CN103735972A - Medicine for treating senile urinary incontinence and preparation method thereof - Google Patents

Medicine for treating senile urinary incontinence and preparation method thereof Download PDF

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CN103735972A
CN103735972A CN201310732318.4A CN201310732318A CN103735972A CN 103735972 A CN103735972 A CN 103735972A CN 201310732318 A CN201310732318 A CN 201310732318A CN 103735972 A CN103735972 A CN 103735972A
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parts
fructus
medicine
urinary incontinence
rhizoma
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CN103735972B (en
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苏海燕
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Abstract

The invention discloses a medicine for treating senile urinary incontinence and a preparation method thereof. The medicine comprises the following bulk drugs in parts by weight: 3-6 parts of herba taxilli, 4-6 parts of yam, 3-6 parts of bighead atractylodes rhizome, 3-6 parts of dogwood fruit pulp, 2-6 parts of moutan bark, 3-5 parts of alpinia oxyphylla, 2-4 parts of mantis egg-case, 2-4 parts of fructus rosae laevigatae, 3-5 parts of poria, 4-6 parts of astragalus membranaceus, 2-5 parts of raspberry, 2-5 parts of liquorice, 2-5 parts of fructus psoraleae, 2-5 parts of salviae miltiorrhizae, 1-3 parts of rhizoma cimicifugae, and 5-7 parts of gordon euryale. The preparation method comprises the following steps: selecting the bulk drugs, washing and drying at low temperature, crushing and screening through a 100-mesh screen; sterilizing, filling into capsules, and inspecting quality. The medicine prepared by the method can be used for strengthening spleen and nourishing kidney, tonifying qi, securing essence and reducing urination, and can treat senile urinary incontinence, frequent micturition, urgent urination, unsuppressed urine and other symptoms, so that the living quality of patients can be remarkably improved.

