embodiment 4
An antiphlogistic antibacterial type tobacco mouth sprays, comprises following material, counts: 5% tobacco extract by mass fraction; 0.12% Chinese herbal medicine extract; 1% flavouring essence for tobacco; All the other are auxiliary material; Wherein, described Chinese medical extract is the extract of purslane, honeysuckle, cape jasmine, dandelion, the fruit of Chinese magnoliavine and mother chrysanthemum.
Described tobacco extract is the extract of flue-cured tobacco, by following steps, obtain: the 1) preparation of tobacco extract: in flue-cured tobacco, nicotine content is 2.2～2.3%, accurately take tobacco leaf powder sample, add 75% alcohol reflux to extract, solid-to-liquid ratio is 1:10, after refluxing extraction 1h, filter and get its filtrate, water-bath concentrated filtrate at 55 ℃, obtains tobacco extract; 2) by countercurrent chromatography instrument, set different solvents system tobacco extract is carried out to separation; 3) determine cut appearance time; 4) Fractional Collections effective active composition, obtains tobacco extract.
Described Chinese herbal medicine extract extracts according to following steps: each Chinese medicine material is mixed, in 70 ℃ of pure water, flood, solid-to-liquid ratio is 1:10, its filtrate is filtered and got to ultrasonic extraction after extracting 1h, filter residue adds the ultrasonic extraction 1h of water continuation of 7 multiple doses to filter and get its filtrate again, merges twice filtrate; By filtrate add in Rotary Evaporators, be concentrated into filtrate volume within 1/3 o'clock, stop concentrating, cooling concentration liquid, obtains Chinese herbal medicine crude extract; Centrifugal Chinese herbal medicine crude extract, gets supernatant, obtains Chinese herbal medicine extract.
Described flavouring essence for tobacco is dorinone, β-damascone, 2,6,6-trimethyl-2-cyclohexene-1,4-diketone, 2-hydroxyl-3, the mixture (mass ratio 1:2.5:0.5:2:2:3:1.5:2) of 5,5-trimethyl-2-cyclonene, geranyl acetone, alpha, beta-lonone, furfural, 5 methyl furfural.
Described auxiliary material comprise preservative sodium benzoate, pH adjusting agent citric acid, sweetener, solvent (mixture of water and edible glycerol).
Embodiment 5
An antiphlogistic antibacterial type tobacco mouth sprays, comprises following material, counts: 5% tobacco extract by mass fraction; 0.6% purslane extract, 0.6% Honegsukle flower P.E, 0.6% capejasmine extract, 0.6% dandelion extract, 0.6% Schisandra chinens P.E, 0.6% Flos Chrysanthemi Indici extract; 3% flavouring essence for tobacco; All the other are auxiliary material.The pH value of described tobacco mouth sprays is 7.
Described tobacco extract is the extract of burley tobaccos, Maryland and wrapper cigarette, by following steps, obtain: the 1) preparation of tobacco extract: by composite raw material, guarantee that nicotine content in tobacco leaf is 2.2～2.3%, accurately take tobacco leaf powder sample, add 75-80% alcohol reflux to extract, solid-to-liquid ratio is 1:10～15, filters and get its filtrate after refluxing extraction 1～2h, at 55～65 ℃, water-bath concentrated filtrate, obtains tobacco extract; 2) by countercurrent chromatography instrument, set different solvents system tobacco extract is carried out to separation; 3) determine cut appearance time; 4) Fractional Collections effective active composition, obtains tobacco extract.
Described Chinese herbal medicine extract extracts according to following steps: each Chinese medicine material is mixed, in 75 ℃ of pure water, flood, solid-to-liquid ratio is 1:15, its filtrate is filtered and got to ultrasonic extraction after extracting 3h, filter residue adds the ultrasonic extraction 3h of water continuation of 9 multiple doses to filter and get its filtrate again, merges twice filtrate; By filtrate add in Rotary Evaporators, be concentrated into filtrate volume within 2/3 o'clock, stop concentrating, cooling concentration liquid, obtains Chinese herbal medicine crude extract; Centrifugal Chinese herbal medicine crude extract, gets supernatant, obtains Chinese herbal medicine extract.
