CN103083429A - Blood fat-reducing traditional Chinese medicine formula - Google Patents
Blood fat-reducing traditional Chinese medicine formula Download PDFInfo
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Abstract
The invention provides a medicine for treating hyperlipidemia and in particular relates to a blood fat-reducing traditional Chinese medicine formula. The traditional Chinese medicine formula consists of the following raw materials in parts by weight: 100-150 parts of elaeagnus mollis leaf extract, 50-70 parts of hawthorn extract, 100-150 parts of prepared fleece flower root extract and 80-120 parts of semen cassiae extract. Various raw materials in the traditional Chinese medicine formula are formed by performing drying, crushing, ultrasonic extraction, extraction, concentration, freeze drying and grinding on the raw material medicines. The animal experiment and clinic treatment prove that the traditional Chinese medicine formula has the powerful function of reducing blood fat. The traditional Chinese medicine is a pure natural medicine and has the advantages of fast effect, high cure rate and no side effect. When a patient with hyperlipidemia takes the medicine generally, the effect is achieved within half one month, the curative effect is obvious, and the total efficiency is up to 96.5 percent. The medicine is properly taken in a strengthened mode after healing, the hyperlipidemia does not resurge after healing, and the complication caused by hyperlipidemia can be prevented.
Description
Technical field
The present invention relates to a kind of Chinese prescription, belong to the treating cardiovascular disease technical field, specifically a kind of antilipemic Chinese herbal medicine prescription.
Background technology
Blood fat is neutral fat (triglyceride and cholesterol) in blood plasma and the general name of lipoid (phospholipid, glycolipid, sterin, steroid), is the essential material of basal metabolism of life cells.But the long-term too high meeting of blood fat causes hyperlipidemia, it is dyslipidemia, also referred to as hyperlipoproteinemia, be a kind of systemic disease, its basic pathology physiology is: T-CHOL in blood (TC), triglyceride (TG) is too high or HDL-C (HDL-C) is too low.Hyperlipidemia is the principal element of bringing out the cardiovascular disease such as coronary heart disease, pulse atherosclerosis, hypertension.The whole world has 1,700 ten thousand people (account for total death toll 50%) die from cardiovascular disease every year.Hyperlipidemia pathogenic factor and inherited genetic factors, health pathological changes, dietary habit, the mental status etc. are closely related.In recent years, raising along with people's living standard, in diet structure, high heat food ratio obviously increases, the minimizing of people's activity in addition, the hyperlipidemia sickness rate constantly increases, only China's hyperlipemia just reaches 1.6 hundred million, and number of the infected is to increase every year on average 1500 ten thousand people's rising situation.How to prevent that curing hyperlipemia has become the health problem that people pay close attention to increasingly.
In the accent lipid of using clinically at present both at home and abroad, western class medicine is a lot.Western medicine such as fenofibrate, etofylline clofibrate, furaprbal, Statins etc. are occupied an leading position with Statins, though statins can effectively reduce serum cholesterol content, but report that this medicine is relevant with muscle changes etc.Domestic curative effect blood fat reducing Chinese patent medicine preferably mainly contains: JIANGZHILINGPIAN, tablets for invigorating circulation and reducing bloodfat, soft pulse spirit, Zhibituo Tabiet, anluoning etc., these medicines are being brought into play very large effect aspect the treatment hyperlipidemia.But along with the increase of hyperlipemia quantity, exploitation prevent safely and effectively and the medicine for the treatment of hyperlipidemia with the still important realistic meaning of tool that meets clinical needs.
Summary of the invention
To the objective of the invention is in order addressing the above problem, and a kind of antilipemic Chinese herbal medicine prescription to be provided.
The present invention is achieved by the following technical solutions:
A kind of antilipemic Chinese herbal medicine prescription is comprised of the raw material of following parts by weight:
Elaeagnus mollis blade extract 100-150 part, Fructus Crataegi extract 50-70 part, Radix Polygoni Multiflori Preparata extract 100-150 part, Semen Cassiae extract 80-120 part.
