CN101254199A - Panax saponin Rg1 and thein combination and uses thereof - Google Patents
Panax saponin Rg1 and thein combination and uses thereof Download PDFInfo
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- CN101254199A CN101254199A CNA2008100078640A CN200810007864A CN101254199A CN 101254199 A CN101254199 A CN 101254199A CN A2008100078640 A CNA2008100078640 A CN A2008100078640A CN 200810007864 A CN200810007864 A CN 200810007864A CN 101254199 A CN101254199 A CN 101254199A
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Abstract
The invention relates to a composition comprising ginsenoside Rg1 and caffeine with antifatigue, memory improving and central exciting effects and an application thereof. The composition comprises the following raw ingredients (wt %): ginsenoside Rg1 1-99 and caffeine 99-1. The reasonable formula of ginsenoside Rg1 and caffeine overcomes the shortcoming of caffeine that can only resist short-term sports fatigue, and takes synergistic antifatigue, memory improving and central exciting effects. The inventive composition can be mixed with proper pharmaceutical or food adjutants to prepare into pharmaceutically-acceptable preparations or food preparations.
Description
Technical field:
The present invention relates to a kind of compositions that has resisting fatigue, improves memory and central excitation effect, especially relate to the Chinese medicine composition that a kind of ginsenoside Rg1 and caffeine are formed, and the purposes of said composition on preparation medicine and food.
Background technology:
Tired (fatigue) is a comprehensive physiological process that relates to many Physiology and biochemistry factors, it is a kind of normal physiological phenomenon that body mental activity or physical exertion must occur during to certain phase, it had both indicated the temporary transient decline of the original ability to work of body, might be the tendency that body develops into sick and wounded state.According to the biochemical meeting of international movement fatigue is defined as: " physiological process of body can not remain on its function one specified level or each organ can not keep its predetermined exercise intensity the time, is called fatigue ".By the difference of tired happening part, can be divided into tired three classes of periphery of nervus centralis fatigue, nerve-muscle contact fatigue and limbs.On the Chinese medicine fatigue roughly is divided into three types: body fatigue, internal organs fatigue and mind fatigue.
We think that fatigue can be divided into physical fatigue and mental fatigue, and physical fatigue is that the muscle of body self-report lacks the energy sense, and it is faint often to show as muscle.Mental fatigue then is a kind of subjective sensation of amotivational and vigilance, show as feel dizzy, absent minded, thinking difficulty, inefficiency, hypomnesis.
The generation of delay fatigue and/or the tired elimination of promotion, promptly resisting fatigue is a hot issue of present sports medical science research.Can eliminate organism fatigue by rest, sleep and some physical method on the one hand, then can rely on additional, the Chinese medicine conditioning of nutrient substance to reach the antifatigue purpose on the other hand.
Advance along with socioeconomic in recent years, the fatigue that rhythm of life accelerates, factors such as operating pressure increases, sleep deprivation cause has become the able-bodied problem of the people that has a strong impact on, even can develop into chronic fatigue syndrome.That fatigue has often shown as is faint, muscular soreness, daytime somnolence, attention laxes and hypomnesis.The medicine or the functional food of reply fatigue symptom can not address the above problem at present.
Caffeine is used very wide in fatigue resistant health food, and it is central nervous system's excitement that caffeine mainly acts on, inspire enthusiasm, make the people to keep clear-headed and alertness.Recently discover that caffeine also has the effect that promotes learning and memory.But long-term use separately can produce side reactions such as anxiety, agitation, insomnia, irritability and fine movement function be impaired.
Radix Ginseng Rg1 is the significant composition of Radix Ginseng, has many biological activitys of Radix Ginseng.Present known biologic activity has: nootropics, the basic synapse transmission of enhancing, defying age, resisting fatigue, immunostimulant, sexual function improving and promotion memory obtain, consolidate and reproduce.Radix Ginseng Rg1 can improve the overall process of learning and memory.
