CN103735614A - Method for processing raw folium orthosiphoni and folium orthosiphoni product - Google Patents
Method for processing raw folium orthosiphoni and folium orthosiphoni product Download PDFInfo
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- CN103735614A CN103735614A CN201410012073.2A CN201410012073A CN103735614A CN 103735614 A CN103735614 A CN 103735614A CN 201410012073 A CN201410012073 A CN 201410012073A CN 103735614 A CN103735614 A CN 103735614A
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Abstract
The invention discloses a method for processing raw folium orthosiphoni. The method comprises the following steps of soaking fresh raw folium orthosiphoni in an acid solution at pH of 5 to 7 for 3 to 15 minutes to obtain soaked raw folium orthosiphoni; cleaning the soaked raw folium orthosiphoni with purified water to obtain cleaned raw folium orthosiphoni; and processing the cleaned raw folium orthosiphoni by parting off, moist heat sterilization, and gradient temperature raise and drying in sequence to obtain the folium orthosiphoni product. The invention also provides the folium orthosiphoni product. With the adoption of the method for preparing the folium orthosiphoni product, the loss of active ingredients in the raw folium orthosiphoni can be reduced during preparing, and the prepared folium orthosiphoni product is high in content of active ingredients.
Description
Technical field
The present invention relates to a kind of processing method of kidney tea raw material and the kidney tea product obtaining by the method.
Background technology
Kidney tea (Clerodendranthus spicatus) is Labiatae herbaceos perennial, and according to the literature, kidney tea effective ingredient is mainly: liposoluble ingredient.From kidney tea, separate at present 8 liposoluble ingredients, i.e. caffeic acid, caffeinic dimer rosmarinic acid, caffeic acid and tartaric contracting platform thing and four caffeic acid tetramers.Wherein rosmarinic acid is one of kidney tea effective content of anti inflammation.Kidney tea has the characteristic of clearing heat and removing internal wetness, calculus diuretic, for acute nephritis, cystitis, lithangiuria, rheumatic arthritis, has certain health care and therapeutical effect.
After traditional kidney tea material processing normally carries out the kidney tea raw material of gathering soaking and washing in water at present, cutting is dried, and obtains dry kidney tea product.The defect of the method is, water carries out soaking and washing to kidney tea raw material, kidney tea effective ingredient in raw material is dissolved in the water in a large number, cause the loss of effective ingredient, in addition, calcium ions and magnesium ions in water reacts with the effective ingredient of kidney tea the loss that has also caused effective ingredient, has reduced the health-care effect of kidney tea.
Summary of the invention
For this reason, the present invention proposes a kind of processing method of a kind of kidney tea raw material that can address the above problem or that at least can partly address the above problem.
The processing method that the invention provides a kind of kidney tea raw material, wherein, the method comprises the following steps:
In the acid solution that is 5-7 at pH by fresh kidney tea raw material, soak the kidney tea raw material obtaining after soaking for 3-15 minute; By purified water, the kidney tea raw material after soaking is cleaned to the kidney tea raw material obtaining after cleaning again; Kidney tea raw material after cleaning is carried out to cutting, moist heat sterilization and gradient increased temperature drying steps successively.
Preferably, in the method acid solution that to comprise fresh kidney tea raw material be 5.5-6.5 at pH, soak the kidney tea raw material obtaining after soaking for 5-10 minute.
The present invention also provides a kind of kidney tea product, and wherein, described kidney tea product is the kidney tea product preparing according to method of the present invention.
The present invention also provides the application in the pharmaceutical composition that kidney tea product of the present invention contains kidney tea effective ingredient in preparation.
Utilize method provided by the present invention to prepare kidney tea product, reduced the loss of the effective ingredient of preparation process middle kidney tea raw material, in the kidney tea product of acquisition, active constituent content is high.
The specific embodiment
The invention provides many applicable creative concepts, this creativeness concept can be reflected in a large number of in concrete context.The specific embodiment of describing in following embodiments of the present invention is only as the exemplary illustration of specific implementation of the present invention, and do not form limitation of the scope of the invention.
