CN101244073A - Panoxatriol saponin and caffeinum pharmaceutical combination, and uses thereof - Google Patents
Panoxatriol saponin and caffeinum pharmaceutical combination, and uses thereof Download PDFInfo
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- CN101244073A CN101244073A CNA200810007866XA CN200810007866A CN101244073A CN 101244073 A CN101244073 A CN 101244073A CN A200810007866X A CNA200810007866X A CN A200810007866XA CN 200810007866 A CN200810007866 A CN 200810007866A CN 101244073 A CN101244073 A CN 101244073A
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Abstract
The invention relates to an anti-fatigue and memory-improving drug composition of ginseng triol saponin and caffeine, comprising ginseng triol saponin of a weight percentage from 1% to 99%, and caffeine of a weight percentage from 99% to 1%. The drug composition is characterized in that the ginseng triol saponin and the caffeine are rationally prescript, mutually promoted and complemented, synergistically functioning after being compounded, so that the defect short anti-fatigue time span of the caffeine is overcome by exciting the central nervous, reinforcing the functions of viscera, regulating the energy metabolism and nourishing the nervous system for good and long time anti-fatigue effect and drug efficacy of improving study memory. The anti-fatigue and memory-improving drug composition of ginseng triol saponin and caffeine has the advantages of increasing strength, improving memory, strengthening spleen and benefiting vital qi, exciting spirit, soothing the nerves and promoting intelligence, which represents the new trend of using natural medicine to fight against fatigue and improve memory. The anti-fatigue and memory-improving drug composition of ginseng triol saponin and caffeine can be used to make preparations acceptable in medicine or food by adding pharmaceutical or edible accessories of appropriate amount.
Description
Technical field:
The present invention relates to the pharmaceutical composition that a kind of protopanaxatriol ginsenoside and caffeine are formed, and the purposes of said composition on preparation medicine and food.Belong to medical technical field.
Background technology:
Tired (fatigue) is a comprehensive physiological process that relates to many Physiology and biochemistry factors, it is a kind of normal physiological phenomenon that body mental activity or physical exertion must occur during to certain phase, it had both indicated the temporary transient decline of the original ability to work of body, might be the tendency that body develops into sick and wounded state.According to the biochemical meeting of international movement fatigue is defined as: " physiological process of body can not remain on its function one specified level or each organ can not keep its predetermined exercise intensity the time, is called fatigue ".By the difference of tired happening part, can be divided into tired three classes of periphery of nervus centralis fatigue, nerve-muscle contact fatigue and limbs.On the Chinese medicine fatigue roughly is divided into three types: body fatigue, internal organs fatigue and mind fatigue.
We think that fatigue can be divided into physical fatigue and mental fatigue, and physical fatigue is that the muscle of body self-report lacks the energy sense, and it is faint often to show as muscle.Mental fatigue then is a kind of subjective sensation of amotivational and vigilance, show as feel dizzy, absent minded, thinking difficulty, inefficiency, hypomnesis.
The generation of delay fatigue and/or the tired elimination of promotion, promptly resisting fatigue is a hot issue of present sports medical science research.Can eliminate organism fatigue by rest, sleep and some physical method on the one hand, then can rely on additional, the Chinese medicine conditioning of nutrient substance to reach the antifatigue purpose on the other hand.
Advance along with socioeconomic in recent years, the fatigue that rhythm of life accelerates, factors such as operating pressure increases, sleep deprivation cause has become the able-bodied problem of the people that has a strong impact on, even can develop into chronic fatigue syndrome.That fatigue has often shown as is faint, muscular soreness, daytime somnolence, attention laxes and hypomnesis.The medicine or the functional food of reply fatigue symptom can not address the above problem at present.
Caffeine is used very wide in fatigue resistant health food, and it is central nervous system's excitement that caffeine mainly acts on, inspire enthusiasm, make the people to keep clear-headed and alertness.Recently discover that caffeine also has the effect that promotes learning and memory.But long-term use separately can produce side reactions such as anxiety, agitation, insomnia, irritability and fine movement function be impaired.
