CN110101793A - A kind of anti-fatigue traditional Chinese preparation and preparation method thereof - Google Patents
A kind of anti-fatigue traditional Chinese preparation and preparation method thereof Download PDFInfo
- Publication number
- CN110101793A CN110101793A CN201910548288.9A CN201910548288A CN110101793A CN 110101793 A CN110101793 A CN 110101793A CN 201910548288 A CN201910548288 A CN 201910548288A CN 110101793 A CN110101793 A CN 110101793A
- Authority
- CN
- China
- Prior art keywords
- preparation
- parts
- reserve liquid
- traditional chinese
- stoste
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 73
- 230000002929 anti-fatigue Effects 0.000 title claims abstract description 42
- 239000002398 materia medica Substances 0.000 claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 19
- 239000007788 liquid Substances 0.000 claims description 61
- 238000001802 infusion Methods 0.000 claims description 47
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 244000307697 Agrimonia eupatoria Species 0.000 claims description 18
- 241000208340 Araliaceae Species 0.000 claims description 18
- 239000009636 Huang Qi Substances 0.000 claims description 18
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 18
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 18
- 240000001341 Reynoutria japonica Species 0.000 claims description 18
- 235000018167 Reynoutria japonica Nutrition 0.000 claims description 18
- 235000000125 common agrimony Nutrition 0.000 claims description 18
- 235000008434 ginseng Nutrition 0.000 claims description 18
- 235000005340 Asparagus officinalis Nutrition 0.000 claims description 16
- 239000002994 raw material Substances 0.000 claims description 12
- 238000002791 soaking Methods 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 244000003416 Asparagus officinalis Species 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 30
- 239000003814 drug Substances 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 10
- 210000004369 blood Anatomy 0.000 abstract description 9
- 239000008280 blood Substances 0.000 abstract description 9
- 210000004185 liver Anatomy 0.000 abstract description 9
- 210000000952 spleen Anatomy 0.000 abstract description 8
- 210000003734 kidney Anatomy 0.000 abstract description 7
- 230000008569 process Effects 0.000 abstract description 7
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 206010057315 Daydreaming Diseases 0.000 abstract description 5
- 230000000857 drug effect Effects 0.000 abstract description 5
- 230000009471 action Effects 0.000 abstract description 4
- 230000003796 beauty Effects 0.000 abstract description 4
- 210000001124 body fluid Anatomy 0.000 abstract description 4
- 239000010839 body fluid Substances 0.000 abstract description 4
- 238000010791 quenching Methods 0.000 abstract description 3
- 230000035922 thirst Effects 0.000 abstract description 3
- 230000032683 aging Effects 0.000 abstract description 2
- 208000033065 inborn errors of immunity Diseases 0.000 abstract description 2
- 208000028529 primary immunodeficiency disease Diseases 0.000 abstract description 2
- 230000001737 promoting effect Effects 0.000 abstract 1
- 238000002156 mixing Methods 0.000 description 21
- 241000234427 Asparagus Species 0.000 description 12
- 241000699666 Mus <mouse, genus> Species 0.000 description 10
- 241000699670 Mus sp. Species 0.000 description 10
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 10
- 238000005259 measurement Methods 0.000 description 9
- 229920002527 Glycogen Polymers 0.000 description 8
- 229940096919 glycogen Drugs 0.000 description 8
- 230000002440 hepatic effect Effects 0.000 description 8
- 206010016256 fatigue Diseases 0.000 description 5
- 235000014655 lactic acid Nutrition 0.000 description 5
- 239000004310 lactic acid Substances 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 230000007423 decrease Effects 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 235000021096 natural sweeteners Nutrition 0.000 description 4
- 102100026189 Beta-galactosidase Human genes 0.000 description 3
- 241000721047 Danaus plexippus Species 0.000 description 3
- 108010059881 Lactase Proteins 0.000 description 3
- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 108010005774 beta-Galactosidase Proteins 0.000 description 3
- 229940116108 lactase Drugs 0.000 description 3
- 238000011017 operating method Methods 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004737 colorimetric analysis Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 description 1
- 206010034719 Personality change Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- RJGDLRCDCYRQOQ-UHFFFAOYSA-N anthrone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3CC2=C1 RJGDLRCDCYRQOQ-UHFFFAOYSA-N 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000021552 granulated sugar Nutrition 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 238000009343 monoculture Methods 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to Chinese medicine and its preparation field, a kind of anti-fatigue traditional Chinese preparation and preparation method thereof is disclosed.The Chinese materia medica preparation is to be prepared by the Chinese medicine for selecting all kinds of drug effects applicable, and clinically applied.Each medicinal material compatibility in the Chinese materia medica preparation is proper, substantially enhances the effect that Xiang Zuoxiang is helped, suitably merged between each medicinal material, thus the effect of reaching tonifying spleen qi-regulating, invigorating qi and benefiting blood, protect liver beauty treatment and promoting the production of body fluid to quench thirst.At the same time, under the action of all kinds of medicinal materials cooperate, antifatigue effect is effectively strengthened, the plumpness of the human body state of mind is significantly improved, to tired, absent-minded and aging of human body etc. is resisted with high curative effect, achieved the purpose that from the root antifatigue.The preparation method operating process of the Chinese materia medica preparation is simple and direct, and step is fewer but better, low in cost.The Chinese materia medica preparation is without any side effects, securely and reliably, the crowd being had damage etc. suitable for all kinds of hypoimmunities, long-distance vehicle driver and liver,kidney,spleen function.
