CN103735972B - A kind of medicine treating senile urinary incontinence and preparation method thereof - Google Patents
A kind of medicine treating senile urinary incontinence and preparation method thereof Download PDFInfo
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- CN103735972B CN103735972B CN201310732318.4A CN201310732318A CN103735972B CN 103735972 B CN103735972 B CN 103735972B CN 201310732318 A CN201310732318 A CN 201310732318A CN 103735972 B CN103735972 B CN 103735972B
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Abstract
The invention discloses a kind of medicine treating senile urinary incontinence and preparation method thereof, the parts by weight proportioning of described various crude drug, is made up of following various crude drug: Herba Taxilli 3～6 parts, Rhizoma Dioscoreae 4～8 parts, the Rhizoma Atractylodis Macrocephalae 3～6 parts, Fructus Corni 3～6 parts, Cortex Moutan 2～6 parts, Fructus Alpiniae Oxyphyllae 3～5 parts, Ootheca Mantidis 2～4 parts, Fructus Rosae Laevigatae 2～4 parts, Poria 3～5 parts, the Radix Astragali 4～6 parts, Fructus Rubi 2～5 parts, Radix Glycyrrhizae 2～5 parts, Fructus Psoraleae 2～5 parts, Radix Salviae Miltiorrhizae 2～5 parts, Rhizoma Cimicifugae 1～3 parts, Semen Euryales 5～7 parts.Its technological process of the method for described preparation is various crude drug belonging to taking, and cleans that post rinse is clean, after cold drying, pulverized 100 mesh sieves, sterilizing, encapsulating capsule, quality examination.Medicine prepared by the present invention can strengthening spleen, tonifying kidney, QI invigorating controlling nocturnal emission with astringent drugs reducing urination, treat senile urinary incontinence, frequent micturition, urgent micturition, can't help doing the symptoms such as urine.It is obviously improved the quality of life of patient.
Description
Technical field
The present invention relates to a kind of medicine treating old urinary incontinence and preparation method thereof.
Background technology
Often there is paruria in old people's clinic, such as dribbling urination not to the utmost, frequent micturition, urgent micturition, can't help doing urine, even urinary incontinence, occurs wetting the bed, or has urinary hesitancy, and non-urethral catheterization treatment can not solve its pain.Chinese society mother and child care center society's point difference display: the sickness rate of female incontinence is 87%.Long-term urokinase incontinence can concurrently urinary tract infection, nephritis, the disease such as hydronephrosis.It is the healthy important killer of old people.Western modern medicine therapeutic effect is the best, therefore awaits developing a kind of medicine, it is possible to overcome the deficiency of existing medicine, effectively treat senile urinary incontinence.
Summary of the invention
It is an object of the invention to provide a kind of medicine treating senile urinary incontinence and preparation method thereof, in order to overcome the deficiency of existing medicine.
To achieve these goals, a kind of medicine treating senile urinary incontinence provided by the present invention is named as Mulberry cornel capsule, and technical scheme is: Herba Taxilli 3～6 parts, Rhizoma Dioscoreae 4～8 parts, the Rhizoma Atractylodis Macrocephalae 3～6 parts, Fructus Corni 3～6 parts, Cortex Moutan 2～6 parts, Fructus Alpiniae Oxyphyllae 3～5 parts, Ootheca Mantidis 2～4 parts, Fructus Rosae Laevigatae 2～4 parts, Poria 3～5 parts, the Radix Astragali 4～6 parts, Fructus Rubi 2～5 parts, Radix Glycyrrhizae 2～5 parts, Fructus Psoraleae 2～5 parts, Radix Salviae Miltiorrhizae 2～5 parts, Rhizoma Cimicifugae 1～3 parts, Semen Euryales 5～7 parts.