Described flavouring essence for tobacco is the mixture (mass ratio 1:2.5:0.5:2:2:3:1.5:2:1) of benzaldehyde, phenylacetaldehyde, phenmethylol, palmitic acid, isovaleric acid, 2 methyl valeric acid, acetic acid, phenylacetic acid, dihydroactinidiolide.
Described auxiliary material comprise anticorrisive agent propionic acid, pH adjusting agent malic acid, sweetener, solvent (mixture of water and edible glycerol).
Embodiment 6
An antiphlogistic antibacterial type tobacco mouth sprays, comprises following material, counts: 30% tobacco extract by mass fraction; 0.6% purslane extract, 0.6% Honegsukle flower P.E, 0.02% capejasmine extract, 0.02% dandelion extract, 0.02% Schisandra chinens P.E, 0.02% Flos Chrysanthemi Indici extract; 10% flavouring essence for tobacco; All the other are auxiliary material.The pH value of described tobacco mouth sprays is 8.
Described tobacco extract is Turkish tobaccos, shine red cigarette, shine the extract of tobacco and Nicotiniana rustica, by following steps, obtain: the 1) preparation of tobacco extract: by composite raw material, guarantee that nicotine content in tobacco leaf is 2.2～2.3%, accurately take tobacco leaf powder sample, add 78% alcohol reflux to extract, solid-to-liquid ratio is 1:12, filters and get its filtrate after refluxing extraction 1.5h, at 60 ℃, water-bath concentrated filtrate, obtains tobacco extract; 2) by countercurrent chromatography instrument, set different solvents system tobacco extract is carried out to separation; 3) determine cut appearance time; 4) Fractional Collections effective active composition, obtains tobacco extract.
Described Chinese herbal medicine extract extracts according to following steps: each Chinese medicine material is mixed, in 72 ℃ of pure water, flood, solid-to-liquid ratio is 1:12, its filtrate is filtered and got to ultrasonic extraction after extracting 2h, filter residue adds the ultrasonic extraction 2h of water continuation of 8 multiple doses to filter and get its filtrate again, merges twice filtrate; By filtrate add in Rotary Evaporators, be concentrated into filtrate volume within 1/2 o'clock, stop concentrating, cooling concentration liquid, obtains Chinese herbal medicine crude extract; Centrifugal Chinese herbal medicine crude extract, gets supernatant, obtains Chinese herbal medicine extract.
Described flavouring essence for tobacco is dimethyl succinate, indoles, pyridine, 3-acetylpyridine, 3-ethylpyridine, 2-methylpyrazine, 2,3, the mixture in 5-trimethylpyrazine (mass ratio 2.5:0.5:2:2:3:1.5:1).
Described auxiliary material comprise anticorrisive agent sorbic acid, pH adjusting agent sodium acid carbonate, sweetener, solvent (mixture of water and edible glycerol).
Embodiment 7
With embodiment 6, difference is: anticorrisive agent is that potassium metabisulfite, pH adjusting agent are sorbic acid.
Embodiment 8
With embodiment 6, difference is: anticorrisive agent is that sodium pyrosulfite, pH adjusting agent are sodium hydrogen phosphate.
Embodiment 9
With embodiment 6, difference is: anticorrisive agent is sodium hydrogensulfite.
Embodiment 10
With embodiment 6, difference is: anticorrisive agent is sodium sulfite.
Embodiment 11
With embodiment 6, difference is: anticorrisive agent is Hydros.
Embodiment 12
With embodiment 6, difference is: anticorrisive agent is p-hydroxybenzoate.
Embodiment 13
With embodiment 6, difference is: anticorrisive agent is ethyl-para-hydroxybenzoate.