Description

A kind of medicine for the treatment of senile urinary incontinence and preparation method thereof
Technical field
The present invention relates to a kind of medicine for the treatment of old urinary incontinence and preparation method thereof.
Background technology
The clinical paruria that often occurs of old people, as dribbling urination not to the utmost, frequent micturition, urgent micturition, can't help doing urine, even urinary incontinence, occurs wetting the bed, or has urinary hesitancy, non-urethral catheterization treatment can not be separated its pain.The poor demonstration of Chinese society mother and child care center society point: the sickness rate of female incontinence is 87%.Long-term urokinase incontinence can concurrent urinary tract infection, nephritis, the diseases such as hydronephrosis.The healthy important killer of old people.Western modern medicine therapeutic effect is not good, therefore awaits developing a kind of medicine, can overcome the existing deficiency with medicine, effectively treats senile urinary incontinence.
Summary of the invention
The object of the present invention is to provide a kind of medicine for the treatment of senile urinary incontinence and preparation method thereof, in order to overcome the existing deficiency with medicine.
To achieve these goals, a kind of medicine for the treatment of senile urinary incontinence provided by the present invention is named as Mulberry cornel capsule, and technical scheme is: 3~6 parts of Herba Taxillis, 4~8 parts of Rhizoma Dioscoreaes, 3~6 parts of the Rhizoma Atractylodis Macrocephalaes, 3~6 parts of Fructus Corni, 2~6 parts of Cortex Moutans, 3~5 parts of Fructus Alpiniae Oxyphyllae, 2~4 parts of Ootheca Mantidiss, 2~4 parts of Fructus Rosae Laevigatae, 3~5 parts, Poria, 4~6 parts of the Radixs Astragali, 2~5 parts of Fructus Rubies, 2~5 parts, Radix Glycyrrhizae, 2~5 parts of Fructus Psoraleaes, 2~5 parts of Radix Salviae Miltiorrhizaes, 1~3 part of Rhizoma Cimicifugae, 5~7 parts of Semen Euryaless.
Medicine of the present invention is that the raw material by following optimum weight umber proportioning is prepared from: 4 parts of Herba Taxillis, 6 parts of Rhizoma Dioscoreaes, 4 parts of the Rhizoma Atractylodis Macrocephalaes, 4 parts of Fructus Corni, 4 parts of Cortex Moutans, 4 parts of Fructus Alpiniae Oxyphyllae, 3 parts of Ootheca Mantidiss, 3 parts of Fructus Rosae Laevigatae, 4 parts, Poria, 5 parts of the Radixs Astragali, 3 parts of Fructus Rubies, 2 parts, Radix Glycyrrhizae, 3 parts of Fructus Psoraleaes, 4 parts of Radix Salviae Miltiorrhizaes, 1 part of Rhizoma Cimicifugae, 6 parts of Semen Euryaless.
For realizing the object of above-mentioned Mulberry cornel capsule, technological process provided by the present invention is: described various crude drug, clean the rinsing of rear use drinking water clean, and after cold drying, pulverized 100 mesh sieves, sterilizing, encapsulating capsule, quality examination.
Described dry run is to adopt hot air circulation drying baker to dry, and controls between 40-60 ℃ of temperature, dries 18--24 hour.
Described sterilization process is to adopt ultraviolet radiation sterilization 3 times, each sterilization time 30-50 minute.
Medicine provided by the present invention is natural animal and plant medicine, has the effect of kidney and spleen invigorating controlling nocturnal emission with astringent drugs reducing urination, and the clinical urinary incontinence in patients with incomplete symptom that makes alleviates or disappears, and treatment effectively.
Fructus Rosae Laevigatae in medicine prescription, Semen Euryales have the effect of reinforcing the kidney and only losing.Fructus Rosae Laevigatae can reinforcing the kidney and controlling nocturnal emission, reducing urination and antidiarrheal.Ten doses of > > clouds of < < Bencao Jingshu > > < <: astringents being suitable for treating collapsesyndrome, insufficiency of the spleen lingering diarrhea be can't help, and non-astringent is difficult to consolidate it.This medicine temperature, sour-puckery flavor, enters three warps and the gas of convergence collapse.Semen Euryales has the power of reinforcing the kindey to control nocturnal emission, spleen reinforcing stopping leak.< < book on Chinese herbal medicine is looked for the truth in > > and is said: how spleen reinforcing of Semen Euryales, with its sweet in the mouth therefore; How Semen Euryales reinforces the kidney, with the event of its puckery.Precisely because sweet in the mouth spleen reinforcing, therefore energy dampness removing, precisely because puckery reinforces the kidney, therefore can hold one's breath, is all healed and make to lose band incontinence of urine.Merit is similar to Rhizoma Dioscoreae.So the moon of Rhizoma Dioscoreae, originally has too Semen Euryales, and Semen Euryales is puckery, more has the Rhizoma Dioscoreae of being far more than; And Rhizoma Dioscoreae has tonifying the lung the moon concurrently, and Semen Euryales terminates in spleen kidney and not as good as in lung.Fructus Corni, acid, tepor, invigorating the liver and kidney, Gu collapse, beneficial Yuanyang, invigorating primordial QI, primordial QI reinforcing essence, primordial qi strengthening essence.In < < Records of Tradition Chinese and Western Medicine in Combination > >, say: Fructus Corni, gas that greatly can convergence, cheers up, astringent or styptic treatment for spontaneous sweating slippage, among astringent therapy, have orderly and clearly property concurrently, thus tonneau nine orifices again, circulation blood vessels.Rhizoma Dioscoreae spleen invigorating, the benefit of reinforcing the kidney essence, the main damaging the spleen and stomach of < < herbal classic > >, tonify deficiency, except cold and heat pathogen, invigorating the spleen and replenishing QI power, longue meat, takes normal hearing and eyesight for a long time.Cortex Moutan can heat clearing and blood stasis dispersing, and the Rhizoma Atractylodis Macrocephalae, holds up spleen spleen invigorating; Coordinate Poria, Rhizoma Dioscoreae to have the effect of invigorating spleen to remove dampness.Rhizoma Dioscoreae Heshan Fructus Corni has the effect of kidney-yang nourishing.The Radix Astragali is sweet, tepor, has the effect of tonifying Qi and lifting yang.Ootheca Mantidis, sweet, salty, flat, return liver, kidney channel, can reinforcing the kidney and supporting YANG, controlling nocturnal emission with astringent drugs reducing urination.Fructus Rubi, sweet, sour, tepor, return liver, kidney channel, effect kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination.Full side's tonifying speen and tonifying kidney is main, treatment must aim at the pathogenesis of disease, and curative effect is better.