Medicine of the present invention is to be prepared from by the raw material of following optimum weight number proportioning: Herba Taxilli 4 parts, Rhizoma Dioscoreae 6 parts, the Rhizoma Atractylodis Macrocephalae 4 parts, Fructus Corni 4 parts, Cortex Moutan 4 parts, Fructus Alpiniae Oxyphyllae 4 parts, Ootheca Mantidis 3 parts, Fructus Rosae Laevigatae 3 parts, 4 parts of Poria, the Radix Astragali 5 parts, Fructus Rubi 3 parts, 2 parts of Radix Glycyrrhizae, Fructus Psoraleae 3 parts, Radix Salviae Miltiorrhizae 4 parts, Rhizoma Cimicifugae 1 part, Semen Euryales 6 parts.
For realizing the purpose of above-mentioned Mulberry cornel capsule, technological process provided by the present invention is: described various crude drug, clean with potable water rinse after cleaning, and after cold drying, pulverizes 100 mesh sieves, sterilizing, encapsulating capsule, quality examination.
Described dry run is to use hot air circulation drying baker to dry, and controls, between temperature 40-60 DEG C, to dry 18--24 hour.
Described sterilization process is to use ultraviolet radiation sterilization 3 times, each sterilization time 30-50 minute.
Medicine provided by the present invention is natural animal and plant medicine, has effect of kidney and spleen invigorating controlling nocturnal emission with astringent drugs reducing urination, and clinic makes urinary incontinence in patients with incomplete symptom alleviate or disappear, and treatment is effectively.
Fructus Rosae Laevigatae in medicine prescription, Semen Euryales have the effect only lost of reinforcing the kidney.Fructus Rosae Laevigatae can reinforcing the kidney and controlling nocturnal emission, reducing urination and antidiarrheal." Bencao Jingshu " " ten doses " cloud: astringents being suitable for treating collapsesyndrome, insufficiency of the spleen lingering diarrhea can't help, non-astringent be difficult solid it.This medicine temperature, sour-puckery flavor, enter three warps and restrain the gas of collapse.Semen Euryales has reinforcing the kindey to control nocturnal emission, the power of spleen reinforcing stopping leak." book on Chinese herbal medicine is looked for the truth " is said: Semen Euryales how spleen reinforcing, former with its sweet in the mouth；How Semen Euryales reinforces the kidney, with the event of its puckery.Precisely because sweet in the mouth spleen reinforcing, therefore energy dampness removing, precisely because puckery reinforces the kidney, therefore can hold one's breath, and make something lost band incontinence of urine all heal.Merit is similar to Rhizoma Dioscoreae.So the moon of Rhizoma Dioscoreae, originally has excessively Semen Euryales, and Semen Euryales is puckery, more has more than Rhizoma Dioscoreae；And Rhizoma Dioscoreae to have tonifying the lung concurrently cloudy, and Semen Euryales terminates in spleen kidney and not as good as in lung.Fructus Corni, acid, tepor, invigorating the liver and kidney, Gu collapse, benefit Yuanyang, invigorating primordial QI, primordial QI reinforcing essence, primordial qi strengthening essence." Records of Tradition Chinese and Western Medicine in Combination " is said: Fructus Corni, greatly can the gas of convergence, cheer up, astringent or styptic treatment for spontaneous sweating slippage, have orderly and clearly property among astringent therapy concurrently, therefore tonneau nine orifices again, circulation blood vessels.Chinese yam spleen-strengtheningporridge, benefit of reinforcing the kidney essence, " herbal classic " main damaging the spleen and stomach, qi-restoratives, except cold and heat pathogen, invigorating the spleen and replenishing QI power, long muscle, take normal hearing and eyesight for a long time.Cortex Moutan can heat clearing and blood stasis dispersing, the Rhizoma Atractylodis Macrocephalae, hold up spleen spleen invigorating；Poria, Rhizoma Dioscoreae is coordinated to have the effect of invigorating spleen to remove dampness.Rhizoma Dioscoreae Heshan Fructus Corni has the effect of kidney-yang nourishing.The Radix Astragali is sweet, tepor, has the effect of tonifying Qi and lifting yang.Ootheca Mantidis, sweet, salty, flat, return liver, kidney channel, can reinforcing the kidney and supporting YANG, controlling nocturnal emission with astringent drugs reducing urination.Fructus Rubi, sweet, sour, tepor, return liver, kidney channel, effect kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination.Full side tonifying speen and tonifying kidney is main, and treatment must aim at the pathogenesis of disease, curative effect is preferable.