Though above-mentioned two medicines have certain resisting fatigue, improve memory and central excitation effect, its comprehensive therapeutic effect has much room for improvement.How to overcome the shortcoming of taking single medicinal material, with Radix Ginseng Rg1 and caffeine reasonable compatibility, short complementary mutually, making it at aspect performance the best use ofs such as resisting fatigue, improvement memory and stimulating central nervous system systems is its difficult point places.
Utilize the synergism of Radix Ginseng Rg1 and caffeine at present, composition of prescription, the medicine or the food that be used to prepare resisting fatigue, improve memory and stimulating central nervous system system do not appear in the newspapers as yet.
Summary of the invention:
Purpose of the present invention aims to provide a kind of ginsenoside Rg1 and caffeine compositions product that has resisting fatigue, improves memory and central excitation effect, require its prescription reasonable mixture ratio, preparation method simply effective, and the purposes of this product on preparation medicine and food is provided.
Product of the present invention is made up of following raw materials by weight percent: the ginsenoside Rg1: 1%～99% and caffeine: 99%～1%, and be equipped with an amount of medicinal or edible adjuvant, make pharmaceutically or acceptable preparation on the food.
The percentage by weight preferable range of product of the present invention is: the ginsenoside Rg1: 20%～80% and caffeine: 80%～20%.
Raw material ginsenoside Rg1 and caffeine in the product of the present invention all can be buied on medical market.
Pharmaceutical preparation of the present invention can be injection, injectable powder, tablet, capsule, slow releasing tablet, slow releasing capsule, drop pill, oral administration solution, syrup, powder, mixture, granule, buccal tablet, microcapsule etc., and described food formulation can be beverage, confection, cookies, fruit jelly, chewing gum etc.
Adjuvant of the present invention is the conventional adjuvant of various preparations.
The main component effect of product of the present invention is as follows:
The ginsenoside Rg1: the significant composition of Radix Ginseng is the effective monomer in the Radix Ginseng, has many biological activitys of Radix Ginseng.Present known biologic activity has: nootropics, the basic synapse transmission of enhancing, defying age, resisting fatigue, immunostimulant, sexual function improving and promotion memory obtain, consolidate and reproduce.The ginsenoside Rg1 can improve the overall process of learning and memory.
Factors such as the generation of sports fatigue and energy expenditure, metabolite accumulation and interior environmental change have close ties.The ginsenoside Rg1 can increase the glycogen deposit, keeps glucostasis, increases fatty energy supply ratio, thereby saves the utilization of endogenous glycogen, suppresses blood urea nitrogen and piles up, and quickens lactic acid and eliminates, and alleviates sports fatigue.
Factors such as age, environment, sick and wounded, fatigue can make people's ability of learning and memory descend.The ginsenoside Rg1 can promote the cerebral tissue protein synthesis, improves the neurotransmitter propagation function, promotes the hippocampus neuronal function, promote the cranial nerve growth, plays the effect that promotes learning and memory.In addition, the ginsenoside Rg1 has slight excitation to the central nervous system.
Caffeine: the central nervous system is had excitation, and the excited cerebral cortex of caffeine increases corticocerebral process of excitation, can cheer up, and reduces feeling of fatigue, eliminates sleepiness, improves thinking activities.Improve attention, self-confidence and work efficiency.Strengthen Vigilance, enhancing your vigilance property and keep persistent ability to work.Strengthen identification ability, shorten fast and the selection reflection time, and can improve instantaneous oral memory.Caffeine promotes the effect of learning and memory in addition.But separately caffeine is applied to improve tired symptom, first excitement can occur, the phenomenon that the back is dispirited.
Product of the present invention is ginsenoside Rg1 and caffeine rational formula, remedied the deficiency that caffeine can only resist short-term movement fatigue, can synergism behind the compound recipe, and play good resisting fatigue jointly, improve the drug effect of memory and stimulating central nervous system system.
It below is the pharmacological experiments of this product.
