CN106668326A - Traditional Chinese medicine composition for treating hyperlipemia and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating hyperlipemia and preparation method thereof Download PDFInfo
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention provides a traditional Chinese medicine composition for treating hyperlipemia, prepared from the following components: 10-15 parts by weight of pummelo peel, 10-15 parts by weight of cortex dictamni, 7-9 parts by weight of lotus leaves, 7-9 parts by weight of radix codonopsitis, 7-9 parts by weight of root of kudzuvine, 7-9 parts by weight of dodder, 7-9 parts by weight of wolfberry, 7-9 parts by weight of hawthorn and 7-9 parts by weight of costus root. The traditional Chinese medicine composition provided by the invention has the efficacies of eliminating dampness, eliminating phlegm, removing dampness through diuresis and strengthening spleen, is suitable for treating hyperlipemia with repression of phlegm dampness, has the advantages of simple preparation, obvious curative effects, no toxic or side effects and high safety, and is favorable for relieving the symptoms of patients.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, more particularly to a kind of Chinese medicine composition for treating hyperlipemia and its preparation side
Method.
Background technology
Hyperlipemia is a kind of disease that internal disorders of lipid metabolism causes serum lipids concentration level beyond normal range (NR),
And thus trigger a series of illness of clinical case performances.Research shows, hyperlipemia and cardiac sudden death, myocardial infarction, blood high
The morbidity of pressure, fatty liver, diabetes etc. suffers from substantial connection.
Most hyperlipemias are the result that family genetic defect interacts with environmental factor, quite a few primary
There are one or more genetic defects in hyperlipemia；Additionally, bad eating habit, Underactivity, smoking, excessive drinking
Etc. being also the factor that causes hyperlipemia.
The illness rate of China's high fat of blood substantially rises, so anti-curing hyperlipemia is to extending the life-span, improving the quality of living
There is highly important meaning.
The content of the invention
In view of this, the technical problem to be solved in the present invention be provide a kind of Chinese medicine composition for treating hyperlipemia and
Its preparation method, has preferable curative effect to hyperlipemia.
The invention provides a kind of Chinese medicine composition for treating hyperlipemia, including：
The present invention with Exocarpium Citri Grandis, the root bark of shaggy-fruited dittany as monarch drug in a prescription, with heat-clearing, eliminating dampness, resolving sputum effect, the two clinically constitute from
Phlegm-blood stasis opinion is controlled.Exocarpium Citri Grandis, it is eliminating dampness and eliminating phlegm, there are good effects to eating accumulation；The root bark of shaggy-fruited dittany, clearing heat and promoting diuresis, for being caused because damp and hot
Various illnesss.The two synergy, with clearing heat and promoting diuresis, it is eliminating dampness and eliminating phlegm the effect of, with the domination of pathogen that eliminating phlegm stasis blocking is stagnant.
Wherein, the content of Exocarpium Citri Grandis is 10~15 weight portions, preferably 10~12 weight portions, and some are specific of the invention
In embodiment, its content is 10 weight portions, 12 weight portions or 15 weight portions.
The content of the root bark of shaggy-fruited dittany is 10~15 weight portions, preferably 10~12 weight portions, in some specific implementations of the invention
In example, its content is 10 weight portions, 12 weight portions or 15 weight portions.
Lotus leaf, Radix Codonopsis, the root of kudzu vine are ministerial drug.Lotus leaf bitter, puckery, mild-natured, energy dampness removing.Radix Codonopsis, tonifying middle-Jiao and Qi, invigorating the spleen and stomach；
The root of kudzu vine, can hair tonic taste yang-energy；Three shares, and to attain dampness removing invigorating the spleen, dissolve the turbid effect of fat, can mend deficiency of the spleen causing weakness of QI originally.
Wherein, the content of lotus leaf is 7~9 weight portions, preferably 7~8 weight portions, in some embodiments of the invention
In, its content is 8 weight portions.
The content of Radix Codonopsis be 7~9 weight portions, preferably 7~8 weight portions, in some embodiments of the invention, its
Content is 8 weight portions.
The content of the root of kudzu vine be 7~9 weight portions, preferably 7~8 weight portions, in some embodiments of the invention, its
Content is 8 weight portions.