Used by the present invention, the plant origin of various raw medicinal materials is described as follows:
Herba Taxilli is the stem and branch with leaf of Loranthaceae evergreen dwarf shrub Herba Taxilli.There is effect of wind-damp dispelling tonifying liver and kidney and strengthening bones and muscles.
Fructus Rosae Laevigatae is ripe pseudocarp or the ripe holder of removing achene of Rosaceae evergreen climbing shrub plant Fructus Rosae Laevigatae.There is effect of controlling nocturnal emission with astringent drugs reducing urination relieving diarrhea with astringents.Modern pharmacological research: tannin contained by Fructus Rosae Laevigatae has astriction, decocting liquid has inhibitory action to staphylococcus aureus, escherichia coli, bacillus pyocyaneus, clostridium tetani.Its decoct has study of anti-atherogenic effect.
Fructus Rubi is the immature fruit of Rosaceae defoliation bush plant Fructus Rubi.Modern pharmacological research: Fructus Rubi has inhibitory action to staphylococcus, vibrio cholera, has estrogen-like effects simultaneously.
Ootheca Mantidis is Mantidae insecticide Chinese mantid, maculated mantis or the ootheca of European mantid.Pharmacological evaluation proves have diuresis and sweat restrain action.
The Rhizoma Atractylodis Macrocephalae is the rhizome of the Compositae herbaceos perennial Rhizoma Atractylodis Macrocephalae, has effect of air making-up and spleen enlivening dampness diuretic.The pharmacological research Rhizoma Atractylodis Macrocephalae can promote cellular immune function, can have strong effect by antibacterial antitumor.
Rhizoma Dioscoreae is the tuber of the perennial herbaceous plant Rhizoma Dioscoreae that overgrows of Dioscoreaceae, has effect of supplementing QI and nourishing YIN spleen reinforcing lung kidney.Body's immunity there is facilitation.
The Radix Astragali is the pulse family herbaceos perennial Radix Astragali and the root of Inner Mongolia Astragalis.Main containing glycoside, polysaccharide, flavone, aminoacid, trace element etc..Organism metabolism, antiviral can be promoted.Promote serum and the renewal of hepatic protein.Strengthen regulation body's immunity.There is antibacterial action widely.
Radix Salviae Miltiorrhizae is the root of Labiatae herbaceos perennial Radix Salviae Miltiorrhizae.Modern pharmacological research: Radix Salviae Miltiorrhizae can improve microcirculation, promotes velocity of blood flow, expands blood vessel, improves renal function, have antiinflammatory anti-allergic effects.
Fructus Psoraleae is the seed of pulse family annual herb plant Fructus Psoraleae.Containing Coumarins, flavonoid.Bakuchiol has estrogen-like effects, can strengthen immunity and endocrine function.Thus play anti-aging effects.
Fructus Alpiniae Oxyphyllae is the mature fruit of Zingiberaceae herbaceos perennial Fructus Alpiniae Oxyphyllae.Warming the spleen is had to whet the appetite, effect of warming the kidney controlling nocturnal emission with astringent drugs reducing urination.
Poria is the sclerotium of On Polyporaceae Poria, and multiparasitization is on the tree roots such as pinaceae plant Pinus densiflora or Pinus massoniana Lamb.
Semen Euryales is the mature seed kernel of Nymphaeceae annual aquatic herbaceous plant Semen Euryales.This product has convergence and nourishing effect.