1 test material and method
1.1 test sample: product mix composite capsule of the present invention, ginsenoside Rg1, caffeine percentage by weight are 6: 4, self-control; Other reagent: scopolamine hydrobromide, Shanghai He Feng pharmaceutical factory, normal saline, the Chifeng is the monumental work pharmaceutical factory forever
1.2 healthy male mice in kunming is used in the laboratory animal experiment, body constitution amount 18～22g is provided by University of the Inner Mongol's medical college.The laboratory animal sub-cage rearing, 10 in every cage, ad lib, drinking-water.
1.3 antifatigue effect experimental technique mice continuous irrigation stomach 14 days.
1.3.1 power exhausts swimming test: get 40 of mices and be divided into 4 groups at random, be i.e. blank group, test sample low dose group, middle dosage group and high dose group.Every group 10, irritate stomach with distilled water 0.2ml/10g, test sample 10mg/kg, 20mg/kg, 40mg/kg respectively successively, every day 1 time, successive administration 30 days, behind the last administration 30min, at the sheet lead of mouse tail root heavy burden body weight 5%, to put into the swimming groove of 30 ℃ of water temperatures, depth of water 25cm and swim, record mice record mice exhausts the death time from swimming to power.Power exhausts criterion: mice sinks under water above 10s, after picking up immediately, can't finish righting reflex in the plane.
1.3.2 lactic acid is measured: get 40 of mices and be divided into 4 groups at random, be i.e. blank group, test sample low dose group, middle dosage group and high dose group.Every group 10, irritate stomach with distilled water 0.2ml/10g, test sample 10mg/kg, 20mg/kg, 40mg/kg respectively successively, every day 1 time, successive administration 30 days, behind the last administration 30min, put into 30 ℃ of swimming of water temperature groove heavy burden, 2% swimming 60min, full blood lactic concentration is measured in eyeball blood taking method blood sampling at once.
1.3.3 serum urea nitrogen determination: get 40 of mices and be divided into 4 groups at random, be i.e. blank group, test sample low dose group, middle dosage group and high dose group.Every group 10, irritate stomach with distilled water 0.2ml/10g, test sample 10mg/kg, 20mg/kg, 40mg/kg respectively successively, every day 1 time, successive administration 30 days behind the last administration 30min, is put into the no swimming with a load attached to the body 90min of water temperature 30 ℃ of swimming groove, behind the rest 60min, the blood sampling of eyeball blood taking method, separation of serum is measured serum urea nitrogen.
1.4 improve the memory effect experimental technique
1.4.1 product of the present invention is to the influence of normal learning and memory of little mouse: use darkness avoidance test, get 40 of mices and be divided into 4 groups at random, be i.e. blank group, test sample low dose group, middle dosage group and high dose group.Every group 10, irritate stomach with distilled water 0.2ml/10g, test sample 10mg/kg, 20mg/kg, 40mg/kg respectively successively, every day 1 time, successive administration 14 days, behind the last administration 60min, adopt darkness avoidance test training mice, animal is put into bright chamber, the record mice enters incubation period in darkroom by putting into bright chamber to getting into the cave, and the errors number that enters the darkroom in 5 minutes, as the index of study test, test again after 24 hours is as the memory experiment index.
1.4.2 product of the present invention is to the amnemonic influence of scopolamine hydrobromide induced mice: get 50 of mices and be divided into 5 groups at random, be i.e. blank group, model group, test sample low dose group, middle dosage group and high dose group.Every group 10, test sample low dose group, middle dosage group and high dose group dosage are the same; Matched group and model group are given contrast liquid distilled water 0.2ml/10g body weight.Each is organized and irritates stomach every day respectively 1 time, and gastric infusion is 14 days continuously.After administration in the 15th day, carried out the diving tower training in 1 hour, 15minip scopolamine hydrobromide 2mg/kg before training, capacity normal saline such as matched group injection.Mice is put into the diving tower instrument by grouping in batches, adapt to 3min earlier, energising is jumped onto diving tower after mice is shocked by electricity then, avoids electric shock.Training 5min also writes down electric shock number of times in the 5min, is the wrong reaction number of times.Again test behind the 24h, the electric shock number of times and the first time get an electric shock incubation period in the record 5min.