The processing method that the invention provides a kind of kidney tea raw material, wherein, the method comprises the following steps:
In the acid solution that is 5-7 at pH by fresh kidney tea raw material, soak the kidney tea raw material obtaining after soaking for 3-15 minute; By purified water, the kidney tea raw material after soaking is cleaned to the kidney tea raw material obtaining after cleaning again; Kidney tea raw material after cleaning is carried out to cutting, moist heat sterilization and gradient increased temperature drying steps successively.In order better to preserve the effective ingredient in kidney tea raw material, in the acid solution that it is 5.5-6.5 at pH that the method preferably includes fresh kidney tea raw material, soak the kidney tea raw material obtaining after soaking for 5-10 minute.
Acid solution of the present invention is selected from the one in hydrochloric acid solution, salpeter solution, acetum and citric acid solution.In preferred situation, described acid solution is hydrochloric acid solution.
In the present invention, described kidney tea raw material was preferably to gather and does not occur the kidney tea plant that alabastrum is not also bloomed between annual April to October, and the effective ingredient rosmarinic acid contents in the branch and leaf of the kidney tea plant in this period is high, and raw materials quality is good.When gathering, preferably at stubble height 10-30cm place, cut off branch and leaf.
In method provided by the present invention, with respect to the kidney tea raw material of 1000g, the consumption of acid solution is 4000-6000ml, and the temperature of immersion is 15-30 ℃.In preferred situation, with respect to the kidney tea raw material of 1000g, the consumption of acid solution is 4500-5500ml, and the temperature of immersion is 20-25 ℃.In method of the present invention, the kind of kidney tea raw material being soaked to used container has no particular limits, and can be to meet any suitable container that soaks environmental condition.
In immersion process of the present invention, can be that standing immersion also can frequently be stirred in immersion process, the speed of stirring is unsuitable too fast, in order to avoid destroy the integrity of raw material, causes the loss of effective ingredient.
After immersion, kidney tea raw material can be taken out and the most moisture of filtering, then kidney tea raw material is cleaned, the present invention has no particular limits the mode of cleaning, and can be to clean in circulating water, can be also in the container that fills water, to carry out soaking and washing.
In method provided by the present invention, for the water of the kidney tea raw material after cleaning and dipping, be purified water.
In method provided by the present invention, cleaning can be carried out one or more times, preferably carries out at twice.
When cleaning at twice, in cleaning for the first time, with respect to the kidney tea raw material of 1000g, for the consumption of the purified water of the kidney tea raw material after cleaning and dipping, be 8000-12000ml, the temperature of immersion is 15-30 ℃.In cleaning for the second time, with respect to the kidney tea raw material of 1000g, the consumption that is used for the purified water of the kidney tea raw material after cleaning and dipping is 13000-17000ml, after cleaning, drain away the water and in machine, carry out cutting operation, in a kind of preferred implementation of the present invention, kidney tea raw material can be cut into the segment that length is 0.5-1cm.
After cutting operation, in order to remove the microorganism that affects kidney tea product quality, preferably also to carry out sterilization steps, can adopt the mode of moist heat sterilization, under the condition of 121 ℃, sterilizing 15-20 minute.Disinfecting action can carry out in the high-pressure sterilizing pot of this area routine.
After sterilizing, the kidney tea raw material after sterilizing is transferred in drying baker, adopt the method for gradient increased temperature to be dried kidney tea raw material, concrete gradient increased temperature condition is 37-42 ℃, 5.5-6.5h; 58-62 ℃, 1.5-2.5h.
The present invention also provides a kind of kidney tea product, and wherein, described kidney tea product is the kidney tea product preparing according to method provided by the present invention.
The kidney tea product preparing according to method provided by the present invention can be applied to the pharmaceutical composition that preparation contains kidney tea effective ingredient, when application, can be further processed this kidney tea product, described processing example is as comprised the operations such as grinding, extracts active ingredients.For example, described kidney tea product can be ground to form to granule, as raw material, be applied in the pharmaceutical composition that contains kidney tea effective ingredient.
