CN103735614B - The processing method and kidney tea product of a kind of kidney tea raw material - Google Patents
The processing method and kidney tea product of a kind of kidney tea raw material Download PDFInfo
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- CN103735614B CN103735614B CN201410012073.2A CN201410012073A CN103735614B CN 103735614 B CN103735614 B CN 103735614B CN 201410012073 A CN201410012073 A CN 201410012073A CN 103735614 B CN103735614 B CN 103735614B
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Abstract
The invention discloses a kind of processing method of kidney tea raw material, wherein, this method comprises the following steps：Fresh kidney tea raw material is soaked into the kidney tea raw material after being soaked 3 15 minutes in the acid solution that pH is 57；The kidney tea raw material after immersion is carried out to the kidney tea raw material after being cleaned with purified water again；Carry out segment, moist heat sterilization and gradient increased temperature drying steps successively to the kidney tea raw material after cleaning and obtain kidney tea product.Present invention also offers a kind of kidney tea product.Kidney tea product is prepared using method provided by the present invention, reduces the loss of the active ingredient of kidney tea raw material in preparation process, active constituent content is high in the kidney tea product of acquisition.
Description
Technical field
The kidney tea product obtained the present invention relates to a kind of processing method of kidney tea raw material and by this method.
Background technology
Kidney tea (Clerodendranthus spicatus) is Labiatae herbaceos perennial, according to the literature, kidney tea
Active ingredient is mainly：Liposoluble ingredient.8 liposoluble ingredients, i.e. caffeic acid, caffeinic dimerization are separated from kidney tea at present
The contracting platform thing of body Rosmarinic acid, caffeic acid and tartaric acid and four caffeic acid tetramers.Wherein Rosmarinic acid is that kidney tea anti-inflammatory has
Imitate one of composition.Kidney tea has clearing heat and removing internal wetness, row's stone Li Shui characteristic, for acute nephritis, cystitis, lithangiuria, rheumatism
Property arthritis has certain health care and therapeutic action.
Kidney tea material processing traditional at present is typically after the kidney tea raw material of harvesting is carried out into soaking and washing in water
Cutting drying, obtains dry kidney tea product.The defects of this method, is, soaking and washing, raw material are carried out to kidney tea raw material with water
In kidney tea active ingredient be largely dissolved in the water, the loss of active ingredient is caused, in addition, the calcium ions and magnesium ions in water and kidney tea
Active ingredient reacts the loss that also result in active ingredient, reduces the health-care effect of kidney tea.
The content of the invention
Therefore, the present invention proposes one kind that is a kind of can solving the above problems or at least can partly solving the above problems
The processing method of kidney tea raw material.
The invention provides a kind of processing method of kidney tea raw material, wherein, this method comprises the following steps：
Kidney tea raw material after fresh kidney tea raw material is soaked in immersion 3-15 minutes during pH is 5-7 acid solution；
The kidney tea raw material after immersion is carried out to the kidney tea raw material after being cleaned with purified water again；To the kidney tea raw material after cleaning according to
Secondary progress segment, moist heat sterilization and gradient increased temperature drying steps.
Preferably, this method includes fresh kidney tea raw material soaking 5-10 minutes in the acid solution that pH is 5.5-6.5
Kidney tea raw material after being soaked.
Present invention also offers a kind of kidney tea product, wherein, the kidney tea product is according to method system of the present invention
The standby kidney tea product obtained.
Present invention also offers kidney tea product of the present invention to prepare the pharmaceutical composition containing kidney tea active ingredient
In application.
Kidney tea product is prepared using method provided by the present invention, reduces the active ingredient of kidney tea raw material in preparation process
Loss, active constituent content is high in the kidney tea product of acquisition.
Embodiment
The invention provides many applicable creative concepts, the creative concept can be reflected in a large number of on specific
Hereinafter.Specific embodiment described in following embodiments of the present invention is only as specific implementation of the invention
Exemplary illustration, and be not meant to limit the scope of the invention.
The invention provides a kind of processing method of kidney tea raw material, wherein, this method comprises the following steps：
Kidney tea raw material after fresh kidney tea raw material is soaked in immersion 3-15 minutes during pH is 5-7 acid solution；
The kidney tea raw material after immersion is carried out to the kidney tea raw material after being cleaned with purified water again；To the kidney tea raw material after cleaning according to
Secondary progress segment, moist heat sterilization and gradient increased temperature drying steps.In order to preferably preserve the active ingredient in kidney tea raw material, the party
Method preferably includes the kidney tea after fresh kidney tea raw material is soaked in immersion 5-10 minutes during pH is 5.5-6.5 acid solution
Raw material.
The one kind of acid solution of the present invention in hydrochloric acid solution, salpeter solution, acetum and citric acid solution.