The plant origin of the present invention's various raw medicinal materials used is described as follows:
Herba Taxilli is the stem and branch with leaf of Loranthaceae evergreen dwarf shrub Herba Taxilli.The effect that has wind-damp dispelling tonifying liver and kidney and strengthening bones and muscles.
Fructus Rosae Laevigatae is the ripe pseudocarp of the evergreen climbing shrub plant of Rosaceae Fructus Rosae Laevigatae or the ripe holder of removing achene.The effect that has controlling nocturnal emission with astringent drugs reducing urination relieving diarrhea with astringents.Modern pharmacological research: the contained tannin of Fructus Rosae Laevigatae has astriction, and decocting liquid has inhibitory action to staphylococcus aureus, escherichia coli, bacillus pyocyaneus, clostridium tetani.Its decoct has study of anti-atherogenic effect.
Fructus Rubi is the immature fruit of Rosaceae defoliation bush plant Fructus Rubi.Modern pharmacological research: Fructus Rubi has inhibitory action to staphylococcus, vibrio cholera has estrogen-like effects simultaneously.
Ootheca Mantidis is the ootheca of Mantidae insecticide Chinese mantid, maculated mantis or European mantid.Pharmacological evaluation proof has diuresis and sweat restrain action.
The Rhizoma Atractylodis Macrocephalae is the rhizome of the Compositae herbaceos perennial Rhizoma Atractylodis Macrocephalae, has the effect of air making-up and spleen enlivening dampness diuretic.The pharmacological research Rhizoma Atractylodis Macrocephalae can promote cellular immune function, can have strong effect by antibacterial antitumor.
Rhizoma Dioscoreae is the tuber of the perennial herbaceous plant Rhizoma Dioscoreae that overgrows of Dioscoreaceae, has the effect of supplementing QI and nourishing YIN spleen reinforcing lung kidney.Body's immunity is had to facilitation.
The Radix Astragali is the root of the pulse family herbaceos perennial Radix Astragali and Inner Mongolia Astragalis.Main containing glycoside, polysaccharide, flavone, aminoacid, trace element etc.Can promote organism metabolism, antiviral.Promote the renewal of serum and hepatic protein.Strengthen and regulate body's immunity.There is antibacterial action widely.
Radix Salviae Miltiorrhizae is the root of Labiatae herbaceos perennial Radix Salviae Miltiorrhizae.Modern pharmacological research: Radix Salviae Miltiorrhizae can improve microcirculation, promotes velocity of blood flow, and blood vessel dilating, improves renal function, has antiinflammatory anti-allergic effects.
Fructus Psoraleae is the seed of pulse family annual herb plant Fructus Psoraleae.Contain Coumarins, flavonoid.Bakuchiol has estrogen-like effects, can strengthen immunity and endocrine function.Thereby performance anti-aging effects.
Fructus Alpiniae Oxyphyllae is the mature fruit of Zingiberaceae herbaceos perennial Fructus Alpiniae Oxyphyllae.There is warming the spleen appetizing, the effect of warming the kidney controlling nocturnal emission with astringent drugs reducing urination.
Poria is the sclerotium of On Polyporaceae Poria, and multiparasitization is on the tree roots such as pinaceae plant Pinus densiflora or Pinus massoniana Lamb.
Semen Euryales is the mature seed kernel of the annual aquatic herbaceous plant of Nymphaeceae Semen Euryales.This product has convergence and nourishing effect.
Fructus Corni is that Cornaceae defoliation small arbor plant Fructus Corni is except the sarcocarp of removal core.Contained tannin has astriction.
Cortex Moutan is the root bark of the perennial machaka plant of Ranunculaceae Paeonia suffruticosa.Contained paeonol and glucosides constituents in addition thereof all have antiinflammatory action.
Rhizoma Cimicifugae is the rhizome of Ranunculaceae, Rattleroot plant Rhizoma Cimicifugae.Yang invigorating, delivers, rash, removing toxic substances.Rhizoma Cimicifugae root stock, controls headache due to pathogenic wind-heat, laryngopharynx swelling and pain, macule and the disease such as is difficult for thoroughly sending out.
Radix Glycyrrhizae is perennial herb, and medicinal part is root and rhizome, and Medicinal Materials Characters root is cylindrical.Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Compared with prior art, the present invention has following characteristics:
1, reasonable recipe, has the conditioning effect of nourishing to old people and the people who has a delicate constitution.