Embodiment 14
With embodiment 6, difference is: anticorrisive agent is nipagin A sodium salt.
Obviously; the above embodiment of the present invention is only for example of the present invention is clearly described; and be not the restriction to embodiments of the present invention; for those of ordinary skill in the field; can also make other changes in different forms on the basis of the above description; here cannot give all embodiments exhaustive, every still row in protection scope of the present invention of apparent variation that technical scheme of the present invention extends out or change that belong to.
Claims (9)
1. an antiphlogistic antibacterial type tobacco mouth sprays, is characterized in that, comprises following material, by mass fraction, counts: 5-30% tobacco extract; 0.12-3.6% Chinese herbal medicine extract; 1-10% flavouring essence for tobacco; All the other are auxiliary material; Wherein, described Chinese medical extract is the extract of purslane, honeysuckle, cape jasmine, dandelion, the fruit of Chinese magnoliavine and mother chrysanthemum.
2. antiphlogistic antibacterial type tobacco mouth sprays according to claim 1, it is characterized in that, described Chinese herbal medicine extract is: 0.02-0.6% purslane extract, 0.02-0.6% Honegsukle flower P.E, 0.02-0.6% capejasmine extract, 0.02-0.6% dandelion extract, 0.02-0.6% Schisandra chinens P.E and 0.02-0.6% Flos Chrysanthemi Indici extract.
3. antiphlogistic antibacterial type tobacco mouth sprays according to claim 1, is characterized in that, the pH value of described tobacco mouth sprays is 7～9; More preferably, the pH value of described tobacco mouth sprays is 9.
4. antiphlogistic antibacterial type tobacco mouth sprays according to claim 1, is characterized in that, described tobacco extract is one or more mixtures in flue-cured tobacco extract, air-curing of tobacco leaves extract, solarization tobacco extract; Described air-curing of tobacco leaves is burley tobaccos, Maryland, wrapper cigarette; Described suncured tabacco is Turkish tobaccos, shines red cigarette, shines tobacco, Nicotiniana rustica; Wherein, in tobacco leaf, the content of nicotine is 2.2～2.3%.
5. antiphlogistic antibacterial type tobacco mouth sprays according to claim 1, it is characterized in that, described tobacco extract obtains by following steps: the 1) preparation of tobacco extract: by composite raw material, guarantee that in raw tobacco, nicotine content, 2.2～2.3%, accurately takes tobacco leaf powder sample, add 75-80% alcohol reflux to extract, solid-to-liquid ratio is 1:10～15, after refluxing extraction 1～2h, filter and get its filtrate, water-bath concentrated filtrate at 55～65 ℃, obtains tobacco extract; 2) by countercurrent chromatography instrument, set different solvents system tobacco extract is carried out to separation; 3) determine cut appearance time; 4) Fractional Collections effective active composition, obtains tobacco extract.
6. antiphlogistic antibacterial type tobacco mouth sprays according to claim 1, it is characterized in that, described flavouring essence for tobacco is dorinone, β-damascone, 2, 6, 6-trimethyl-2-cyclohexene-1, 4-diketone, 2-hydroxyl-3, 5, 5-trimethyl-2-cyclonene, geranyl acetone, alpha, beta-lonone, furfural, 5 methyl furfural, benzaldehyde, phenylacetaldehyde, phenmethylol, palmitic acid, isovaleric acid, 2 methyl valeric acid, acetic acid, phenylacetic acid, dihydroactinidiolide, dimethyl succinate, indoles, pyridine, 3-acetylpyridine, 3-ethylpyridine, 2-methylpyrazine, 2, 3, one or more mixtures in 5-trimethylpyrazine.
