CN103735694B - Traditional Chinese medicinal formula capable of relieving functional diarrhea and preparation method thereof - Google Patents
Traditional Chinese medicinal formula capable of relieving functional diarrhea and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal formula capable of relieving functional diarrhea. The traditional Chinese medicinal formula mainly comprises the following raw materials in parts by weight: 2-6 parts of cuttle bone, 4-10 parts of fructus evodiae, 6-10 parts of elecampane, 1-3 parts of concha arcae, 6-15 parts of dried alum, 5-12 parts of magnolia obavata, 8-15 parts of rhizoma coptidis, 6-12 parts of nutgall, 14-26 parts of apple vinegar, and 5-12 parts of sesame oil. The traditional Chinese medicinal formula is capable of relieving functional diarrhea with a curative rate of 100%, can improve the poor appetite situation of a patient after taking, not only can relieve the functional diarrhea for the patient, but also can tonify spleen and invigorate stomach. The traditional Chinese medicine formula takes simple and feasible traditional Chinese medicines as raw materials, can become effective rapidly, is free from any toxic or side effects, quickly relieves the pain for the patient, and plays a good effective role for the functional diarrhea due to too strong gastrointestinal function, and too fast gastrointestinal motility.
Description
Technical field
The invention discloses a kind of Chinese medicinal formulae, Chinese medicinal formulae of especially a kind of mitigation capability diarrhoea and preparation method thereof.The invention belongs to traditional Chinese medicine field.
Background technology
Functional diarrhea refers to the diarrhoea without any antibacterial, viral infection, is generally caused by gastrointestinal function excessively strong (gastrointestinal rubs too fast), and primary disease is that one shows as and do not accompany stomachache, the disease of persistence or recurrent solution soft stool, watery stool.Bristol area, England had once carried out Epidemiological study to local resident for feces character, was just defined as functional diarrhea by shapeless for continuous 3 rows.Find according to such diagnostic criteria investigation, functional diarrhea is more more common in the women of more than 50 years old and 50 years old, its sickness rate reaches 3.1%, and the sickness rate of the right side of fifty women is 1.7%, because 50 years old is women's age of meuopause of this area just, therefore, the change of supposition hormonal readiness may be one of risk factor causing women's functional diarrhea.
At present, less to the pathogenetic research of functional diarrhea, the carbohydrate that in diet, some not easily absorb, may bring out patient's diarrhoea.Fructose, sorbitol and mannitol etc. in lactose-intolerant person's EDIBLE LACTOSE, " sugar-free " diet all can cause diarrhoea.Ethanol can make small intestinal edema, sodium malabsorption and cause diarrhoea.
Intestinal transport Time dependent feces character; the most important pathophysiology abnormal change of true property diarrhea patient is accelerate the intestinal transport time; the pathophysiology exception that functional diarrhea patient is important; occur in small intestinal or at colon, be that Instestinal motility exception or sensitivity change and is still not clear actually.The quickening of IBS patient's Colonic transit time is accelerated relevant with Intestinal transit.The food debris that Intestinal transit is accelerated to make more not obtain catapepsis enters colon, and containing short-chain carbohydrates and peptide chain in the food of non-catapepsis, before being decomposed into short-chain fatty acid by intestinal microbial population, osmotically active is very strong. moisture in enteric cavity is increased.Intestinal transit is accelerated also to make the product with secretion effect more, as long-chain fatty acid, two hydroxyl cholic acid etc. enter colon, produces cathartic effect.
There is not inevitable dependency in stool and colon transfer room, the generation of pseudodiarrhea is mostly is because Rectal Sensitivity increases.No matter whether the IBS patient that Rectal Sensitivity increases have diarrhoea all to show as defecation intention frequently, and stool increases relevant with the micturition frequency that hypersensitivity bladder causes usually.Rectal Sensitivity can be improved by hypnotherapy, shows that Nervous and Mental Factors also has certain effect in morbidity.
As everyone knows, acute anxiety often can cause diarrhoea, most healthy population, and especially young woman can affect bowl evacuation habit under stress state, but its pathogenesis is not clear and definite yet at present.Emotion changes has the effect of short colonic activity, but this phenomenon is in normal person and diarrhea patient and zero difference.For IBS, still less to the correlation research of functional diarrhea and chronic anxiety and stress state.