For paruria diseases such as urinary incontinences, Chinese medicine early has research, wherein with dysuria, and drop and being short of, the slow person of patient's condition is infirmity; Inaccessible with urine, drop is obstructed, and patient's condition urgency person is called and closes.Gerontal patient has hypertension, the cerebral infarction chronic disease of waiting indefinitely mostly, walking disorder, and long-term bed very, the course of disease is longer.With the passing of time, the positive deficiency of vital energy declines disease.Stagnation and deficiency of QI is clinical common, and most of patients is older, kidney qi virtual loss, and decline of the fire from the gate of life, QI failing to transform into body fluid, is with depletion of YANG being difficult of the moon.Kidney governing water metabolism and take charge of two just, forming an integral part with bladder, the distribution of water liquid and the main gasification by kidney of excretion in body.The gasification of kidney is normal, opens entire degree of having, if the gasification function of kidney is not normal, closes the door out entire unfavorable, just the difficulty in urination can occur.As the secret allusion quotation opinion of < < Plain Questions LINGLAN piece of writing > > says: " here body fluid is hidden; gasification can go out for bladder person, the viscus likened to a pond ", " under Kidney-Yin, exhaust, first extra large unrooted, the deficiency of vital energy is not changed and is closed ".Therefore suffer from a deficiency of the kidney as disease basis.The present invention has the conditioning effect of nourishing to patient.
2, the strengthening spleen, tonifying kidney that also helps of the present invention, QI invigorating controlling nocturnal emission with astringent drugs reducing urination.
Gerontal patient, worn with age, deficiency-weakness of spleen-QI, or prolonged illness is in bed, and feelings will is not smooth, depression of liver-QI, liver gram spleen soil, dysfunction of the spleen in transportation.The spleen has the function to transport and transform nutrients, and spleen is also transported to the water liquid of needed by human body to be in week when transporting and transforming nutrients from foodstuff is precise and tiny.If spleen loses and transfers, can not ascending the clear and descending the turbid, under < < Zhengzi Huibu, knack difficulty in urination > > explicitly points out: " deficiency of the spleen causing weakness of QI; logical tune lost a surname, and deficiency of QI in middle-JIAO, urinates and just become for it again ", overstrain impairing the spleen, insufficiency of the spleen and clear QI failing to ascend, turbid YIN failing to descend, urine thereby unfavorable.Therefore insufficiency of the spleen sinking of QI of middle-JIAO, the instability of kidney-QI of suffering from a deficiency of the kidney, thereby dribbling urination is endlessly.Deficiency of spleen and stomach is for originally having the wet hot phlegm stasis of blood concurrently, and this is urinary incontinence pathogenesis place.Therefore invigorating spleen and kidney is focused in clinical application, help gasification and reach gasify row urine from logical object, treat senile urinary incontinence, frequent micturition, urgent micturition, can't help doing the symptoms such as urine, make urinary incontinence in patients with incomplete symptom alleviate or disappear, treatment is effective.
The specific embodiment
Embodiment
Get 4 parts of Herba Taxillis, 6 parts of Rhizoma Dioscoreaes, 4 parts of the Rhizoma Atractylodis Macrocephalaes, 4 parts of Fructus Corni, 4 parts of Cortex Moutans, 4 parts of Fructus Alpiniae Oxyphyllae, 3 parts of Ootheca Mantidiss, 3 parts of Fructus Rosae Laevigatae, 4 parts, Poria, 5 parts of the Radixs Astragali, 3 parts of Fructus Rubies, 2 parts, Radix Glycyrrhizae, 3 parts of Fructus Psoraleaes, 4 parts of Radix Salviae Miltiorrhizaes, 1 part of Rhizoma Cimicifugae, 6 parts of Semen Euryaless.
The preparation method of getting said medicine is: clean rear with after drinking water rinsing totally, adopt hot air circulation drying baker to dry, between 40-60 ℃ of control temperature, dry 24 hours, after dry, mixed powder is broken into fine powder, crosses 100 mesh sieves, mixes, adopt ultraviolet radiation sterilization 3 times, each sterilization time 40 minutes.Encapsulating capsule, makes regular check on, selective examination in batches before every batch of medicine clinical practice.Warehouse-in is stored in shady and cool dry place, and temperature 18-20 ℃, between humidity 30-45%, preserves 3 years.
The present embodiment is that clinical diagnosis case history and curative effect efficiency are as follows.
(1) physical data:
1. observe case 60 examples, be my patient of traditional Chinese medical science encephalopathy section of institute, wherein male 22 examples, female's 38 examples, age 60--85 year, used medicine 4-10 week.
2. choice criteria:
Common sympton: frequent micturition, urgent micturition, can't help doing urine, even occur wetting the bed, chronic disease, the course of disease is longer, and part Aeg has prostatic hyperplasia, calcification.Part patient has hypertension, cerebral infarction medical history.Discharge standard: obnubilation, stupor person, has injury of bladder person, acute urinary tract infection person.
(2) treatment and observational technique
1. Therapeutic Method
Herba Taxilli, Rhizoma Dioscoreae, the Rhizoma Atractylodis Macrocephalae, Fructus Corni, Cortex Moutan, Fructus Alpiniae Oxyphyllae, Ootheca Mantidis, Fructus Rosae Laevigatae, Poria, the Radix Astragali, Fructus Rubi, Radix Glycyrrhizae, Fructus Psoraleae, Radix Salviae Miltiorrhizae, Rhizoma Cimicifugae, Semen Euryales.The preparation of being prepared according to the formula of embodiment by Drug Manufacturing Room, each 5-10 grain, every day 3 times is oral.One month is a course for the treatment of, takes medicine 1-2 the course for the treatment of.
2. observation index
Clinical symptom relief or disappearance.Routine urianlysis is normal.
(3) therapeutic outcome
Recovery from illness: urinary incontinence disappears, urinates normal.
Take a turn for the better: without urinary incontinence, have the disease of frequent micturition, compared with alleviating before medication.
Do not heal: symptom is without alleviating.
Clinical treatment 60 examples, recovery from illness 20 examples, 36 examples that take a turn for the better, 4 examples that do not heal, total effective rate 93%.