Description
Technical field
The invention belongs to Chinese medicine and its preparation technical fields, and in particular to a kind of anti-fatigue traditional Chinese preparation and its preparation side
Method.
Background technique
Fatigue, refer to due to work or move cause organism physiology, biochemical change and under causing body work capacity temporary
The phenomenon that drop.Existing research shows that fatigue mainly causes the consumption of body energy substance, causes fatigue due to working or moving
The physiological reactions such as accumulation, endocrine metabolic diseases disorder, immunologic function disorder, protectiveness inhibition, the Free Radical of substance cause tired
The generation of labor, specifically may occur in which it is absent minded, feel dizzy, be slow in reacting, human body is weak, limbs fatigue or the diseases such as drowsiness
Shape, it is serious can the problems such as cause insomnia, dreaminess, Nausea and vomiting, personality change.Psychologically being presented with causes people to work
The enthusiasm of life of opposing and interest are substantially reduced, until generating weary mood.In addition, long-term psychological pressure is big, hormone disturbance, exempts from
Epidemic disease exception etc., is the main inducing for causing chronic fatigue syndrome.The work of excess load, excessive pressure and irregular life
Work and rest living makes people usually feel that feeling of fatigue, taediumvitae are difficult to restore for a long time.
Existing antifatigue drug contains excitant ingredient more currently on the market, and scientific research proves, doping
The physical and mental health of people can seriously be damaged.
Summary of the invention
In order to solve the above problems existing in the present technology, it is an object of that present invention to provide a kind of anti-fatigue traditional Chinese preparation and
Preparation method.
The technical scheme adopted by the invention is as follows: a kind of anti-fatigue traditional Chinese preparation, the Chinese materia medica preparation is mainly by following quality
The raw material of number is prepared:
30-200 parts of hairyvein agrimony, 10-80 parts of Radix Astragali, 10-70 parts of ginseng, 20-80 parts of the fleece-flower root, 20-70 parts of rhizoma polygonati and day
Door winter 20-90 part.
Preferably, which is mainly prepared by the raw material of following mass fraction:
90-140 parts of hairyvein agrimony, 30-65 parts of Radix Astragali, 20-60 parts of ginseng, 45-65 parts of the fleece-flower root, 40-60 parts of rhizoma polygonati and day
Door winter 30-55 part.
Preferably, which is mainly prepared by the raw material of following mass fraction:
100 parts of hairyvein agrimony, 50 parts of Radix Astragali, 50 parts of ginseng, 50 parts of the fleece-flower root, 50 parts of rhizoma polygonati and 50 parts of lucid asparagus.
The anti-fatigue traditional Chinese preparation provided by the invention is prepared by the Chinese medicine for selecting all kinds of drug effects applicable,
And it is clinically applied.Each medicinal material monarch compatibility in the Chinese materia medica preparation is proper, substantially enhance each medicinal material it
Between the Xiang Zuoxiang effect helping, suitably merge, to reach tonifying spleen qi-regulating, invigorating qi and benefiting blood, kidney tonifying permanent tooth, protect liver beauty treatment and promote the production of body fluid only
Thirsty effect.At the same time, under the action of all kinds of medicinal materials cooperate, antifatigue effect is effectively strengthened, people is significantly improved
The plumpness of the body state of mind reaches from the root to tired, absent-minded and aging of human body etc. is resisted with high curative effect
Antifatigue purpose.