In the present invention, described pharmaceutical composition can for this area conventional contain the medicine composition dosage form that kidney tea is main component, can be for example the dosage forms such as tablet, granule, capsule, pill, unguentum.
Below by embodiment, the present invention is described in more detail.
In following examples, the measuring method of rosmarinic acid is high performance liquid chromatography, and the concrete steps of chromatographic condition and system suitability are: take octadecylsilane chemically bonded silica as filler; Take acetonitrile-01% phosphoric acid solution (25: 75) as mobile phase; Detection wavelength is 210nm.Number of theoretical plate press rosmarinic acid peak calculate not the end in 4000.The preparation of reference substance solution comprises: get rosmarinic acid reference substance appropriate, and accurately weighed, add 50% methanol and make the solution of every 1ml containing 16 μ g.The preparation of need testing solution comprises: precision takes kidney tea powder end (crossing sieve No. four) 0.3g, is positioned in 50ml volumetric flask and adds the appropriate ultrasonic 30min of 50% methanol, puts to room temperature, adds 50% methanol to scale, shakes up, and gets subsequent filtrate.Assay method is drawn reference substance solution and the each 5 μ l of need testing solution for difference is accurate, after injection liquid chromatography, measures.
The kidney tea raw material using in the present invention is to pluck the fresh kidney tea raw material from Xishuangbanna of Yunnan province in August, 2013.
Embodiment 1
The present embodiment is for illustrating the preparation method of kidney tea raw material provided by the invention.
Under the soaking temperature of 22 ℃, in the 5000ml hydrochloric acid solution that is 6 at pH by kidney tea raw material fresh 1000g, soak the kidney tea raw material obtaining after soaking for 8 minutes; Then by the purified water of 25 ℃ of 10000ml, the kidney tea raw material after soaking is cleaned for the first time, then with the water of 25 ℃ of 15000ml, the kidney tea raw material after soaking is cleaned to obtain for the second time and clean, obtain the kidney tea raw material after cleaning; Moisture is drained, with medical material cutting machine, the kidney tea raw material after cleaning is carried out to cutting successively and obtain the segment that length is 0.8cm, by the moist heat sterilization 15 minutes at 121 ℃ of the kidney tea segment that obtains after cutting, sterilizing finishes the rear 2h acquisition kidney tea product 1 that is dried at 60 ℃ after dry 6h at 40 ℃ with drying baker.
The content that detects rosmarinic acid in kidney tea product 1, the results are shown in Table 1.
Embodiment 2
The present embodiment is for illustrating the preparation method of kidney tea raw material provided by the invention.
Under the soaking temperature of 20 ℃, in the 4500ml hydrochloric acid solution that is 5.5 at pH by kidney tea raw material fresh 1000g, soak the kidney tea raw material obtaining after soaking for 5 minutes; Then with the water of 20 ℃ of 8000ml, the kidney tea raw material after soaking is cleaned for the first time, then with the water of 20 ℃ of 14000ml, the kidney tea raw material after soaking is cleaned to obtain for the second time and clean, obtain the kidney tea raw material after cleaning; Moisture is drained, with medical material cutting machine, the kidney tea raw material after cleaning is carried out to cutting successively and obtain the segment that length is 0.8cm, by the moist heat sterilization 15 minutes at 121 ℃ of the kidney tea segment that obtains after cutting, sterilizing finishes the rear 2h acquisition kidney tea product 2 that is dried at 60 ℃ after dry 6h at 40 ℃ with drying baker.
The content that detects rosmarinic acid in kidney tea product 2, the results are shown in Table 1.
Embodiment 3
The present embodiment is for illustrating the preparation method of kidney tea raw material provided by the invention.
