CN103735857B - The application in preparation treatment pharyngitis medicine of the Dendrobium officinale fruit extract - Google Patents
The application in preparation treatment pharyngitis medicine of the Dendrobium officinale fruit extract Download PDFInfo
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- CN103735857B CN103735857B CN201310699189.3A CN201310699189A CN103735857B CN 103735857 B CN103735857 B CN 103735857B CN 201310699189 A CN201310699189 A CN 201310699189A CN 103735857 B CN103735857 B CN 103735857B
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- dendrobium officinale
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Abstract
The invention belongs to field of medicaments, relate to the pharmaceutic usage of Dendrobium officinale fruit extract, to provide Dendrobium officinale fruit extract new opplication in preparation treatment pharyngitis medicine.Proving through clinical efficacy, Dendrobium officinale fruit extract has obvious anastalsis to pharyngitis.These act on the conventional research of Dendrobium officinale fruit extract and have no report and application clinically.Can be made into various dosage form, clinical application demand is huge, and the present invention has the strongest practicality, and its application prospect in terms of pharyngitis is the most wide.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of Dendrobium officinale fruit extract in preparation
Application in treatment pharyngitis medicine.
Background technology
Herba Dendrobii is orchid, and it is grown in the in the shade part of overhanging cliff, and root does not enters
Soil, have nourishing Tianjin, health invigorating, strengthen the spleen and stomach, hepatoprotective function of gallbladder promoting, strong muscle blood fat reducing, fall
Hypoglycemia, suppression tumor, bright eyes, nourishing effect such as skin and life lengthening.Tang Kai
In Taoist school between the first year classical " Taoist Scriptures " once Dendrobium officinale fruit extract, Herba Saussureae Involueratae,
Three double Radix Ginsengs, 120 years Radix Polygoni Multiflori, the Poria of cycle of sixty years, Herba Cistanches, remote mountains Ganoderma, seabed treasure
Pearl, Cordyceps are classified as " China's nine big Herba mesonae chinensis ", and Herba Dendrobii is then by named as " nine is big
Herba mesonae chinensis " first of.Because peculiar effect of Herba Dendrobii, successive dynasties imperial palace noble regards it as curing the disease
Elixir, long-lived good recipe, ask among the people as tribute." China's pharmacy dictionary " claims iron sheet
Herba Dendrobii " specially control the gas-liquid of lung stomach, gas-liquid rush prosperous, kidney water is spontaneous ".It is good at Yin-nourishing and body fluid promoting, controls
Treat all diseases of Yin and fluid deficiency.Shennong's Herbal is recorded: " the Herba Dendrobii eliminating impediment therapeutic method to keep the adverse QI flowing downwards, tonifying five ZANG-organs asthenia
Sea is thin, reinforcing YIN-essence benefit essence, takes for a long time, thick the intestines and stomach ", " main damaging the spleen and stomach, the eliminating impediment therapeutic method to keep the adverse QI flowing downwards are mended to claim it to have
The five internal organs asthenia " effect.The work that will be handed on from age to age " detailed outline is picked up any lost article from the road " of Qing Dynasty well-known doctor Zhao Shuxuan praises iron sheet
Herba Dendrobii is " YIN nourishing tonification treasure ".
Modern medicine study shows, Herba Dendrobii has multiple pharmacological effect, such as enhancing body
Immunocompetence, antioxidation, defying age, blood sugar lowering, blood fat reducing, expansion blood vessel, YIN nourishing and the production of body fluid promoting etc.
Deng.
But up to now, there is not yet Dendrobium officinale fruit extract for treating the research of pharyngitis
Report.
Summary of the invention
It is an object of the invention to provide one and pharyngitis is had obvious therapeutical effect；There is treatment
Imitate Dendrobium officinale fruit extract medicine notable, easy to use.
The technical solution used in the present invention is: provide Dendrobium officinale fruit extract in preparation pharyngitis
Application in medicine；
Described Dendrobium officinale fruit extract is Dendrobium officinale fruit ethanol extraction.
