CN103736084A - Composite lysozyme oral spray and preparation method thereof - Google Patents
Composite lysozyme oral spray and preparation method thereof Download PDFInfo
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- CN103736084A CN103736084A CN201310720028.8A CN201310720028A CN103736084A CN 103736084 A CN103736084 A CN 103736084A CN 201310720028 A CN201310720028 A CN 201310720028A CN 103736084 A CN103736084 A CN 103736084A
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Abstract
The invention relates to a composite lysozyme oral spray and a preparation method thereof. The composite lysozyme oral spray is remarkable in effect and convenient to use, and does not contain alcohol; all components are extracted from natural products, enable fresh breath after used and do not have toxic or side effect under combined action of lysozyme, tea polyphenol and vitamin C; the oral spray has good prevention and treatment effects to dental ulcer, decsyed teeth, aphtha, ozostomia, glossitis, sphagitis and other dental diseases; the preparation method is concise and effect, and low in cost; the prepared composite lysozyme oral spray is good in stability.
Description
Technical field
The present invention relates to, for killing the mouthspray biological preparation of oral cavity malignant bacteria, refer more particularly to a kind of composite lysozyme oral spray and preparation method thereof.
Background technology
Oral cavity is the important component part of human body digestion, respiratory system, and along with the aggravation of the problems such as air pollution, ecological deterioration, oral disease is in rising trend.
Oral disease is caused a disease by oral cavity bacterium mostly, as oral ulcer, and periodontal disease, glossopathy, dental caries, halitosis, pharyngolaryngitis etc., these disease modern medicines think, oral disease can cause septicemia, diabetes, heart disease etc.Therefore, kill the key that oral cavity malignant bacteria is treatment and prevention oral disease.
Kill oral cavity malignant bacteria and conventionally adopt traditionally antibiotic, antibacterial, for easy to use, rapid-action, oral disease administration adopts spray conventionally, but spray contains ethanol mostly, gives suffering from oral disease as made troubles the aspect such as drive.Meanwhile, antibiotic and antibacterial easily make antibacterial produce the side effect such as drug resistance or gastrointestinal upset, and especially, when oral disease is shown effect repeatedly, antibiotic and antibacterial sterilization functions can reduce gradually, affect therapeutic effect.In like manner, the spray that contains antibiotic and antibacterial can not life-time service, can not be used as daily health caring prevention oral disease or daily cleaning oral cavity, fresh breath.
Summary of the invention
For the problems referred to above, it is remarkable that the present invention aims to provide a kind of effect, easy to use, soft, all the components is all natural product, can cure various oral cavities, laryngopharyngeal diseases, also can be used for oral disease prevention and daily oral cavity health simultaneously, with rear breath freshening, have no side effect efficiently, broad-spectrum sterilization mouthspray biological preparation.
A kind of composite lysozyme oral spray provided by the invention is grouped into by following ingredients one-tenth by weight percentage:
All the other are distilled water.
A kind of composite lysozyme oral spray preparation method is divided following steps:
By proportioning take staphylococcus lysozyme, lysozyme is dissolved in distilled water;
By proportioning take sorbitol, xanthan gum is dissolved in distilled water;
3. by step 1,2 gained solution mix and blends, obtain liquid A;
By proportioning take vitamin C, tea polyphenols is dissolved in distilled water;
5. by proportioning, take lecithin and add the olive oil taking by proportioning, stir water bath with thermostatic control and dissolve;
6. by step 4,5 gained solution mix and blends, obtain liquid B;
7. liquid A, B are mixed, use high pressure homogenizer high pressure 25MP homogenizing 3 times, gained is this product;
8. temperature is higher than 80 celsius temperature fills.
Beneficial effect of the present invention is mainly manifested in the following aspects:
1. the composite lysozyme sterilization mechanism that glucose coccus enzyme, lysozyme form is very unique, by By Direct Pyrolysis somatic cells wall, thoroughly kills antibacterial, thereby is difficult for producing drug resistance.As the pure biological preparation that is in the nature protein, can drains with human body metabolism, it also has feature without any side effects, and it is readily solved drug resistance and toxic and side effects two hang-ups that antibiotic, antibacterial bring.