Under the soaking temperature of 25 ℃, in the 5500ml hydrochloric acid solution that is 6.5 at pH by kidney tea raw material fresh 1000g, soak the kidney tea raw material obtaining after soaking for 10 minutes; Then with the water of 30 ℃ of 12000ml, the kidney tea raw material after soaking is cleaned for the first time, then with the water of 30 ℃ of 16000ml, the kidney tea raw material after soaking is cleaned to obtain for the second time and clean, obtain the kidney tea raw material after cleaning; Moisture is drained, with medical material cutting machine, the kidney tea raw material after cleaning is carried out to cutting successively and obtain the segment that length is 0.8cm, by the moist heat sterilization 15 minutes at 121 ℃ of the kidney tea segment that obtains after cutting, sterilizing finishes the rear 2h acquisition kidney tea product 3 that is dried at 60 ℃ after dry 6h at 40 ℃ with drying baker.
Detect rosmarinic acid, caffeic acid and tartaric content in kidney tea product 3, the results are shown in Table 1.
Embodiment 4
The present embodiment is for illustrating the preparation method of kidney tea raw material provided by the invention.
Under the soaking temperature of 15 ℃, in the 4000ml hydrochloric acid solution that is 5 at pH by kidney tea raw material fresh 1000g, soak the kidney tea raw material obtaining after soaking for 3 minutes; Then with the water of 9000ml20 ℃, the kidney tea raw material after soaking is cleaned for the first time, then with the water of 13000ml20 ℃, the kidney tea raw material after soaking is cleaned to obtain for the second time and clean, obtain the kidney tea raw material after cleaning; Moisture is drained, with medical material cutting machine, the kidney tea raw material after cleaning is carried out to cutting successively and obtain the segment that length is 0.8cm, by the moist heat sterilization 15 minutes at 121 ℃ of the kidney tea segment that obtains after cutting, sterilizing finishes the rear 2h acquisition kidney tea product 4 that is dried at 60 ℃ after dry 6h at 40 ℃ with drying baker.
Detect rosmarinic acid contents in kidney tea product 4, the results are shown in Table 1.
Embodiment 5
The present embodiment is for illustrating the preparation method of kidney tea raw material provided by the invention.
Under the soaking temperature of 30 ℃, in the 6000ml hydrochloric acid solution that is 7 at pH by kidney tea raw material fresh 1000g, soak the kidney tea raw material obtaining after soaking for 15 minutes; Then with the water of 30 ℃ of 11000ml, the kidney tea raw material after soaking is cleaned for the first time, then with the water of 30 ℃ of 17000ml, the kidney tea raw material after soaking is cleaned to obtain for the second time and clean, obtain the kidney tea raw material after cleaning; Moisture is drained, with cutting machine, the kidney tea raw material after cleaning is carried out to cutting successively and obtain the segment that length is 0.8cm, by the moist heat sterilization 15 minutes at 121 ℃ of the kidney tea segment that obtains after cutting, sterilizing finishes the rear 2h acquisition kidney tea product 5 that is dried at 60 ℃ after dry 6h at 40 ℃ with drying baker.
The content that detects rosmarinic acid in kidney tea product 5, the results are shown in Table 1.
Comparative example 1
This comparative example is for illustrating the preparation method of prior art middle kidney tea raw material.
Adopt the method identical with embodiment 1 to prepare kidney tea product, different, do not adopt hydrochloric acid solution to soak kidney tea raw material.Obtain kidney tea product 6.The content that detects rosmarinic acid in kidney tea product 6, the results are shown in Table 1.
Comparative example 2
Adopt the method identical with embodiment 1 to prepare kidney tea product, different, for the water that cleans kidney tea raw material, be hard water.Obtain kidney tea product 7.Detect the content of rosmarinic acid in kidney tea product 7,
The results are shown in Table 1.
Table 1
By kidney tea product 1 and kidney tea product 6 are contrasted and can be found out, when adopting method provided by the present invention to prepare kidney tea product, the active constituent content in the product of acquisition is high.
