CN103734734A - Functional food capable of improving cognition and relieving fatigue - Google Patents
Functional food capable of improving cognition and relieving fatigue Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention relates to the field of functional foods, in particular to a functional food capable of improving cognition and relieving fatigue. The functional food comprises the following active ingredients in parts by weight: 10 to 500 parts of taurine, 10 to 350 parts of cafferine, 10 to 350 parts of maca powder, and 1 to 80 parts of ginsenoside. The functional food has the functions of improving cognition and relieving fatigue, and is suitable for the operation personnel requiring to maintain attention and high alertness for a long time, such as flight personnel.
Description
Technical field
The present invention relates to functional food field, relate in particular to a kind of functional food that improves cognitive and fatigue-relieving that has, be applicable to aircrew and wait the occupational population that needs to keep lastingly notice and great vigilance.
Background technology
Cognitive function is brain comprehensive perception of things to external world, comprises sensation, consciousness, attention, study, memory, language, thinking and consciousness etc.In recent years, cognitive function has been carried out to a large amount of research both at home and abroad, result shows, amino acid, polyunsaturated fatty acid, vitamin C, vitamin E, B family vitamin and phytochemical etc. have the biological action that improves cognitive function.Fatigue refers to is engaged in muscle power or mental activity, through certain hour or the mobility occurring that acquires a certain degree decline, main manifestations is that ability to work declines, absent minded, failure of memory etc.
Nervous and the complicated flight work that aircrew carries out under the comprehensive stress factor impacts such as climatic environment of hypoxemia, low pressure, vibration, noise, acceleration, ionising radiation and constantly variation is one of the most complicated work of modern society.In whole flight course, aircrew must energy concentrates, operation accurately, flexible movements, be swift in response, keep lasting notice and the alertness of height.But because aircrew flies for a long time in sealed cabin, operating environment is dull, extend cruising time, night flight increases, irregular work, the state of high stress and sleep deprivation and Transmeridian flight variation etc., can cause mental fatigue in various degree; The specific factors such as hypoxemia, air pressure change, vibration, noise, acceleration and radiation can cause physical fatigue again.Along with the continuous progress of science and technology of aviation and the fast development of shipping business both at home and abroad, flying fatigue problem highlights day by day.Under modernization high-tech local war condition, high-performance fighter aircraft equips our troops successively.New equipment aircraft has the features such as labour intensity is large, cognitive load is high, cruising time is long, more than the follow-on mission activity duration can reach for ten a few hours.Battle bird is engaged in for a long time special military operation work under spirit height stress situation, is bearing huge physical load and Mental Workload, and flying fatigue and cognitive ability decline problem are more outstanding.
Cognition is extremely complicated psychology, a physiology and chemistry process, relates to change, the Ca of change, central neurotransmitter and the acceptor of neurotrophic change, Synaptic Morphology and function
2+the change of the change of concentration, Apoptosis and related gene expression, the change of signal transduction etc.The factors such as tired generation and energy substance consumption, metabolite accumulation, homeostasis sexual maladjustment, radical damage are closely related.
Taurine is the free amino acid of central nervous system rich content; can affect cognitive function by multiple channel; as promote the Proliferation, Differentiation of nerve cell, increase the content of arginine vasopressin and beta-endorphin in Fos albumen, hippocampus and cortex, Ca in bidirectional modulation cell
2+neuroprotective cell, the mediator that affects the nerves secretion and the interior trace element zinc content of brain etc., play the effect that improves learning and memory.The taurine of human body approximately 75% is distributed in skeletal muscle, is a kind of important cell-protecting, protective action that can be by cell membrane lipid peroxidation, the free radical that suppresses to produce in motion process, regulates cardiac muscle cell Ca
2+the mechanism such as balance, the blood plasma branched-amino acid concentration that improves, reduction aromatic amino acid/branched-chain amino acid ratio, the hormone metabolism of adjusting human body, keep central excitatory state, promote the recovery of membrane structure and function, postpone tired appearance and the degree that lessens fatigue.
Caffeine is most popular mental excitation class material in the world at present, be prevalent in the soft drinks such as tea and coffee, there is the physiological actions such as excited heart, skeletal muscle and central nervous system and anti-oxidant, vasodilator, relaxing smooth muscle, to maintaining watchful, alleviating physical fatigue, there is certain effect.Zooscopy finds that caffeine can improve the Spatial learning and memory ability of rat and mouse, and clinical research finds that its cognition of aged women of the medium-term and long-term a large amount of absorption caffeines of life and memory capability test performance will be significantly better than the aged women who does not take in caffeine.