In the method for existing mitigation capability diarrhoea, application publication number CN 103285165 A(application number 201310183758.9) disclose a kind of Chinese medicine for the treatment of functional diarrhea, be made up of following component, the weight portion of each component is: Radix Ginseng 1-3, Pericarppium arachidis hypogaeae 10-12, Galla Chinensis 8-10, Rhizoma Coptidis 10-12, Rhizoma Atractylodis Macrocephalae (parched) 8-10, Herba Pogostemonis 10-12, Herba Ludwigiae Prostratae 10-12, Fructus Crataegi (parched to brown) 10-12, Fructus Mume 10-12, Radix Ilicis Asprellae 8-10, Radix Notoginseng 3-5, Flos Camelliae Japonicae 5-8, Semen Granati 8-10, Rhizoma Chuanxiong 5-8, Terra Flava Usta 10-12.Application publication number CN 103349695 A(application number 201310209108.7) disclose a kind of Chinese medicine for the treatment of functional diarrhea, be made up of following component, the weight portion of each component is: Radix Codonopsis 10-12, Rhizoma Atractylodis Macrocephalae (parched) 9-11, Poria 10-12, Polyalthia nemoralis A. D C. 10-12, Galla Chinensis 5-8, Radix Notoginseng 3-5, Rhizoma Coptidis 3-5, Semen Myristicae 5-8, Radix anthrisci 10-12, Flos Granati 10-12, Fructus Aurantii 5-8, Pericarpium Citri Reticulatae 5-8, Fructus Crataegi 10-12, Herb Gynostemmae Pentaphylli 10-12, Radix Ginkgo 10-12.Application publication number CN 102716406 A(application number 201210156498.1) disclose a kind of pill for the treatment of functional diarrhea, the component containing following weight portion: Radix Codonopsis 18-22, Rhizoma Atractylodis Macrocephalae (parched) 14-16, Poria 14-16, Pericarpium Citri Reticulatae 8-10, Radix Paeoniae Alba (parched) 14-16, Radix Glycyrrhizae 5-7, Fructus Amomi 3-5, carbonized Fructus Mume 8-10, Radix Puerariae 14-16, Radix Scutellariae (parched) 8-12, Radix Ginseng 1-2, Fructus Evodiae 1-2, Rhizoma Cyperi 1-2, hair ash 1-2, Fructus Schisandrae Chinensis 1-2, Herba Euphorbiae Humifusae 1-2, Fructus Rosae Laevigatae 1-2, Semen Plantaginis 3-5, Fructus Psoraleae 3-5, Radix Aucklandiae (Radix Vladimiriae) 3-5, Rhizoma Corydalis 3-5.Though in patent existing at present, functional diarrhea effect is good, but its preparation method is complicated, and narrow application range, and be not suitable for child.
Summary of the invention
For the present situation of existing mitigation capability anti-diarrhea drug deficiency, an object of the present invention is the Chinese medicinal formulae providing a kind of mitigation capability to suffer from diarrhoea, have and make simply, action effect is obvious, the feature such as applied widely, and it adopts Chinese crude drug comparatively common in the localities as raw material, with low cost.
Another object of the present invention is just to provide the preparation method of above-mentioned Chinese medicinal formulae.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of Chinese medicinal formulae of mitigation capability diarrhoea, take off the primary raw material stating weight proportion to be prepared from: Os Sepiae 2-6 part, Fructus Evodiae 4-10 part, Radix Aucklandiae 6-10 part, Concha Arcae 1-3 part, dried Alumen 6-15 part, Cortex Magnoliae Officinalis 5-12 part, Rhizoma Coptidis 8-15 part, Galla Turcica (Galla Helepensis) 6-12 part, apple vinegar 14-26 part, Oleum Sesami 5-12 part.
Foregoing Chinese medicinal formulae, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Os Sepiae 3-5 part, Fructus Evodiae 6-8 part, Radix Aucklandiae 7-9 part, Concha Arcae 1.5-2.5 part, dried Alumen 9-12 part, Cortex Magnoliae Officinalis 8-10 part, Rhizoma Coptidis 11-13 part, Galla Turcica (Galla Helepensis) 8-10 part, apple vinegar 18-23 part, Oleum Sesami 7-10 part.