In the case of preferable, the acid solution is hydrochloric acid solution.
In the present invention, the kidney tea raw material is preferably to harvest also not having from annual April to the bud that do not occur between October
There is a kidney tea plant to bloom, the active ingredient rosmarinic acid contents in the branches and leaves of the kidney tea plant in the period are high, and material quality is good.
In harvesting, preferably branches and leaves are cut off at stubble height 10-30cm.
In method provided by the present invention, relative to 1000g kidney tea raw material, the dosage of acid solution is 4000-
6000ml, the temperature of immersion is 15-30 DEG C.In the case of preferable, relative to 1000g kidney tea raw material, the dosage of acid solution is
4500-5500ml, the temperature of immersion is 20-25 DEG C.In method of the present invention, kidney tea raw material is soaked used in
The species of container has no particular limits, and can be any suitable container that disclosure satisfy that immersion environmental condition.
Can be standing and soak for be stirred frequently in immersion process in immersion process of the present invention
Mix, the speed of stirring is unsuitable too fast, in order to avoid destroying the integrality of raw material, causes the loss of active ingredient.
Kidney tea raw material can be taken out after steeping and filter out most moisture, then kidney tea raw material is cleaned, this
Invention has no particular limits to the mode of cleaning, can be cleaned or in the container of water is filled in circulating water
Carry out soaking and washing.
In method provided by the present invention, the water for the kidney tea raw material after cleaning and dipping is purified water.
In method provided by the present invention, cleaning can be carried out one or more times, preferably be carried out at twice.
When being cleaned at twice, in first time cleans, relative to 1000g kidney tea raw material, for cleaning and dipping
The dosage of the purified water of kidney tea raw material afterwards is 8000-12000ml, and the temperature of immersion is 15-30 DEG C.In second is cleaned,
Relative to 1000g kidney tea raw material, the dosage for the purified water of the kidney tea raw material after cleaning and dipping is 13000-17000ml,
Drained away the water later in cleaning and carry out segment operation in the machine, in the preferred embodiment of the present invention, can be by kidney
Tea raw material cuts into the segment that length is 0.5-1cm.
After segment operates, in order to remove the microorganism for influenceing kidney tea product quality, sterilization steps are preferably also carried out,
It can be sterilized 15-20 minutes by the way of moist heat sterilization, under conditions of 121 DEG C.Disinfecting action can be conventional in this area
High-pressure sterilizing pot in carry out.
After sterilizing, the kidney tea raw material after sterilizing is transferred in drying box, using the method for gradient increased temperature to kidney tea
Raw material is dried, and specific gradient increased temperature condition is 37-42 DEG C, 5.5-6.5h；58-62 DEG C, 1.5-2.5h.
Present invention also offers a kind of kidney tea product, wherein, the kidney tea product is according to method provided by the present invention
The kidney tea product prepared.
The kidney tea product prepared according to method provided by the present invention can apply to prepare containing kidney tea effectively into
The pharmaceutical composition divided, in use, the kidney tea product can be further processed, the processing is for example including grinding
The processes such as mill, extracts active ingredients.For example, the kidney tea product can be ground into particle, it is applied to contain kidney as raw material
In the pharmaceutical composition of tea active ingredient.
In the present invention, described pharmaceutical composition can contain the medicine group that kidney tea is main component to be commonly used in the art
Compound formulation, such as can be the formulations such as tablet, granule, capsule, pill, paste.
The present invention is more fully described below by embodiment.
In following examples, the measuring method of Rosmarinic acid is high performance liquid chromatography, chromatographic condition and system suitability
Experiment concretely comprises the following steps：Using octadecylsilane chemically bonded silica as filler；It is stream with the phosphoric acid solution of acetonitrile -01% (25: 75)
Dynamic phase；Detection wavelength is 210nm.Number of theoretical plate by Rosmarinic acid peak calculate should not bottom in 4000.The preparation bag of reference substance solution
Include：Take Rosmarinic acid reference substance appropriate, it is accurately weighed, add 50% methanol that the solution that every 1ml contains 16 μ g is made.Need testing solution
Preparation includes：Precision weighs kidney tea powder (crossing No. four sieves) 0.3g, is positioned in 50ml volumetric flasks plus 50% methanol is ultrasonic in right amount
30min, put to room temperature, add 50% methanol to shake up to scale, take subsequent filtrate.Assay method draws reference substance solution to be accurate respectively
With each 5 μ l of need testing solution, it is measured after injecting liquid chromatograph.
Kidney tea raw material used in the present invention is former from the fresh kidney tea of Xishuangbanna of Yunnan province for the harvesting of in August, 2013
Material.
Embodiment 1
The present embodiment is used for the preparation method for illustrating kidney tea raw material provided by the invention.
