CN103735860A - Application of Dendrobium officinale fruit in preparing medicines for treating external hemorrhage - Google Patents

Abstract

The invention belongs to the field of medicine, and relates to new application of Dendrobium officinale fruit in preparing medicines, particularly new application of Dendrobium officinale fruit in preparing medicines for treating external hemorrhage. The animal experiment proves that the Dendrobium officinale fruit has obvious action on treating external hemorrhage. The action of the Dendrobium officinale fruit has not been reported and applied in the past research and clinic. The Dendrobium officinale fruit can be prepared into various preparation formulations, is greatly demanded in clinical application, has high practicality, and has wide application prospects in stopping external hemorrhage.

Description

The application of Herba Dendrobii fruit in preparation treatment external haemorrhage medicine

Technical field

The invention belongs to field of medicaments, be specifically related to a kind of pharmaceutic usage of Herba Dendrobii fruit.

Background technology

Herba Dendrobii is orchid, it is grown in the in the shade part of overhanging cliff, root does not bury, and has nourishing Tianjin, health invigorating, strengthens the spleen and stomach, hepatoprotective function of gallbladder promoting, strong muscle blood fat reducing, reduces blood glucose, suppresses tumor, bright eyes, nourishes the effects such as skin and life lengthening.Tang opens in the classical < < Taoist Scriptures > > of Taoist school between the first year and once Herba Dendrobii fruit, Herba Saussureae Involueratae, three double Radix Ginsengs, 120 years Radix Polygoni Multiflori, the Poria of cycle of sixty years, Herba Cistanches, remote mountains Ganoderma, seabed Margarita, Cordyceps was classified as to " China's nine large Herba mesonae chinensis ", and Herba Dendrobii is by first of " nine large Herba mesonae chinensis ".Because the peculiar effect of Herba Dendrobii, successive dynasties imperial palace noble regards it as the elixir of curing the disease, long-lived good recipe, as tribute, among the people, asks for.< < China pharmacy dictionary > > claims Herba Dendrobii " gas-liquid, the gas-liquid of specially controlling lung stomach rushed prosperous, kidney water is spontaneous ".Be good at Yin-nourishing and body fluid promoting, all diseases for the treatment of Yin and fluid deficiency.< < Sheng Nong's herbal classic > > records: " the Herba Dendrobii eliminating impediment therapeutic method to keep the adverse QI flowing downwards, tonifying five ZANG-organs asthenia sea are thin, reinforcing YIN-essence benefit essence, for a long time clothes; thick the intestines and stomach ", claim it to have the effect of " main damaging the spleen and stomach, the eliminating impediment therapeutic method to keep the adverse QI flowing downwards, tonifying five ZANG-organs asthenia ".The work that will be handed on from age to age < < detailed outline of the well-known doctor Zhao Shuxuan of the Qing Dynasty is picked up any lost article from the road, and to praise Herba Dendrobii be " YIN nourishing tonification treasure " to > >.

Modern medicine study shows, Herba Dendrobii has multiple pharmacological effect, as the immunocompetence of enhancing body, and antioxidation, defying age, blood sugar lowering, blood fat reducing, expansion blood vessel, YIN nourishing and the production of body fluid promoting etc.

But up to now, there is not yet the research report that Herba Dendrobii fruit is used for the treatment of external haemorrhage.

Summary of the invention

The object of the invention is to: develop the new application of a kind of Herba Dendrobii fruit.

The technical solution used in the present invention is to provide the application of Herba Dendrobii fruit in preparation treatment external haemorrhage medicine;

Described Herba Dendrobii fruit is the ripe Herba Dendrobii fruit of gathering JIUYUE-November;

Described Herba Dendrobii fruit is Herba Dendrobii fruit powder;

Further, the grinding particle size of described Herba Dendrobii fruit powder is >=60 orders;

In the present invention, fresh goods or dry product that described Herba Dendrobii fruit is Herba Dendrobii fruit;

Described external haemorrhage comprises the wound of lancinating, stabs, hemorrhage due to gunshot wound and spreading wound;

Described medicine comprises people's use and for animals.

The invention still further relates to and take Herba Dendrobii fruit as active component, the pharmaceutical composition that the external haemorrhage of take is indication.This pharmaceutical composition can be by the product in the present invention, is combined with one or more pharmaceutically acceptable solids or liquid excipient and/or adjuvant, makes and is suitable for any dosage form that human or animal uses.Route of administration can be intestinal or parenteral route, as: oral, intravenous injection, intramuscular injection, subcutaneous injection, nasal cavity, oral mucosa, eye, lung and respiratory tract, skin, vagina, rectum etc.Form of administration can be liquid dosage form, solid dosage forms or semisolid dosage form.Liquid dosage form can be solution (comprising true solution and colloid solution), Emulsion, microemulsion, suspensoid, injection (comprising aqueous injection, injectable powder and transfusion), eye drop, nasal drop, lotion, liniment etc.; Solid preparation can be tablet (comprising ordinary tablet, enteric coatel tablets, buccal tablet, dispersible tablet, chewable tablet, effervescent tablet, oral cavity disintegration tablet etc.), capsule (comprising hard capsule, soft capsule, enteric coated capsule), granule, powder, micropill, drop pill, suppository, membrane, paster, the agent of gas (powder) mist, spray etc.; Semi-solid preparation can be ointment, gel, paste etc.Preparation can be made ordinary preparation, also can be slow releasing agent, controlled release agent, targeting preparation and various particulate delivery system.