In prescription, the extracting method of each material medicine is as follows:
1. the extracting method of elaeagnus mollis blade extract: get the elaeagnus mollis blade, drying and crushing is to the 60-80 order, adds 60% ethanol in 80 ℃ of lower supersound extraction 30min, and amount of alcohol added is that 1g elaeagnus mollis blade adds 10-20ml ethanol; Repeat as stated above to extract 3 times, with the filtrate merging of 3 supersound extraction, merging filtrate is concentrated into the extractum shape through ethyl acetate extraction with extract, and after last lyophilization, pulverize gets final product;
2. the extracting method of Fructus Crataegi extract: get Fructus Crataegi, drying and crushing adds deionized water supersound extraction 40min in boiling water to the 60-80 order, and the deionized water addition is that the 1g Fructus Crataegi adds the 10-20ml deionized water; Repeat as stated above to extract 3 times, the filtrate merging with 3 supersound extraction is concentrated into the extractum shape with merging filtrate, and after last lyophilization, pulverize gets final product;
3. the extracting method of Radix Polygoni Multiflori Preparata extract: get Radix Polygoni Multiflori Preparata, drying and crushing is to the 60-80 order, adds 60% ethanol in 80 ℃ of lower supersound extraction 30min, and amount of alcohol added is that the 1g Radix Polygoni Multiflori Preparata adds 10-20ml ethanol; Repeat as stated above to extract 3 times, the filtrate merging with 3 supersound extraction is concentrated into the extractum shape with merging filtrate, and after last lyophilization, pulverize gets final product;
4. the extracting method of Semen Cassiae extract: depend on pine torch, drying and crushing adds deionized water supersound extraction 40min in boiling water to the 60-80 order, and the deionized water addition is that the 1g Semen Cassiae adds the 10-20ml deionized water; Repeat as stated above to extract 3 times, with the filtrate merging of 3 supersound extraction, merging filtrate is concentrated into the extractum shape through ethyl acetate extraction with extract, and after last lyophilization, pulverize gets final product.
When the antilipemic Chinese herbal medicine prescription prepares antilipemic Chinese herbal medicine according to the present invention, its preparation method is simple, after each material medicine in Chinese prescription of the present invention is mixed by described proportioning, adopting conventional Chinese medicinal preparation method to be prepared gets final product, simultaneously also can add again pharmaceutically acceptable adjuvant and give certain dosage form, as: capsule, tablet, electuary, drop pill, oral liquid, buccal tablet, granule, powder, suspensoid etc.
From pharmacologically active, in Chinese prescription of the present invention, each contained material medicine component all contains the pharmacological component of effective reduction blood fat.
Elaeagnus mollis is Fructus Elaeagni section plant, is one of Relict Plant after China's glacial action fourth season.Existing studies show that, be rich in the elaeagnus mollis blade alkaloid, flavone, polysaccharide and terpenoid, Vc and with the closely-related trace element of health; And its leaf extract has stronger antioxidant activity.Separately have the local resident often to drink its blade is soaked, but long-term drink have the effect of blood fat reducing, blood pressure lowering life lengthening.In addition, shown that through animal (rat) high blood lipid model test the above-mentioned elaeagnus mollis blade extract of feeding can effectively reduce the content of rat blood serum T-CHOL (TC) and triglyceride (TG) (Fig. 1-Fig. 2).
Process of the test is: 1. hyperlipidemia model: get 50 rats, feed high lipid food (normal feedstuff 78.6%, yolk powder 10%, cholesterol 1%, cholate 0.2%, Adeps Sus domestica 10%, Frentirox sheet 0.2%) 30d, freely drink water and search for food every day, after 30d, water is can't help in fasting, after 12h, tail vein blood is surveyed serum lipid concentrations, detects qualified rear as hyperlipidemia model; 2. pharmacodynamic analysis: 50 of high blood lipid model rats are divided into 5 groups at random, every group 10, be set to: model group, basic, normal, high dosage group (elaeagnus mollis blade extract) and zhibituo matched group, with 10 of the healthy rats of synchronous raising as the blank group.Day gastric infusion 1 time, blank group be to the equivalent normal saline, and respectively at after administration the 28th day and the 42nd day, before experiment, water 12h was can't help in fasting, 2h blood sampling after the last administration, survey serum lipid concentrations.In figure, a, b, c, d represent respectively group difference significance p＜0.05.
Fructus Crataegi is rosaceous plant, slightly warm in nature, and sour in the mouth, sweet.Be rich in triterpenes, flavone, ursolic acid, saponin, organic acid isoreactivity composition.Large quantity research has confirmed that the triterpenes and the flavone compound that are rich in Fructus Crataegi have the effect of blood vessel dilating, adjusting blood fat and cholesterol level.
