CN103732589B - 可用作抗细胞凋亡bcl抑制剂的取代的磺酰胺 - Google Patents
可用作抗细胞凋亡bcl抑制剂的取代的磺酰胺 Download PDFInfo
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- CN103732589B CN103732589B CN201280037247.XA CN201280037247A CN103732589B CN 103732589 B CN103732589 B CN 103732589B CN 201280037247 A CN201280037247 A CN 201280037247A CN 103732589 B CN103732589 B CN 103732589B
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- Prior art keywords
- alkyl
- phenyl
- och
- methyl
- carbonyl
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 CC(C)c1c(*)[n](CCC=C)nc1* Chemical compound CC(C)c1c(*)[n](CCC=C)nc1* 0.000 description 37
- YPKBCLZFIYBSHK-UHFFFAOYSA-N Cc1ccc2[nH]ccc2c1 Chemical compound Cc1ccc2[nH]ccc2c1 YPKBCLZFIYBSHK-UHFFFAOYSA-N 0.000 description 2
- XZSMCRSGEHSPEC-UHFFFAOYSA-N C/C=S(\c(cc1CC2)ccc1N2C(c1ccccc1)=O)/N Chemical compound C/C=S(\c(cc1CC2)ccc1N2C(c1ccccc1)=O)/N XZSMCRSGEHSPEC-UHFFFAOYSA-N 0.000 description 1
- FNXLGWHGSSDZSV-UHFFFAOYSA-N C/C=S(\c1cc(cc(cc2)OCc3ncc[n]3C)c2cc1)/O Chemical compound C/C=S(\c1cc(cc(cc2)OCc3ncc[n]3C)c2cc1)/O FNXLGWHGSSDZSV-UHFFFAOYSA-N 0.000 description 1
- SQXCOYLECFBXJF-UHFFFAOYSA-N C/C=S(\c1ccc(ccc(OCCCc2ccncc2)c2)c2c1)/N Chemical compound C/C=S(\c1ccc(ccc(OCCCc2ccncc2)c2)c2c1)/N SQXCOYLECFBXJF-UHFFFAOYSA-N 0.000 description 1
- XESBZICYEXRVIW-UHFFFAOYSA-N CCCCN(C(c(c(Cl)c1C)n[n]1-c(c(C(N(CC1)Cc2c1cccc2)=O)c1)ccc1C(NS(c1cc(cccc2)c2cc1)(=O)=O)=O)=O)c1ccc(CCC(N(CC2)CCC2C(O)=O)=O)cc1 Chemical compound CCCCN(C(c(c(Cl)c1C)n[n]1-c(c(C(N(CC1)Cc2c1cccc2)=O)c1)ccc1C(NS(c1cc(cccc2)c2cc1)(=O)=O)=O)=O)c1ccc(CCC(N(CC2)CCC2C(O)=O)=O)cc1 XESBZICYEXRVIW-UHFFFAOYSA-N 0.000 description 1
- RAWQTLCWWFAPFQ-UHFFFAOYSA-N CCCCN(CCCC)C(c1cccc(Br)n1)=O Chemical compound CCCCN(CCCC)C(c1cccc(Br)n1)=O RAWQTLCWWFAPFQ-UHFFFAOYSA-N 0.000 description 1
- JBKLUPSOIMSORY-ORHMFCTNSA-N CCCCN(CCCC)c1nc(-c(ccc(/C=[N+](/[O-])\S(c2ccc(cccc3)c3c2)(=O)=O)c2)c2C(N(CC2)Cc3c2cccc3)=O)ccn1 Chemical compound CCCCN(CCCC)c1nc(-c(ccc(/C=[N+](/[O-])\S(c2ccc(cccc3)c3c2)(=O)=O)c2)c2C(N(CC2)Cc3c2cccc3)=O)ccn1 JBKLUPSOIMSORY-ORHMFCTNSA-N 0.000 description 1
- TYMLPKNAKKUFRF-UHFFFAOYSA-N CCCCN(CCCC)c1nccc(-c(ccc(C(O)=O)c2)c2C(N(CC2)Cc3c2cccc3)=O)n1 Chemical compound CCCCN(CCCC)c1nccc(-c(ccc(C(O)=O)c2)c2C(N(CC2)Cc3c2cccc3)=O)n1 TYMLPKNAKKUFRF-UHFFFAOYSA-N 0.000 description 1