Under 22 DEG C of soaking temperature, kidney tea raw material fresh 1000g is soaked in the 5000ml hydrochloric acid solutions that pH is 6
Kidney tea raw material after being soaked for 8 minutes；Then the kidney tea raw material after immersion is carried out with 25 DEG C of 10000ml purified water
Once clean, then the kidney tea raw material after immersion is carried out second with 25 DEG C of 15000ml water and cleaned, acquisition is clearly
Kidney tea raw material after washing；Moisture is drained, segment is carried out successively to the kidney tea raw material after cleaning with medicinal material cutting machine and obtains length
For 0.8cm segment, by the kidney tea segment obtained after cutting, moist heat sterilization 15 minutes, sterilizing use drying after terminating at 121 DEG C
Case dries 2h acquisition kidneys tea product 1 after 6h is dried at 40 DEG C at 60 DEG C.
The content of Rosmarinic acid in kidney tea product 1 is detected, the results are shown in Table 1.
Embodiment 2
The present embodiment is used for the preparation method for illustrating kidney tea raw material provided by the invention.
Under 20 DEG C of soaking temperature, kidney tea raw material fresh 1000g is soaked in the 4500ml hydrochloric acid solutions that pH is 5.5
Steep the kidney tea raw material after being soaked 5 minutes；Then the kidney tea raw material after immersion is carried out for the first time with 20 DEG C of 8000ml water
Cleaning, then by the kidney tea raw material after immersion cleaned for the second time with 20 DEG C of 14000ml water, after being cleaned
Kidney tea raw material；Moisture is drained, carrying out segment acquisition length successively to the kidney tea raw material after cleaning with medicinal material cutting machine is
0.8cm segment, by the kidney tea segment obtained after cutting, moist heat sterilization 15 minutes, sterilizing use drying box after terminating at 121 DEG C
2h acquisition kidneys tea product 2 is dried at 60 DEG C after 6h is dried at 40 DEG C.
The content of Rosmarinic acid in kidney tea product 2 is detected, the results are shown in Table 1.
Embodiment 3
The present embodiment is used for the preparation method for illustrating kidney tea raw material provided by the invention.
Under 25 DEG C of soaking temperature, kidney tea raw material fresh 1000g is soaked in the 5500ml hydrochloric acid solutions that pH is 6.5
Steep the kidney tea raw material after being soaked 10 minutes；Then the kidney tea raw material after immersion is carried out first with 30 DEG C of 12000ml water
Secondary cleaning, then the kidney tea raw material after immersion is carried out second with 30 DEG C of 16000ml water and cleaned, cleaned
Kidney tea raw material afterwards；Moisture is drained, carrying out segment acquisition length successively to the kidney tea raw material after cleaning with medicinal material cutting machine is
0.8cm segment, by the kidney tea segment obtained after cutting, moist heat sterilization 15 minutes, sterilizing use drying box after terminating at 121 DEG C
2h acquisition kidneys tea product 3 is dried at 60 DEG C after 6h is dried at 40 DEG C.
The content of Rosmarinic acid, caffeic acid and tartaric acid in kidney tea product 3 is detected, the results are shown in Table 1.
Embodiment 4
The present embodiment is used for the preparation method for illustrating kidney tea raw material provided by the invention.
Under 15 DEG C of soaking temperature, kidney tea raw material fresh 1000g is soaked in the 4000ml hydrochloric acid solutions that pH is 5
Kidney tea raw material after being soaked for 3 minutes；Then the kidney tea raw material after immersion is carried out with 9000ml20 DEG C of water clear for the first time
Wash, then the kidney tea raw material after immersion is carried out second with 13000ml20 DEG C of water and cleaned, the kidney after being cleaned
Tea raw material；Moisture is drained, it is 0.8cm's to carry out segment successively to the kidney tea raw material after cleaning with medicinal material cutting machine and obtain length
Segment, by the kidney tea segment obtained after cutting, moist heat sterilization 15 minutes, sterilizing use drying box at 40 DEG C at 121 DEG C after terminating
2h acquisition kidneys tea product 4 is dried at 60 DEG C after drying 6h.
Rosmarinic acid contents in kidney tea product 4 are detected, the results are shown in Table 1.
Embodiment 5
The present embodiment is used for the preparation method for illustrating kidney tea raw material provided by the invention.