The effect that Semen Cuscutae, the fruit of Chinese wolfberry are respectively provided with tonifying kidney and benefiting sperm, nourish the liver to improve visual acuity, can make nourishing liver and kidney, reinforcing grease removal and be used,
Two medicines are adjutant.
Wherein, the content of Semen Cuscutae is 7~9 weight portions, preferably 7~8 weight portions, in some specific implementations of the invention
In example, its content is 8 weight portions.
The content of the fruit of Chinese wolfberry be 7~9 weight portions, preferably 7~8 weight portions, in some embodiments of the invention,
Its content is 8 weight portions.
Crataegolic acid is sweet, and tepor is not hot, arrogates to oneself promoting digestion and removing indigestion, digestion is arrogated to oneself especially greasy；The banksia rose, dispersing stagnated hepatoqi, reinforcing spleen to promote digestion；Two medicines
Share, up to the effect of orderly and clearly mechanism of qi, promotion transporting and transforming function of the spleen and stomach, to be taken as making medicine.
The content of hawthorn be 7~9 weight portions, preferably 7~8 weight portions, in some embodiments of the invention, its
Content is 8 weight portions.
The content of the banksia rose be 7~9 weight portions, preferably 7~8 weight portions, in some embodiments of the invention, its
Content is 8 weight portions.
Used as some embodiments of the invention, the Chinese medicine composition includes：
The weight portion of Exocarpium Citri Grandis 10；The weight portion of the root bark of shaggy-fruited dittany 10；The weight portion of lotus leaf 8；The weight portion of Radix Codonopsis 8；The weight portion of the root of kudzu vine 8；Tu
Sub 8 weight portion of silk；The weight portion of the fruit of Chinese wolfberry 8；The weight portion of hawthorn 8 and the weight portion of the banksia rose 8；
Or including the weight portion of Exocarpium Citri Grandis 12；The weight portion of the root bark of shaggy-fruited dittany 12；The weight portion of lotus leaf 8；The weight portion of Radix Codonopsis 8；The weight of the root of kudzu vine 8
Amount part；The weight portion of Semen Cuscutae 8；The weight portion of the fruit of Chinese wolfberry 8；The weight portion of hawthorn 8 and the weight portion of the banksia rose 8；
Or including the weight portion of Exocarpium Citri Grandis 15；The weight portion of the root bark of shaggy-fruited dittany 15；The weight portion of lotus leaf 8；The weight portion of Radix Codonopsis 8；The weight of the root of kudzu vine 8
Amount part；The weight portion of Semen Cuscutae 8；The weight portion of the fruit of Chinese wolfberry 8；The weight portion of hawthorn 8 and the weight portion of the banksia rose 8.
The present invention provide above-mentioned Chinese medicine composition can also include pharmaceutically acceptable auxiliary material, be prepared into granule,
Tablet, capsule or pill.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, i.e., water extraction and alcohol precipitation are carried out successively to bulk drug.
It specifically includes following steps：
A) each bulk drug is mixed, extraction 2~5 times is added water to cook, 1~3 hour every time, extract solution is filtered to obtain；
B the extract solution) is concentrated into 50 DEG C of relative densities 1.08~1.10, concentrate is obtained；
C) concentrate is mixed with ethanol, is 60%~70% to alcohol content, carry out alcohol precipitation, obtain alcohol precipitation supernatant
Liquid；
D) by the alcohol precipitation supernatant concentration to 50 DEG C of relative densities 1.25~1.28, concentrate is obtained；
E) step D) concentrate that obtains is through being dried to obtain the Chinese medicine composition.
Above-mentioned nine tastes medicinal material is carried out into water extraction jointly first, extraction 2~5 times is added water to cook, 1~3 hour every time, filtered
Filtrate, the filtrate of multiple water extraction is merged.The mass ratio of water and each bulk drug total amount is preferably 9~15：1.
In some embodiments of the invention, 10 times of water of weight are added to extract 2 times, every time 2 hours.
Then the extract solution that will be obtained is concentrated into 50 DEG C of relative densities 1.08~1.10, obtains concentrate.The temperature of the concentration
Degree is preferably 55~70 DEG C.