1.5 central excitation effect experimental technique
1.5.1 product of the present invention is to the influence of mice autonomic activities: get 40 of mices and be divided into 4 groups at random, be i.e. blank group, test sample low dose group, middle dosage group and high dose group.Every group 10, irritate stomach with distilled water 0.2ml/10g, test sample 10mg/kg, 20mg/kg, 40mg/kg respectively successively, every day 1 time, successive administration 14 days uses mice autonomic activities instrument to measure the autonomic activities number of times in 15～65min after the last administration.
1.6 statistical procedures: data mean ± standard deviation (
x± s) expression.With t check carrying out statistical analysis.
2 experimental results
2.1 antifatigue effect experimental result
Show 2.1.1 power exhausts the swimming test result: product test sample low dose group of the present invention, middle dosage group and the high dose group mice swimming power time that exhausts all prolong than blank group, low dose group, middle dosage group are compared with matched group, the equal highly significant of difference (P＜0.01).High dose group is compared with matched group, there was no significant difference (P＞0.05).The results are shown in Table 1.
Table 1 product of the present invention to mice power exhaust swimming time influence (
x± s, n=10)
2.1.2 product of the present invention is to lactic acid, the metabolic influence of serum urea nitrogen: in this test, observe product of the present invention to removing the mice metabolite and piling up or/and reduce the influence of its generation effect, the main index that adopts is serum urea nitrogen and full blood lactic.Each dosage group full blood lactic concentration all reduces than blank group, and low dose group is compared there was no significant difference (P＞0.05) with matched group, and middle and high dosage group is compared significant difference (P＜0.05) with matched group.The serum urea nitrogen measurement result shows that the serum urea nitrogen content that produces during each dosage group mouse movement reduces, and middle and high dosage group is compared difference and is highly significant (P＜0.01) with the blank group, and low dose group is significant difference (P＜0.05) by comparison.The results are shown in Table 2.
Table 2 product of the present invention to the influence of mice blood lactic acid, serum urea nitrogen (
x± s, n=10)
2.1.3 sum up: per os gave mice various dose sample after 30 days, had antifatigue effect.
2.2 improve the memory effect experimental result
2.2.1 product of the present invention is to the influence of normal learning and memory of little mouse: experimental result shows, the basic, normal, high dosage group of product of the present invention all can prolong normal mouse to be learnt the incubation period of test and test of memory, reduces errors number in the 5min, and the relatively more equal difference of each dosage group school grade and memory achievement and matched group is (P＜0.05) significantly.Point out product of the present invention that the learning and memory of normal mouse is had certain promotion.The results are shown in Table 3.
Table 3 product of the present invention to the influence of normal learning and memory of little mouse (
x± s, n=10)
2.2.2 product of the present invention is to the amnemonic influence of scopolamine hydrobromide induced mice: experimental result shows, (P＜0.01) is significantly shortened in model group and matched group comparison incubation period, 5min introskip digital display work next time increases (P＜0.01), illustrates that scopolamine hydrobromide has caused dysmnesia.Basic, normal, high dosage group of product of the present invention and model group compare, and errors number obviously reduces (P＜0.01) in significant prolongation incubation period (P＜0.01), 5min, illustrates that product of the present invention has the improvement effect to scopolamine hydrobromide induced mice memory acquisition disturbance.The results are shown in Table 4.
Table 4 product of the present invention to the amnemonic influence of scopolamine hydrobromide induced mice (
x± s, n=10)
2.2.3 sum up: product of the present invention is to the mice memory effect that improves significantly.
2.3 central excitation effect experimental result
2.3.1 product of the present invention is to the influence of mice autonomic activities: experimental result shows, the basic, normal, high dosage group of product of the present invention all can obviously increase mice autonomic activities number of times, middle and high dosage group is compared difference and is highly significant (P＜0.01) with the blank group, low dose group is significant difference (P＜0.05) by comparison.The results are shown in Table 5.