Under 30 DEG C of soaking temperature, kidney tea raw material fresh 1000g is soaked in the 6000ml hydrochloric acid solutions that pH is 7
Kidney tea raw material after being soaked for 15 minutes；Then the kidney tea raw material after immersion is carried out for the first time with 30 DEG C of 11000ml water
Cleaning, then by the kidney tea raw material after immersion cleaned for the second time with 30 DEG C of 17000ml water, after being cleaned
Kidney tea raw material；Moisture is drained, it is 0.8cm's to carry out segment successively to the kidney tea raw material after cleaning with cutting machine and obtain length
Segment, by the kidney tea segment obtained after cutting, moist heat sterilization 15 minutes, sterilizing use drying box at 40 DEG C at 121 DEG C after terminating
2h acquisition kidneys tea product 5 is dried at 60 DEG C after drying 6h.
The content of Rosmarinic acid in kidney tea product 5 is detected, the results are shown in Table 1.
Comparative example 1
This comparative example is used for the preparation method for illustrating kidney tea raw material in the prior art.
Kidney tea product is prepared using method same as Example 1, unlike, hydrochloric acid solution is not used to kidney tea raw material
Soaked.Obtain kidney tea product 6.The content of Rosmarinic acid in kidney tea product 6 is detected, the results are shown in Table 1.
Comparative example 2
Kidney tea product is prepared using method same as Example 1, unlike, the water for cleaning kidney tea raw material is hard
Water.Obtain kidney tea product 7.The content of Rosmarinic acid in kidney tea product 7 is detected,
It the results are shown in Table 1.
Table 1
By the way that kidney tea product 1 and kidney tea product 6 are carried out into contrast method system provided by the present invention is used as can be seen that working as
During standby kidney tea product, the active constituent content in the product of acquisition is high.
By the way that kidney tea product 1 and kidney tea product 7 are carried out into contrast as can be seen that clear when being carried out using soft water to kidney tea raw material
When washing, the active constituent content in the product of acquisition is high.
By the way that kidney tea product 1-3 and kidney tea product 4 and 5 contrast as can be seen that when the preferred scope in the present invention
When interior, the active constituent content in the product of acquisition is higher.
It should be noted that the present invention will be described rather than limits the invention for above-described embodiment, and this
Art personnel can design alternative embodiment without departing from the scope of the appended claims.In the claims,
Any reference symbol between bracket should not be configured to limitations on claims.Word "comprising" does not exclude the presence of not
Element or step listed in the claims.
Claims (4)
1. a kind of processing method of kidney tea raw material, it is characterised in that this method comprises the following steps：
By the kidney tea plant for bud do not occur and also not blooming between the annual 4-10 months, the fresh kidney tea branches and leaves of harvesting exist
In the hydrochloric acid solution that pH is 5-6.5 immersion 3-10 minutes soaked after kidney tea raw material, relative to 1000g kidney tea raw material,
The dosage of hydrochloric acid solution is 4000-6000ml, and the temperature of immersion is 15-30 DEG C；Again with purified water by the kidney tea raw material after immersion
The kidney tea raw material after being cleaned is carried out, relative to 1000g kidney tea raw material, for the kidney tea raw material after cleaning and dipping
The dosage of purified water is 21000-25000ml, and temperature is 15-30 DEG C；Carry out segment, damp and hot successively to the kidney tea raw material after cleaning
Sterilizing and gradient increased temperature drying steps obtain kidney tea product.
2. according to the method for claim 1, wherein, this method includes, by the kidney tea raw material segment after the cleaning, obtaining
Length is 0.5-1cm segment.
3. a kind of kidney tea product, it is characterised in that the kidney tea product is the side according to any one of claim 1 or 2
What method prepared.
4. application of the kidney tea product in the pharmaceutical composition containing kidney tea active ingredient is prepared described in claim 3.
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| CN1813747A (en) * | 2005-02-06 | 2006-08-09 | 郭东宇 | Perhexiline injection and its preparing method |
| CN1995007A (en) * | 2005-12-26 | 2007-07-11 | 山东绿叶天然药物研究开发有限公司 | Process for preparing rosmarinic acid |
| CN101628030A (en) * | 2009-07-31 | 2010-01-20 | 芜湖梁氏新材料有限公司 | Method for preparing folium orthosiphoni extractive and composition thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101066292A (en) * | 2007-06-05 | 2007-11-07 | 浙江省亚热带作物研究所 | Clerodendranthus spiatus extract for treating urinary calculus and its prepn process |
| CN102309542B (en) * | 2011-09-23 | 2013-06-19 | 上海交通大学 | Orthosiphon n-butanol fraction medicine for treating chronic nephritis and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813747A (en) * | 2005-02-06 | 2006-08-09 | 郭东宇 | Perhexiline injection and its preparing method |
| CN1995007A (en) * | 2005-12-26 | 2007-07-11 | 山东绿叶天然药物研究开发有限公司 | Process for preparing rosmarinic acid |
| CN101628030A (en) * | 2009-07-31 | 2010-01-20 | 芜湖梁氏新材料有限公司 | Method for preparing folium orthosiphoni extractive and composition thereof |
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