After concentrate is cooled to room temperature, the concentrate is mixed with ethanol, be 60%~70% to alcohol content, stand 24
Hour or so, alcohol precipitation is carried out, obtain alcohol precipitation supernatant.The ethanol is preferably 95% ethanol.In some specific realities of the invention
Apply in example, it is 60% to add 95% ethanol to alcohol content.
Then the alcohol precipitation supernatant concentration that will be obtained, to 50 DEG C of relative densities 1.25~1.28, obtains concentrate.
Finally the concentrate for obtaining is dried.The present invention is to the drying means and is not particularly limited, and can be this
Drying means known to art personnel.
In some embodiments of the invention, concentrate is dried using band-type vacuum drier, belt is true
The temperature setting of empty drying machine is 99,95,100 DEG C, and the time is 2~4 hours, and dried solids is ground into fine powder, crosses 80
Mesh sieve, obtains final product the Chinese medicine composition.The dry time is preferably 2h.
After drying, the Chinese medicine composition can be made corresponding agent according to technique well known to those skilled in the art
Type.
When the Chinese medicine composition is granule, dried solids is crushed, sieving, then is with auxiliary materials and mixing granulation
Can.
When the Chinese medicine composition is tablet, dried solids is crushed, sieving, then with auxiliary materials and mixing pelletizing press sheet
.
When the Chinese medicine composition is capsule, dried solids is crushed, sieving, then is filled with auxiliary materials and mixing granulation
Capsule.
When the Chinese medicine composition is decoction, Chinese medicine material is made decoction through water extraction, concentration.
The effect of Chinese medicine composition that the present invention is provided has eliminating dampness and eliminating phlegm, dampness removing invigorating the spleen, it is adaptable to treat phlegm wet and check
Type hyperlipemia.And prepare simple, and it is evident in efficacy, have no toxic side effect, it is safe, be conducive to sufferer to mitigate symptom.
Specific embodiment
In order to further illustrate the present invention, the Chinese medicine group of the treatment hyperlipemia provided the present invention with reference to embodiment
Compound and preparation method thereof is described in detail.
Embodiment 1
The preparation of medicinal granule
Step 1, extraction：The above-mentioned common water extraction of nine tastes medicinal material, plus 10 times of water boiling and extractions of weight 2 times, 2 hours every time,
Filter to get filtrate, the filtrate of multiple water extraction is merged；
Step 2, extract solution concentration：Extract solution after merging is carried out to be concentrated to give concentrate, thickening temperature is 55~70 DEG C,
Relative density when being concentrated into 50 DEG C is 1.08~1.10；
Step 3, alcohol precipitation：After extraction concentrate is cooled to room temperature, the ethanol for adding volume fraction to be 95% reaches alcohol content
60%, 24 hours are stood, take alcohol precipitation supernatant；
Step 4, alcohol precipitation supernatant concentration：Alcohol precipitation supernatant is carried out to be concentrated to give concentrate, thickening temperature is 55~65 DEG C,
Relative density when being concentrated into 50 DEG C is 1.25~1.28；
Step 5, drying：Concentrate is dried using band-type vacuum drier, the temperature of band-type vacuum drier sets
99 DEG C, 95 DEG C, 100 DEG C are set to, the time is 2 hours, and dried solids is ground into fine powder, cross 80 mesh sieves, then it is normal with appropriate
Rule auxiliary materials and mixing, granulation is made 1000g, obtains final product.
Day for human beings dose：15g~30g.
The preparation of the medicine decoction of embodiment 2
Exocarpium Citri Grandis 10g, root bark of shaggy-fruited dittany 10g, lotus leaf 8g, Radix Codonopsis 8g, root of kudzu vine 8g, Semen Cuscutae 8g, fruit of Chinese wolfberry 8g, hawthorn 8g, wood
Fragrant 8g, plus 10 times of water boiling and extractions of weight 2 times, 2 hours every time, are filtered to get filtrate, and the extract solution after merging is concentrated
Concentrate (relative density at 50 DEG C is 1.08~1.10) is obtained, decoction is made, day takes one.