Radix Ginseng (Korean Ginseng), Radix Panacis Quinquefolii and Radix Notoginseng are rare Chinese medicines commonly used in the panax species, and modern medicine study proof three all has resisting fatigue, improves the effect of memory, and protopanaxatriol ginsenoside is its performance resisting fatigue, improve effective extraction part of memory effect.
Though above-mentioned two medicines have certain resisting fatigue, improve memory effect, its comprehensive therapeutic effect has much room for improvement.How to overcome the shortcoming of taking single medicinal material, with protopanaxatriol ginsenoside and caffeine reasonable compatibility, short complementary mutually, making it at aspect performance the best use ofs such as resisting fatigue, improvement memories is its difficult point place.
Utilize the synergism of protopanaxatriol ginsenoside and caffeine at present, composition of prescription, the medicine or the food that be used to prepare resisting fatigue, improve memory do not appear in the newspapers as yet.
Summary of the invention:
Purpose of the present invention aims to provide a kind of protopanaxatriol ginsenoside and caffeine compositions product that has resisting fatigue, improves memory effect, requires its prescription reasonable mixture ratio, preparation method simply effective, and the purposes of this product on preparation medicine and food is provided.
Product of the present invention is made up of following raw materials by weight percent: protopanaxatriol ginsenoside: 1%～99% and caffeine: 99%～1%, and be equipped with an amount of medicinal or edible adjuvant, make pharmaceutically or acceptable preparation on the food.
The percentage by weight preferable range of product of the present invention is: protopanaxatriol ginsenoside: 20%～80% and caffeine: 80%～20%.
Raw material protopanaxatriol ginsenoside in the product of the present invention can extract in the middle of the total saponins of panax species such as Radix Ginseng (Korean Ginseng), Radix Panacis Quinquefolii and Radix Notoginseng, and the method for separating and preparing that the prior art document discloses has alkaline precipitation, organic solvent extractionprocess, silica gel column chromatography, macroporous adsorbent resin method etc.The protopanaxatriol ginsenoside of product of the present invention, ginsenoside Rg1's content is 45%～99% in its panaxatriol's group, all the other are ginsenoside Rg2, ginsenoside Rf, ginsenoside Re, ginsenoside Rh1 etc.It extracts and preparation method is a known technology, does not give unnecessary details at this.
Pharmaceutical preparation of the present invention can be injection, injectable powder, tablet, capsule, slow releasing tablet, slow releasing capsule, drop pill, oral administration solution, syrup, powder, mixture, granule, buccal tablet, microcapsule etc., and described food formulation can be beverage, confection, cookies, fruit jelly, chewing gum etc.
Adjuvant of the present invention is the conventional adjuvant of various preparations.
The main component effect of product of the present invention is as follows:
Protopanaxatriol ginsenoside: protopanaxatriol ginsenoside is Radix Ginseng (Korean Ginseng), Radix Panacis Quinquefolii and Radix Notoginseng performance resisting fatigue, improve effective extraction part of memory effect.
Factors such as the generation of sports fatigue and energy expenditure, metabolite accumulation and interior environmental change have close ties.Protopanaxatriol ginsenoside can increase the glycogen deposit, keeps glucostasis, increases fatty energy supply ratio, thereby saves the utilization of endogenous glycogen, suppresses blood urea nitrogen and piles up, and quickens lactic acid and eliminates, and alleviates sports fatigue.
Protopanaxatriol ginsenoside can make respond improve, and improves brain function, promotes the learning and memory overall process, particularly attention concentrate and long-term elaborative faculty aspect improvement is arranged, thereby raising work effectiveness, concentration power and load-bearing capacity can make spirit optimistic.In addition, protopanaxatriol ginsenoside has slight excitation to the central nervous system.
Caffeine: the central nervous system is had excitation, and the excited cerebral cortex of caffeine increases corticocerebral process of excitation, can cheer up, and reduces feeling of fatigue, eliminates sleepiness, improves thinking activities.Improve attention, self-confidence and work efficiency.Strengthen Vigilance, enhancing your vigilance property and keep persistent ability to work.Strengthen identification ability, shorten fast and the selection reflection time, and can improve instantaneous oral memory.Caffeine promotes the effect of learning and memory in addition.But separately caffeine is applied to improve tired symptom, first excitement can occur, the phenomenon that the back is dispirited.