A kind of preparation method of anti-fatigue traditional Chinese preparation, the preparation method include the following steps:
(1) it impregnates: adding after weighing hairyvein agrimony, Radix Astragali, ginseng, the fleece-flower root, rhizoma polygonati and lucid asparagus mixing according to corresponding proportion
Solvent soaking；
(2) infusion: the raw material after impregnating in step (1) are subjected to infusion to boiling, obtain stoste reserve liquid；
(3) it cools down and filters: by the stoste reserve liquid cooled and filtered in step (2), obtaining secondary reserve liquid；
(4) finished product is made: carrying out secondary filter after the secondary reserve liquid in step (3) is stood, finished product is made.
The preparation method operating process of the Chinese materia medica preparation provided by the invention is simple and direct, and operating procedure is fewer but better, low in cost.
The Chinese materia medica preparation is without any side effects, securely and reliably, be suitable for all kinds of hypoimmunity crowds, long-distance vehicle driver and
The crowd that liver,kidney,spleen function is had damage etc..
Preferably, institute's solubilizer includes water in step (1), and amount of water and weighed medicinal material total quality ratio are 140-400:7-
20；
Preferably, amount of water and weighed medicinal material total quality ratio are 200-360:10-18；
It is further preferred that amount of water and weighed medicinal material total quality ratio are 240-300:12-15.
Preferably, soaking time is 30-75 minutes in step (1)；
Preferably, soaking time is 50-65 minutes；
It is further preferred that soaking time I 60 minutes.
Preferably, the infusion time is 15-60 minutes in step (2)；
Preferably, the infusion time is 25-40 minutes；
It is further preferred that the infusion time is 30 minutes.
Provided by the invention this be used for antifatigue Chinese materia medica preparation raw material material is impregnated, infusion, to soaking time,
The setting that amount of water needed for infusion time, infusion and infusion need to boil is for setting after raw material obtain sufficiently impregnating
Infusion is carried out at a temperature of fixed infusion, can improve medicinal ingredient in raw material in the case where reducing energy consumption to greatest extent
Amount of precipitation promotes treatment drug effect.
Preferably, stoste reserve liquid is cooled to 30-80 degrees Celsius in step (3)；
Preferably, stoste reserve liquid is cooled to 40-50 degrees Celsius；
It is further preferred that stoste reserve liquid is cooled to 45 degrees Celsius.
Preferably, 100-400 mesh filter screen is crossed after stoste reserve liquid is cooling in step (3)；
Preferably, 200-300 mesh filter screen is crossed after stoste reserve liquid is cooling；
It is further preferred that crossing 280 mesh filter screens after stoste reserve liquid is cooling.
Preferably, time of repose is 5-15 hours in step (4)；
Preferably, time of repose is 6-10 hours；
It is further preferred that time of repose is 8 hours.
Provided by the invention this is used for antifatigue Chinese materia medica preparation and is cooled down after the completion of infusion, is for reducing medicine
After agent temperature, can effectively reduce standing, filter process Chinese medicine liquid volatilization while help to take.Also ensure standing
After a period of time, efficiently separated between medical fluid and remover.
The invention has the benefit that
The invention discloses a kind of anti-fatigue traditional Chinese preparations and preparation method thereof.The anti-fatigue traditional Chinese preparation is to pass through selection
The applicable Chinese medicine of all kinds of drug effects is prepared, and is clinically applied.Each medicinal material the monarch and his subjects in the Chinese materia medica preparation
Assistant keeps compatibility proper, substantially enhances the effect that Xiang Zuoxiang is helped, suitably merged between each medicinal material, to reach tonifying spleen qi-regulating, mend
Gas benefit blood, kidney tonifying permanent tooth, protect liver beauty treatment and the effect of promote the production of body fluid to quench thirst.At the same time, under the action of all kinds of medicinal materials cooperate, effectively
Antifatigue effect is strengthened, the plumpness of the human body state of mind is significantly improved, it is tired, absent-minded and decline to human body is resisted
It waits for a long time with high curative effect, achievees the purpose that from the root antifatigue.The preparation method operating process of the Chinese materia medica preparation is simple and direct,
Operating procedure is fewer but better, low in cost.The Chinese materia medica preparation is without any side effects, securely and reliably, it is low to be suitable for all kinds of immunity
Under, the crowd that has damage etc. of long-distance vehicle driver and liver,kidney,spleen function.
Specific embodiment
Further explaination is done to the present invention combined with specific embodiments below.It will be understood to those of skill in the art that following institute
The embodiment of description is that a part of the embodiment of the present invention is merely to illustrate the present invention instead of all the embodiments, without that should regard
To limit the scope of the invention.Based on the embodiments of the present invention, those of ordinary skill in the art are not making creative labor
Every other embodiment obtained under the premise of dynamic, shall fall within the protection scope of the present invention.Actual conditions are not specified in embodiment
Person carries out according to normal conditions.Agents useful for same is the conventional products that can be obtained by commercially available purchase.