Foregoing Chinese medicinal formulae, better preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Os Sepiae 4 parts, Fructus Evodiae 7 parts, the Radix Aucklandiae 8 parts, Concha Arcae 2 parts, dried Alumen 11 parts, Cortex Magnoliae Officinalis 9 parts, Rhizoma Coptidis 12 parts, Galla Turcica (Galla Helepensis) 9 parts, apple vinegar 20 parts, 8 parts, Oleum Sesami.
According to the preparation method of arbitrary described Chinese medicinal formulae above, preferred scheme is that step is as follows:
1. Fructus Evodiae, the Radix Aucklandiae, dried Alumen, Cortex Magnoliae Officinalis and Rhizoma Coptidis slow fire is fried 8-15 minute, air dry of drying in the air after stir-fry is sallow to surface is done, and pulverizes 90-120 mesh sieve, and obtains medicamental pulverata for subsequent use;
2. by Os Sepiae, Concha Arcae and Galla Turcica (Galla Helepensis) pulverization, cross 80-100 mesh sieve, obtain medicamental pulverata for subsequent use;
3. by step 1. in gained medicamental pulverata boiling water punching melt, wait to dry in the air to temperature 45 C-65 DEG C, add apple vinegar and stir, gained is oral medicine, and the weight proportion of three is boiling water: medicamental pulverata: apple vinegar=20:5:2;
4. by step 2. gained medicamental pulverata mix homogeneously with Oleum Sesami, stir into pasty state and be medicine for external use, the consumption of Oleum Sesami be the 0.3-0.7 of medicamental pulverata consumption doubly.
Foregoing preparation method, preferred scheme is, step 1. slow fire fries 10-13 minute (preferably 12 minutes).
Foregoing preparation method, preferred scheme is, 1. step crosses 95-115 mesh sieve (preferably 110 mesh sieves).
Foregoing preparation method, preferred scheme is, 2. step crosses 85-95 mesh sieve (preferably 90 mesh sieves).
Foregoing preparation method, preferred scheme is, 3. step dries in the air to temperature 50 C-60 DEG C (preferably 55 DEG C).
Foregoing preparation method, preferred scheme is, the consumption of step 4. Oleum Sesami be the 0.4-0.6 of medicamental pulverata consumption doubly (preferably 0.5 times).
Present invention also offers the application of described Chinese medicinal formulae when preparing the medicine for the treatment of acute diarrhea, infantile diarrhea and chronic diarrhea.
Using method: for making Chinese medicinal formulae of the present invention reach optimum therapeuticing effect, oral medicine 2 times on the one, took one hour ante cibum of morning and evening, and medicine for external use 1 time on the one, gets 5-8g at every turn, was placed on adhesive plaster and was attached to SHENQUE acupoint 6 hours.
This Chinese medicinal formulae is applicable to the patient of each age group, interiorly all can play the effect of rapid recovery functional diarrhea with medicine for external use, therefore use inside and outside can selecting according to practical situation simultaneously or select one to use, and suitably can increase and decrease dose according to patient age, more flexible on application method.
A Chinese medicinal formulae for mitigation capability diarrhoea, the pharmacological effect of each crude drug is respectively:
Os Sepiae: have another name called: flower rock, numb black Quarry.Medicine name: Endoconcha Sepiae.Different name: Endoconcha Sepiae crow Quarry bone, sepia bone, cuttlefish lid.Salty, puckery, temperature.Return spleen, kidney channel.Astringing to arrest bleeding, relieving leukorrhea by astringents, antacid, sore.For Peptic Ulcers, hyperchlorhydria, hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge, stomachache acid regurgitation; External treatment bleeding due to trauma, the many pus of skin ulcer.Dehumidifying, antacid, hemostasis, sore.Treat for stomachache acid regurgitation, tells, is defeated in battle, hematemesis, has blood in stool, bleeding not during menses, amenorrhea due to blood depletion, stomachache lump in the abdomen, intermittent fever of deficiency type dysentery, the rotten skin ulcer of the erosion of the vulva.