The preparation of the medicinal tablet of embodiment 3
Exocarpium Citri Grandis 150g root bark of shaggy-fruited dittany 150g lotus leaf 80g Radix Codonopsis 80g root of kudzu vine 80g Semen Cuscutae 80g fruit of Chinese wolfberry 80g hawthorn 80g wood
Fragrant 80g
Step 1, extraction：The above-mentioned common water extraction of nine tastes medicinal material, plus 10 times of water boiling and extractions of weight 2 times, 2 hours every time,
Filter to get filtrate, the filtrate of multiple water extraction is merged；
Step 2, extract solution concentration：Extract solution after merging is carried out to be concentrated to give concentrate, thickening temperature is 55~70 DEG C,
Relative density when being concentrated into 50 DEG C is 1.08~1.10；
Step 3, alcohol precipitation：After extraction concentrate is cooled to room temperature, the ethanol for adding volume fraction to be 95% reaches alcohol content
60%, 24 hours are stood, take alcohol precipitation supernatant；
Step 4, alcohol precipitation supernatant concentration：Alcohol precipitation supernatant is carried out to be concentrated to give concentrate, thickening temperature is 55~65 DEG C,
Relative density when being concentrated into 50 DEG C is 1.25~1.28；
Step 5, drying：Concentrate is dried using band-type vacuum drier, the temperature of band-type vacuum drier sets
99 DEG C, 95 DEG C, 100 DEG C are set to, the time is 2 hours, and dried solids is ground into fine powder, cross 80 mesh sieves, then it is normal with appropriate
Rule auxiliary materials and mixing, granulation, compressing tablet is made 1000.
The preparation of the medicine capsule of embodiment 4
Exocarpium Citri Grandis 120g root bark of shaggy-fruited dittany 120g lotus leaf 80g Radix Codonopsis 80g root of kudzu vine 80g Semen Cuscutae 80g fruit of Chinese wolfberry 80g hawthorn 80g wood
Fragrant 80g
Step 1, extraction：The above-mentioned common water extraction of nine tastes medicinal material, plus 10 times of water boiling and extractions of weight 2 times, 2 hours every time,
Filter to get filtrate, the filtrate of multiple water extraction is merged；
Step 2, extract solution concentration：Extract solution after merging is carried out to be concentrated to give concentrate, thickening temperature is 55~70 DEG C,
Relative density when being concentrated into 50 DEG C is 1.08~1.10；
Step 3, alcohol precipitation：After extraction concentrate is cooled to room temperature, the ethanol for adding volume fraction to be 95% reaches alcohol content
60%, 24 hours are stood, take alcohol precipitation supernatant；
Step 4, alcohol precipitation supernatant concentration：Alcohol precipitation supernatant is carried out to be concentrated to give concentrate, thickening temperature is 55~65 DEG C,
Relative density when being concentrated into 50 DEG C is 1.25~1.28；
Step 5, drying：Concentrate is dried using band-type vacuum drier, the temperature of band-type vacuum drier sets
99 DEG C, 95 DEG C, 100 DEG C are set to, the time is 2 hours, and dried solids is ground into fine powder, cross 80 mesh sieves, then it is normal with appropriate
Rule auxiliary materials and mixing, granulation, encapsulating capsule is made 1000.
The effect experiment of embodiment 5：
1st, experiment material
1.1 by reagent
By reagent：Prepared according to the method for embodiment 1.
1.2 experimental animal
SD rats, SPF grades, 180-200g, male purchases the western pul-Bi Kai experimental animals Co., Ltd in Shanghai, the quality certification
Number：SCXK (Shanghai) 2013-0016.
1.3 experiment reagent
Modeling reagent：High lipid food, maintain feed in add 20.0% sucrose, 15% lard, 1.2% cholesterol,
0.2% sodium taurocholate, appropriate casein, calcium monohydrogen phosphate, stone flour etc..In addition to crude fat, the moisture of model feed, crude protein,
Crude fat, crude fibre, coarse ash, calcium, phosphorus, calcium, phosphorus are intended to reach the national standard for maintaining feed.Kit：The total courage of serum is consolidated
Alcohol (TC), triglycerides (TG), LDL-C (LDL-C), HDL-C (HDL-C) determine examination
Agent box, biotechnology research institute is built up purchased from Nanjing；
1.4 laboratory apparatus
BS224S electronic balances, Beijing Sai Duolisi scientific instrument Co., Ltd；5804R refrigerated centrifuges, Germany
Eppendorf companies；The multi-function microplate readers of FlexStation 3, Molecular Devices companies of the U.S..