The present invention is added during actual fabrication in the specific implementation process in order to promote mouthfeel when patient takes
Natural sweetener, including honey, sucrose, granulated sugar etc..The type and addition Chinese medicine provided by the invention of above-mentioned natural sweetener
Dosage in preparation, patient can select according to the actual conditions of itself, while the natural sweetener has no effect on the present invention
The healing curative effect of the Chinese materia medica preparation of offer.
Embodiment 1:
It chooses and weighs 30 grams of hairyvein agrimony, 10 grams of Radix Astragali, 10 grams of ginseng, 20 grams of the fleece-flower root, 20 grams of rhizoma polygonati and lucid asparagus 20
It is put into container after gram mixing, 2200 grams of water is added into container and impregnate, carry out infusion after impregnating 30 minutes, infusion temperature is not low
After 100 degrees Celsius, infusion 15 minutes, stoste reserve liquid is obtained.Stoste reserve liquid is cooled to 30 degrees Celsius, crosses 100 purposes
Strainer obtains secondary reserve liquid.Secondary reserve liquid is stood 5 minutes after mixing evenly, the strainer of 150 mesh is crossed later, is made into
Product.
Embodiment 2:
It chooses and weighs 30 grams of hairyvein agrimony, 10 grams of Radix Astragali, 10 grams of ginseng, 20 grams of the fleece-flower root, 20 grams of rhizoma polygonati and lucid asparagus 20
It is put into container after gram mixing, 11800 grams of water is added into container and impregnate, carry out infusion after impregnating 75 minutes, infusion temperature is not
Lower than 100 degrees Celsius, infusion after sixty minutes, obtains stoste reserve liquid.Stoste reserve liquid is cooled to 80 degrees Celsius, crosses 400 mesh
Strainer, obtain secondary reserve liquid.Secondary reserve liquid is stood 15 minutes after mixing evenly, the strainer of 600 mesh is crossed later, is made
Finished product.
Embodiment 3:
It chooses and weighs 200 grams of hairyvein agrimony, 80 grams of Radix Astragali, 70 grams of ginseng, 80 grams of the fleece-flower root, 70 grams of rhizoma polygonati and lucid asparagus 90
It is put into container after gram mixing, 2200 grams of water is added into container and impregnate, carry out infusion after impregnating 30 minutes, infusion temperature is not low
After 100 degrees Celsius, infusion 15 minutes, stoste reserve liquid is obtained.Stoste reserve liquid is cooled to 30 degrees Celsius, crosses 100 purposes
Strainer obtains secondary reserve liquid.Secondary reserve liquid is stood 5 minutes after mixing evenly, the strainer of 150 mesh is crossed later, is made into
Product.
Embodiment 4:
It chooses and weighs 200 grams of hairyvein agrimony, 80 grams of Radix Astragali, 70 grams of ginseng, 80 grams of the fleece-flower root, 70 grams of rhizoma polygonati and lucid asparagus 90
It is put into container after gram mixing, 11800 grams of water is added into container and impregnate, carry out infusion after impregnating 75 minutes, infusion temperature is not
Lower than 100 degrees Celsius, infusion after sixty minutes, obtains stoste reserve liquid.Stoste reserve liquid is cooled to 80 degrees Celsius, crosses 400 mesh
Strainer, obtain secondary reserve liquid.Secondary reserve liquid is stood 15 minutes after mixing evenly, the strainer of 600 mesh is crossed later, is made
Finished product.
Embodiment 5:
It chooses and weighs 90 grams of hairyvein agrimony, 30 grams of Radix Astragali, 20 grams of ginseng, 45 grams of the fleece-flower root, 40 grams of rhizoma polygonati and lucid asparagus 30
It is put into container after gram mixing, 5100 grams of water is added into container and impregnate, carry out infusion after impregnating 50 minutes, infusion temperature is not low
After 100 degrees Celsius, infusion 25 minutes, stoste reserve liquid is obtained.Stoste reserve liquid is cooled to 40 degrees Celsius, crosses 200 purposes
Strainer obtains secondary reserve liquid.Secondary reserve liquid is stood 6 minutes after mixing evenly, the strainer of 200 mesh is crossed later, is made into
Product.