Fructus Evodiae: Fructus Evodiae (formal name used at school Tetradium ruticarpum, original name Euodia ruticarpa), another name Fructus Evodiae, tea is peppery, paint spicy, smelly spicy tree, Zuo Lichun deep and remote son, rice spicy etc.Nature and flavor: pungent, bitter, heat; Slightly poisonous.Gui Jing: return liver, spleen, stomach, kidney channel.Effect: dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.Cure mainly: for sun headache of fainting, colic of cold type is suffered from abdominal pain, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea; External treatment aphtha, hypertension.
The Radix Aucklandiae: nature and flavor: pungent, bitter, temperature.Gui Jing: return spleen, stomach, large intestine, three burnt, gallbladder meridians.Effect: promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.Cure mainly: for breast gastral cavity distending pain, heavy after dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).For stomachache of having loose bowels.
Concha Arcae: have another name called Carnis Arca inflata shell, watt room, blood clam skin, row of tiles on a roof clam skin, for Carnis Arca inflata section Carnis Arca inflata belongs to the shell that animal Scapharca subcrenata, Scapharca broughtonii and Tegillarca granosa belong to animal Tegillarca granosa.The property of medicine: matter is hard, sweet in the mouth, salty, property is put down.Composition: main component is calcium carbonate, also containing a small amount of calcium phosphate and magnesium, ferrum, silicate.Find according to modern pharmacological research, this medical instrument has effect of expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache, for pertinacious phlegm chronic cough, and stomachache acid regurgitation, traumatic hemorrhage, gastric and duodenal ulcers.
Dried Alumen: have another name called calcined Alumen.Get and pick clean Alumen, put heating in marmite and dissolve and be calcined to dried-up, taking out, is irregular crystalline solid, not of uniform size.Colourless, transparent or semitransparent, surface is slightly level and smooth or uneven, and the fine and closely woven vertical rib of tool, has hyaloid gloss.Matter is hard and crisp, easily smashes.Feeble QI, taste is micro-sweet and puckery.White with color, transparent, matter is hard and crisp, free from admixture person is good.Soluble in water or glycerol, is insoluble to ethanol.Aqueous solution shows the various reactions of aluminum salt, potassium salt and sulfate.Expectorant, dampness, antidiarrheal, hemostasis, removing toxic substances, parasite killing.Control epilepsy, sore throat, remorse saliva is stopped up very, hepatitis, jaundice, general edema with yellowish skin, duodenal ulcer, uterine prolapse, leucorrhea, dysentery, epistaxis, aphtha of the mouth and tongue, skin ulcer hemorrhoid scabies, water, fire, insect bite.
Cortex Magnoliae Officinalis: Cortex Magnoliae Officinalis, removing dampness by means of aromatics Chinese medicine, cures mainly: stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant stops up QI rising in reverse order; Fullness in the chest is breathed with cough.Come from Shennong's Herbal.Be now country's II grade of Top-rated protected wild plants.Nature and flavor: bitter; Pungent; Warm in nature.
Gui Jing: spleen channel; Stomach warp; Large intestine channel.Function: circulation of qi promoting removing food stagnancy; Dampness is except full; Lowering the adverse QI to relieve asthma.Cure mainly: stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant stops up QI rising in reverse order; Fullness in the chest is breathed with cough.
Rhizoma Coptidis: nature and flavor: bitter, cold.Gui Jing: GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Effect: heat clearing and damp drying, eliminating fire and detoxication.
Cure mainly: tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.
Galla Turcica (Galla Helepensis): have another name called black stone, without infanticide, the parasitized larvae belonging to insecticide gall wasps for gall wasps section cynipid sets the insect gall that sprout produces in Fagaceae oak plant Galla Turcica (Galla Helepensis).The property of medicine: this product is spherical in shape, has short handle, and outer surface Lycoperdon polymorphum Vitt has verruca, and matter heavily fortified point is thick, and bitter in the mouth is warm in nature.Composition: Galla Turcica (Galla Helepensis) insect gall is containing turkish gallotannin, gallic acid and resin etc.Find according to modern pharmacological research, this medical instrument have astringing intestine to stop diarrhea, controlling nocturnal emission with astringent drugs, astringe the lung, effect of hemostasis and pain-relieving, for chronic diarrhea chronic dysentery, night sweat, cough, spitting of blood, has blood in stool.
Apple vinegar: with the Fructus Mali pumilae former vinegar of Sucus Mali pumilae through fermentation, the pectin wherein contained is conducive to the growth of probiotics in intestinal, sour in the mouth, sweet.