Claims (5)

1. treat a medicine for old urinary incontinence, it is characterized in that being formed by weight ratio by following various crude drug: 3~6 parts of Herba Taxillis, 4~8 parts of Rhizoma Dioscoreaes, 3~6 parts of the Rhizoma Atractylodis Macrocephalaes, 3~6 parts of Fructus Corni, 2~6 parts of Cortex Moutans, 3~5 parts of Fructus Alpiniae Oxyphyllae, 2~4 parts of Ootheca Mantidiss, 2~4 parts of Fructus Rosae Laevigatae, 3~5 parts, Poria, 4~6 parts of the Radixs Astragali, 2~5 parts of Fructus Rubies, 2~5 parts, Radix Glycyrrhizae, 2~5 parts of Fructus Psoraleaes, 2~5 parts of Radix Salviae Miltiorrhizaes, 1~3 part of Rhizoma Cimicifugae, 5~7 parts of Semen Euryaless.
2. a kind of medicine for the treatment of old urinary incontinence according to claim 1, is characterized in that being comprised of by weight ratio following various crude drug: 4 parts of Herba Taxillis, 6 parts of Rhizoma Dioscoreaes, 4 parts of the Rhizoma Atractylodis Macrocephalaes, 4 parts of Fructus Corni, 4 parts of Cortex Moutans, 4 parts of Fructus Alpiniae Oxyphyllae, 3 parts of Ootheca Mantidiss, 3 parts of Fructus Rosae Laevigatae, 4 parts, Poria, 5 parts of the Radixs Astragali, 3 parts of Fructus Rubies, 2 parts, Radix Glycyrrhizae, 3 parts of Fructus Psoraleaes, 4 parts of Radix Salviae Miltiorrhizaes, 1 part of Rhizoma Cimicifugae, 6 parts of Semen Euryaless.
3. a kind of preparation method for the treatment of the medicine of old urinary incontinence according to claim 1, is characterized in that its technological process, for getting described various crude drug, cleans post rinse clean, after cold drying, pulverized 100 mesh sieves, sterilizing, encapsulating capsule, quality examination, is prepared as Mulberry cornel capsule.
4. a kind of process for preparing medicine for the treatment of old urinary incontinence of preparation according to claim 3, is characterized in that described dry run is to adopt hot air circulation drying baker to dry, and controls between 40-60 ℃ of temperature, dries 18--24 hour.
5. a kind of process for preparing medicine for the treatment of old urinary incontinence of preparation according to claim 4, is characterized in that described sterilization process is to adopt ultraviolet radiation sterilization 3 times, each sterilization time 30-50 minute.
CN201310732318.4A 2013-12-27 2013-12-27 A kind of medicine treating senile urinary incontinence and preparation method thereof Expired - Fee Related CN103735972B (en)

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* Cited by examiner, † Cited by third party
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CN104398952A (en) * 2014-12-09 2015-03-11 夏征梅 Traditional Chinese medicine tablet for treating urinary incontinence
CN106389992A (en) * 2016-11-11 2017-02-15 东莞市百替生物科技有限公司 Traditional Chinese medicine preparation for treating frequent micturition and urgent micturition and preparation method of traditional Chinese medicine preparation for treating frequent micturition and urgent micturition
CN108635538A (en) * 2018-06-25 2018-10-12 周菲菲 A kind of Chinese medicine composition for treating old women stress incontinence

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104398952A (en) * 2014-12-09 2015-03-11 夏征梅 Traditional Chinese medicine tablet for treating urinary incontinence
CN106389992A (en) * 2016-11-11 2017-02-15 东莞市百替生物科技有限公司 Traditional Chinese medicine preparation for treating frequent micturition and urgent micturition and preparation method of traditional Chinese medicine preparation for treating frequent micturition and urgent micturition
CN108635538A (en) * 2018-06-25 2018-10-12 周菲菲 A kind of Chinese medicine composition for treating old women stress incontinence

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