Embodiment 6:
It chooses and weighs 90 grams of hairyvein agrimony, 30 grams of Radix Astragali, 20 grams of ginseng, 45 grams of the fleece-flower root, 40 grams of rhizoma polygonati and lucid asparagus 30
It is put into container after gram mixing, 8900 grams of water is added into container and impregnate, carry out infusion after impregnating 65 minutes, infusion temperature is not low
In 100 degrees Celsius, infusion after forty minutes, obtains stoste reserve liquid.Stoste reserve liquid is cooled to 50 degrees Celsius, crosses 300 purposes
Strainer obtains secondary reserve liquid.Secondary reserve liquid is stood 10 minutes after mixing evenly, the strainer of 500 mesh is crossed later, is made into
Product.
Embodiment 7:
It chooses and weighs 140 grams of hairyvein agrimony, 65 grams of Radix Astragali, 60 grams of ginseng, 65 grams of the fleece-flower root, 60 grams of rhizoma polygonati and lucid asparagus 55
It is put into container after gram mixing, 5100 grams of water is added into container and impregnate, carry out infusion after impregnating 50 minutes, infusion temperature is not low
After 100 degrees Celsius, infusion 25 minutes, stoste reserve liquid is obtained.Stoste reserve liquid is cooled to 40 degrees Celsius, crosses 200 purposes
Strainer obtains secondary reserve liquid.Secondary reserve liquid is stood 6 minutes after mixing evenly, the strainer of 200 mesh is crossed later, is made into
Product.
Embodiment 8:
It chooses and weighs 140 grams of hairyvein agrimony, 65 grams of Radix Astragali, 60 grams of ginseng, 65 grams of the fleece-flower root, 60 grams of rhizoma polygonati and lucid asparagus 55
It is put into container after gram mixing, 8900 grams of water is added into container and impregnate, carry out infusion after impregnating 65 minutes, infusion temperature is not low
In 100 degrees Celsius, infusion after forty minutes, obtains stoste reserve liquid.Stoste reserve liquid is cooled to 50 degrees Celsius, crosses 300 purposes
Strainer obtains secondary reserve liquid.Secondary reserve liquid is stood 10 minutes after mixing evenly, the strainer of 500 mesh is crossed later, is made into
Product.
Embodiment 9:
It chooses and weighs 100 grams of hairyvein agrimony, 50 grams of Radix Astragali, 50 grams of ginseng, 50 grams of the fleece-flower root, 50 grams of rhizoma polygonati and lucid asparagus 50
It is put into container after gram mixing, 8900 grams of water is added into container and impregnate, carry out infusion after impregnating 65 minutes, infusion temperature is not low
In 100 degrees Celsius, infusion after forty minutes, obtains stoste reserve liquid.Stoste reserve liquid is cooled to 50 degrees Celsius, crosses 300 purposes
Strainer obtains secondary reserve liquid.Secondary reserve liquid is stood 10 minutes after mixing evenly, the strainer of 500 mesh is crossed later, is made into
Product.
Embodiment 10:
It chooses and weighs 100 grams of hairyvein agrimony, 50 grams of Radix Astragali, 50 grams of ginseng, 50 grams of the fleece-flower root, 50 grams of rhizoma polygonati and lucid asparagus 50
It is put into container after gram mixing, 7000 grams of water is added into container and impregnate, immersion carries out infusion after sixty minutes, and infusion temperature is not low
After 100 degrees Celsius, infusion 30 minutes, stoste reserve liquid is obtained.Stoste reserve liquid is cooled to 45 degrees Celsius, crosses 280 purposes
Strainer obtains secondary reserve liquid.Secondary reserve liquid is stood 8 minutes after mixing evenly, the strainer of 450 mesh is crossed later, is made into
Product.
The adult daily dose of the anti-fatigue traditional Chinese preparation provided by the invention is answered are as follows: daily total dose is no more than phase
The 60% of corresponding embodiment chinese raw materials gross mass.
Experimental example
The cleaning grade ICR mouse of 60 weight 23-25g, 8-9 week old is randomly selected as experimental subjects.By above-mentioned experiment
Object carries out a point cage monoculture, is then randomly divided into 10 experimental groups, every group of 6 ICR mouse, wherein in every group ICR mouse it is each
Item index is consistent.1 ICR mouse is extracted from each experimental group at random and compares group, remaining 5 are made experimental group.
Experimental subjects takes the mode of Chinese materia medica preparation provided by the invention: adult human oral is 3 times a day, every time
60mL.The anti-fatigue traditional Chinese preparation that every ICR mouse of experimental group is prepared each taking 10mg/Kg corresponding embodiment, daily 3
It is secondary.Control group takes the water of isodose.After taking 14 days, the following terms index is measured at the 15th day.