Described Dendrobium officinale fruit ethanol extraction is prepared by following method: take Dendrobium officinale fruit,
Add 8-12 times of volume 70% alcohol reflux, each 1-2 hour, filter, 65-70
Relative density 1.10-1.36 when DEG C being concentrated in vacuo to 60 DEG C.
Described Dendrobium officinale fruit is the ripe Dendrobium officinale fruit gathered JIUYUE-November.
Described Dendrobium officinale fruit is fresh goods or the dry product of Dendrobium officinale fruit.
Described pharyngitis includes acute pharyngitis and chronic pharyngitis.
The invention still further relates to Dendrobium officinale fruit extract as active component, with pharyngitis for adapting to
The pharmaceutical composition of disease.This pharmaceutical composition can be by the product in the present invention, with one or more
Pharmaceutically acceptable solid or liquid excipient and/or adjuvant combine, and make and are suitable to people or dynamic
Any dosage form that thing uses.Route of administration can be intestinal or parenteral route, such as: oral, quiet
Arteries and veins injection, intramuscular injection, subcutaneous injection, nasal cavity, oral mucosa, eye, lung and respiratory tract,
Skin, vagina, rectum etc..Form of administration can be liquid dosage form, solid dosage forms or semisolid
Dosage form.Liquid dosage form can be solution (including true solution and colloid solution), Emulsion, micro-
Breast, suspensoid, injection (including aqueous injection, injectable powder and transfusion), eye drop, collunarium
Agent, lotion, liniment etc.；Solid preparation can be that tablet (includes ordinary tablet, enteric coatel tablets, contains
Sheet, dispersible tablet, chewable tablet, effervescent tablet, oral cavity disintegration tablet etc.), capsule (include ebonite
Capsule, soft capsule, enteric coated capsule), granule, powder, micropill, drop pill, suppository, membrane,
Paster, gas (powder) mist agent, spray etc.；Semi-solid preparation can be ointment, gel,
Paste etc..Preparation can be made ordinary preparation, can also be slow releasing agent, controlled release agent, targeting system
Agent and various particulate delivery system.
Effect that the present invention has and advantage:
1. proving through clinical efficacy, pharyngitis is the most only had by Dendrobium officinale fruit extract
Blood effect；There is feature evident in efficacy, easy to use.
2. Dendrobium officinale fruit extract is widely used, and can be made into injection, capsule, dense
The pharmaceutical preparatioies such as contracting ball, granule, tablet, powder, oral liquid.
Detailed description of the invention
Embodiment 1:
Take fresh goods 5kg of the Dendrobium officinale fruit that JIUYUE is gathered, add 8 times of volume 70% second
Alcohol reflux extracts three times, and each 1 hour, 240 mesh filtered, and 65-70 DEG C is concentrated in vacuo to 60
DEG C time relative density 1.10, to obtain final product.
Embodiment 2:
Take the dry product 5kg of the Dendrobium officinale fruit gathered November, add 12 times of volumes 70%
Alcohol reflux three times, each 2 hours, 300 mesh filtered, and 65-70 DEG C is concentrated in vacuo to
When 60 DEG C, relative density 1.36, to obtain final product.
Clinical cure is tested:
1. diagnostic criteria
Pharyngeal pain, is dried discomfort, has foreign body sensation, burning sensation, pharyngeal mucosa
Diffusivity is congested.
2. clinical data
320 examples are patient medical history.Man's 162 examples, female 158 example, age 23-58
In year, the mean age is 36 years old, meets above-mentioned diagnostic criteria；320 examples are all through upper digestive tract X
Line barivm meal fluoroscopy (screem) or fibergastroscopy no abnormality seen.
3. Therapeutic Method
The product of Example 1, one time 5 grams, six times on the one.