Radix Polygoni Multiflori Preparata is polygonaceae plant, slightly warm in nature, bitter in the mouth, sweet, puckery.Contain the multiple active component that can effectively reduce the blood fat activity such as stilbene glycoside, Anthraquinones, flavonoid.Modern study discovery, Radix Polygoni Multiflori Preparata can improve the ability of hepatocyte conversion and metabolism cholesterol, and the scalable serum cholesterol reduces blood glucose.
Semen Cassiae is leguminous plant, and is cold in nature, sweet in the mouth, hardship.Has wind and heat eliminating, liver heat removing tomorrow, the effect of loosening bowel to relieve constipation.Modern pharmacological research shows that Semen Cassiae has the effects such as blood fat reducing, blood pressure lowering, and its blood fat reducing effective ingredient is its contained anthraquinone analog compound.
Further, in Chinese prescription of the present invention, the preferred weight umber of each component raw material is:
150 parts of elaeagnus mollis blade extracts, 50 parts of Fructus Crataegi extracts, 150 parts of Radix Polygoni Multiflori Preparata extracts, 100 parts of Semen Cassiae extracts.
The best proportioning of each component raw material medicine in Chinese prescription of the present invention preferably obtains (table 1-table 2) by orthogonal test:
The impact of the different proportionings of table 1 prescription on hyperlipidemia model Serum TC content
Annotate:Serum TC content is that the hyperlipidemia model rat is cultivated measurement result average in latter stage.
The impact of the different proportionings of table 2 prescription on hyperlipidemia model rat blood serum TG content
Annotate: serum TG content is that high fat mould rat type is cultivated measurement result average in latter stage.
By above-mentioned orthogonal experiments as can be known, in antilipemic Chinese herbal medicine prescription of the present invention, the best proportioning of each material medicine is: 150 parts of elaeagnus mollis blade extracts, 50 parts of Fructus Crataegi extracts, 150 parts of Radix Polygoni Multiflori Preparata extracts, 100 parts of Semen Cassiae extracts.
Antilipemic Chinese herbal medicine prescription of the present invention has stronger blood fat reducing drug effect effect, and in this Chinese prescription, each material medicine synergism confirms to have stronger blood fat reducing drug effect effect (table 3) through animal (rat) high blood lipid model analysis of experiments:
Impact (the mmoL of table 3 prescription on hyperlipemia rat serum lipids level
-1
)
Antilipemic Chinese herbal medicine prescription of the present invention, tested animal (rat) has no any toxic reaction after animal toxicity test shows this prescription of feeding, the every physiology of tested animal (rat) and organs and tissues and normal control more all without significant difference (table 4-table 6), illustrate that to a certain extent this Chinese prescription is safe and reliable.
The impact of table 4 prescription on the final hematological indices of rat
The impact of table 5 prescription on the rat biochemical indicator
The impact of table 6 prescription on the dirty body ratio of rat
In order to show Chinese prescription of the present invention to the therapeutic effect of hyperlipemia, the present invention is through the clinical observation of 86 routine systems.In the process of above-mentioned clinical observation, and the work of above-mentioned patient being recorded its medical history, the state of an illness, age and curative effect.
The criterion of clinical therapeutic efficacy is:
Cure: symptom, sign all disappear, and laboratory indexes is all in normal range.
Take a turn for the better: the basic disappearances such as subjective symptoms such as uncomfortable in chest, abdominal distention, fatigue and weakness, dizziness headache, the chemical examination blood fat is near normal value.
Invalid: symptom, sign, laboratory indexes are without obvious improvement.
Therapeutic outcome: Chinese prescription of the present invention is through treating 86 routine hyperlipemias, and 73 examples are fully recovered, and 10 examples take a turn for the better, and 3 examples are invalid, and total effective rate reaches 96.5%.
Model case:
Case 1: patient Zhang, the man, 38 years old, suffered from hyperlipidemia 2 years, for a long time uncomfortable in chest, nervous, weak, have a dizzy spell, take Chinese medicine of the present invention after eight months, symptom disappears fully, it is normal to chemically examine blood fat.Follow up a case by regular visits to not recurrence in a year.