- UGLGKZFUQSWGOW-UHFFFAOYSA-N CCCCc([n](-c1ccc(C2C=CC=CC2)cc1)nc1C(OCC)=O)c1-c(c(C(N(CC1)Cc2c1cccc2)=O)c1)ccc1C(O)=O Chemical compound CCCCc([n](-c1ccc(C2C=CC=CC2)cc1)nc1C(OCC)=O)c1-c(c(C(N(CC1)Cc2c1cccc2)=O)c1)ccc1C(O)=O UGLGKZFUQSWGOW-UHFFFAOYSA-N 0.000 description 1
- SQKBIYZZVFKIBL-UHFFFAOYSA-N CCOC(c(c(-c(c(C(N(CC1)Cc2c1cccc2)=O)c1)ccc1C(NS(c1cc2ccccc2cc1)(=O)=O)=O)c1C)n[n]1-c1ccccc1)=O Chemical compound CCOC(c(c(-c(c(C(N(CC1)Cc2c1cccc2)=O)c1)ccc1C(NS(c1cc2ccccc2cc1)(=O)=O)=O)c1C)n[n]1-c1ccccc1)=O SQKBIYZZVFKIBL-UHFFFAOYSA-N 0.000 description 1
- BAVHVCOMIQIYGJ-UHFFFAOYSA-N CN(CCO)CC(C1)NCc2c1cccc2 Chemical compound CN(CCO)CC(C1)NCc2c1cccc2 BAVHVCOMIQIYGJ-UHFFFAOYSA-N 0.000 description 1
- GMTBLOULDYNUFF-UHFFFAOYSA-N CN1C(CCOc(cc2)cc3c2ccc(S(O)(=O)=O)c3)CCC1 Chemical compound CN1C(CCOc(cc2)cc3c2ccc(S(O)(=O)=O)c3)CCC1 GMTBLOULDYNUFF-UHFFFAOYSA-N 0.000 description 1
- CUWUZCKEBXYZSO-UHFFFAOYSA-N CN1CCN(CCCOc(cc2)cc3c2ccc(S(N)(=O)=O)c3)CC1 Chemical compound CN1CCN(CCCOc(cc2)cc3c2ccc(S(N)(=O)=O)c3)CC1 CUWUZCKEBXYZSO-UHFFFAOYSA-N 0.000 description 1
- PJJMZLPRTZYYHT-UHFFFAOYSA-N COC(C(C=CC1c2nc(C(N)=O)c[n]2CCN2CCOCC2)=CC1C(OCc1ccccc1)=O)=O Chemical compound COC(C(C=CC1c2nc(C(N)=O)c[n]2CCN2CCOCC2)=CC1C(OCc1ccccc1)=O)=O PJJMZLPRTZYYHT-UHFFFAOYSA-N 0.000 description 1
- OAEYFSYVPSWPBT-UHFFFAOYSA-N CS(c1cc(cc(cc2)OCCCN3CCCCC3)c2cc1)(=O)=O Chemical compound CS(c1cc(cc(cc2)OCCCN3CCCCC3)c2cc1)(=O)=O OAEYFSYVPSWPBT-UHFFFAOYSA-N 0.000 description 1
- ZZJGTQIEPAFLIU-UHFFFAOYSA-N Cc([n](-c(ccc(C(NS(c1ccc(C=CCC2)c2c1)(=O)=O)=O)c1)c1C(N(CC1)Cc2c1cccc2)=O)nc1C(N(C)Cc(cc2)cc(Cl)c2Cl)=O)c1Cl Chemical compound Cc([n](-c(ccc(C(NS(c1ccc(C=CCC2)c2c1)(=O)=O)=O)c1)c1C(N(CC1)Cc2c1cccc2)=O)nc1C(N(C)Cc(cc2)cc(Cl)c2Cl)=O)c1Cl ZZJGTQIEPAFLIU-UHFFFAOYSA-N 0.000 description 1
- CZXQWACQBBZNQW-UHFFFAOYSA-N I[IH]c1ccc(CCN2)c2c1 Chemical compound I[IH]c1ccc(CCN2)c2c1 CZXQWACQBBZNQW-UHFFFAOYSA-N 0.000 description 1
- FYEJQVUIMYPIFP-UHFFFAOYSA-N N=NS(c1cc(cc(cc2)OCc3ccccc3)c2cc1)(=O)=O Chemical compound N=NS(c1cc(cc(cc2)OCc3ccccc3)c2cc1)(=O)=O FYEJQVUIMYPIFP-UHFFFAOYSA-N 0.000 description 1
- SJMZQBHSPCMOBB-UHFFFAOYSA-N NS(c(cc(c(CC1)c2)N1C(c(cc1Cl)ccc1Cl)=O)c2Br)(=O)=O Chemical compound NS(c(cc(c(CC1)c2)N1C(c(cc1Cl)ccc1Cl)=O)c2Br)(=O)=O SJMZQBHSPCMOBB-UHFFFAOYSA-N 0.000 description 1