Agate coffee is South America conventional food and pure natural medicinal plant, and edible with a long history, be approved for new resource food in China in May, 2011.Research is found, contains rich in protein, amino acid, mineral matter, unrighted acid in agate coffee, and especially the anti-fatigue nutrient content of material such as taurine, zinc, branched-chain amino acid (leucine, valine, isoleucine) is abundant.Branched-chain amino acid can reduce aromatic amino acid/branched-chain amino acid ratio, improve the ratio of blood plasma glutamate, effectively improves mental fatigue; Zinc is the important component of energetic supersession relevant enzyme, also the increase significantly effect of cognitive and fatigue-relieving of tool of taurine.Other compositions in agate coffee are as Cobastab
1, Cobastab
2, linoleic acid, leukotrienes, sterol etc. also have certain antifatigue effect.
Panaxoside is the main composition of the traditional nourishing and health preserving rare medicinal herbs ginseng of China.Long-term clinical practice proof panaxoside has the effect that many target spots, too many levels comprehensively promote learning and memory, can be by affecting central nervous system neurotransmitter metabolism, promote central nervous system nucleic acid and protein to synthesize, affect hippocampus form, improving the cognitive level that the effects such as nerve cell membrane fluidity improve bodies.Its biological action also comprises the generation, the removing of accelerating free radical that suppress free radical, strengthen superoxide dismutase activity, regulate glycometabolism, alleviate intracellular calcium overload, strengthen lactic acid dehydrogenase activity, reduce lactic acid piles up, increases content of hemoglobin etc., there is the effect of powerful anti-oxidant and removing free radical, and can improve the content of muscle glycogen, hepatic glycogen, reduce blood lactate concentration, animal experiment shows, it is tired that panaxoside can effectively be alleviated animal used as test muscle power.
Summary of the invention
The object of this invention is to provide a kind of functional food that improves cognitive and fatigue-relieving, be applicable to aircrew and wait the occupational population that needs lasting maintenance notice and great vigilance.
In order to realize the object of the invention, functional food of the present invention, main component comprises taurine, caffeine, pueraria root powder and panaxoside, it comprises the active component of following weight portion:
10～500 parts of taurines, 10～350 parts of caffeines, 10～350 parts of pueraria root powders, 1～80 part of panaxoside.
Preferably: 15～400 parts of taurines, 15～300 parts of caffeines, 30～300 parts of pueraria root powders, 2～50 parts of panaxosides.
Of the present invention part is weight portion, for the conventional microgram in this area, milligram, gram, two, the unit of weight such as kilogram, ton.
The preparation method of functional food of the present invention: 10～500 weight portion taurines, 10～350 weight portion caffeines, 10～350 weight portion pueraria root powders, 1～80 weight portion panaxoside are mixed, obtain functional food of the present invention as above.
Functional food of the present invention can mix with acceptable carrier in pharmacy/bromatology, is prepared into the common formulations such as capsule, tablet, chewable tablets, granule, beverage, oral liquid according to known preparation technique.
The present invention is directed to tired generation and cognitive ability decline mechanism; choose taurine, caffeine, pueraria root powder and panaxoside and carry out prescription as functional component; a kind of functional food that improves cognitive and fatigue-relieving of development and design, and adopt zoopery and human trial to evaluate.Result of study shows, functional food of the present invention has the cognition of raising and function of alleviating fatigue.
The specific embodiment
Following examples are used for illustrating the present invention, but are not used for limiting the scope of the invention.
Embodiment 1-3
By above-mentioned formula, various compositions are mixed, obtain respectively composition 1, composition 2, composition 3.
Experimental example 1
The object of this experimental example is to study functional food of the present invention and whether has the effect that improves cognitive function.
Animal used as test
40 of male mouse of kunming, body weight (20 ± 2) g, feeding environment is the clean level of full frame barrier animal experiment chamber, room temperature (22 ± 2) ℃, relative humidity (50 ± 5) %, 12h～12h illumination and dark surrounds circulation.Feed and raise full nutrition pellet.Before experiment, adaptability is raised 3 days.