Case 2: patient Chen, the female, 435 years old, suffer from hyperlipidemia, oral administration medicine of the present invention is after six months, and transference cure is chemically examined blood fat normal.Follow up a case by regular visits to not recurrence in a year.
Case 3: patient Yang, the man, 50 years old, suffered from hyperlipidemia 3 years, multi-treatment is invalid, and oral administration medicine of the present invention is after 1 year, and transference cure is chemically examined blood fat normal.Follow up a case by regular visits to not recurrence in a year.
The invention has the beneficial effects as follows: Chinese medicine of the present invention is pure natural medical, have advantages of rapid-action, cure rate is high, have no side effect.General hyperlipemic patients is taken two weeks and is namely taken effect really, and evident in efficacy, total effective rate is up to 96.5%.More suitably again after consolidate medication, hyperlipidemia more after no longer bounce-back, and can prevent the caused complication of hyperlipidemia.
Description of drawings
Fig. 1 is that elaeagnus mollis blade extract is to rat blood serum T-CHOL (TC) concentration as influencing factor.
Fig. 2 is that elaeagnus mollis blade extract is to rat blood serum triglyceride (TG) concentration as influencing factor.
The specific embodiment
Embodiment 1
A kind of antilipemic Chinese herbal medicine prescription forms (every part is 1g) by the raw material of following parts by weight:
Elaeagnus mollis blade extract 150g, Fructus Crataegi extract 50g, Radix Polygoni Multiflori Preparata extract 150g, Semen Cassiae extract 100g.
In prescription, the extracting method of each raw material is as follows:
1. the extracting method of elaeagnus mollis blade extract: get the elaeagnus mollis blade, drying and crushing to 60 order adds 60% ethanol in 80 ℃ of lower supersound extraction 30min, and amount of alcohol added is that 1g elaeagnus mollis blade adds 17ml ethanol; Repeat as stated above to extract 3 times, with the filtrate merging of 3 supersound extraction, merging filtrate is concentrated into the extractum shape through ethyl acetate extraction with extract, and after last lyophilization, pulverize gets final product; 2. the extracting method of Fructus Crataegi extract: get Fructus Crataegi, drying and crushing to 70 order adds deionized water supersound extraction 40min in boiling water, and the deionized water addition is that the 1g Fructus Crataegi adds the 20ml deionized water; Repeat as stated above to extract 3 times, the filtrate merging with 3 supersound extraction is concentrated into the extractum shape with merging filtrate, and after last lyophilization, pulverize gets final product; 3. the extracting method of Radix Polygoni Multiflori Preparata extract: get Radix Polygoni Multiflori Preparata, drying and crushing to 74 order adds 60% ethanol in 80 ℃ of lower supersound extraction 30min, and amount of alcohol added is that the 1g Radix Polygoni Multiflori Preparata adds 14ml ethanol; Repeat as stated above to extract 3 times, the filtrate merging with 3 supersound extraction is concentrated into the extractum shape with merging filtrate, and after last lyophilization, pulverize gets final product; 4. the extracting method of Semen Cassiae extract: depend on pine torch, drying and crushing to 63 order adds deionized water supersound extraction 40min in boiling water, and the deionized water addition is that the 1g Semen Cassiae adds the 15ml deionized water; Repeat as stated above to extract 3 times, with the filtrate merging of 3 supersound extraction, merging filtrate is concentrated into the extractum shape through ethyl acetate extraction with extract, and after last lyophilization, pulverize gets final product.
Above-mentioned each raw extract powder is pressed: elaeagnus mollis blade extract 150g, Fructus Crataegi extract 50g, Radix Polygoni Multiflori Preparata extract 150g, the abundant mixing of Semen Cassiae extract 100g, can make becomes electuary, and taking after mixing it with water by the dose boiled water when taking gets final product.
A kind of antilipemic Chinese herbal medicine prescription forms (every part is 1kg) by the raw material of following parts by weight:
Elaeagnus mollis blade extract 115 kg, Fructus Crataegi extract 70 kg, Radix Polygoni Multiflori Preparata extract 120 kg, Semen Cassiae extract 90kg.
