CN103735737A - Composition for treating hyperlipemia - Google Patents
Composition for treating hyperlipemia Download PDFInfo
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- CN103735737A CN103735737A CN201410037777.5A CN201410037777A CN103735737A CN 103735737 A CN103735737 A CN 103735737A CN 201410037777 A CN201410037777 A CN 201410037777A CN 103735737 A CN103735737 A CN 103735737A
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Abstract
The invention belongs to the field of biological medicines and relates to a composition for treating hyperlipemia. The composition is mainly prepared from hawthorn, wolfberry and dodder as main raw materials. The composition disclosed by the invention has the characteristics of definite treatment effect, safety and reliability, convenience in taking, low price and the like and is suitable for long-term use.
Description
Technical field
The invention belongs to biomedicine field, relate to a kind of compositions for the treatment of hyperlipemia.
Background technology
Cardiovascular diseases has become first cause of death of China city and rural crowd, and China cardiovascular diseases's feature is that apoplexy is occurred frequently and Incidence of CHD is lower, but recent 20 years Incidence of CHD and mortality rate progressively rise; Economic development faster big city as Beijing, monitoring result shows, from 1984 to 1999, hemorrhagic apoplexy sickness rate was obvious downward trend, and cerebral infarction sickness rate obviously rises, indication turns to basic ischemic cardiovascular (comprising coronary heart disease and cerebral infarction) sickness rate with Atherosclerosis and raises.Research shows, serum total cholesterol (total cholesterol, TC) or low-density lipoprotein cholesterol (low density lipoproten-cholesterol, LDL-C) to raise be one of independent hazard factor of occurring of coronary heart disease and cerebral infarction.For this reason, to the control of dyslipidemia, must attach the importance early.
Blood fat refers to that cholesterol, triglyceride (triglyceide, TG) and lipoid in blood plasma is as the general name of phospholipid etc.With clinical closely-related blood fat be mainly cholesterol and triglyceride, other also have free fatty (FFA) and phospholipid etc.At cholesterol in human body, mainly with free cholesterol and cholesteryl ester form, exist.Triglyceride is that three hydroxyls in glycerol molecule are formed by fatty acid esterification.Cholesterol in blood circulation and triglyceride must be that apolipoprotein (apolipoprotein, ap) combination forms lipoprotein with special protein, just can be transported to tissue and carry out metabolism.
Because dyslipidemia and diet and life style have substantial connection, so Diet Therapy and the mode of making the life better are the basic measures of dyslipidemia treatment.Whether carrying out medicine adjusts fat treatment all must adhere to keeping on a diet and making the life better mode.According to the type of dyslipidemia and the treatment object that need to reach, select suitable lipid-regulation medicine.Need to regularly adjust the monitoring of fat curative effect and adverse effect.When determining to adopt medicine to adjust fat treatment, need to fully understand the risk factor situation that patient suffers from coronary heart disease and follows.When adjusting fat treatment, should will reduce LDL-C as primary goal.Determine to start medicine when adjusting fat treatment and drafting the desired value reaching clinically, need to consider that whether simultaneously and deposit the Major Risk Factors (i.e. risk factor except LDL-C) of other coronary heart disease patient.The Major Risk Factors of analyzing these coronary heart disease judges by helping the degree of danger of suffering from coronary heart disease, determines to reduce thus the desired value of LDL-C.
The lipid-regulation medicine of at present Gong selecting clinically is mainly divided into five classes: (1) Statins; (2) the special class of shellfish; (3) nicotinic acid class; (4) resinae; (5) cholesterol absorption inhibitor.But individual have very large individual variation to curative effect of medication and side effect, and side effect is many, and generally needs long-term taking.So only after diet and Exercise therapy for treatment of knee joint, just on probation in the time of still can not effectively reducing blood fat.
Summary of the invention
The object of the invention is the deficiency in controlling for above-mentioned blood fat and a kind of compositions for the treatment of hyperlipemia is provided.
To be said composition be comprised of the component of following weight proportion technical solution of the present invention: Fructus Crataegi 10-30 part, Fructus Lycii 6-12 part, Semen Cuscutae 9-15 part.
Below primary raw material used in the present invention is set forth one by one.
Fructus Crataegi: this product is the mature fruit of rosaceous plant Fructus Pyri Pashiae Crataegus pinnatifida Bge.var.major N.E.Br. or Fructus Crataegi C.pinnatifida Bge..Main product in Henan, the ground such as Shandong, Hebei, good with the large matter of Shandong output.Mostly be cultivation product.Gather during fruit maturation autumn.Section, dry.Raw using or stir-fry use.Sour in the mouth, sweet, slightly warm in nature.Return spleen, stomach, Liver Channel.There is promoting digestion and removing stagnation, the effect of circulation of qi promoting dissipating blood stasis.Fructus Crataegi is containing flavonoid, triterpene saponin (ursolic acid, oleanolic acid, Crataegolic acid etc.), saponin tannin, free acid, fatty acid, vitamin C, inorganic salt, red pigment etc.Institute's fatty acids can promote fat digestion, and increases the secretion of peptic digestion enzyme and facilitating digestion, and gastrointestinal function is had to certain Accommodation.Its extract energy coronary artery dilator, increases coronary flow, Ischemic myocardium anoxia; And can heart tonifying, blood pressure lowering and arrhythmia; Blood fat reducing again, atherosclerosis, it reduces serum cholesterol and triglyceride, may be that the excretion that increases cholesterol realizes by improving serum middle-high density cholesterol and subfraction concentration thereof.
Fructus Lycii: be the mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Main product in Ningxia, the ground such as Gansu, Xinjiang.Two autumn of autumn in summer gathers when fruit is orange red, dries in the air to rhicnosis, then shines to crust stiffly, and sarcocarp is soft, raw using.Sweet in the mouth, property is flat.Return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.This product is containing compositions such as betanin, polysaccharide, crude fat, crude protein, thiamine, riboflavin, nicotinic acid, carotene, ascorbic acid, nicotinic acid, cupreol, linoleic acid, trace element and aminoacid.Fructus Lycii has facilitation to immunity, has immunoregulation effect simultaneously; Can improve plasma testosterone level, play strong effect; Hemopoietic function is had to facilitation; Normal healthy people is also had to remarkable effect in increasing leukocyte; Also have defying age, mutation, antitumor, blood fat reducing, protect the liver and anti-fatty liver, blood sugar lowering, hypotensive activity.
Semen Cuscutae: be the mature seed of convolvulus cuscuta plant Cuscuta chinensis Lam. or cuscuta japonica Choisy C.japonica Choisy.All there is distribution China most areas.Extract aerial parts during fruit maturation autumn, dries, and lays seed.Raw use, or boil to mash and be used as cake.Acrid in the mouth, sweet is flat.Return kidney,liver,spleen warp.The kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, antidiarrheal is antiabortive.Semen Cuscutae water decoction can obviously strengthen Drosophila melanogaster number of copulations; Semen Cuscutae gavage has therapeutical effect to rat galactose-cataract; The continuous gavage of Semen Cuscutae water decoction 1 month, can obviously strengthen the activity of murine myocardium homogenate lactic acid dehydrogenase, and the lactic acid dehydrogenase of myocardium catalase and cerebral tissue and catalase activity are had to enhancing trend.
The compositions of foregoing invention, can also contain appropriate pharmaceutics acceptable carrier, comprise excipient and adjuvant, described excipient and adjuvant have starch, microcrystalline Cellulose, inorganic salts, hydroxypropyl emthylcellulose, ethyl cellulose, polyacrylic resin class, polycarboxy ethene, the solubility of alginic acid/insoluble salt, octadecanol, stearic acid, sucrose, dextrin, lactose, Icing Sugar, glucose, sodium chloride, cysteine, the compositions of one or more materials of citric acid and sodium sulfite etc., coating material comprises Lac, cellulose acetate, CAP, ethyl cellulose, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, crylic acid resin, polyvinyl acetate phthalic acid ester, Hydroxypropyl Methyl Cellulose Phthalate, succinic acid acetic acid hydroxypropyl methylcellulose, hydroxypropylmethylcellulose acetate methylcellulose phthalate ester, glyceryl monostearate, and the various medicaments adjuvant such as plasticizer and porogen.
A kind of dosage form for the treatment of the compositions of hyperlipemia of the present invention is pill or tablet or granule or capsule.
A kind of compositions for the treatment of hyperlipemia provided by the invention has determined curative effect, safe and reliable, taking convenience, lower-price characteristic, suitable long-term taking.
The specific embodiment
Embodiment 1. main raw materials in proportion
10 parts of Fructus Crataegis, 6 parts of Fructus Lyciis, 15 parts of Semen Cuscutae.
Extracting method is as follows:
Medical material is pulverized by weight ratio, added 10 times of amount 75% ethanol, flash continuous extraction 3 times, each 5 minutes, merge extractive liquid,, sucking filtration, reclaim under reduced pressure is dry, standby.
Embodiment 2. main raw materials in proportion
30 parts of Fructus Crataegis, 12 parts of Fructus Lyciis, 9 parts of Semen Cuscutae.
Extracting method is as follows with embodiment 1.
Embodiment 3. regulates the effect Journal of Sex Research of blood fat
Test method: rat adaptability is raised after 5d, according to content of triglyceride, animal is divided into 3 groups, 12 every group.Negative control group gives normal diet, and model control group and administration group give high fat diet, feeds and within 28 days, measures afterwards on an empty stomach content of triglyceride after 12h.
Result of the test: feed and finish rear model control group blood fat for 28 days and significantly increase; With model control group comparison, the equal significance of prevention administration group blood fat reduces (table 1).
Table 1 is fed and within 28 days, is finished rear animal lipid content
With model control group comparison
△p < 0.05
Conclusion (of pressure testing): the present composition can reduce tested rat blood serum content of triglyceride, prompting has the effect that regulates blood fat.
Claims (1)
1. treat a compositions for hyperlipemia, it is characterized in that being formed by the component of following weight proportion: Fructus Crataegi 10-30 part, Fructus Lycii 6-12 part, Semen Cuscutae 9-15 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410037777.5A CN103735737A (en) | 2014-01-26 | 2014-01-26 | Composition for treating hyperlipemia |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410037777.5A CN103735737A (en) | 2014-01-26 | 2014-01-26 | Composition for treating hyperlipemia |
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| CN103735737A true CN103735737A (en) | 2014-04-23 |
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| CN201410037777.5A Pending CN103735737A (en) | 2014-01-26 | 2014-01-26 | Composition for treating hyperlipemia |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106668326A (en) * | 2017-03-02 | 2017-05-17 | 江苏康缘药业股份有限公司 | Traditional Chinese medicine composition for treating hyperlipemia and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225120A (en) * | 2011-06-16 | 2011-10-26 | 安徽安科生物工程（集团）股份有限公司 | Medicine for treating fatty liver and preparation method thereof |
-
2014
- 2014-01-26 CN CN201410037777.5A patent/CN103735737A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225120A (en) * | 2011-06-16 | 2011-10-26 | 安徽安科生物工程（集团）股份有限公司 | Medicine for treating fatty liver and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 段晓猛: "《高血脂防治与用餐》", 30 June 2009, 内蒙古人民出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106668326A (en) * | 2017-03-02 | 2017-05-17 | 江苏康缘药业股份有限公司 | Traditional Chinese medicine composition for treating hyperlipemia and preparation method thereof |
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Application publication date: 20140423 |