Oleum Sesami: English name OLEUM SESAMI.Base is former: this product is the fatty oil that the mature seed milling process of Pedaliaceae plant sesame obtains.Purposes: lubricant and excipient, for oral administration can intestine moistening, lung moistening; Be used as ointment machin plaster substrate (Oleum Sesami used in the present invention is extracted by Semen Sesami) outward.
The principle that Chinese medicinal formulae of the present invention is suffered from diarrhoea based on Chinese medicine mitigation capability, the Chinese medicinal material selected all has effect of mitigation capability diarrhoea, spleen invigorating, stomach function regulating, and oral medicine taste is sour-sweet, avoids the embarrassment of good medicine tastes bitter, this Chinese medicinal formulae compatibility is proper, is applicable to the patient of each age group.
Compared with prior art, its technique effect is embodied in the present invention:
(1) extraction process is simple, and extraction efficiency is high, energy consumption and loss little, cost is low;
(2) add nutritional labeling and active ingredient, but do not change the curative effect that each crude drug cooperatively interacts;
(3) long-term taking this product has special efficacy to acute diarrhea, chronic diarrhea, functional diarrhea, more can improve immunity.
Accompanying drawing explanation
Fig. 1 is that after taking prescription of the present invention, symptom of diarrhea obviously improves or Disappearance Scenarios design sketch;
Fig. 2 takes appetite recovery situation design sketch after prescription of the present invention.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1a Chinese medicinal formulae for mitigation capability diarrhoea, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Os Sepiae 2 parts, Fructus Evodiae 4 parts, the Radix Aucklandiae 6 parts, Concha Arcae 1 part, dried Alumen 6 parts, Cortex Magnoliae Officinalis 5 parts, Rhizoma Coptidis 8 parts, Galla Turcica (Galla Helepensis) 6 parts, apple vinegar 14 parts, 5 parts, Oleum Sesami.
The preparation method of above-mentioned Chinese medicinal formulae, step is:
1. Fructus Evodiae, the Radix Aucklandiae, Cortex Magnoliae Officinalis and Rhizoma Coptidis slow fire is fried 8 minutes, air dry of drying in the air after stir-fry is sallow to surface is done, and pulverizes 90 mesh sieves, and obtains medicamental pulverata for subsequent use;
2. by Os Sepiae, Concha Arcae, dried Alumen and Galla Turcica (Galla Helepensis) pulverization, cross 80 mesh sieves, obtain medicamental pulverata for subsequent use;
3. by step 1. in gained medicamental pulverata boiling water punching melt, wait to dry in the air to temperature 45 C, add apple vinegar and stir, gained is oral medicine, and the weight proportion of three is boiling water: medicamental pulverata: apple vinegar=20:5:2;
4. by step 2. gained medicamental pulverata mix homogeneously with Oleum Sesami, stir into pasty state and be medicine for external use, the consumption of Oleum Sesami is 0.3 times of medicamental pulverata consumption.
model case onezhu XX, female, 20 years old, Jinan, Shandong Province people.Symptom: when in December, 2012 is examined, egg soup sample of suffering from diarrhoea the same day has just reached 10 times, without having blood in stool vomiting phenomenon, going to hospital to conduct a survey and being diagnosed as functional diarrhea.
Use the embodiment of the present invention 1 gained Chinese medicinal formulae, get medicine for external use 8g and be all affixed on infant SHENQUE acupoint with being placed on adhesive plaster, after 3 hours, patient's symptom of diarrhea obviously alleviates, and 4 as a child again without phenomenon of suffering from diarrhoea.Supper is got oral medicine 10g for last hour and is drunk, and second day supper patient appetite is normal, after meal also without diarrhoea phenomenon.
embodiment 2a Chinese medicinal formulae for mitigation capability diarrhoea, takes off the primary raw material stating weight proportion and is prepared from (getting 5g for every part): Os Sepiae 6 parts, Fructus Evodiae 10 parts, the Radix Aucklandiae 10 parts, Concha Arcae 3 parts, dried Alumen 15 parts, Cortex Magnoliae Officinalis 12 parts, Rhizoma Coptidis 15 parts, Galla Turcica (Galla Helepensis) 12 parts, apple vinegar 26 parts, 12 parts, Oleum Sesami.