By kidney tea product 1 and kidney tea product 7 are contrasted and can be found out, when adopting soft water to clean kidney tea raw material, the active constituent content in the product of acquisition is high.
By kidney tea product 1-3 and kidney tea product 4 and 5 are contrasted and can be found out, when in preferable range of the present invention, the active constituent content in the product of acquisition is higher.
It should be noted, the present invention will be described rather than limit the invention for above-described embodiment, and those skilled in the art can design alternative embodiment in the situation that not departing from claims scope.In the claims, any reference marks between bracket should be configured to limitations on claims.Word " comprises " not to be got rid of existence and is not listed as element or step in the claims.
Claims (10)
1. a processing method for kidney tea raw material, is characterized in that, the method comprises the following steps:
In the acid solution that is 5-7 at pH by fresh kidney tea raw material, soak the kidney tea raw material obtaining after soaking for 3-15 minute; By purified water, the kidney tea raw material after soaking is cleaned to the kidney tea raw material obtaining after cleaning again; Kidney tea raw material after cleaning is carried out to cutting, moist heat sterilization and gradient increased temperature drying steps successively and obtain kidney tea product.
2. processing method according to claim 1, wherein, soaks the kidney tea raw material obtaining after soaking for 5-10 minute in the acid solution that it is 5.5-6.5 at pH that the method comprises fresh kidney tea raw material.
3. processing method according to claim 1 and 2, wherein, described acid solution is selected from the one in hydrochloric acid solution, salpeter solution, acetum and citric acid solution.
4. processing method according to claim 3, wherein, described acid solution is hydrochloric acid solution.
5. processing method according to claim 1 and 2, wherein, with respect to the kidney tea raw material of 1000g, the consumption of acid solution is 4000-6000ml, the temperature of immersion is 15-30 ℃.
6. processing method according to claim 1, wherein, with respect to the kidney tea raw material of 1000g, is 21000-25000ml for the consumption of the purified water of the kidney tea raw material after cleaning and dipping, and temperature is 15-30 ℃.
7. method according to claim 1, wherein, described kidney tea raw material is the kidney tea branch and leaf of gathering between the annual 4-10 month.
8. method according to claim 1, wherein, the method comprises the kidney tea raw material cutting after described cleaning, the segment that acquisition length is 0.5-1cm.
9. a kidney tea product, is characterized in that, described kidney tea product is to prepare according to the method described in any one in claim 1-8.
10. the application in the pharmaceutical composition that kidney tea product claimed in claim 9 contains kidney tea effective ingredient in preparation.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115192562A (en) * | 2022-08-15 | 2022-10-18 | 北京中医药大学 | Application of caffeic acid in preparation of medicine for treating crescent nephritis |
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| CN100462077C (en) * | 2005-02-06 | 2009-02-18 | 郭东宇 | Perhexiline injection and its preparing method |
| CN1995007B (en) * | 2005-12-26 | 2011-12-07 | 山东绿叶天然药物研究开发有限公司 | Process for preparing rosmarinic acid |
| CN101628030A (en) * | 2009-07-31 | 2010-01-20 | 芜湖梁氏新材料有限公司 | Method for preparing folium orthosiphoni extractive and composition thereof |
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Patent Citations (2)
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| CN101066292A (en) * | 2007-06-05 | 2007-11-07 | 浙江省亚热带作物研究所 | Clerodendranthus spiatus extract for treating urinary calculus and its prepn process |
| CN102309542A (en) * | 2011-09-23 | 2012-01-11 | 上海交通大学 | Orthosiphon n-butanol fraction medicine for treating chronic nephritis and preparation method thereof |
Non-Patent Citations (1)
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115192562A (en) * | 2022-08-15 | 2022-10-18 | 北京中医药大学 | Application of caffeic acid in preparation of medicine for treating crescent nephritis |
| CN115192562B (en) * | 2022-08-15 | 2024-06-28 | 北京中医药大学 | Application of caffeic acid in preparation of medicine for treating crescent nephritis |
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