Experimental technique
Use the functional food composition of the present invention 1 of preparation in embodiment 1, to improving cognitive function, test.Laboratory mice is divided into 4 groups at random by body weight, low dose group, middle dosage group, high dose group and blank group, 10 every group.Basic, normal, high dosage group dosage is respectively 0.25g/kg.bw every day, 0.50g/kg.bw and 1.50g/kg.bw (be equivalent to human body recommended amounts 5,10,30 times), product of the present invention are prepared with deionized water, per os gavage gives each dosage treated animal once a day, control group gives equal-volume deionized water, and gavage is 30 days continuously.Administration weighs Mouse Weight once on the 1st day, and dosage is converted to administration volume according to body weight by 0.4mL/20g, within every 7 days afterwards, weighs once, and administration volume is regularly adjusted according to the variation of body weight.The < < health food check of issuing according to health ministry and assessment technique standard > > (2003 editions) method by 4 groups of mouse by diving tower experiment, keep away dark experiment, shuttle box experiment, morris water maze laboratory and test in turn.
Experimental result
1, the impact of functional food on the experiment of mouse diving tower
The results are shown in Table 1 and table 2.The middle and high dosage group of test and control group comparison are consolidated in memory, and obviously extend incubation period, and in mouse 3min, errors number is obviously less than control group, has significant difference (P<0.05).
The memory of table 1 diving tower experiment mice obtains and the result of consolidating
* with control group comparison, P<0.05.
Memory represents-table 2 diving tower experiment mice disappears experimental result
2, functional food is kept away the impact of dark experiment on mouse
The results are shown in Table 3 and table 4.Memory acquisition and memory represents-disappear in experiment, middle dosage group and control group comparison, incubation period, significant prolongation, had significant difference (P<0.05).
Table 3 is kept away dark experiment mice memory and is obtained and the result of consolidating
* with control group comparison, P<0.05.
Table 4 is kept away the result of dark experiment mice memory represents-disappear
* with control group comparison, P<0.05.
3, the impact that functional food shuttles back and forth and tests mouse
The results are shown in Table 5.Low dose group and control group comparison, significantly shortened in the active/passive avoidance time of first day and training in the 3rd day, has significant difference (P<0.05); Middle dosage group and control group comparison, avoid the time in the active/passive of the 3rd day and the 5th day training and significantly shorten, and has significant difference (P<0.05); High dose group and control group comparison, significantly shortened in the active/passive avoidance time of training in the 3rd day, has significant difference (P<0.05).
The table 5 experiment mice active/passive of shuttling back and forth is avoided the result of time
* with control group comparison, P<0.05.
4, the impact of functional food on mouse morris water maze laboratory
The results are shown in Table 6.Detect in experiment, middle dosage group and control group comparison, in 60s, target approach quadrant number of times significantly increases, and has significant difference (P<0.05); In contraposition, detect in experiment, basic, normal, high dosage group and control group comparison, target approach quadrant is taken time and is significantly shortened, there is significant difference (P<0.05), middle dosage group and control group comparison, in 60s, target approach quadrant number of times significantly increases, and has significant difference (P<0.05).
Table 6 water maze laboratory is detected with contraposition and is detected experimental result
* with control group comparison, P<0.05.
Interpretation of result
In diving tower experiment, middle and high dosage group and control group comparison, memory is consolidated and is obviously extended incubation period, in mouse 3min, errors number is obviously less than control group, difference has conspicuousness (P<0.05), points out the functional food of the present invention of middle and high dosage group to have facilitation to mouse memory procurement process.Keep away in dark experiment, middle dosage group and control group comparison, its memory obtains and memory represents-significant prolongation in incubation period that disappears, difference has conspicuousness (P<0.05), and in prompting, the functional food of the present invention of dosage group has certain facilitation to the memory acquisition of mouse passive avoidance response and memory represents.Shuttle back and forth in experiment, basic, normal, high dosage group and control group comparison, all there is significant difference (P<0.05) the active/passive avoidance time in different cycles of training, points out the functional food of the present invention of basic, normal, high dosage group to have some improvement to mouse memory.In water maze laboratory, basic, normal, high dosage group and control group comparison, detect and detect experiment with contraposition and have significant difference (P<0.05), point out the Physique about Functional Food of the present invention of basic, normal, high dosage group to improve significantly the memory represents ability of spatial discrimination or the spatial discrimination of mouse.