The preparation method of above-mentioned Chinese medicinal formulae, step is:
1. Fructus Evodiae, the Radix Aucklandiae, Cortex Magnoliae Officinalis and Rhizoma Coptidis slow fire is fried 15 minutes, air dry of drying in the air after stir-fry is sallow to surface is done, and pulverizes 120 mesh sieves, and obtains medicamental pulverata for subsequent use;
2. by Os Sepiae, Concha Arcae, dried Alumen and Galla Turcica (Galla Helepensis) pulverization, cross 100 mesh sieves, obtain medicamental pulverata for subsequent use;
3. by step 1. in gained medicamental pulverata boiling water punching melt, wait to dry in the air to temperature 65 DEG C, add apple vinegar and stir, gained is oral medicine, and the weight proportion of three is boiling water: medicamental pulverata: apple vinegar=20:5:2;
4. by step 2. gained medicamental pulverata mix homogeneously with Oleum Sesami, stir into pasty state and be medicine for external use, the consumption of Oleum Sesami is 0.7 times of medicamental pulverata consumption.
model case twopoplar XX, man, 5 years old, Zhengzhou, henan people from city.Symptom: when in June, 2013, infant was examined, egg soup sample of suffering from diarrhoea the same day has just reached 5 times, without having blood in stool vomiting phenomenon, goes examination in hospital to be diagnosed as functional diarrhea.
Use the embodiment of the present invention 2 gained Chinese medicinal formulae, get medicine for external use 5g and be all affixed on infant SHENQUE acupoint with being placed on adhesive plaster, after 2 hours, infant symptom of diarrhea obviously alleviates, and 5 as a child again without phenomenon of suffering from diarrhoea.Supper is got oral medicine 10g for last hour and is drunk, and the appetite of supper infant is normal, after meal also without diarrhoea phenomenon.
embodiment 3a Chinese medicinal formulae for mitigation capability diarrhoea, takes off the primary raw material stating weight proportion and is prepared from (getting 15g for every part): Os Sepiae 3 parts, Fructus Evodiae 6 parts, the Radix Aucklandiae 7 parts, Concha Arcae 1.5 parts, dried Alumen 9 parts, Cortex Magnoliae Officinalis 8 parts, Rhizoma Coptidis 11 parts, Galla Turcica (Galla Helepensis) 8 parts, apple vinegar 18 parts, 7 parts, Oleum Sesami.
The preparation method of above-mentioned Chinese medicinal formulae, step is:
1. Fructus Evodiae, the Radix Aucklandiae, Cortex Magnoliae Officinalis and Rhizoma Coptidis slow fire is fried 10 minutes, air dry of drying in the air after stir-fry is sallow to surface is done, and pulverizes 95 mesh sieves, and obtains medicamental pulverata for subsequent use;
2. by Os Sepiae, Concha Arcae, dried Alumen and Galla Turcica (Galla Helepensis) pulverization, cross 85 mesh sieves, obtain medicamental pulverata for subsequent use;
3. by step 1. in gained medicamental pulverata boiling water punching melt, wait to dry in the air to temperature 50 C, add apple vinegar and stir, gained is oral medicine, and the weight proportion of three is boiling water: medicamental pulverata: apple vinegar=20:5:2;
4. by step 2. gained medicamental pulverata mix homogeneously with Oleum Sesami, stir into pasty state and be medicine for external use, the consumption of Oleum Sesami is 0.4 times of medicamental pulverata consumption.
model case threefield XX, female, 15 years old, Jinan, Shandong Province people, the student in certain middle school, to eat after meal morning in the dining room of school, sensation stomach-ache, general weakness, egg soup sample of suffering from diarrhoea the same day has just reached 8 times, and without having blood in stool vomiting phenomenon, belly has cluck,coo sound, goes examination in hospital to be diagnosed as functional diarrhea.