- KEDZPWGURXFRBW-UHFFFAOYSA-N NS(c1ccc2N(CCSC3=CCC=CC=C3)CCc2c1)(=O)=O Chemical compound NS(c1ccc2N(CCSC3=CCC=CC=C3)CCc2c1)(=O)=O KEDZPWGURXFRBW-UHFFFAOYSA-N 0.000 description 1
- OLZGXNJTKSZKCK-UHFFFAOYSA-N Nc(cc1)c(ccc(SO)c2)c2c1Cl Chemical compound Nc(cc1)c(ccc(SO)c2)c2c1Cl OLZGXNJTKSZKCK-UHFFFAOYSA-N 0.000 description 1
- OGGXWOQQZVECBJ-UHFFFAOYSA-N O=C(c(cc(cc1)C(Oc2ccccc2)=O)c1F)N(CC1)Cc2c1cccc2 Chemical compound O=C(c(cc(cc1)C(Oc2ccccc2)=O)c1F)N(CC1)Cc2c1cccc2 OGGXWOQQZVECBJ-UHFFFAOYSA-N 0.000 description 1
- JBHWGROZAIILTG-UHFFFAOYSA-N O=C(c(cc1Cl)ccc1Cl)N(CCc1c2)c1ccc2Br Chemical compound O=C(c(cc1Cl)ccc1Cl)N(CCc1c2)c1ccc2Br JBHWGROZAIILTG-UHFFFAOYSA-N 0.000 description 1
- KWLAFLHFDMLAHB-UHFFFAOYSA-N O=C(c(cc1Cl)ccc1Cl)N1c2ccccc2CC1 Chemical compound O=C(c(cc1Cl)ccc1Cl)N1c2ccccc2CC1 KWLAFLHFDMLAHB-UHFFFAOYSA-N 0.000 description 1
- YAYMLIBHRGHVBN-UHFFFAOYSA-O [NH3+]S(c1ccc(ccc(OCCOc2ccccc2)c2)c2c1)(=O)=O Chemical compound [NH3+]S(c1ccc(ccc(OCCOc2ccccc2)c2)c2c1)(=O)=O YAYMLIBHRGHVBN-UHFFFAOYSA-O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161489865P | 2011-05-25 | 2011-05-25 | |
| US61/489,865 | 2011-05-25 | ||
| PCT/US2012/039094 WO2012162365A1 (en) | 2011-05-25 | 2012-05-23 | Substituted sulfonamides useful as antiapoptotic bcl inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103732589A CN103732589A (zh) | 2014-04-16 |
| CN103732589B true CN103732589B (zh) | 2016-03-30 |
Family
ID=46229924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280037247.XA Expired - Fee Related CN103732589B (zh) | 2011-05-25 | 2012-05-23 | 可用作抗细胞凋亡bcl抑制剂的取代的磺酰胺 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9346795B2 (enExample) |
| EP (1) | EP2714681B1 (enExample) |
| JP (1) | JP2014521595A (enExample) |
| CN (1) | CN103732589B (enExample) |
| WO (1) | WO2012162365A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015503516A (ja) * | 2011-12-23 | 2015-02-02 | ノバルティス アーゲー | Ｂｃｌ２と結合相手の相互作用を阻害するための化合物 |