7. antiphlogistic antibacterial type tobacco mouth sprays according to claim 1, is characterized in that, described auxiliary material comprise anticorrisive agent, pH adjusting agent, sweetener, solvent;
Preferably, described anticorrisive agent is benzoic acid and sodium benzoate, propionic acid and sodium salt thereof or calcium salt, parabens and sodium salt thereof, sorbic acid and sylvite thereof, potassium metabisulfite, sodium pyrosulfite, sodium sulfite, sodium hydrogensulfite or Hydros; More preferably, described parabens and sodium salt thereof are parabens and sodium salt, ethyl-para-hydroxybenzoate and sodium salt thereof;
Described pH adjusting agent is citric acid, sorbic acid, malic acid, sodium acid carbonate or sodium hydrogen phosphate;
Described sweetener is one or more synthetic sugar or natural sugar;
Described solvent is the mixture of pure water or pure water and edible glycerol.
8. the preparation method of the antiphlogistic antibacterial type tobacco mouth sprays as described in as arbitrary in claim 1～7, is characterized in that, comprises the following steps:
1) purslane extract, Honegsukle flower P.E, capejasmine extract, dandelion extract, Schisandra chinens P.E and Flos Chrysanthemi Indici extract are dissolved, obtain mixed solution A, standby;
2) flavouring essence for tobacco is added edible glycerol dissolve, obtain mixed solution B, standby;
3) mixed solution A and mixed solution B are merged, add wherein tobacco extract, auxiliary material, stir, regulate pH to appropriate pH value, then filling in spraying bottle, make finished product.
9. the preparation method of antiphlogistic antibacterial type tobacco mouth sprays according to claim 8, is characterized in that, comprises the following steps:
1) extract of purslane, honeysuckle, cape jasmine, dandelion, the fruit of Chinese magnoliavine and mother chrysanthemum Six-element Chinese herbal medicine is mixed, add dissolved in purified water, obtain mixed solution A, standby;
2) flavouring essence for tobacco is added edible glycerol dissolve, obtain mixed solution B, standby;
3) the mixed solution B of mixed solution A and exact mass is merged, add wherein tobacco extract, other auxiliary material, pure water is quantitative, stirs, and goods are adjusted to appropriate pH value by pH adjusting agent, then filling in spraying bottle, makes finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410027414.3A CN103750540B (en) | 2014-01-21 | 2014-01-21 | A kind of antiphlogistic antibacterial type tobacco oral spray agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410027414.3A CN103750540B (en) | 2014-01-21 | 2014-01-21 | A kind of antiphlogistic antibacterial type tobacco oral spray agent and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103750540A true CN103750540A (en) | 2014-04-30 |
| CN103750540B CN103750540B (en) | 2016-03-23 |
Family
ID=50517993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410027414.3A Active CN103750540B (en) | 2014-01-21 | 2014-01-21 | A kind of antiphlogistic antibacterial type tobacco oral spray agent and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103750540B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115153081A (en) * | 2022-06-28 | 2022-10-11 | 深圳市艾普生物科技有限公司 | Herbal atomized liquid and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1129088A (en) * | 1995-09-26 | 1996-08-21 | 岑立鹏 | Substitute for cigarette and using method thereof |
| CN1961679A (en) * | 2005-11-08 | 2007-05-16 | 广州暨南大学医药生物技术研究开发中心 | A compound antivirus sprayer and preparation method thereof |
| CN101671600A (en) * | 2009-09-23 | 2010-03-17 | 华宝食用香精香料（上海）有限公司 | Additives used in compound Chinese herbal medicine cigarette and use thereof |
| CN102028306A (en) * | 2010-12-07 | 2011-04-27 | 张志军 | Throat nourishing health-care type electronic cigarette liquid |
| RU2462108C1 (en) * | 2011-06-10 | 2012-09-27 | Олег Иванович Квасенков | Method for production of non-smoking products of tobacco (versions) |
-
2014