Result of the test shows: the composite lysozyme that glucose coccus enzyme, lysozyme form is to gram positive bacteria family, as on current clinical medicine, feel most the methicillin-resistant staphylococcus aureus of hands and clinically the common common anaerobe Fusobacterium in staphylococcus epidermidis, Diplococcus pneumoniae, D group enterococcus, tetracoccus, Listeria monocytogenes, streptococcus and oral cavity, gingiva bacteroid, Wei Ge Shi coccus, peptostreptococcus and carbon dioxide have a liking for fiber bacterium and stomach pyloric bacteria and revolve spiral shell etc. and all have obvious inhibitory or killing effect.
2. tea polyphenols has inhibitory action widely to antibacterial, the pathogenetic bacterias such as Bacillus typhi, Salmonella paratyphi, yellow blood dissolubility staphylococcus, dysentery, cholera bacteria are had to obvious inhibitory action, to the unrestraint effect as equal in fungus, yeast, lactobacillus and acetic acid bacteria of the probiotics in oral cavity.The oral cavity Streptococcus mutans that can effectively suppress to cause in oral cavity dental caries, anticariogenic effect is better than fluoride.Meanwhile, tea polyphenols has pure and fresh green tea taste.But the less stable of tea polyphenols, to light, oxygen sensitivity, the present invention utilizes emulsifying technology to improve the stability of tea polyphenols, olive oil and lecithin are as oil phase, tea polyphenols and vitamin C are interior water, and vitamin C is conducive to human body wound healing, prevention gingival atrophy, hemorrhage, can improve enzymatic activity, to improving the stability of tea polyphenols, also have certain effect simultaneously.
In sum: a kind of composite lysozyme oral spray provided by the invention effect is remarkable, easy to use, soft, all the components is all natural product extraction, meeting under lysozyme, tea polyphenols, vitamin C synergy, with rear breath freshening, have no side effect, the oral diseases such as oral ulcer, dental caries, aphtha, halitosis, glossitis, pharyngolaryngitis are had to extraordinary prevention and therapeutic effect, preparation method is succinctly effective, cost is low, prepared composite lysozyme oral spray good stability.
The specific embodiment
Below in conjunction with the specific embodiment, a kind of composite lysozyme oral spray of the present invention and preparation method thereof is described further.
Embodiment 1
Take that to produce 100 grams of composite lysozyme oral sprays be example:
1. taking 20 grams of 3 grams of staphylococcus lysozymes, lysozyme is dissolved in 30 grams of distilled water;
2. taking 0.01 gram of 1 gram of sorbitol, xanthan gum is dissolved in 30 grams of distilled water;
3. by step 1,2 gained solution mix and blends, obtain liquid A;
4. taking 0.02 gram of 1 gram of vitamin C, tea polyphenols is dissolved in 12.47 grams of distilled water;
5. take 1 gram, lecithin and add in 1.5 grams of olive oil, stir water bath with thermostatic control and dissolve;
6. by step 4,5 gained solution mix and blends, obtain liquid B;
7. liquid A, B are mixed, use high pressure homogenizer high pressure 25MP homogenizing 3 times, gained is this product;
8. temperature is higher than 80 celsius temperature fills.
Embodiment 2
Take that to produce 200 grams of composite lysozyme oral sprays be example:
1. taking 45 grams of 7 grams of staphylococcus lysozymes, lysozyme is dissolved in 50 grams of distilled water;
2. taking 0.1 gram of 6 grams of sorbitol, xanthan gum is dissolved in 50 grams of distilled water;
3. by step 1,2 gained solution mix and blends, obtain liquid A;
4. taking 0.5 gram of 3 grams of vitamin C, tea polyphenols is dissolved in 38.4 grams of distilled water;
5. take 3 grams, lecithin and add in 5 grams of olive oil, stir water bath with thermostatic control and dissolve;
6. by step 4,5 gained solution mix and blends, obtain liquid B;
7. liquid A, B are mixed, use high pressure homogenizer high pressure 25MP homogenizing 3 times, gained is this product;
8. temperature is higher than 80 celsius temperature fills.