The effect that the present invention has and advantage:

1. through animal experiment, prove, Herba Dendrobii fruit has obvious anastalsis to experimental animal; There is feature evident in efficacy, easy to use.

2. Herba Dendrobii fruit is widely used, and can be made into the pharmaceutical preparatioies such as injection, capsule, concentrated pill, granule, tablet, powder, oral liquid.

The specific embodiment

Embodiment 1:

Get the fresh goods 5kg of the Herba Dendrobii mature fruit that JIUYUE gathers, pulverize, porphyrize be end, and mistake 60 mesh sieves, obtain Herba Dendrobii fruit powder; In sterilizing room, be distributed into 10 grams/bag, sealing is preserved, and obtains.

Embodiment 2:

Get the dry product 5kg of the Herba Dendrobii fruit of gathering November, pulverize, porphyrize is end, crosses 300 mesh sieves, obtains Herba Dendrobii fruit powder; In sterilizing room, be distributed into 10 grams/bag, sealing is preserved, and obtains.

By pharmacodynamics test, prove beneficial effect of the present invention below:

Test (one):

1, test material

Herba Dendrobii fruit powder

Anisodus carniolicoides C.Y.Wu et C.Chen (production of Tongrentang Pharmaceutical Factory, Beijing TongrenTang Co., Ltd)

2, test method

Hemostasis trial compares with Anisodus carniolicoides C.Y.Wu et C.Chen.Hemostasis standard is not penetrated blood or oozing phenomenon with otch (or wound surface) and is occurred, or oozes out that trace solidifies and oozing of blood no longer again.

2.1 mice docking hemostasis

In tail middle part, with tissue shear, cut off it, apply medicine, with stopwatch, record when hemorrhage and ask.

2.2 rabbit ear back of the body tremulous pulsies cut off hemostasis entirely

With the cross-section hard of hearing trunk of scalpel, after blood flows out, medicine-feeding rapidly, oppresses after 2-3s a little, while measuring hemostasis, asks.

2.3 rabbit femoral arteries cut off hemostasis entirely

With 2% pentobarbital sodium water solution ear vein injection, after anesthesia, lie on the back and be fixed on operating-table, in thigh inner side, cut skin, fully expose femoral artery and vein, one cutter is cut off entirely, during blood ejection, rapidly off-the-shelf medicine is directly applied on otch, press after about 5s, measure bleeding stopping period.

3, experimental animal hemostasis trial the results are shown in Table 1.

Table 1 medicine is to experimental animal bleeding stopping period

Note: * P < 0.05, * * P < 0.01

Result: Herba Dendrobii fruit to the average bleeding stopping period of experimental animal all than matched group short (p<0.01).

Test (two):

1, experimental animal

Kunming kind white mice, clean level, male and female half and half, body weight 18-20g;

2, hemostasis trial

With oral iron-sheet dendrobe fresh product fruit and the administration of dry product fruit, dosage is as the criterion with adult 0.1g/kg respectively, by body surface area conversion, is mice dosage.

Mice is divided into 3 groups at random, 12 every group, is respectively Normal group, iron-sheet dendrobe fresh product fruit group (0.45g/kg), Herba Dendrobii dry product fruit group (0.45g/kg);

Continuous 14d, last gastric infusion 1h, mice is clamping fixed, in order to cutting cross-section apart from Mouse Tail-tip 0.5cm place, starts timing when blood overflows voluntarily, every 30s, with filter paper, sucks drop of blood once, naturally stops (depletion of blood when filter paper is inhaled) until hemorrhage.

Result of the test

Note: with Normal group comparison: * P < 0.05, * * P < 0.01

Conclusion: after the oral Herba Dendrobii fruit of mice, bleeding stopping period obviously shortens, and comparing difference with Normal group has statistical significance, prompting has anastalsis.

Claims (7)

1. the application of Herba Dendrobii fruit in preparation treatment external haemorrhage medicine.

2. application as claimed in claim 1, is characterized in that described Herba Dendrobii fruit is the ripe Herba Dendrobii fruit of gathering JIUYUE-November.

3. application as claimed in claim 1 or 2, is characterized in that described Herba Dendrobii fruit is Herba Dendrobii fruit powder.

4. application as claimed in claim 3, is characterized in that the grinding particle size of described Herba Dendrobii fruit powder is >=60 orders.

5. the application as described in claim 1-4 any one, is characterized in that fresh goods or dry product that described Herba Dendrobii fruit is Herba Dendrobii fruit.

6. the application as described in claim 1-5 any one, is characterized in that: described external haemorrhage comprises the wound of lancinating, stabs, hemorrhage due to gunshot wound and spreading wound.

7. the application as described in claim 1-6 any one, is characterized in that described medicine comprises people's use and for animals.