In prescription, the extracting method of each raw material is as follows:
1. the extracting method of elaeagnus mollis blade extract: get the elaeagnus mollis blade, drying and crushing to 80 order adds 60% ethanol in 80 ℃ of lower supersound extraction 30min, and amount of alcohol added is that 1g elaeagnus mollis blade adds 10ml ethanol; Repeat as stated above to extract 3 times, with the filtrate merging of 3 supersound extraction, merging filtrate is concentrated into the extractum shape through ethyl acetate extraction with extract, and after last lyophilization, pulverize gets final product; 2. the extracting method of Fructus Crataegi extract: get Fructus Crataegi, drying and crushing to 80 order adds deionized water supersound extraction 40min in boiling water, and the deionized water addition is that the 1g Fructus Crataegi adds the 12ml deionized water; Repeat as stated above to extract 3 times, the filtrate merging with 3 supersound extraction is concentrated into the extractum shape with merging filtrate, and after last lyophilization, pulverize gets final product; 3. the extracting method of Radix Polygoni Multiflori Preparata extract: get Radix Polygoni Multiflori Preparata, drying and crushing to 60 order adds 60% ethanol in 80 ℃ of lower supersound extraction 30min, and amount of alcohol added is that the 1g Radix Polygoni Multiflori Preparata adds 10ml ethanol; Repeat as stated above to extract 3 times, the filtrate merging with 3 supersound extraction is concentrated into the extractum shape with merging filtrate, and after last lyophilization, pulverize gets final product; 4. the extracting method of Semen Cassiae extract: depend on pine torch, drying and crushing to 72 order adds deionized water supersound extraction 40min in boiling water, and the deionized water addition is that the 1g Semen Cassiae adds the 20ml deionized water; Repeat as stated above to extract 3 times, with the filtrate merging of 3 supersound extraction, merging filtrate is concentrated into the extractum shape through ethyl acetate extraction with extract, and after last lyophilization, pulverize gets final product.
Above-mentioned each raw extract powder is pressed: elaeagnus mollis blade extract 115 kg, Fructus Crataegi extract 70 kg, Radix Polygoni Multiflori Preparata extract 120 kg, the abundant mixing of Semen Cassiae extract 90kg, be ground into again fine powder, add starch, microcrystalline Cellulose, low substituted cellulose with 70% ethanol wet granulation, tabletting, coating namely get tablet.
Embodiment 3
A kind of antilipemic Chinese herbal medicine prescription forms (every part is 1 liang) by the raw material of following parts by weight:
100 liang of elaeagnus mollis blade extracts, 65 liang of Fructus Crataegi extracts, 135 liang of Radix Polygoni Multiflori Preparata extracts, 80 liang of Semen Cassiae extracts.
In prescription, the extracting method of each raw material is as follows:
1. the extracting method of elaeagnus mollis blade extract: get the elaeagnus mollis blade, drying and crushing to 75 order adds 60% ethanol in 80 ℃ of lower supersound extraction 30min, and amount of alcohol added is that 1g elaeagnus mollis blade adds 13ml ethanol; Repeat as stated above to extract 3 times, with the filtrate merging of 3 supersound extraction, merging filtrate is concentrated into the extractum shape through ethyl acetate extraction with extract, and after last lyophilization, pulverize gets final product; 2. the extracting method of Fructus Crataegi extract: get Fructus Crataegi, drying and crushing to 65 order adds deionized water supersound extraction 40min in boiling water, and the deionized water addition is that the 1g Fructus Crataegi adds the 10ml deionized water; Repeat as stated above to extract 3 times, the filtrate merging with 3 supersound extraction is concentrated into the extractum shape with merging filtrate, and after last lyophilization, pulverize gets final product; 3. the extracting method of Radix Polygoni Multiflori Preparata extract: get Radix Polygoni Multiflori Preparata, drying and crushing to 80 order adds 60% ethanol in 80 ℃ of lower supersound extraction 30min, and amount of alcohol added is that the 1g Radix Polygoni Multiflori Preparata adds 20ml ethanol; Repeat as stated above to extract 3 times, the filtrate merging with 3 supersound extraction is concentrated into the extractum shape with merging filtrate, and after last lyophilization, pulverize gets final product; 4. the extracting method of Semen Cassiae extract: depend on pine torch, drying and crushing to 80 order adds deionized water supersound extraction 40min in boiling water, and the deionized water addition is that the 1g Semen Cassiae adds the 17ml deionized water; Repeat as stated above to extract 3 times, with the filtrate merging of 3 supersound extraction, merging filtrate is concentrated into the extractum shape through ethyl acetate extraction with extract, and after last lyophilization, pulverize gets final product.