4. therapeutic effect judges
Recovery from illness: pharyngalgia, the disappearance of dry, scorching hot, foreign body sensation, pharyngeal mucosa without
Substantially diffusivity is congested；Taking a turn for the better: pharyngalgia, dry, scorching hot, foreign body sensation substantially alleviates,
Diffusivity that pharyngeal mucosa is slight is congested；Invalid: pharyngalgia, dry, scorching hot, foreign body sensation without
Substantially alleviating, pharyngeal mucosa is still congested in diffusivity.
5. therapeutic outcome
Sum 320 examples, wherein cure 250 examples, and take a turn for the better 60 examples, and invalid 10
Example, total effective rate is 96.8%；Dendrobium officinale fruit extract pair in the present invention is described
Acute pharyngitis and chronic pharyngitis have significant therapeutic effect.
Claims (4)
1. Dendrobium officinale fruit extract application in preparation treatment pharyngitis medicine, it is characterised in that: described Dendrobium officinale fruit
Extract is Dendrobium officinale fruit ethanol extraction；Described Dendrobium officinale fruit ethanol extraction is prepared by following method: take iron sheet
Herba Dendrobii fruit, adds 8-12 times of volume 70% alcohol reflux, each 1-2 hour, filters, and 65-70 DEG C is concentrated in vacuo
To relative density 1.10-1.36 when 60 DEG C.
2. the Dendrobium officinale fruit extract as claimed in claim 1 application in preparation treatment pharyngitis medicine, it is characterised in that
Described Dendrobium officinale fruit is the ripe Dendrobium officinale fruit gathered JIUYUE-November.
3. the Dendrobium officinale fruit extract as claimed in claim 1 application in preparation treatment pharyngitis medicine, it is characterised in that
Described Dendrobium officinale fruit is fresh goods or the dry product of Dendrobium officinale fruit.
4. the application in preparation treatment pharyngitis medicine of the Dendrobium officinale fruit extract as described in claim 1-3 any one,
It is characterized in that described pharyngitis includes acute pharyngitis and chronic pharyngitis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310699189.3A CN103735857B (en) | 2013-12-18 | 2013-12-18 | The application in preparation treatment pharyngitis medicine of the Dendrobium officinale fruit extract |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310699189.3A CN103735857B (en) | 2013-12-18 | 2013-12-18 | The application in preparation treatment pharyngitis medicine of the Dendrobium officinale fruit extract |
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| Publication Number | Publication Date |
|---|---|
| CN103735857A CN103735857A (en) | 2014-04-23 |
| CN103735857B true CN103735857B (en) | 2017-01-04 |
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| CN201310699189.3A Expired - Fee Related CN103735857B (en) | 2013-12-18 | 2013-12-18 | The application in preparation treatment pharyngitis medicine of the Dendrobium officinale fruit extract |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102319364A (en) * | 2011-09-22 | 2012-01-18 | 澄思源生物科技（上海）有限公司 | Manufacturing method of dendrobium candidum wallex lindll pure powder tablets |
| CN102552699A (en) * | 2012-01-16 | 2012-07-11 | 澄思源生物科技（上海）有限公司 | Preparation method of dendrobium candidum ultrafine powder |
-
2013
- 2013-12-18 CN CN201310699189.3A patent/CN103735857B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102319364A (en) * | 2011-09-22 | 2012-01-18 | 澄思源生物科技（上海）有限公司 | Manufacturing method of dendrobium candidum wallex lindll pure powder tablets |
| CN102552699A (en) * | 2012-01-16 | 2012-07-11 | 澄思源生物科技（上海）有限公司 | Preparation method of dendrobium candidum ultrafine powder |
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| CN103735857A (en) | 2014-04-23 |
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Effective date of registration: 20171102 Address after: 537500, 267, Chengnan Avenue, Rong Zhou Town, Yulin, the Guangxi Zhuang Autonomous Region, Rongxian County Patentee after: Guangxi rainbow boiler Co., Ltd Address before: 537500 the Guangxi Zhuang Autonomous Region, Yulin, South Road, No. 267, Patentee before: Guangxi strong gem dry measure used in former times Co., Ltd |
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Granted publication date: 20170104 Termination date: 20171218 |