Fructus Corni is the sarcocarp that Cornaceae defoliation small arbor plant Fructus Corni removes pit.Contained tannin has astriction.
Cortex Moutan is the root bark of Ranunculaceae perennial machaka plant Paeonia suffruticosa.Contained paeonol and glucosides constituents in addition thereof all have antiinflammatory action.
Rhizoma Cimicifugae is Ranunculaceae, the rhizome of Rattleroot plant Rhizoma Cimicifugae.Yang invigorating, delivers, rash, removing toxic substances.Rhizoma Cimicifugae root stock, controls headache due to pathogenic wind-heat, laryngopharynx swelling and pain, macule are difficult to diseases such as sending out.
Radix Glycyrrhizae is perennial herb, and medicinal part is root and rhizome, and Medicinal Materials Characters root is cylinder.Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Compared with prior art, the invention have the characteristics that:
1, reasonable recipe, has the conditioning effect of nourishing to old people and people of weak constitution.
For paruria diseases such as urinary incontinences, Chinese medicine early has research, wherein with dysuria, drop and be short of, the patient's condition person of delaying is infirmity；Inaccessible with urine, drop is obstructed, and patient's condition urgency person is referred to as closing.Gerontal patient has hypertension, cerebral infarction to wait indefinitely chronic disease mostly, and walking disorder, the most then long-term bed, the course of disease is longer.With the passing of time, the positive deficiency of vital energy declines disease.Stagnation and deficiency of QI clinic is common, and most of patients is older, kidney qi virtual loss, decline of the fire from the gate of life, QI failing to transform into body fluid, is with depletion of YANG then being difficult of the moon.Kidney governing water metabolism and take charge of two just, forming an integral part with bladder, and the distribution of internal water liquid and excretion are mainly by the gasification of kidney.The gasification of kidney is normal, then open entire degree of having, if the gasification function of kidney is not normal, then close the door out entire unfavorable, it is possible to the difficulty in urination occurs.As " a Plain Questions LINGLAN secret allusion quotation opinion piece " is said: " here body fluid is hidden, gasified then can go out for bladder person, the viscus likened to a pond ", " exhausting under Kidney-Yin, unit's sea unrooted, the deficiency of vital energy is not changed and closed ".Therefore suffer from a deficiency of the kidney into disease originally.The present invention has the conditioning effect of nourishing to patient.
2, the present invention also help strengthening spleen, tonifying kidney, QI invigorating controlling nocturnal emission with astringent drugs reducing urination.
Gerontal patient, worn with age, deficiency-weakness of spleen-QI, or prolonged illness is in bed, and feelings will is not smooth, depression of liver-QI, liver gram spleen soil, dysfunction of the spleen in transportation.The spleen has the function to transport and transform nutrients, and spleen also is transported to the water liquid of needed by human body to be in week while transporting and transforming nutrients from foodstuff is precise and tiny.If spleen loses and transfers, it is impossible to ascending the clear and descending the turbid, " the knack difficulty in urination under Zhengzi Huibu " explicitly points out: " deficiency of the spleen causing weakness of QI, logical tune is lost a surname, deficiency of QI in middle-JIAO again, urinated and become the most for it ", overstrain impairing the spleen, insufficiency of the spleen and clear QI failing to ascend, turbid YIN failing to descend, urine thus unfavorable.Therefore insufficiency of the spleen then sinking of QI of middle-JIAO, then instability of kidney-QI of suffering from a deficiency of the kidney, thus dribbling urination is endlessly.Deficiency of spleen and stomach is for originally to have the wet hot phlegm stasis of blood concurrently, and this is urinary incontinence pathogenesis place.Therefore invigorating spleen and kidney is focused in clinical application, help gasification and reach to gasify row urine from logical purpose, treat senile urinary incontinence, frequent micturition, urgent micturition, can't help doing the symptoms such as urine, make urinary incontinence in patients with incomplete symptom alleviate or disappear, treatment is effective.