Above-mentioned each raw extract powder is pressed: 100 liang of elaeagnus mollis blade extracts, 65 liang of Fructus Crataegi extracts, 135 liang of Radix Polygoni Multiflori Preparata extracts, 80 liang of abundant mixings of Semen Cassiae extract, then be ground into fine powder, make according to a conventional method capsule and get final product.
Embodiment 4
A kind of antilipemic Chinese herbal medicine prescription forms (every part is 1 jin) by the raw material of following parts by weight:
140 jin of elaeagnus mollis blade extracts, 60 jin of Fructus Crataegi extracts, 100 jin of Radix Polygoni Multiflori Preparata extracts, 120 jin of Semen Cassiae extracts.
In prescription, the extracting method of each raw material is as follows: the extracting method of elaeagnus mollis blade extract: get the elaeagnus mollis blade, drying and crushing to 65 order, add 60% ethanol in 80 ℃ of lower supersound extraction 30min, amount of alcohol added is that 1g elaeagnus mollis blade adds 20ml ethanol; Repeat as stated above to extract 3 times, with the filtrate merging of 3 supersound extraction, merging filtrate is concentrated into the extractum shape through ethyl acetate extraction with extract, and after last lyophilization, pulverize gets final product; 2. the extracting method of Fructus Crataegi extract: get Fructus Crataegi, drying and crushing to 60 order adds deionized water supersound extraction 40min in boiling water, and the deionized water addition is that the 1g Fructus Crataegi adds the 18ml deionized water; Repeat as stated above to extract 3 times, the filtrate merging with 3 supersound extraction is concentrated into the extractum shape with merging filtrate, and after last lyophilization, pulverize gets final product; 3. the extracting method of Radix Polygoni Multiflori Preparata extract: get Radix Polygoni Multiflori Preparata, drying and crushing to 67 order adds 60% ethanol in 80 ℃ of lower supersound extraction 30min, and amount of alcohol added is that the 1g Radix Polygoni Multiflori Preparata adds 18ml ethanol; Repeat as stated above to extract 3 times, the filtrate merging with 3 supersound extraction is concentrated into the extractum shape with merging filtrate, and after last lyophilization, pulverize gets final product; 4. the extracting method of Semen Cassiae extract: depend on pine torch, drying and crushing to 60 order adds deionized water supersound extraction 40min in boiling water, and the deionized water addition is that the 1g Semen Cassiae adds the 10ml deionized water; Repeat as stated above to extract 3 times, with the filtrate merging of 3 supersound extraction, merging filtrate is concentrated into the extractum shape through ethyl acetate extraction with extract, and after last lyophilization, pulverize gets final product.
Above-mentioned each raw extract powder is pressed: 140 jin of elaeagnus mollis blade extracts, 60 jin of Fructus Crataegi extracts, 100 jin of Radix Polygoni Multiflori Preparata extracts, 120 jin of abundant mixings of Semen Cassiae extract, make according to a conventional method oral liquid and get final product.
Claims (3)
1. an antilipemic Chinese herbal medicine prescription, is characterized in that being comprised of the raw material of following parts by weight: elaeagnus mollis blade extract 100-150 part, Fructus Crataegi extract 50-70 part, Radix Polygoni Multiflori Preparata extract 100-150 part, Semen Cassiae extract 80-120 part; Wherein, in prescription, the extracting method of each raw material is as follows: the 1. extracting method of elaeagnus mollis blade extract: get the elaeagnus mollis blade, drying and crushing is to the 60-80 order, adds 60% ethanol in 80 ℃ of lower supersound extraction 30min, and amount of alcohol added is that 1g elaeagnus mollis blade adds 10-20ml ethanol; Repeat as stated above to extract 3 times, with the filtrate merging of 3 supersound extraction, merging filtrate is concentrated into the extractum shape through ethyl acetate extraction with extract, and after last lyophilization, pulverize gets final product; 2. the extracting method of Fructus Crataegi extract: get Fructus Crataegi, drying and crushing adds deionized water supersound extraction 40min in boiling water to the 60-80 order, and the deionized water addition is that the 1g Fructus Crataegi adds the 10-20ml deionized water; Repeat as stated above to extract 3 times, the filtrate merging with 3 supersound extraction is concentrated into the extractum shape with merging filtrate, and after last lyophilization, pulverize gets final product; 3. the extracting method of Radix Polygoni Multiflori Preparata extract: get Radix Polygoni Multiflori Preparata, drying and crushing is to the 60-80 order, adds 60% ethanol in 80 ℃ of lower supersound extraction 30min, and amount of alcohol added is that the 1g Radix Polygoni Multiflori Preparata adds 10-20ml ethanol; Repeat as stated above to extract 3 times, the filtrate merging with 3 supersound extraction is concentrated into the extractum shape with merging filtrate, and after last lyophilization, pulverize gets final product; 4. the extracting method of Semen Cassiae extract: depend on pine torch, drying and crushing adds deionized water supersound extraction 40min in boiling water to the 60-80 order, and the deionized water addition is that the 1g Semen Cassiae adds the 10-20ml deionized water; Repeat as stated above to extract 3 times, with the filtrate merging of 3 supersound extraction, merging filtrate is concentrated into the extractum shape through ethyl acetate extraction with extract, and after last lyophilization, pulverize gets final product.
