CN103735858A - Application of Dendrobium officinale fruit extract in preparing medicines for treating upper gastrointestinal bleeding - Google Patents
Application of Dendrobium officinale fruit extract in preparing medicines for treating upper gastrointestinal bleeding Download PDFInfo
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- CN103735858A CN103735858A CN201310699190.6A CN201310699190A CN103735858A CN 103735858 A CN103735858 A CN 103735858A CN 201310699190 A CN201310699190 A CN 201310699190A CN 103735858 A CN103735858 A CN 103735858A
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Abstract
The invention belongs to the field of medicine, and relates to new application of Dendrobium officinale fruit extract in preparing medicines, particularly new application of Dendrobium officinale fruit extract in preparing medicines for treating upper gastrointestinal bleeding. The clinical curative effect proves that the Dendrobium officinale fruit extract has obvious action on stopping upper gastrointestinal bleeding. The action of the Dendrobium officinale fruit extract has not been reported and applied in the past research and clinic. The Dendrobium officinale fruit extract can be prepared into various preparation formulations, is greatly demanded in clinical application, has high practicality, and has wide application prospects in upper gastrointestinal bleeding.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of Herba Dendrobii fruit extract in the application of preparing in upper gastrointestinal hemorrhage medicine.
Background technology
Herba Dendrobii is orchid, it is grown in the in the shade part of overhanging cliff, root does not bury, and has nourishing Tianjin, health invigorating, strengthens the spleen and stomach, hepatoprotective function of gallbladder promoting, strong muscle blood fat reducing, reduces blood glucose, suppresses tumor, bright eyes, nourishes the effects such as skin and life lengthening.Tang opens in the classical < < Taoist Scriptures > > of Taoist school between the first year and once Herba Dendrobii fruit extract, Herba Saussureae Involueratae, three double Radix Ginsengs, 120 years Radix Polygoni Multiflori, the Poria of cycle of sixty years, Herba Cistanches, remote mountains Ganoderma, seabed Margarita, Cordyceps was classified as to " China's nine large Herba mesonae chinensis ", and Herba Dendrobii is by first of " nine large Herba mesonae chinensis ".Because the peculiar effect of Herba Dendrobii, successive dynasties imperial palace noble regards it as the elixir of curing the disease, long-lived good recipe, as tribute, among the people, asks for.< < China pharmacy dictionary > > claims Herba Dendrobii " gas-liquid, the gas-liquid of specially controlling lung stomach rushed prosperous, kidney water is spontaneous ".Be good at Yin-nourishing and body fluid promoting, all diseases for the treatment of Yin and fluid deficiency.< < Sheng Nong's herbal classic > > records: " the Herba Dendrobii eliminating impediment therapeutic method to keep the adverse QI flowing downwards, tonifying five ZANG-organs asthenia sea are thin, reinforcing YIN-essence benefit essence, clothes for a long time; thick the intestines and stomach ", claim it to have the effect of " main damaging the spleen and stomach, the eliminating impediment therapeutic method to keep the adverse QI flowing downwards, tonifying five ZANG-organs asthenia ".The work that will be handed on from age to age < < detailed outline of the well-known doctor Zhao Shuxuan of the Qing Dynasty is picked up any lost article from the road, and to praise Herba Dendrobii be " YIN nourishing tonification treasure " to > >.
Modern medicine study shows, Herba Dendrobii has multiple pharmacological effect, as the immunocompetence of enhancing body, and antioxidation, defying age, blood sugar lowering, blood fat reducing, expansion blood vessel, YIN nourishing and the production of body fluid promoting etc.
But up to now, there is not yet the research report that Herba Dendrobii fruit extract is used for the treatment of upper gastrointestinal hemorrhage.
Summary of the invention
The object of the present invention is to provide one to there is obvious anastalsis to upper gastrointestinal hemorrhage; There is Herba Dendrobii fruit extract medicine evident in efficacy, easy to use, and Herba Dendrobii fruit extract is applied in digestive tract hemorrhage medicine.
The technical solution used in the present invention is: provide Herba Dendrobii fruit extract in the application of preparing in upper gastrointestinal hemorrhage medicine;
Described Herba Dendrobii fruit extract is Herba Dendrobii fruit water extract;
Described Herba Dendrobii fruit water extract is made by following method: get Herba Dendrobii fruit, 90-100 ℃ adds 8-10 times of water gaging and extract three times, and each 1-2 hour, filters, relative density 1.10-1.36 during 65-70 ℃ vacuum concentration to 60 ℃.