Detailed description of the invention
Embodiment
Take Herba Taxilli 4 parts, Rhizoma Dioscoreae 6 parts, the Rhizoma Atractylodis Macrocephalae 4 parts, Fructus Corni 4 parts, Cortex Moutan 4 parts, Fructus Alpiniae Oxyphyllae 4 parts, Ootheca Mantidis 3 parts, Fructus Rosae Laevigatae 3 parts, 4 parts of Poria, the Radix Astragali 5 parts, Fructus Rubi 3 parts, 2 parts of Radix Glycyrrhizae, Fructus Psoraleae 3 parts, Radix Salviae Miltiorrhizae 4 parts, Rhizoma Cimicifugae 1 part, Semen Euryales 6 parts.
The preparation method taking said medicine is: after cleaning with potable water rinse clean after, use hot air circulation drying baker to dry, control between temperature 40-60 DEG C, drying 24 hours, dried mixed powder is broken into fine powder, crosses 100 mesh sieves, mixing, uses ultraviolet radiation sterilization 3 times, each sterilization time 40 minutes.Encapsulating capsule, makes regular check on, batch selective examination before every batch of medicine clinical practice.Warehouse-in is stored in shady and cool being dried and locates, and temperature 18-20 DEG C, between humidity 30-45%, preserves 3 years.
The present embodiment be clinical diagnosis case history and curative effect efficiency as follows.
(1) physical data:
1. observe case 60 example, be my traditional Chinese medical science encephalopathy section of institute patient, the maleest 22 examples, female 38 example, age 60--85 year, use medicine 4-10 week.
2. selection standard:
Wetting the bed, even occurs in common sympton: frequent micturition, urgent micturition, can't help doing urine, and chronic disease, the course of disease is longer, and part Aeg has prostatic hyperplasia, calcification.Some patients has hypertension, cerebral infarction medical history.Discharge standard: obnubilation, stupor person, there are injury of bladder person, acute urinary tract infection person.
(2) treatment and observational technique
1. Therapeutic Method
Herba Taxilli, Rhizoma Dioscoreae, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, Cortex Moutan, Fructus Alpiniae Oxyphyllae, Ootheca Mantidis, Fructus Rosae Laevigatae, Poria, the Radix Astragali, Fructus Rubi, Radix Glycyrrhizae, Fructus Psoraleae, Radix Salviae Miltiorrhizae, Rhizoma Cimicifugae, Semen Euryales.The preparation prepared according to the formula of embodiment by Drug Manufacturing Room, each 5-10 grain, it is administered orally three times a day.One month is a course for the treatment of, takes medicine 1-2 the course for the treatment of.
2. observation index
Clinical symptom relief or disappearance.Routine urianlysis is normal.
(3) therapeutic outcome
Recovery from illness: urinary incontinence disappears, urinates normal.
Take a turn for the better: without urinary incontinence, alleviate before having the disease of frequent micturition, relatively medication.
Do not heal: symptom is without alleviating.
Clinical treatment 60 example, 20 examples of fully recovering, take a turn for the better 36 examples, the most 4 examples, total effective rate 93%.
Claims (5)
1. the medicine treating old urinary incontinence, it is characterised in that be made up of by weight ratio following various crude drug: Herba Taxilli 3～6 parts, Rhizoma Dioscoreae 4～8 parts, the Rhizoma Atractylodis Macrocephalae 3～6 parts, Fructus Corni 3～6 parts, Cortex Moutan 2～6 parts, Fructus Alpiniae Oxyphyllae 3～5 parts, Ootheca Mantidis 2～4 parts, Fructus Rosae Laevigatae 2～4 parts, Poria 3～5 parts, the Radix Astragali 4～6 parts, Fructus Rubi 2～5 parts, Radix Glycyrrhizae 2～5 parts, Fructus Psoraleae 2～5 parts, Radix Salviae Miltiorrhizae 2～5 parts, Rhizoma Cimicifugae 1～3 parts, Semen Euryales 5～7 parts.