2. a kind of antilipemic Chinese herbal medicine prescription according to claim 1, is characterized in that being comprised of the raw material of following parts by weight: 150 parts of elaeagnus mollis blade extracts, 50 parts of Fructus Crataegi extracts, 150 parts of Radix Polygoni Multiflori Preparata extracts, 100 parts of Semen Cassiae extracts; Wherein, in prescription, the extracting method of each raw material is as follows: the 1. extracting method of elaeagnus mollis blade extract: get the elaeagnus mollis blade, drying and crushing is to the 60-80 order, adds 60% ethanol in 80 ℃ of lower supersound extraction 30min, and amount of alcohol added is that 1g elaeagnus mollis blade adds 10-20ml ethanol; Repeat as stated above to extract 3 times, with the filtrate merging of 3 supersound extraction, merging filtrate is concentrated into the extractum shape through ethyl acetate extraction with extract, and after last lyophilization, pulverize gets final product; 2. the extracting method of Fructus Crataegi extract: get Fructus Crataegi, drying and crushing adds deionized water supersound extraction 40min in boiling water to the 60-80 order, and the deionized water addition is that the 1g Fructus Crataegi adds the 10-20ml deionized water; Repeat as stated above to extract 3 times, the filtrate merging with 3 supersound extraction is concentrated into the extractum shape with merging filtrate, and after last lyophilization, pulverize gets final product; 3. the extracting method of Radix Polygoni Multiflori Preparata extract: get Radix Polygoni Multiflori Preparata, drying and crushing is to the 60-80 order, adds 60% ethanol in 80 ℃ of lower supersound extraction 30min, and amount of alcohol added is that the 1g Radix Polygoni Multiflori Preparata adds 10-20ml ethanol; Repeat as stated above to extract 3 times, the filtrate merging with 3 supersound extraction is concentrated into the extractum shape with merging filtrate, and after last lyophilization, pulverize gets final product; 4. the extracting method of Semen Cassiae extract: depend on pine torch, drying and crushing adds deionized water supersound extraction 40min in boiling water to the 60-80 order, and the deionized water addition is that the 1g Semen Cassiae adds the 10-20ml deionized water; Repeat as stated above to extract 3 times, with the filtrate merging of 3 supersound extraction, merging filtrate is concentrated into the extractum shape through ethyl acetate extraction with extract, and after last lyophilization, pulverize gets final product.
3. a kind of antilipemic Chinese herbal medicine prescription according to claim 1 and 2, it is characterized in that: this prescription can be made into capsule, tablet, electuary, drop pill, oral liquid, buccal tablet, granule, powder, suspensoid.