Described Herba Dendrobii fruit is the ripe Herba Dendrobii fruit of gathering JIUYUE-November;
Fresh goods or dry product that described Herba Dendrobii fruit is Herba Dendrobii fruit;
Described upper gastrointestinal hemorrhage comprises that harmonization of the stomach is duodenal hemorrhage;
Described medicine comprises people's use and for animals.
The invention still further relates to take Herba Dendrobii fruit extract as active component the pharmaceutical composition take upper gastrointestinal hemorrhage as indication.This pharmaceutical composition can be by the product in the present invention, is combined with one or more pharmaceutically acceptable solids or liquid excipient and/or adjuvant, makes and is suitable for any dosage form that human or animal uses.Route of administration can be intestinal or parenteral route, as: oral, intravenous injection, intramuscular injection, subcutaneous injection, nasal cavity, oral mucosa, eye, lung and respiratory tract, skin, vagina, rectum etc.Form of administration can be liquid dosage form, solid dosage forms or semisolid dosage form.Liquid dosage form can be solution (comprising true solution and colloid solution), Emulsion, microemulsion, suspensoid, injection (comprising aqueous injection, injectable powder and transfusion), eye drop, nasal drop, lotion, liniment etc.; Solid preparation can be tablet (comprising ordinary tablet, enteric coatel tablets, buccal tablet, dispersible tablet, chewable tablet, effervescent tablet, oral cavity disintegration tablet etc.), capsule (comprising hard capsule, soft capsule, enteric coated capsule), granule, powder, micropill, drop pill, suppository, membrane, paster, the agent of gas (powder) mist, spray etc.; Semi-solid preparation can be ointment, gel, paste etc.Preparation can be made ordinary preparation, also can be slow releasing agent, controlled release agent, targeting preparation and various particulate delivery system.
The effect that the present invention has and advantage:
1. through clinical efficacy, prove, Herba Dendrobii fruit extract has obvious anastalsis to upper gastrointestinal hemorrhage; There is feature evident in efficacy, easy to use.
2. Herba Dendrobii fruit extract is widely used, and can be made into the pharmaceutical preparatioies such as injection, capsule, concentrated pill, granule, tablet, powder, oral liquid.
The specific embodiment
Embodiment 1:
Get the fresh goods 5kg of the Herba Dendrobii fruit that JIUYUE gathers, 90-100 ℃ adds 8 times of water gagings and extracts three times, and each 1 hour, 240 orders filtered, and relative density 1.10 during 65-70 ℃ vacuum concentration to 60 ℃, obtains.
Embodiment 2:
Get the dry product 5kg of the Herba Dendrobii fruit of gathering November, 90-100 ℃ adds 10 times of water gagings and extracts three times, and each 2 hours, 300 orders filtered, and relative density 1.36 during 65-70 ℃ vacuum concentration to 60 ℃, obtains.
By pharmacodynamics test, prove beneficial effect of the present invention below:
Physical data: 133 examples are seen and inpatient for hospital emergency stays, and all show as hematemesis, melena that degree is different, make a definite diagnosis through gastroscope, Fecal Occult Blood Testing and blood cell analysis, are divided at random two groups.Treatment group 68 examples, male's 45 examples, women's 23 examples; Age 17-70 year, average 43.5 years old; Wherein duodenal bulbar ulcer 35 examples, gastric ulcer 22 examples, Acute hemorrhage of gastric mucous membrane 5 examples, plyability ulcer 5 examples, Therapy for Gastric Variceal 1 example; Hemorrhage severe (>1000ml) 24 examples, moderate (500-1000ml) 33 examples, slight (<500ml) 11 examples.Matched group 65 examples, male's 43 examples, women's 22 examples; Age 16-68 year, average 42 years old; Duodenal bulbar ulcer 31 examples, gastric ulcer 16 examples, Acute hemorrhage of gastric mucous membrane 9 examples, plyability ulcer 4 examples, Therapy for Gastric Variceal 5 examples; Hemorrhage severe 23 examples, moderate 31 examples, slight 11 examples.There are no significant (P>0.05) for two groups of above-mentioned data differences, has comparability.
Therapeutic Method: two groups all after being admitted to hospital fasting 2-3d (except medicine) give again liquid diet, be progressively transitioned into half liquid food (having more meals a day but less food at each).During fasting, give without exception liquid supporting treatment, maintain water, electrolyte and acid-base balance; The severe person of losing blood is defeated by homotype blood or Red Blood Cells Concentrate, has the positive shock treatment of shock person.Matched group gives doctor trained in Western medicine conventional treatment and lies up, and keeps respiratory passage unblocked; Replenishment of blood content; Gastric acid inhibitory and protection gastric mucosa, enter liquid quiet every day 2 times to famotidine 20mg; Severe bleeding person gives the rear oral or Injection by stomach duct of norepinephrine 6-8mg normal saline 200-250ml dilution on the rocks at every turn; At the bottom of stomach, the esophageal varix person of breaking can give Sandostatin LAR Depot 1ml subcutaneous injection, every 8 hours 1 time.Treatment group, when bed, keeping respiratory passage unblocked, replenishment of blood content, is given Herba Dendrobii fruit extract oral (taking from embodiment 1), each 1.5g, every day 2 times (severe bleeding person every day 3 times).The only rear above-mentioned dosage of drug of blood reduces by half.