Although carried out as above describing according to embodiments of the invention, it will be appreciated by those skilled in the art that the embodiment that described invention is proposed, can also on the basis that does not depart from content of the present invention, make various improvement.Therefore, protection scope of the present invention should be determined by the content of appending claims.
Claims (3)
1. a composite lysozyme oral spray is grouped into by following ingredients one-tenth by weight percentage:
All the other are distilled water, and the percentage by weight summation of each component is 100%.
2. a kind of composite lysozyme oral spray its preparation method as claimed in claim 1 divides following steps:
1.. by proportioning take staphylococcus lysozyme, lysozyme is dissolved in distilled water;
2.. by proportioning take sorbitol, xanthan gum is dissolved in distilled water;
3.. by step 1., 2. gained solution mix and blend, obtain liquid A;
4.. by proportioning take vitamin C, tea polyphenols is dissolved in distilled water;
5.. by proportioning, take lecithin and add the olive oil taking by proportioning, stir water bath with thermostatic control and dissolve;
6.. by step 4., 5. gained solution mix and blend, obtain liquid B;
7.. liquid A, B are mixed, use high pressure homogenizer high pressure 25MP homogenizing 3 times, gained is this product.
3. a kind of composite lysozyme oral spray its preparation method as claimed in claim 2 is further characterized in that temperature is higher than 80 celsius temperature fills.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310720028.8A CN103736084A (en) | 2013-12-24 | 2013-12-24 | Composite lysozyme oral spray and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310720028.8A CN103736084A (en) | 2013-12-24 | 2013-12-24 | Composite lysozyme oral spray and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN103736084A true CN103736084A (en) | 2014-04-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310720028.8A Pending CN103736084A (en) | 2013-12-24 | 2013-12-24 | Composite lysozyme oral spray and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983600A (en) * | 2015-06-01 | 2015-10-21 | 湖北神地生物科技有限公司 | Lysozyme oral care health-care fluid and preparation method thereof |
| CN106075415A (en) * | 2016-06-30 | 2016-11-09 | 史留喜 | A kind of spray treating pharyngolaryngitis and preparation method thereof |
| CN106259463A (en) * | 2016-08-03 | 2017-01-04 | 安徽省华凯轻工科技有限公司 | A kind of environment protection biological antibacterial |
| CN110236976A (en) * | 2019-06-06 | 2019-09-17 | 好维股份有限公司 | A kind of oral care composition comprising stablizing lysozyme |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1327854A (en) * | 2000-06-08 | 2001-12-26 | 上海高科生物工程有限公司 | Composite lysostaphin enzyme spray for oral cavity and its preparing process |
| CN1373652A (en) * | 1999-09-08 | 2002-10-09 | 宝洁公司 | Oral compositions comprising tea polyphenol |
-
2013
- 2013-12-24 CN CN201310720028.8A patent/CN103736084A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1373652A (en) * | 1999-09-08 | 2002-10-09 | 宝洁公司 | Oral compositions comprising tea polyphenol |
| CN1327854A (en) * | 2000-06-08 | 2001-12-26 | 上海高科生物工程有限公司 | Composite lysostaphin enzyme spray for oral cavity and its preparing process |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983600A (en) * | 2015-06-01 | 2015-10-21 | 湖北神地生物科技有限公司 | Lysozyme oral care health-care fluid and preparation method thereof |
| CN104983600B (en) * | 2015-06-01 | 2018-06-19 | 湖北神地生物科技有限公司 | Lysozyme oral care health promoting liquid and preparation method thereof |
| CN106075415A (en) * | 2016-06-30 | 2016-11-09 | 史留喜 | A kind of spray treating pharyngolaryngitis and preparation method thereof |
| CN106259463A (en) * | 2016-08-03 | 2017-01-04 | 安徽省华凯轻工科技有限公司 | A kind of environment protection biological antibacterial |
| CN110236976A (en) * | 2019-06-06 | 2019-09-17 | 好维股份有限公司 | A kind of oral care composition comprising stablizing lysozyme |
| CN110236976B (en) * | 2019-06-06 | 2022-05-13 | 好维股份有限公司 | An oral care composition comprising stabilized lysozyme |
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Application publication date: 20140423 |