Test index:
(1) measurement of blood glucose: every experimental mice of tail hematometry is taken to swim after sixty minutes with Folin-Malmors method
Blood-sugar content.
(2) measurement of blood lactase acid: taking every mouse of tail hematometry to swim 20 minutes with acetaldehyde-parazon colorimetric method,
Serum lactic acid content when resting 25 minutes from water.
(3) measurement of hepatic glycogen content: liver anthrone colorimetry measurement hepatic glycogen is taken to contain after sacrificed by decapitation mouse immediately
Amount.
Measurement result:
The measurement table of 1 blood-sugar content of table, Serum lactic acid content and hepatic glycogen content
Note: blood-sugar content is a reference value that standard value refers to 100%, is determined on the basis of a reference value.
As the result is shown by table 1, it is known that:
(1) measurement result of blood-sugar content: in the embodiment of the anti-fatigue traditional Chinese preparation provided by the invention, embodiment 9
Experimental mice blood-sugar content is set only to have dropped 17% with embodiment 10, effect is best.Remaining each embodiment is small for experimental group
Apparent effect is all had for mouse.Meanwhile from the data in table it can be found that experimental mice 1-4 is using implementation
After example 1-4, blood-sugar content decrease speed is retarded；After having used embodiment 5-8, blood glucose contains experimental mice 5-8
Measuring decrease speed significantly reduces.
(2) measurement result of Serum lactic acid content: in the embodiment of the anti-fatigue traditional Chinese preparation provided by the invention, embodiment
9 and embodiment 10 promote experimental mice Serum lactic acid content conspicuousness, effect is best.Remaining each embodiment is small for experimental group
Apparent effect is all had for mouse.Meanwhile from the data in table it can be found that experimental mice 1-4 is using implementation
After example 1-4, it is relatively slow that Serum lactic acid content promotes speed；After having used embodiment 5-8, blood lactase acid contains experimental mice 5-8
Amount promotes speed and gradually accelerates.
(3) measurement result of hepatic glycogen content: in the embodiment of the anti-fatigue traditional Chinese preparation provided by the invention, embodiment
9 and embodiment 10 increase experimental mice hepatic glycogen content conspicuousness, effect is best.Remaining each embodiment is small for experimental group
Apparent effect is all had for mouse.Meanwhile from the data in table it can be found that experimental mice 1-4 is using implementation
After example 1-4, hepatic glycogen content is increased speed relatively slow；After having used embodiment 5-8, hepatic glycogen contains experimental mice 5-8
Amount, which is increased speed, gradually to be accelerated.
In conclusion the anti-fatigue traditional Chinese preparation provided by the invention can significantly improve body hepatic glycogen content, improve
The content of blood lactase acid enhances endurance of the body in physical load, has good antifatigue effect.
It is needed to pay attention to when taking this product: the effect of this product irreplaceable intermittent rest and sleep.This product is in use process
In, guarantee the safety etc. for drinking environment.
The anti-fatigue traditional Chinese finished dosage form provided by the invention can be by being added natural sweetener in post production process
Or other natural flavourings, it mixes, packaging, obtains anti-fatigue beverage product after high-temperature sterilization.It is not only convenient for carrying, and is convenient for
Storage.
The invention discloses a kind of anti-fatigue traditional Chinese preparations and preparation method thereof.The anti-fatigue traditional Chinese preparation is to pass through selection
The applicable Chinese medicine of all kinds of drug effects is prepared, and is clinically applied.Each medicinal material the monarch and his subjects in the Chinese materia medica preparation
Assistant keeps compatibility proper, substantially enhances the effect that Xiang Zuoxiang is helped, suitably merged between each medicinal material, to reach tonifying spleen qi-regulating, mend
Gas benefit blood, kidney tonifying permanent tooth, protect liver beauty treatment and the effect of promote the production of body fluid to quench thirst.At the same time, under the action of all kinds of medicinal materials cooperate, effectively
Antifatigue effect is strengthened, the plumpness of the human body state of mind is significantly improved, it is tired, absent-minded and decline to human body is resisted
It waits for a long time with high curative effect, achievees the purpose that from the root antifatigue.The preparation method operating process of the Chinese materia medica preparation is simple and direct,
Operating procedure is fewer but better, low in cost.The Chinese materia medica preparation is without any side effects, securely and reliably, it is low to be suitable for all kinds of immunity
Under, the crowd that has damage etc. of long-distance vehicle driver and liver,kidney,spleen function.