- 2014-01-21 CN CN201410027414.3A patent/CN103750540B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1129088A (en) * | 1995-09-26 | 1996-08-21 | 岑立鹏 | Substitute for cigarette and using method thereof |
| CN1961679A (en) * | 2005-11-08 | 2007-05-16 | 广州暨南大学医药生物技术研究开发中心 | A compound antivirus sprayer and preparation method thereof |
| CN101671600A (en) * | 2009-09-23 | 2010-03-17 | 华宝食用香精香料（上海）有限公司 | Additives used in compound Chinese herbal medicine cigarette and use thereof |
| CN102028306A (en) * | 2010-12-07 | 2011-04-27 | 张志军 | Throat nourishing health-care type electronic cigarette liquid |
| RU2462108C1 (en) * | 2011-06-10 | 2012-09-27 | Олег Иванович Квасенков | Method for production of non-smoking products of tobacco (versions) |
Non-Patent Citations (3)
| Title |
|---|
| 上海市标准化研究院: "《农产品市场准入指南》", 31 January 2005, 中国计量出版社 * |
| 严冬等: "《中医临床必备知识表解手册》", 31 January 2011, 湖南科学技术出版社 * |
| 王亚伟: "《食品安全与卫生》", 30 September 2011, 科学出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115153081A (en) * | 2022-06-28 | 2022-10-11 | 深圳市艾普生物科技有限公司 | Herbal atomized liquid and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103750540B (en) | 2016-03-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kishore | Monograph of tobacco (Nicotiana tabacum) | |
| CN103750538B (en) | A kind of throat-clearing throat-moistening type tobacco oral spray agent and preparation method thereof | |
| CN104839885B (en) | A kind of electronic cigarette liquid and preparation method thereof of improvement | |
| CN103768435B (en) | A kind of fresh breath type tobacco oral spray agent and preparation method thereof | |
| CN104397871B (en) | A kind of electronic cigarette tobacco tar containing tea extract and preparation method thereof | |
| US20160199299A1 (en) | Cannabis Infused Chewing Composition | |
| US20070042055A1 (en) | Herbal formulations and cigarettes containing same useful in controlling body weight | |
| CN105876846A (en) | Ampelopsis grossedentata extract-containing electronic tobacco liquid and preparation method thereof | |
| CN102793264A (en) | Preparation method of magnolia fruit extract and application thereof in cigarette | |
| CN103750539B (en) | A kind of antiphlogistic antibacterial type tobacco nasal spray composition and method of making the same | |
| Lingappa et al. | Areca nut: To chew or not to chew? | |
| CN105326089A (en) | Mixed cigarette | |
| CN103768367B (en) | A kind of expelling phlegm for arresting cough type tobacco oral spray agent and preparation method thereof | |
| CN103734904B (en) | A kind of nourishing Yin and falling fire type tobacco oral spray agent and preparation method thereof | |
| CN103750540B (en) | A kind of antiphlogistic antibacterial type tobacco oral spray agent and preparation method thereof | |
| CN105105315B (en) | A kind of clear throat type tobacco powder spray and preparation method thereof | |
| CN103751252A (en) | Antiseptic disinfectant wash-free type tobacco gel composition and preparation method thereof | |
| CN102657375B (en) | Method for preparing extract from traditional Chinese medicines and application of extract as tobacco additive | |
| KR100339828B1 (en) | Manufacturing method of product made out of chief materials of perilla frutescens in replace of smoking | |
| CN103271441B (en) | Application of moringa oleifera seed extractive to cigarette filter stick and cigarette filter stick | |
| CN106509978A (en) | Thuja sutchuenensis Franch formula for cigarettes | |
| CN103798952B (en) | Sensible type tobacco nasal spray composition and method of making the same of refreshing oneself | |
| CN103798953B (en) | A kind of inrigorating qi and promoting blood circulation type tobacco oral spray agent and preparation method thereof | |
| CN103767061B (en) | A kind of preventing decayed tooth is good for flute profile tobacco oral spray agent and preparation method thereof | |
| CN103767063B (en) | A kind of anti-blooming antiemetic type tobacco oral spray agent and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |