CN103461980A - Health food with function of adjusting blood fat - Google Patents
Health food with function of adjusting blood fat Download PDFInfo
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- CN103461980A CN103461980A CN2012101875088A CN201210187508A CN103461980A CN 103461980 A CN103461980 A CN 103461980A CN 2012101875088 A CN2012101875088 A CN 2012101875088A CN 201210187508 A CN201210187508 A CN 201210187508A CN 103461980 A CN103461980 A CN 103461980A
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Abstract
The invention belongs to the field of biological medicine, and relates to health food with function of adjusting blood fat. The health food is prepared by taking haw, gynostemma pentaphylla, cassia seed and red koji as main raw materials according to a conventional preparation technology. The health food is developed by combining modern newest scientific research accomplishments based on traditional Chinese medicine syndrome differentiation and treatment. The health food provided by the invention has the characteristics of definite therapeutic effect, safety, reliability, convenient taking, low price and the like, and is suitable for long-term taking.
Description
Technical field
The invention belongs to biomedicine field, relate to a kind of health food of regulating blood fat function that has.
Background technology
Cardiovascular disease has become first dead disease of China city and rural crowd, and the characteristics of China's cardiovascular disease are that cerebral apoplexy is occurred frequently and Incidence of CHD is lower, but recent 20 years Incidence of CHD and the death rate progressively rise.Economic development faster big city as Beijing, monitoring result shows, from 1999 to 2009, the hemorrhagic apoplexy incidence of disease was obvious downward trend, and the cerebral arterial thrombosis incidence of disease obviously rises, indication turns to basic ICD (comprising coronary heart disease and the cerebral arterial thrombosis) incidence of disease with Atherosclerosis and raises.Research shows, serum total cholesterol (total cholesterol, TC) or LDL-C (low density lipoproten-cholesterol, LDL-C) to raise be one of independent hazard factor of occurring of coronary heart disease and cerebral arterial thrombosis.For this reason, to the control of dyslipidemia, must attach the importance early.
Blood fat refers to cholesterol, triglycerides (triglyceide, TG) and lipoid in the blood plasma general name as phosphatide etc.With clinical closely-related blood fat be mainly cholesterol and triglycerides, other also have free fatty and phosphatide etc.At cholesterol in human body, mainly with CHF and cholesteryl ester form, exist.Triglycerides is that three hydroxyls in glycerol molecule are formed by fatty acid esterification.Cholesterol in blood circulation and triglycerides must be that apolipoprotein (apolipoprotein, ap) combination forms lipoprotein with special protein, just can be transported to tissue and carry out metabolism.
Because dyslipidemia and diet and life style have substantial connection, so dietary therapy and the mode of making the life better are the basic measures of dyslipidemia treatment.Whether carrying out medicine adjusts the fat treatment all must adhere to keeping on a diet and making the life better mode.The purpose that need to reach according to the type of dyslipidemia and treatment, select suitable lipid-regulation medicine.Need to regularly be adjusted the monitoring of fat curative effect and adverse drug reaction.When determining to adopt medicine to be adjusted the fat treatment, the hazards situation that needs the overall understanding patient to suffer from coronary heart disease and follow.When being adjusted the fat treatment, should will reduce LDL-C as primary goal.Determine to start medicine when adjusting the fat treatment and drafting the desired value reached clinically, needing to consider that whether simultaneously and deposit the Major Risk Factors (i.e. hazards except LDL-C) of other coronary heart disease the patient.The Major Risk Factors of analyzing these coronary heart disease will help the degree of danger that coronary heart disease is suffered from judgement, determine to reduce thus the desired value of LDL-C.
The lipid-regulation medicine of at present Gong selecting clinically mainly is divided into five classes: (1) Statins; (2) the special class of shellfish; (3) nicotinic acid class; (4) resinae; (5) cholesterol absorption inhibitor.But individual have very large individual difference to curative effect of medication and side effect, and side effect is many, and generally needs long-term taking.So only after diet and Exercise therapy for treatment of knee joint, just on probation in the time of still can not effectively reducing blood fat.
Summary of the invention
The objective of the invention is provides a kind of effect to regulate significantly the health food of blood fat for the deficiency in above-mentioned blood fat control.
Technical solution of the present invention is that the health food of this adjusting blood fat function is comprised of the component of following weight proportion: 113 ~ 163 parts of hawthorn, 66 ~ 103 parts of gynostemma pentaphylla, 37 ~ 77 parts of cassia seeds, 47 ~ 87 parts, red colouring agent for food, also used as a Chinese medicine.
Preferably, the component that health food of the present invention contains the following weight proportioning: 130 ~ 160 parts of hawthorn, 75 ~ 95 parts of gynostemma pentaphylla, 50 ~ 70 parts of cassia seeds, 60 ~ 80 parts, red colouring agent for food, also used as a Chinese medicine.
More preferably, the component that health food of the present invention contains the following weight proportioning: 150 parts of hawthorn, 85 parts of gynostemma pentaphylla, 60 parts of cassia seeds, 70 parts, red colouring agent for food, also used as a Chinese medicine.
Below primary raw material used in the present invention is set forth one by one.
Hawthorn: the ripening fruits that this product is rosaceous plant large-fruited Chinese hawthorn Crataegus pinnatifida Bge.var.major N.E.Br. or hawthorn C.pinnatifida Bge..Main product in Henan, the ground such as Shandong, Hebei, good with the large matter of Shandong output.Mostly be the cultivation product.Gather during fruit maturation autumn.Section, drying.Give birth to or fry and use.Flavor acid, sweet, slightly warm in nature.Return spleen, stomach, Liver Channel.There is promoting digestion and removing indigestion, the effect of the loose stasis of blood of promoting the circulation of qi.Hawthorn is containing flavonoids, triterpene saponin (ursolic acid, oleanolic acid, crataegolic acid etc.), saponin(e tannin, free acid, aliphatic acid, vitamin C, inorganic salts, haematochrome etc.Institute's fatty acids can promote fat digestion, and increases the secretion of peptic digest enzyme and promote digestion, and gastrointestinal function is had to certain corrective action.Its extract energy coronary artery dilator, increase coronary flow, the Ischemic myocardium anoxic; But and cardiac stimulant, hypotensive and anti-arrhythmia; Reducing blood lipid again, antiatherosclerosis, it reduces serum cholesterol and triglycerides, may be that the excretion that increases cholesterol realizes by improving serum middle-high density cholesterol and subfraction concentration thereof.
Gynostemma pentaphylla: be rhizome or the herb of cucurbitaceous plant gynostemma pentaphylla Gynostemma pentaphllam (Thunb.) Makino.Main product in Guangdong, the ground such as Yunnan, Sichuan, Fujian.Wild or family plants, and gather autumn, cleans, and dries, and segment, give birth to and use.Distinguish the flavor of sweet, bitter, cold in nature.Return spleen, lung channel.Have and replenish qi to invigorate the spleen, preventing phlegm from forming and stopping coughing, the effect such as clearing heat and detoxicating.This product is containing more than 80 kind of saponin(e, wherein have 6 kinds similar to ginsenoside.Also contain carbohydrate, flavonoids, vitamin C, and 18 seed amino acids and multiple inorganic elements etc.Gynostemma pentaphylla and gypenoside all have antifatigue, anti-anoxic, high temperature resistance, anti-low temperature, extend the life-span of biological cell and fruit bat, mouse, energy is the increased SOD activity obviously, reduces the content of the heart, brain, liver cell lipofuscin, prevent the normal cell cancerization, improve tumor animal immunity; Can obviously increase the function of nospecific immunity, cellular immunity, humoral immunity, and the tool immunoregulation effect; There is obvious reducing blood lipid, hypoglycemic activity, and can improve the synthesis rate of spleen, testis, brain and hematoglobin protein, and there is calmness, hypnosis, analgesia, increase coronary flow, resist myocardial ischemia, increase cerebral blood flow (CBF), suppress thrombosis, protect the liver, the effect such as antiulcer.
Cassia seed: be the dry mature seed of legume Cassia tora Cassia obtusifolia L. or little Cassia tora C.tora L..All there is cultivation north and south various places, the whole nation, main product in Anhui, the ground such as Guangxi, Sichuan, Zhejiang, Guangdong, the ripening fruits of gathering autumn, dry, and lays seed, removes impurity.Give birth to use, or fry and use.Distinguish the flavor of sweet, bitter, salty, cold nature.Return liver, large intestine channel.Have removing heat to brighten vision, the effect such as relax bowel.This product master is containing anthraquinones such as Rheins, archen, aloe-emodin, cassia seed element, orange cassia seed element, obtusin, and the naphthazole letones such as Cassiaside, Cassia tora ketone, toralactone; In addition, still containing sterol, aliphatic acid, carbohydrate, protein etc.The water-leach liquor of this product, pure water-leach liquor and the alcohol leaching liquid effect of reducing blood pressure; This product has the effect that reduces total plasma cholesterol and triglyceride; Its parenteral solution can make the mouse thymus atrophy, and the phagocyte phagocytic function is had to humidification; Its contained anthraquinones has the discharge function of mitigation; After its alcohol extract is removed alcohol, staphylococcus aureus, staphylococcus albus, tangerine look staphylococcus, corynebacterium diphtheriae, bacillus megaterium, typhoid bacillus, paratyphosum Bacterium, Bacillus paratyphosus B and Escherichia coli are all had to inhibitory action; Its infusion has inhibitory action in various degree to dermatophyte.
Red colouring agent for food, also used as a Chinese medicine: the traditional Chinese medicine that is a kind of medicine-food two-purpose.Begin for the Tang Dynasty, the history of existing more than 1,000 year is subject to successive dynasties people's favor always so far.Ming Dynasty Song answers the star Exploitation of the Works of Nature, Li Shizhen (1518-1593 A.D.) Compendium of Material Medica to do more comprehensive record to red colouring agent for food, also used as a Chinese medicine, thinks that it has the effect of " break blood, invigorate blood circulation ".Modern science proves: the effect of red colouring agent for food, also used as a Chinese medicine not only is to contain antibacterial material, help digest various enzymes and the several amino acids of nourishing the stomach, the more important thing is and can produce multiple blood fat-reducing blood pressure-decreasing active material, as y-aminobutyric acid, N-acetyl-glucosamine and ergosterol, the rate-limiting enzyme HMG-COA that especially can produce synthetic cholesterol has special inhibitory action material---Lovastatin.
In the health food of the invention described above, can also contain appropriate pharmacy acceptable carrier, comprise excipient and auxiliary material, described excipient and auxiliary material have starch, microcrystalline cellulose, inorganic salts, hydroxypropyl methylcellulose, ethyl cellulose, the polyacrylic resin class, polycarboxy ethene, the solubility of alginic acid/insoluble salt, 18 alcohol, stearic acid, sucrose, dextrin, lactose, Icing Sugar, glucose, sodium chloride, cysteine, the composition of one or more materials of citric acid and sodium sulfite etc., coating material comprises shellac, cellulose acetate, CAP, ethyl cellulose, hydroxypropyl methylcellulose, hydroxypropyl cellulose, crylic acid resin, the polyvinyl acetate phthalic acid ester, Hydroxypropyl Methyl Cellulose Phthalate, butanedioic acid acetic acid HPMC, hydroxypropylmethylcellulose acetate methylcellulose phthalate ester, glycerin monostearate, and the various medicaments auxiliary materials such as plasticizer and pore-foaming agent.
Formulation with health food of regulating blood fat function of the present invention is pill or tablet or granule or capsule.
Health food provided by the invention has determined curative effect, safe and reliable, taking convenience, lower-price characteristic, suitable long-term taking.
The specific embodiment
Embodiment 1. main raw materials in proportion
150 parts of hawthorn, 85 parts of gynostemma pentaphylla, 60 parts of cassia seeds, 70 parts, red colouring agent for food, also used as a Chinese medicine.
Extracting method is as follows:
Medicinal material is pulverized by weight ratio, added 10 times of amount 75% ethanol, flash continuous extraction 3 times, each 5 minutes, merge extract, suction filtration, the recovered under reduced pressure drying, standby.
Embodiment 2. main raw materials in proportion
113 parts of hawthorn, 66 parts of gynostemma pentaphylla, 77 parts of cassia seeds, 87 parts, red colouring agent for food, also used as a Chinese medicine.
Extracting method is as follows:
Medicinal material is pulverized by weight ratio, added 10 times of amount 80% ethanol, flash continuous extraction 3 times, each 5 minutes, merge extract, suction filtration, the recovered under reduced pressure drying, standby.
Embodiment 3. main raw materials in proportion
163 parts of hawthorn, 103 parts of gynostemma pentaphylla, 37 parts of cassia seeds, 47 parts, red colouring agent for food, also used as a Chinese medicine.
Extracting method is as follows:
Medicinal material is pulverized by weight ratio, added 8 times of amount 70% ethanol, flash continuous extraction 3 times, each 5 minutes, merge extract, suction filtration, the recovered under reduced pressure drying, standby.
Embodiment 4. effect of regulating blood fat Journal of Sex Research
Test method: after rat adaptability is raised to 5d, 12h serum triglyceride (TC) content is on an empty stomach measured in blood sampling, according to content of triglyceride, animal is divided into to 5 groups, and 12 every group, male and female half and half.Negative control group gives normal diet, and model control group and three administration groups give high fat diet, feeds and within 28 days, measures afterwards on an empty stomach triglycerides and cholesterol level after 12h.
Result of the test: after feeding end in 28 days, the model control group blood fat significantly increases; With model control group, compare, prophylactic is respectively organized the equal conspicuousness of blood fat and is reduced (table 1).
Table 1 is fed and within 28 days, is finished rear animal lipid content
With model control group, compare
△p<0.05,
△ △p<0.01
Conclusion (of pressure testing): health food of the present invention can reduce T-CHOL and the triglyceride content of tested rat blood serum, and prompting has the effect of regulating blood fat, can be developed further into health food.
Claims (4)
1. one kind has the health food of regulating blood fat function, it is characterized in that being comprised of the component of following weight proportion: 113 ~ 163 parts of hawthorn, 66 ~ 103 parts of gynostemma pentaphylla, 37 ~ 77 parts of cassia seeds, 47 ~ 87 parts, red colouring agent for food, also used as a Chinese medicine.
2. a kind of health food of regulating blood fat function that has according to claim 1, is characterized in that being comprised of the component of following weight proportion: 130 ~ 160 parts of hawthorn, 75 ~ 95 parts of gynostemma pentaphylla, 50 ~ 70 parts of cassia seeds, 60 ~ 80 parts, red colouring agent for food, also used as a Chinese medicine.
3. according to the described a kind of health food of regulating blood fat function that has of claim 1 ~ 2, it is characterized in that being formed by the component of following weight proportion: 150 parts of hawthorn, 85 parts of gynostemma pentaphylla, 60 parts of cassia seeds, 70 parts, red colouring agent for food, also used as a Chinese medicine.
4. according to the described a kind of health food of regulating blood fat function that has of claim 1 ~ 3, the formulation that it is characterized in that described health food is pill or tablet or granule or capsule.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101875088A CN103461980A (en) | 2012-06-08 | 2012-06-08 | Health food with function of adjusting blood fat |
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| CN2012101875088A CN103461980A (en) | 2012-06-08 | 2012-06-08 | Health food with function of adjusting blood fat |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103960730A (en) * | 2014-05-22 | 2014-08-06 | 汤敏 | Rhodiola rosea beverage and preparation method thereof |
| CN106729092A (en) * | 2016-12-29 | 2017-05-31 | 山东龙力生物科技股份有限公司 | A kind of blood fat reducing preparation containing xylo-oligosaccharide and its preparation method and application |
-
2012
- 2012-06-08 CN CN2012101875088A patent/CN103461980A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103960730A (en) * | 2014-05-22 | 2014-08-06 | 汤敏 | Rhodiola rosea beverage and preparation method thereof |
| CN106729092A (en) * | 2016-12-29 | 2017-05-31 | 山东龙力生物科技股份有限公司 | A kind of blood fat reducing preparation containing xylo-oligosaccharide and its preparation method and application |
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Application publication date: 20131225 |