Use the embodiment of the present invention 3 gained Chinese medicinal formulae, get medicine for external use 6g and be all affixed on infant SHENQUE acupoint with being placed on adhesive plaster, after 4 hours, patient's symptom of diarrhea obviously alleviates, and phenomenon of suffering from diarrhoea after 5 hours disappears substantially.Supper is got oral medicine 18g for last hour and is drunk, and second day breakfast patient appetite is normal, after meal also without diarrhoea phenomenon.
embodiment 4a Chinese medicinal formulae for mitigation capability diarrhoea, takes off the primary raw material stating weight proportion and is prepared from (getting 20g for every part): Os Sepiae 5 parts, Fructus Evodiae 8 parts, the Radix Aucklandiae 9 parts, Concha Arcae 2.5 parts, dried Alumen 12 parts, Cortex Magnoliae Officinalis 10 parts, Rhizoma Coptidis 13 parts, Galla Turcica (Galla Helepensis) 10 parts, apple vinegar 23 parts, 10 parts, Oleum Sesami.
The preparation method of above-mentioned Chinese medicinal formulae, step is:
1. Fructus Evodiae, the Radix Aucklandiae, Cortex Magnoliae Officinalis and Rhizoma Coptidis slow fire is fried 13 minutes, air dry of drying in the air after stir-fry is sallow to surface is done, and pulverizes 115 mesh sieves, and obtains medicamental pulverata for subsequent use;
2. by Os Sepiae, Concha Arcae, dried Alumen and Galla Turcica (Galla Helepensis) pulverization, cross 95 mesh sieves, obtain medicamental pulverata for subsequent use;
3. by step 1. in gained medicamental pulverata boiling water punching melt, wait to dry in the air to temperature 60 C, add apple vinegar and stir, gained is oral medicine, and the weight proportion of three is boiling water: medicamental pulverata: apple vinegar=20:5:2;
4. by step 2. gained medicamental pulverata mix homogeneously with Oleum Sesami, stir into pasty state and be medicine for external use, the consumption of Oleum Sesami is 0.6 times of medicamental pulverata consumption.
embodiment 5a Chinese medicinal formulae for mitigation capability diarrhoea, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part): Os Sepiae 4 parts, Fructus Evodiae 7 parts, the Radix Aucklandiae 8 parts, Concha Arcae 2 parts, dried Alumen 11 parts, Cortex Magnoliae Officinalis 9 parts, Rhizoma Coptidis 12 parts, Galla Turcica (Galla Helepensis) 9 parts, apple vinegar 20 parts, 8 parts, Oleum Sesami.
The preparation method of above-mentioned Chinese medicinal formulae, step is:
1. Fructus Evodiae, the Radix Aucklandiae, Cortex Magnoliae Officinalis and Rhizoma Coptidis slow fire is fried 12 minutes, air dry of drying in the air after stir-fry is sallow to surface is done, and pulverizes 110 mesh sieves, and obtains medicamental pulverata for subsequent use;
2. by Os Sepiae, Concha Arcae, dried Alumen and Galla Turcica (Galla Helepensis) pulverization, cross 90 mesh sieves, obtain medicamental pulverata for subsequent use;
3. by step 1. in gained medicamental pulverata boiling water punching melt, wait to dry in the air to temperature 55 DEG C, add apple vinegar and stir, gained is oral medicine, and the weight proportion of three is boiling water: medicamental pulverata: apple vinegar=20:5:2;
4. by step 2. gained medicamental pulverata mix homogeneously with Oleum Sesami, stir into pasty state and be medicine for external use, the consumption of Oleum Sesami is 0.5 times of medicamental pulverata consumption.
experimental examplein order to verify the definite curative effect that this Chinese medicinal formulae mitigation capability is suffered from diarrhoea, randomly draw to examine diarrhea patient 30 people (gastrointestinal function excessively strong, gastrointestinal rub the too fast functional diarrhea caused), the mean age is 45 years old, minimum 10 years old, maximum 75 years old.Be divided into administration group and matched group according to the state of an illness and pathology, often organize each 15 people, guarantee administration group and matched group situation basically identical, wherein respectively organize functional diarrhea patient 8 people.
Administration group uses the embodiment of the present invention 5 gained Chinese medicinal formulae every day, and for making Chinese medicinal formulae of the present invention reach optimum therapeuticing effect, oral medicine 2 times on the one, one hour ante cibum of morning and evening.Medicine for external use 1 time on the one, gets 5-8g at every turn, is placed on adhesive plaster and is attached to SHENQUE acupoint 6 hours.The medicine (as XIELITING, the medicine of the conventional mitigation capability diarrhoea such as umbilicus subsides) that experimental group uses other mitigation capabilitys to suffer from diarrhoea.Criterion: cure, malaise symptoms disappears; Effectively, malaise symptoms disappears substantially; Invalid, malaise symptoms is unchanged.