Criterion of therapeutical effect: work out by < < new Chinese medicine guideline of clinical investigations > >.Recovery from illness: in 1 week, hematemesis or melena stop, the continuous 3d feminine gender of Fecal Occult Blood Testing result, hemorrhage and simultaneous phenomenon obviously improves.Effective: hematemesis or have blood in stool stops in 1 week, and the continuous 3d of Fecal Occult Blood Testing result is (+), and hemorrhage and symptom makes moderate progress.Effective: in 1 week, hematemesis reduces, and Fecal Occult Blood Testing result transfers (++) to by strong positive.Do not heal: through controlling 1 week, even increase the weight of without taking a turn for the better after hemorrhage still more than or severe bleeding is treated 24h.
Result: treatment group 68 examples, recovery from illness 44 examples (64.71%), effective 17 examples (25.0%), effective 6 examples (8.8%), 3 examples (1.49%) that do not heal, total effective rate 98.51%; Matched group 65 examples, recovery from illness 33 examples (50.77%), effective 19 examples (29.23%), effective 10 examples (15.38%), 3 examples (4.62%) that do not heal, total effective rate 95.38%.Treatment group is better than matched group (P<0.05).The treatment group Fecal Occult Blood Testing average natural law of turning out cloudy is (3.01 ± 0.80) d, and matched group is (4.61 ± 0.70) d, and two groups of differences have significance (P<0.05).
Claims (7)
1. the application of Herba Dendrobii fruit extract in preparation treatment upper gastrointestinal hemorrhage medicine.
2. the application of Herba Dendrobii fruit extract as claimed in claim 1 in preparation treatment upper gastrointestinal hemorrhage medicine, is characterized in that: described Herba Dendrobii fruit extract is Herba Dendrobii fruit water extract.
3. the application of Herba Dendrobii fruit extract as claimed in claim 2 in preparation treatment upper gastrointestinal hemorrhage medicine, it is characterized in that described Herba Dendrobii fruit water extract is made by following method: get Herba Dendrobii fruit, 90-100 ℃ adds 8-10 times of water gaging and extracts three times, each 1-2 hour, filter relative density 1.10-1.36 during 65-70 ℃ vacuum concentration to 60 ℃.
4. the application of Herba Dendrobii fruit extract as claimed in claim 3 in preparation treatment upper gastrointestinal hemorrhage medicine, is characterized in that described Herba Dendrobii fruit is the ripe Herba Dendrobii fruit of gathering JIUYUE-November.
5. the application of Herba Dendrobii fruit extract as claimed in claim 3 in preparation treatment upper gastrointestinal hemorrhage medicine, is characterized in that fresh goods or dry product that described Herba Dendrobii fruit is Herba Dendrobii fruit.
6. the application of the Herba Dendrobii fruit extract as described in claim 1-5 any one in preparation treatment upper gastrointestinal hemorrhage medicine, is characterized in that described upper gastrointestinal hemorrhage comprises that harmonization of the stomach is duodenal hemorrhage.
7. the application of the Herba Dendrobii fruit extract as described in claim 1-6 any one in preparation treatment upper gastrointestinal hemorrhage medicine, is characterized in that described medicine comprises people's use and for animals.
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| Application Number | Priority Date | Filing Date | Title |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103099967A (en) * | 2013-02-05 | 2013-05-15 | 云南农业大学 | Dendrobe aqueous extract and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103099967A (en) * | 2013-02-05 | 2013-05-15 | 云南农业大学 | Dendrobe aqueous extract and application thereof |
Non-Patent Citations (4)
| Title |
|---|
| 冯霞等: ""铁皮石斛水提物对SD 大鼠胃损伤的预防效果"", 《江苏农业科学》 * |
| 梁楚燕等: ""铁皮石斛护肝及抗胃溃疡作用研究"", 《世界科学技术-中医药现代化》 * |
| 江苏新医学院: "《中药大辞典》", 31 May 1986, 上海科学技术出版社 * |
| 田令群: ""中草药治疗上消化道出血"", 《贵阳中医学院学报》 * |
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Application publication date: 20140423 |