2nd, modeling
2.1 according to document：Luo Jiaoyan, Gao Ying, Wang Chunyi, wait the Radixs Astragali to dissipate and Radix Astragali Gegen Decoction Regulation serum lipids research [J]
Pharmacology and Clinics of Chinese Materia Medica pharmacology, 2013,24 (3):221-226. methods described modelings, feeding rats high lipid food 13 weeks.
2.2 rat adaptability are raised one week
2.3 are randomly divided into 5 groups：Normal group, model group, the low dose group of embodiment 1, the middle dose group of embodiment 1, embodiment 1
High dose group, 10/group.Blank control group and model control group give the coordinative solvent of same volume simultaneously, and three dosage groups are every
Its orally administration given the test agent, Normal group feeding full-valence pellet feed, remaining each group feeding high lipid food.Successive administration 13
Week, and periodically weigh in, after water 18h is can't help in fasting in the 13rd week, eyeground vein clump takes blood.
3rd, experimental specimen acquisition process and result judgement method
3.1 blood sample collections and treatment：Non-fasting blood sampling, separates serum, according to examination as early as possible at the end of experiment after blood sampling
Agent box specification determines serum TC, TG, LDL-C, HDL-C level.
3.2 data processings and result judgement
It is general to use variance analysis, but homogeneity test of variance need to be first carried out by the program of variance analysis, variance is neat, calculates F
Value, F values<0.05, conclusion：No significant difference between each group mean；F value >=0.05, P≤0.05, with multiple experimental groups and
The comparative approach two-by-two of mean is counted between control group；Data to abnormal or heterogeneity of variance carry out appropriate variable turn
Change, after normal state or the neat requirement of variance is met, counted with the data after conversion；If variable conversion after still be not up to normal state or
The neat purpose of variance, uses rank test instead and is counted.
3.3 results of animal judge
Blood-fat-decreasing function result judgement：Model control group and blank control group compare, and serum triglyceride is raised,
Serum total cholesterol or LDL-C are raised, and difference has conspicuousness, and decision model is set up.(1) each dosage group
Compare with model control group, any dosage group serum total cholesterol or LDL-C are reduced, and any dosage group
Serum triglyceride reduction, difference has conspicuousness, while each dosage group serum High Density Lipoprotein Cholesterol is not significantly lower than
Model control group, can determine that the given the test agent blood-fat-decreasing function results of animal is positive.(2) each dosage group and model
Control group compares, and any dosage group serum total cholesterol or LDL-C are reduced, and difference has conspicuousness, while
Each dosage group serum triglyceride is not significantly higher than model control group, and each dosage group serum High Density Lipoprotein Cholesterol is not notable
Less than model control group, can determine that given the test agent auxiliary reduces cholesterol function results of animal positive.(3) each dosage group
Compare with model control group, any dosage group serum triglyceride reduction, difference has conspicuousness, while each dosage group serum is total
Cholesterol and LDL-C are not significantly higher than model control group, and serum High Density Lipoprotein Cholesterol is not significantly low
In model control group, can determine that given the test agent auxiliary reduces triglycerides function results of animal positive.
4th, result
As shown in table 1, table 2, table 1 is TC, LDL-C comparision contents in each group rat blood serum to statistics, and table 2 is big each group
TG, HDL-C comparision contents in mouse serum.
Influence of the table 1 to high blood lipid model rat TC, LDL-C
Compare with normal group：#P<0.05；##P<0.01；###P<0.001
Compare with model group：*P<0.05；**P<0.01；***P<0.001
Influence of the table 2 to high blood lipid model rat TG, HDL-C
Compare with normal group：#P<0.05；##P<0.01；###P<0.001
Compare with model group：*P<0.05；**P<0.01；***P<0.001
Model group rats administration 13 weeks after, compare with normal group, serum total cholesterol, LDL-C,
Triglycerides is significantly raised, and illustrates that model is successfully prepared.After embodiment 1 is administered 13 weeks, compare with model group, embodiment 1 is high
Dosage, middle dose group rat blood serum T-CHOL, LDL-C are significantly reduced (be shown in Table 1)；While and model group
Compare, the high dose of embodiment 1, middle dose group rat blood serum triglyceride levels are significantly reduced, and normal group, model group, reality
Each administration group rat blood serum High-density Lipoprotein-cholesterol of example 1 is applied without significant difference (being shown in Table 2).Blood is reduced according to auxiliary
Fat function result judgement standard, judges that the reduction blood fat function results of animal of embodiment 1 is positive.