Mouse diving tower experiment, keep away dark experiment, the experiment of shuttling back and forth is to measure the common experimental method that whether can improve animal used as test memory, morris water maze is a kind of research space learning memory models directly related with hippocampus function, can reflect more exactly the space learning memory capability of animal.This result of study shows, shuttle back and forth experiment, water maze laboratory result of low dose group is positive, the experiment of middle dosage group diving tower, keep away dark experiment, the experiment of shuttling back and forth, water maze laboratory result be all positive, the experiment of high dose group diving tower, the experiment of shuttling back and forth, water maze laboratory result are all positive, point out each dosage group functional food of the present invention all to have clear improvement to the learning and memory of mouse, have and improve cognitive function.
Experimental example 2
The object of this experimental example is to study the function whether functional food of the present invention has alleviating physical fatigue.
Animal used as test
200 of male mouse of kunming, body weight (20 ± 2) g, feeding environment, hello feed are with experimental example 1.
Before experiment, adaptability is raised 3 days.
Experimental technique
Use the functional food composition of the present invention 2 of preparation in embodiment 2, alleviating physical fatigue function is tested.Laboratory mice is divided into 4 groups at random by body weight, 50 every group.Experiment grouping, dosage design with experimental example 1.Product of the present invention are prepared with deionized water, and per os gavage gives each dosage treated animal once a day, and control group gives equal-volume deionized water, and gavage is 30 days continuously.After last gavage, every treated animal is divided into again to 5 groups, 10 mouse of every group.The < < health food check of issuing according to health ministry is carried out respectively swimming with a load attached to the body time, serum urea nitrogen, hepatic glycogen, blood lactic acid and 5 index determinings of Serum Creatine Kinase of Patients with assessment technique standard > > (2003 editions) method by the mouse of 5 groups.
Experimental result
The results are shown in Table 7, basic, normal, high dosage group mice burden swimming time, hepatic glycogen all increase compared with control group, Serum Creatine Kinase of Patients all reduces compared with control group, difference highly significant (P<0.01), middle and high dosage group Mouse Blood lactic acid TG-AUC reduces compared with control group, difference highly significant (P<0.01).The serum urea nitrogen content of three dosage groups all has decline compared with control group, but does not find significant difference (P>0.05).
Table 7 functional food is to mice burden swimming time, serum urea ammonia, hepatic glycogen, Serum Creatine Kinase of Patients, blood lactic acid
The impact of TG-AUC
* with control group comparison, P<0.05, * * and control group comparison, P<0.01.
Interpretation of result
The length of swimming with a load attached to the body time is relevant with exercise tolerance, can reflect the degree of body movement fatigue.Hepatic glycogen is the important stock that maintains glucose in blood normal level, and body glycogen deposit can be reflected in the source of energy while being also muscle fibers contract.It is to cause tired major reason that lactic acid is piled up, and different times Serum lactic acid content before and after moving by mensuration, can make an appraisal to degree of fatigue and recovery situation.Creatine phosphokinase is mainly present in skeletal muscle and cardiac muscle, participate in the contraction energy supply of glucolytic control, mitochondrial breathing and muscle, be the key enzyme of body ATP-CP energy supplying system metabolism, can be used as the important sensitive indicator that evaluation muscle bears stimulation, the trickle damage of skeletal muscle and adapts to and recover.
The experiment of the basic, normal, high dosage group of this functional food mice burden swimming, hepatic glycogen are all positive, middle and high dosage group Mouse Blood lactic acid result is positive, and after pointing out this functional food can significantly improve exercise tolerance, promote glycogen deposit or reducing glycogen use, minimizing motion, lactic acid is piled up.According to the < < of Ministry of Public Health health food, check thinks that with assessment technique standard (2003 editions) > > evaluation criterion functional food of the present invention has the function of alleviating physical fatigue, and the effect of middle and high dosage group is more remarkable.Within 2011, the Ministry of Public Health adjusts in < < function of health food scope the detection of advising increasing Serum Creatine Kinase of Patients in scheme > > (exposure draft) in zoopery again.The basic, normal, high dosage group of functional food of the present invention Serum Creatine Kinase of Patients all significantly reduces compared with control group, further illustrates this functional food in the useful effect of alleviating physical fatigue function aspects.
Experimental example 3
The object of this experimental example is to study the effect whether functional food of the present invention has rapid recovery mental fatigue function.