Observe 2 days time limits, observed content is as follows:
1, take medicine in 1-6 hour, observed once every 2 hours, record the number that disease is obviously alleviated, result is as accompanying drawing 1:
Analyze: as can be seen from accompanying drawing 1, though Chinese medicinal formulae of the present invention is Chinese medicine preparation, but mitigation capability diarrhoea speed is substantially identical with other mitigation capabilitys diarrhoea medicine class, in 1-4 hour, substantially obviously can improves the symptom of diarrhea of patient, reach the object of rapid recovery patient suffering.
2, to vomiting in each group and with 8 patients of diarrhoea taking medicine in 2 days, get 3 with meal (being first day lunch respectively, first day dinner, and the lunch of second day), they are taken medicine after appetite recovery situation statistics and record, result is as accompanying drawing 2:
Analyze: as can be seen from accompanying drawing 2, Chinese medicinal formulae of the present invention can make diarrhoea and with the patient of vomiting phenomenon, recover its appetite, for the continuation rehabilitation of patient and the absorption of nutrition are laid a good foundation taking medicine in the shorter time.
3, matched group takes other functional diarrhea medicines and experimental group takes Chinese medicine composition Comparison of therapeutic of the present invention, and result is as shown in table 1:
Table 1
Analyze: as can be seen from Table 1, take and use Chinese medicine composition effective percentage of the present invention up to 100%, cure rate is up to 93%, and successful is better than taking other functional diarrhea medicines.
efficacy analysis:administration group (Chinese medicinal formulae of the present invention) and matched group all can reach the object of rapid recovery functional diarrhea in 2 days of the observation period, but in matched group diarrhoea and with vomiting phenomenon patient, the recovery of appetite is starkly lower than administration group after the tablet has been ingested.Prove through clinical trial, Chinese medicinal formulae of the present invention can mitigation capability diarrhoea rapidly, and effective percentage is 100%, and can improve the situation that patient is off one's feed after taking medicine, and can not only be that patient's mitigation capability is suffered from diarrhoea, can also play effect of spleen-and-stomach-invigorating.Chinese medicinal formulae of the present invention adopts Chinese medicinal material simple and easy to get as raw material, instant effect, and without any side effects, can reach the object alleviating rapidly patient's misery, gastrointestinal excessively strong to gastrointestinal function rubs the too fast functional diarrhea caused good therapeutical effect.
Claims (1)
1. the Chinese medicine composition of mitigation capability diarrhoea, is characterized in that, take off the raw material stating weight proportion: Os Sepiae 4 parts, Fructus Evodiae 7 parts, the Radix Aucklandiae 8 parts, Concha Arcae 2 parts, dried Alumen 11 parts, Cortex Magnoliae Officinalis 9 parts, Rhizoma Coptidis 12 parts, Galla Turcica (Galla Helepensis) 9 parts, apple vinegar 20 parts, 8 parts, Oleum Sesami; Preparation method step is as follows:
1. Fructus Evodiae, the Radix Aucklandiae, dried Alumen, Cortex Magnoliae Officinalis and Rhizoma Coptidis slow fire is fried 8-15 minute, air dry of drying in the air after stir-fry is sallow to surface is done, and pulverizes 90-120 mesh sieve, and obtains medicamental pulverata for subsequent use;
2. by Os Sepiae, Concha Arcae and Galla Turcica (Galla Helepensis) pulverization, cross 80-100 mesh sieve, obtain medicamental pulverata for subsequent use;
3. by step 1. in gained medicamental pulverata boiling water punching melt, wait to dry in the air to temperature 45 C-65 DEG C, add apple vinegar and stir, gained is oral medicine, and the weight proportion of three is boiling water: medicamental pulverata: apple vinegar=20:5:2;
4. by step 2. gained medicamental pulverata mix homogeneously with Oleum Sesami, stir into pasty state and be medicine for external use, the consumption of Oleum Sesami be the 0.3-0.7 of medicamental pulverata consumption doubly.
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