Although illustrate and describing the present invention with specific embodiment, it will be appreciated that the present invention is not limited to
Optional embodiment is stated, anyone can obtain other various forms of products under the inspiration of the present invention.Above-mentioned specific reality
The mode of applying should not be understood the limitation of pairs of protection scope of the present invention, those skilled in the art should understand that, it is not carrying on the back
In the case where from the spirit and scope of the present invention, it is possible to modify the technical solutions described in the foregoing embodiments, or
Equivalent substitution of some or all of the technical features, these are modified or replaceed at the same time, can't make corresponding
The essence of technical solution depart from the scope of the technical solutions of the embodiments of the present invention；Protection scope of the present invention should be wanted with right
It asks subject to being defined in book, and specification can be used for interpreting the claims.
Claims (10)
1. a kind of anti-fatigue traditional Chinese preparation, which is characterized in that the Chinese materia medica preparation is mainly prepared by the raw material of following mass fraction
It obtains:
30-200 parts of hairyvein agrimony, 10-80 parts of Radix Astragali, 10-70 parts of ginseng, 20-80 parts of the fleece-flower root, 20-70 parts of rhizoma polygonati and lucid asparagus
20-90 parts.
2. a kind of anti-fatigue traditional Chinese preparation according to claim 1, which is characterized in that the Chinese materia medica preparation is mainly by following
The raw material of mass fraction is prepared:
90-140 parts of hairyvein agrimony, 30-65 parts of Radix Astragali, 20-60 parts of ginseng, 45-65 parts of the fleece-flower root, 40-60 parts of rhizoma polygonati and lucid asparagus
30-55 parts.
3. a kind of anti-fatigue traditional Chinese preparation according to claim 2, which is characterized in that the Chinese materia medica preparation is mainly by following
The raw material of mass fraction is prepared:
100 parts of hairyvein agrimony, 50 parts of Radix Astragali, 50 parts of ginseng, 50 parts of the fleece-flower root, 50 parts of rhizoma polygonati and 50 parts of lucid asparagus.
4. a kind of preparation method of anti-fatigue traditional Chinese preparation according to claim 1 to 3, which is characterized in that the system
Preparation Method includes the following steps:
(1) it impregnates: weighing solubilizer after hairyvein agrimony, Radix Astragali, ginseng, the fleece-flower root, rhizoma polygonati and lucid asparagus mix according to corresponding proportion
It impregnates；
(2) infusion: the raw material after impregnating in step (1) are subjected to infusion to boiling, obtain stoste reserve liquid；
(3) it cools down and filters: by the stoste reserve liquid cooled and filtered in step (2), obtaining secondary reserve liquid；
(4) finished product is made: carrying out secondary filter after the secondary reserve liquid in step (3) is stood, finished product is made.
5. a kind of preparation method of anti-fatigue traditional Chinese preparation according to claim 4, which is characterized in that the step (1)
Middle institute's solubilizer includes water, and amount of water and weighed medicinal material total quality ratio are 140-400:7-20；
Preferably, the amount of water and weighed medicinal material total quality ratio are 200-360:10-18；
It is further preferred that the amount of water and weighed medicinal material total quality ratio are 240-300:12-15.
6. a kind of preparation method of anti-fatigue traditional Chinese preparation according to claim 4, which is characterized in that the step (1)
Middle soaking time is 30-75 minutes；
Preferably, the soaking time is 50-65 minutes；
It is further preferred that the soaking time I 60 minutes.
7. a kind of preparation method of anti-fatigue traditional Chinese preparation according to claim 4, which is characterized in that the step (2)
The middle infusion time is 15-60 minutes；
Preferably, the infusion time is 25-40 minutes；
It is further preferred that the infusion time is 30 minutes.
8. a kind of preparation method of anti-fatigue traditional Chinese preparation according to claim 4, which is characterized in that the step (3)
It is middle that stoste reserve liquid is cooled to 30-80 degrees Celsius；
Preferably, described that stoste reserve liquid is cooled to 40-50 degrees Celsius；
It is further preferred that described be cooled to 45 degrees Celsius for stoste reserve liquid.
9. a kind of preparation method of anti-fatigue traditional Chinese preparation according to claim 4, which is characterized in that the step (3)
100-400 mesh filter screen is crossed after middle stoste reserve liquid is cooling；
Preferably, 200-300 mesh filter screen is crossed after the stoste reserve liquid is cooling；
It is further preferred that crossing 280 mesh filter screens after the stoste reserve liquid is cooling.