Subjects
8 of health young man volunteers, 29.2 ± 5.8 years old mean age, the important organ illness such as the heart, liver, kidney are not found in health check-up, daily life rule, readme is without sleep-disorder.By study subject, according to general status index, be parameter pairing, be divided at random test group and control group, every group of 4 people.
Test method
Use the functional food composition of the present invention 3 of preparation in embodiment 3, rapid recovery mental fatigue function is tested.The edible functional food composition 3 of the present invention of test group 0.5h before test, control group is taken placebo.Before experiment, sleep well, starts No drinking strong tea, coffee, alcoholic beverage and relevant medicine morning.Process of the test divides two stages to carry out: 1. training stage: experimenter concentrates explanation to be also familiar with after experimental procedure and method of testing, mainly carry out religion eight Aircraft Simulator synthetic flight trainings, comprise the exercise such as flight and two task operatings when religion eight Aircraft Simulators are simulated large airline operation, the long boat of simulation, to simulated flight achievement good (correct conservation rate reaches more than 80%, and the achievement in continuous 2～3 operations is stable).2. implementation phase: take functional food of the present invention 0: 30 morning, within 01: 00～05: 00, complete flight simulation test.Airwork is large airline operation: vertical velocity 8, wind direction 0, wind-force 0,7 limits of flying altogether, every limit 5min.Before test and after on-test, 1h, 2h, 3h, 4h aerial mission are measured main task (simulated flight achievement), the attachment of a task, flicker fusion frequency (CFF) and fill in Sleepiness Scale and fatigue scale after completing respectively.
Result of the test
The results are shown in Table 8, table 9.Test group and control group main task (model flight flying score) conservation rate and the attachment of a task 2h, 3h, 4h and 1h after on-test are relatively showed no significant difference (P>0.05), but during test group correct response, time and the number of finishing the work maintain comparatively steadily level all the time, and raise gradually during control group correct response, the number of finishing the work reduces gradually, after on-test, the 4h number of finishing the work reduces the most obvious.Test group and control group be all significantly risings (P<0.05) before test of 1h, 2h, 3h, 4h Sleepiness Scale and fatigue scale score after on-test.Control group CFF reduces gradually, and difference has statistical significance (P<0.05), and test group CFF compares and has no significant difference with before test.
The impact of main task and attachment of a task when table 8 functional food navigates on simulating length
Fly when the simulating long boat impact of Sleepiness Scale, fatigue scale, CFF of table 9 functional food
* with on the same group interior test is relatively front, P<0.05, and * * and on the same group interior test are relatively front, P<0.01.
Interpretation of result
Model flight flying score conservation rate can reflect experimenter's operational capacity, and the attachment of a task is the reserve of investigating experimenter's main task operational capacity, can indirectly reflect the work load that main task is shared.After flying during the long boat of simulation, control group main task conservation rate, the attachment of a task all have reduction or prolongation in various degree, sense that experimenter is drowsiness, sense of fatigue all have to a certain degree to be increased, the 4h that flies when especially simulation at night length is navigated obviously reduces, now flight operation ability and obviously reduction of deposit are described, drowsiness sense, sense of fatigue also obviously increase, and after the edible functional food of the present invention of test group, can alleviate to a certain extent this situation.Prolongation along with the flight time, control group CFF obviously reduces, illustrate that central nerve fatigue degree is increasing the weight of, and CFF remains steady level after the edible functional food 1h of the present invention of test group, 2h, 3h, 4h, show that functional food of the present invention has the effect of quick antagonism central nervous system fatigue, can maintain alertness.
In sum, functional food of the present invention has the function that improves cognitive and fatigue-relieving.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements, all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (2)
1. a functional food that improves cognitive and fatigue-relieving, is characterized in that, comprises the active component of following weight portion: 10～500 parts of taurines, 10～350 parts of caffeines, 10～350 parts of pueraria root powders, 1～80 part of panaxoside.
2. functional food according to claim 1, is characterized in that, comprises following active component: 15～400 parts of taurines, 15～300 parts of caffeines, 30～300 parts of pueraria root powders, 2～50 parts of panaxosides.
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| CN105166896A (en) * | 2015-09-06 | 2015-12-23 | 吉林大学 | Health-care food capable of improving memory in auxiliary manner |
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| CN107836708A (en) * | 2017-10-31 | 2018-03-27 | 北京同仁堂健康药业股份有限公司 | A kind of composition for promoting muscle synthesis and preparation method thereof |
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