Product of the present invention is with protopanaxatriol ginsenoside and caffeine rational formula, short complementary mutually, energy synergism behind the compound recipe, remedied the deficiency that caffeine can only resist short-term movement fatigue, pass through stimulating central nervous system, strengthen function, regulate energy metabolism, that the trophic nerve system plays jointly is good, long lasting resisting fatigue and promote the drug effect of learning and memory, have the strong will of times power, invigorating the spleen and replenishing QI, inspire enthusiasm and the effect of the Fructus Alpiniae Oxyphyllae of calming the nerves, represented the natural drug resisting fatigue and improved the new trend of memory.
The specific embodiment:
By following specific embodiment, can further understand the present invention, but protection scope of the present invention is not limited to this.The protopanaxatriol ginsenoside of product of the present invention, ginsenoside Rg1's content is 45%～99% in its panaxatriol's group.
Embodiment one compound ginseng saponin triol and caffeine freeze-dried powder
Precision is measured protopanaxatriol ginsenoside (ginsenoside Rg1=95%) 80 grams, caffeine 20 grams, and mannitol 1000 grams adopt conventional injectable powder preparation method can make the compound ginseng saponin triol and the caffeine freeze-dried powder of the specification of 1000 100mg.
Embodiment two compound ginseng saponin triols and caffeine oral liquid
Precision is measured protopanaxatriol ginsenoside (ginsenoside Rg1=45%) 150 grams, caffeine 50 grams, and Mel 1000 grams, distilled water adds to 10kg, adopts conventional oral liquor can prepare 1000 (every nearly weighs 11 grams) oral liquids.Each edible one, every day 1～2 time.
Embodiment three compound ginseng saponin triols and caffeine capsule
Precision is measured protopanaxatriol ginsenoside (ginsenoside Rg1=65%) 80 grams, caffeine 20 grams, and starch 100 grams adopt conventional capsule preparation method thereof can prepare 1000 (the tolerant 200mg of every intragranular) capsules.Each edible 1～2, every day 1～2 time.
Embodiment four compound ginseng saponin triols and caffeine granule
Precision is measured protopanaxatriol ginsenoside (ginsenoside Rg1=55%) 75 grams, caffeine 25 grams, and sucrose 2500 grams, dextrin 400 grams, ethanol is an amount of, adopts conventional granulation to granulate, and is distributed into 1000 bags (every bag of about 3.0 grams).Each edible 1～2 bag, every day 1～2 time.
Claims (4)
1, the pharmaceutical composition of the protopanaxatriol ginsenoside of a kind of resisting fatigue and improvement memory and caffeine composition is characterized in that being made up of following raw materials by weight percent: protopanaxatriol ginsenoside 1%～99%, caffeine 99%～1%.
2, compositions according to claim 1 is characterized in that being made up of following raw materials by weight percent: protopanaxatriol ginsenoside 20%～80%, caffeine 80%～20%.
3, the purposes of compositions according to claim 1 is characterized in that being equipped with an amount of medicinal or edible adjuvant, makes pharmaceutically or acceptable preparation on the food.
4,, it is characterized in that the application in preparation resisting fatigue and improvement memory medicine or functional food as claim 1,2 or 3 described compositionss.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200810007866XA CN101244073A (en) | 2008-02-26 | 2008-02-26 | Panoxatriol saponin and caffeinum pharmaceutical combination, and uses thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200810007866XA CN101244073A (en) | 2008-02-26 | 2008-02-26 | Panoxatriol saponin and caffeinum pharmaceutical combination, and uses thereof |
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| Publication Number | Publication Date |
|---|---|
| CN101244073A true CN101244073A (en) | 2008-08-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA200810007866XA Pending CN101244073A (en) | 2008-02-26 | 2008-02-26 | Panoxatriol saponin and caffeinum pharmaceutical combination, and uses thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011173849A (en) * | 2010-02-25 | 2011-09-08 | Lion Corp | Stabilized panaxatriol composition |
-
2008
- 2008-02-26 CN CNA200810007866XA patent/CN101244073A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011173849A (en) * | 2010-02-25 | 2011-09-08 | Lion Corp | Stabilized panaxatriol composition |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20080820 |