10. a kind of preparation method of anti-fatigue traditional Chinese preparation according to claim 4, which is characterized in that the step (4)
Middle time of repose is 5-15 hours；
Preferably, the time of repose is 6-10 hours；
It is further preferred that the time of repose is 8 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910548288.9A CN110101793A (en) | 2019-06-24 | 2019-06-24 | A kind of anti-fatigue traditional Chinese preparation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910548288.9A CN110101793A (en) | 2019-06-24 | 2019-06-24 | A kind of anti-fatigue traditional Chinese preparation and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110101793A true CN110101793A (en) | 2019-08-09 |
Family
ID=67495695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910548288.9A Pending CN110101793A (en) | 2019-06-24 | 2019-06-24 | A kind of anti-fatigue traditional Chinese preparation and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110101793A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113197270A (en) * | 2021-06-10 | 2021-08-03 | 周国尧 | Herbal beverage prepared from three materials and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006335640A (en) * | 2005-05-06 | 2006-12-14 | Daicho Kikaku:Kk | Drug for animal |
| CN102319356A (en) * | 2011-08-11 | 2012-01-18 | 连云港邦特生物科技有限公司 | Traditional Chinese medicine composition for regulating body immunity and alleviating fatigue and preparation method thereof |
-
2019
- 2019-06-24 CN CN201910548288.9A patent/CN110101793A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006335640A (en) * | 2005-05-06 | 2006-12-14 | Daicho Kikaku:Kk | Drug for animal |
| CN102319356A (en) * | 2011-08-11 | 2012-01-18 | 连云港邦特生物科技有限公司 | Traditional Chinese medicine composition for regulating body immunity and alleviating fatigue and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 武谦虎: "《常用治疗肝病中药》", 31 January 2014, 中国医药科技出版社 * |
| 老中医养生堂: "《活性蛋白质和肽的制备及在功能食品中的应用》", 30 April 2016, 福建科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113197270A (en) * | 2021-06-10 | 2021-08-03 | 周国尧 | Herbal beverage prepared from three materials and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103271346B (en) | Health-care food for relieving physical fatigue | |
| CN101327297B (en) | Chinese medicine composition for treating insomnia | |
| CN104606612A (en) | Alcohol-expelling kidney-tonifying tablet candy and preparation method thereof | |
| CN102526474A (en) | Chinese medicine composition for treating neurasthenia | |
| CN104474417A (en) | Medicinal-edible homologous traditional Chinese medicine composition and use thereof and grape wine and preparation method of grape wine | |
| CN104274546B (en) | A kind of external medicine composition, traditional Chinese medicine for outer use and its preparation method and application | |
| CN110101793A (en) | A kind of anti-fatigue traditional Chinese preparation and preparation method thereof | |
| CN101766778B (en) | Traditional Chinese medicine composite for improving male sexual function and curing sexual disfunction and preparation method thereof | |
| CN104337920B (en) | Traditional Chinese medicine composition for improving sleep quality | |
| CN103520302B (en) | Sea-buckthorn leaf anti-fatigue capsule and preparation method thereof | |
| CN102008083A (en) | Health food for alleviating physical fatigue and removing chloasma | |
| CN103223080B (en) | Traditional Chinese medicinal composition for tranquilizing mind by nourishing the heart and preparation method thereof | |
| CN102048913B (en) | Traditional Chinese medicine preparation for treating climacteric syndrome and preparation method thereof | |
| CN1070065C (en) | Health wine for nourishing marrow and benefitting semen | |
| CN110237132B (en) | Kidney-tonifying and lipid-lowering medicine, preparation method and application thereof | |
| CN103877554B (en) | Pharmaceutical composition for treating heart disease and preparation method and use thereof | |
| CN106039172B (en) | There is the Chinese medicine composition for improving memory function and its application containing centella | |
| CN111643581A (en) | Traditional Chinese medicine composition with weight-losing effect, sachet containing traditional Chinese medicine composition and preparation method of sachet | |
| CN103638336A (en) | Full rhizoma gastrodiae tablet | |
| CN100509019C (en) | Application of Baji capsule in preparing immune enhancement medicament | |
| CN101254199A (en) | Panax saponin Rg1 and thein combination and uses thereof | |
| CN110496212A (en) | A kind of Chinese medicine composition and preparation method thereof improving wine poison constitution | |
| CN104523932B (en) | A kind of Chinese medicine composition for treating children's hyperkinetic syndrome, and its preparation method and application | |
| CN115429836B (en) | Traditional Chinese medicine preparation for treating arrhythmia | |
| CN102948663A (en) | Rana japonica oil granules and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190809 |