From above-described embodiment, the Chinese medicine composition that the present invention is provided has good curative effect to hyperlipemia.
The explanation of above example is only intended to help and understands the method for the present invention and its core concept.It should be pointed out that right
For those skilled in the art, under the premise without departing from the principles of the invention, the present invention can also be carried out
Some improvement and modification, these are improved and modification is also fallen into the protection domain of the claims in the present invention.
Claims (10)
1. a kind of Chinese medicine composition for treating hyperlipemia, it is characterised in that including：
2. Chinese medicine composition according to claim 1, it is characterised in that including：
3. Chinese medicine composition according to claim 1, it is characterised in that including：
The weight portion of Exocarpium Citri Grandis 10；The weight portion of the root bark of shaggy-fruited dittany 10；The weight portion of lotus leaf 8；The weight portion of Radix Codonopsis 8；The weight portion of the root of kudzu vine 8；Semen Cuscutae 8
Weight portion；The weight portion of the fruit of Chinese wolfberry 8；The weight portion of hawthorn 8 and the weight portion of the banksia rose 8；
Or including the weight portion of Exocarpium Citri Grandis 12；The weight portion of the root bark of shaggy-fruited dittany 12；The weight portion of lotus leaf 8；The weight portion of Radix Codonopsis 8；The weight of the root of kudzu vine 8
Part；The weight portion of Semen Cuscutae 8；The weight portion of the fruit of Chinese wolfberry 8；The weight portion of hawthorn 8 and the weight portion of the banksia rose 8；
Or including the weight portion of Exocarpium Citri Grandis 15；The weight portion of the root bark of shaggy-fruited dittany 15；The weight portion of lotus leaf 8；The weight portion of Radix Codonopsis 8；The weight of the root of kudzu vine 8
Part；The weight portion of Semen Cuscutae 8；The weight portion of the fruit of Chinese wolfberry 8；The weight portion of hawthorn 8 and the weight portion of the banksia rose 8.
4. Chinese medicine composition according to claim 1, it is characterised in that also including pharmaceutically acceptable auxiliary material.
5. Chinese medicine composition according to claim 1, it is characterised in that the formulation of the composition be granule, decoction,
Tablet, capsule or pill.
6. the preparation method of Chinese medicine composition described in any one of Claims 1 to 5, it is characterised in that comprise the following steps：
Water extraction and alcohol precipitation are carried out successively to bulk drug.
7. preparation method according to claim 6, it is characterised in that the step is specially：
A) each bulk drug is mixed, extraction 2~5 times is added water to cook, 1~3 hour every time, extract solution is filtered to obtain；
B the extract solution) is concentrated into 50 DEG C of relative densities 1.08~1.10, concentrate is obtained；
C) concentrate is mixed with ethanol, is 60%~70% to alcohol content, carry out alcohol precipitation, obtain alcohol precipitation supernatant；
D) by the alcohol precipitation supernatant concentration to 50 DEG C of relative densities 1.25~1.28, concentrate is obtained；
E) step D) concentrate that obtains is through being dried to obtain the Chinese medicine composition.
8. preparation method according to claim 7, it is characterised in that the step A) in, water and each bulk drug total amount
Mass ratio is 9~15：1.
9. preparation method according to claim 7, it is characterised in that the step B) thickening temperature be 55~70 DEG C.
10. preparation method according to claim 7, it is characterised in that the step D) thickening temperature be 55~65 DEG C.
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| CN108969591A (en) * | 2018-08-31 | 2018-12-11 | 王志强 | A kind of preparation purifying blood |
| CN111773328A (en) * | 2020-08-20 | 2020-10-16 | 西北大学 | Traditional Chinese medicine composition for treating prosopalgia and application thereof |
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| CN111773328A (en) * | 2020-08-20 | 2020-10-16 | 西北大学 | Traditional Chinese medicine composition for treating prosopalgia and application thereof |
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