A kind of medicine treating old urinary incontinence the most according to claim 1, it is characterised in that be made up of by weight ratio following various crude drug: Herba Taxilli 4 parts, Rhizoma Dioscoreae 6 parts, the Rhizoma Atractylodis Macrocephalae 4 parts, Fructus Corni 4 parts, Cortex Moutan 4 parts, Fructus Alpiniae Oxyphyllae 4 parts, Ootheca Mantidis 3 parts, Fructus Rosae Laevigatae 3 parts, 4 parts of Poria, the Radix Astragali 5 parts, Fructus Rubi 3 parts, 2 parts of Radix Glycyrrhizae, Fructus Psoraleae 3 parts, Radix Salviae Miltiorrhizae 4 parts, Rhizoma Cimicifugae 1 part, Semen Euryales 6 parts.
3. the preparation method of the medicine treating old urinary incontinence, it is characterized in that its technological process is as follows: take Herba Taxilli 3～6 parts, Rhizoma Dioscoreae 4～8 parts, the Rhizoma Atractylodis Macrocephalae 3～6 parts, Fructus Corni 3～6 parts, Cortex Moutan 2～6 parts, Fructus Alpiniae Oxyphyllae 3～5 parts, Ootheca Mantidis 2～4 parts, Fructus Rosae Laevigatae 2～4 parts, Poria 3～5 parts, the Radix Astragali 4～6 parts, Fructus Rubi 2～5 parts, Radix Glycyrrhizae 2～5 parts, Fructus Psoraleae 2～5 parts, Radix Salviae Miltiorrhizae 2～5 parts, Rhizoma Cimicifugae 1～3 parts, Semen Euryales 5～7 parts are crude drug, clean post rinse clean, after cold drying, pulverized 100 mesh sieves, sterilizing, encapsulating capsule, quality examination, it is prepared as capsule.
The preparation method of a kind of medicine treating old urinary incontinence the most according to claim 3, it is characterised in that described dry run is to use hot air circulation drying baker to dry, controls, between temperature 40-60 DEG C, to dry 18--24 hour.
The preparation method of a kind of medicine treating old urinary incontinence the most according to claim 4, it is characterised in that described sterilization process is to use ultraviolet radiation sterilization 3 times, each sterilization time 30-50 minute.
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| CN104398952A (en) * | 2014-12-09 | 2015-03-11 | 夏征梅 | Traditional Chinese medicine tablet for treating urinary incontinence |
| CN106389992A (en) * | 2016-11-11 | 2017-02-15 | 东莞市百替生物科技有限公司 | Traditional Chinese medicine preparation for treating frequent micturition and urgent micturition and preparation method of traditional Chinese medicine preparation for treating frequent micturition and urgent micturition |
| CN108635538A (en) * | 2018-06-25 | 2018-10-12 | 周菲菲 | A kind of Chinese medicine composition for treating old women stress incontinence |
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| CN1631417A (en) * | 2004-11-17 | 2005-06-29 | 吴桂芝 | Chinese medicinal formulation for treating enuresis and urinary incontinence |
| CN101579499A (en) * | 2008-05-16 | 2009-11-18 | 欧敏 | Traditional Chinese medicine for treating urinary incontinence |
| CN101804169A (en) * | 2010-05-28 | 2010-08-18 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating urinary incontinence and preparation method thereof |
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| CN1631417A (en) * | 2004-11-17 | 2005-06-29 | 吴桂芝 | Chinese medicinal formulation for treating enuresis and urinary incontinence |
| CN101579499A (en) * | 2008-05-16 | 2009-11-18 | 欧敏 | Traditional Chinese medicine for treating urinary incontinence |
| CN101804169A (en) * | 2010-05-28 | 2010-08-18 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating urinary incontinence and preparation method thereof |
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