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| CN107509907A (en) * | 2017-10-18 | 2017-12-26 | 山西琪尔康翅果生物制品有限公司 | A kind of solid beverage with preventing alcoholic liver injury |
| CN111758809A (en) * | 2020-06-30 | 2020-10-13 | 郑屹 | Astragalus membranaceus and samara leaf health-care tea |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0873369A (en) * | 1994-09-01 | 1996-03-19 | Fuairudo:Kk | Tea for health |
| CN1143516A (en) * | 1996-04-05 | 1997-02-26 | 何志信 | Balanced nutritious food-kangfusu and preparing process thereof |
| JPH09208480A (en) * | 1995-12-01 | 1997-08-12 | Kao Corp | Substance p-antagonizing medicine |
| WO2004002503A1 (en) * | 2002-06-27 | 2004-01-08 | Chinese Medicines Scientific Consultants Pty Ltd | Compositions and methods for treating gynaecological disorders |
| CN1631480A (en) * | 2004-11-19 | 2005-06-29 | 中国科学院山西煤炭化学研究所 | Method by extracting samara essence by supercritical CO2 |
| CN1660287A (en) * | 2004-12-08 | 2005-08-31 | 郭来旺 | Capsule for descend of blood fat and preparing method |
| CN1788757A (en) * | 2005-10-18 | 2006-06-21 | 安微济人药业有限公司 | Hyperlipemia-treating Chinese traditional medicinal tablet and its preparation process |
| CN1911334A (en) * | 2006-07-28 | 2007-02-14 | 湖南恒伟药业有限公司 | Traditional Chinese medicine composition for lowering blood fat, and prepn. method therefor |
| CN101698032A (en) * | 2008-12-09 | 2010-04-28 | 浙江天一堂集团有限公司 | Method for preparing tablets for treating hyperlipemia and prepared product |
| CN102085305A (en) * | 2009-12-02 | 2011-06-08 | 彭伟洪 | Dripping pill capable of reducing fat |
-
2013
- 2013-01-04 CN CN201310001562.3A patent/CN103083429B/en not_active Expired - Fee Related
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0873369A (en) * | 1994-09-01 | 1996-03-19 | Fuairudo:Kk | Tea for health |
| JPH09208480A (en) * | 1995-12-01 | 1997-08-12 | Kao Corp | Substance p-antagonizing medicine |
| CN1143516A (en) * | 1996-04-05 | 1997-02-26 | 何志信 | Balanced nutritious food-kangfusu and preparing process thereof |
| WO2004002503A1 (en) * | 2002-06-27 | 2004-01-08 | Chinese Medicines Scientific Consultants Pty Ltd | Compositions and methods for treating gynaecological disorders |
| CN1631480A (en) * | 2004-11-19 | 2005-06-29 | 中国科学院山西煤炭化学研究所 | Method by extracting samara essence by supercritical CO2 |
| CN1660287A (en) * | 2004-12-08 | 2005-08-31 | 郭来旺 | Capsule for descend of blood fat and preparing method |
| CN1788757A (en) * | 2005-10-18 | 2006-06-21 | 安微济人药业有限公司 | Hyperlipemia-treating Chinese traditional medicinal tablet and its preparation process |
| CN1911334A (en) * | 2006-07-28 | 2007-02-14 | 湖南恒伟药业有限公司 | Traditional Chinese medicine composition for lowering blood fat, and prepn. method therefor |
| CN101698032A (en) * | 2008-12-09 | 2010-04-28 | 浙江天一堂集团有限公司 | Method for preparing tablets for treating hyperlipemia and prepared product |
| CN102085305A (en) * | 2009-12-02 | 2011-06-08 | 彭伟洪 | Dripping pill capable of reducing fat |
Non-Patent Citations (3)
| Title |
|---|
| 《"第二届中草药提取关键技术与提取物产业应用"研讨会》 20091231 张直峰等 翅果油树不同部位总黄酮含量及抗氧化活性比较研究 第137-141页 , * |
| 张直峰等: "翅果油树不同部位总黄酮含量及抗氧化活性比较研究", 《"第二届中草药提取关键技术与提取物产业应用"研讨会》, 31 December 2009 (2009-12-31), pages 137 - 141 * |
| 黄志海等: "清脂颗粒制备与鉴别方法研究", 《数理医药学杂志》, vol. 21, no. 3, 31 December 2008 (2008-12-31), pages 340 - 341 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106262876A (en) * | 2016-08-08 | 2017-01-04 | 司鸿娟 | A kind of multi-functional samara oil oral liquid and preparation method thereof |
| CN107509907A (en) * | 2017-10-18 | 2017-12-26 | 山西琪尔康翅果生物制品有限公司 | A kind of solid beverage with preventing alcoholic liver injury |
| CN111758809A (en) * | 2020-06-30 | 2020-10-13 | 郑屹 | Astragalus membranaceus and samara leaf health-care tea |
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