Table 5 product of the present invention to the influence of spontaneous activity in mice (
x± s, n=10)
Sum up: the basic, normal, high dosage group of product of the present invention is in experimentation, and first excitement, the dispirited or phenomena of mortality in back do not appear in animal.Each dosage group all can increase the autonomic activities number of times of mice.
The specific embodiment:
By following specific embodiment, can further understand the present invention, but protection scope of the present invention is not limited to this.
Embodiment one compound ginseng saponin Rg1 and caffeine freeze-dried powder
Precision is measured ginsenoside Rg1's 80 grams, caffeine 20 grams, and mannitol 1000 grams adopt conventional injectable powder preparation method can make the compound ginseng saponin Rg1 and the caffeine freeze-dried powder of the specification of 1000 100mg.
Embodiment two compound ginseng saponin Rg1 and caffeine oral liquid
Precision is measured ginsenoside Rg1's 150 grams, caffeine 50 grams, and Mel 1000 grams, distilled water adds to 10kg, adopts conventional oral liquor can prepare 1000 (every nearly weighs 11 grams) oral liquids.Each edible one, every day 1～2 time.
Embodiment three compound ginseng saponin Rg1 and caffeine capsule
Precision is measured ginsenoside Rg1's 80 grams, caffeine 20 grams, and starch 100 grams adopt conventional capsule preparation method thereof can prepare 1000 (the tolerant 200mg of every intragranular) capsules.Each edible 1～2, every day 1～2 time.
Embodiment four compound ginseng saponin Rg1 and caffeine granule
Precision is measured ginsenoside Rg1's 75 grams, caffeine 25 grams, and sucrose 2500 grams, dextrin 400 grams, ethanol is an amount of, adopts conventional granulation to granulate, and is distributed into 1000 bags (every bag of about 3.0 grams).Each edible 1～2 bag, every day 1～2 time.
Claims (4)
1, a kind of ginsenoside Rg1 and caffeine compositions that has resisting fatigue, improves memory and central excitation effect is characterized in that being made up of following raw materials by weight percent: the ginsenoside Rg1: 1%～99% and caffeine: 99%～1%.
2, compositions according to claim 1 is characterized in that being made up of following raw materials by weight percent: the ginsenoside Rg1: 20%～80% and caffeine: 80%～20%.
3, the purposes of compositions according to claim 1 is characterized in that being equipped with an amount of medicinal or edible adjuvant, makes pharmaceutically or acceptable preparation on the food.
4,, it is characterized in that having resisting fatigue in preparation, improving the application in memory and central excitation drugs with function or the functional food as claim 1,2 or 3 described compositionss.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008100078640A CN101254199A (en) | 2008-02-26 | 2008-02-26 | Panax saponin Rg1 and thein combination and uses thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103734734A (en) * | 2014-01-29 | 2014-04-23 | 中国人民解放军空军航空医学研究所 | Functional food capable of improving cognition and relieving fatigue |
| CN106265703A (en) * | 2015-05-11 | 2017-01-04 | 东北师范大学 | Ginsenoside Rg1's application in preparation improves body movement ability health product |
| CN112641765A (en) * | 2021-01-22 | 2021-04-13 | 中国人民解放军军事科学院军事医学研究院 | Anti-fatigue pharmaceutical application of propofol |
-
2008
- 2008-02-26 CN CNA2008100078640A patent/CN101254199A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103734734A (en) * | 2014-01-29 | 2014-04-23 | 中国人民解放军空军航空医学研究所 | Functional food capable of improving cognition and relieving fatigue |
| CN106265703A (en) * | 2015-05-11 | 2017-01-04 | 东北师范大学 | Ginsenoside Rg1's application in preparation improves body movement ability health product |
| CN112641765A (en) * | 2021-01-22 | 2021-04-13 | 中国人民解放军军事科学院军事医学研究院 | Anti-fatigue pharmaceutical application of propofol |
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Open date: 20080903 |