| FR2986002B1 (fr) | 2012-01-24 | 2014-02-21 | Servier Lab | Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3008975A1 (fr) | 2013-07-23 | 2015-01-30 | Servier Lab | Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3008977A1 (fr) | 2013-07-23 | 2015-01-30 | Servier Lab | Nouveaux derives d'isoindoline ou d'isoquinoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3008978A1 (fr) | 2013-07-23 | 2015-01-30 | Servier Lab | "nouveaux derives d'indole et de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent" |
| FR3008976A1 (fr) * | 2013-07-23 | 2015-01-30 | Servier Lab | "nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent" |
| US10385040B2 (en) | 2014-08-12 | 2019-08-20 | Loyola University Of Chicago | Indoline sulfonamide inhibitors of DapE and NDM-1 and use of the same |
| CN104525253B (zh) * | 2014-12-05 | 2017-05-10 | 西华大学 | 三乙烯二胺在催化芳香醛与硝基烃反应生成硝基芳香醇中的催化剂用途 |
| CN104529784B (zh) * | 2014-12-05 | 2017-01-18 | 西华大学 | 一种硝基芳香醇的制备方法 |
| US10195213B2 (en) | 2015-03-13 | 2019-02-05 | Unity Biotechnology, Inc. | Chemical entities that kill senescent cells for use in treating age-related disease |
| CN105693522A (zh) * | 2016-03-10 | 2016-06-22 | 中国农业科学院上海兽医研究所 | 一种对硝基邻甲酚的制备方法 |
| CN108251104B (zh) * | 2018-02-27 | 2019-11-05 | 山东大学 | 一种取代吲哚-2-羧酸类Bcl-2小分子荧光探针及其应用 |
| US12030879B2 (en) | 2018-03-02 | 2024-07-09 | Inflazome Limited | Sulfonyl acetamides as NLRP3 inhibitors |
| JP2021521138A (ja) | 2018-04-29 | 2021-08-26 | ベイジーン リミテッド | Ｂｃｌ−２阻害剤 |
| AU2021256580A1 (en) | 2020-04-15 | 2022-09-29 | Beone Medicines I Gmbh | Bcl-2 inhibitor |
| WO2022255778A1 (ko) * | 2021-06-01 | 2022-12-08 | 주식회사 에즈큐리스 | Ｉｌ-33 단백질 저해용 화합물의 스크리닝 방법 및 상기 화합물을 포함하는 알러지성 질환 치료용 약학조성물 |
| CA3240077A1 (en) * | 2021-12-29 | 2023-07-06 | Volodymyr KYSIL | Bcl-2 inhibitors |
| US20250304535A1 (en) * | 2024-03-29 | 2025-10-02 | Beigene Switzerland Gmbh | KAT6 Inhibitors |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008024337A2 (en) * | 2006-08-21 | 2008-02-28 | Infinity Discovery, Inc. | Compounds and methods for inhibiting the interaction of bcl proteins with binding partners |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19621522A1 (de) | 1996-05-29 | 1997-12-04 | Hoechst Schering Agrevo Gmbh | Neue N-Acylsulfonamide, neue Mischungen aus Herbiziden und Antidots und deren Verwendung |
| UY26942A1 (es) * | 2000-09-20 | 2002-04-26 | Abbott Lab | N-acilsulfonamidas promotoras de la apoptosis |
| US6831193B2 (en) | 2001-05-18 | 2004-12-14 | Abbott Laboratories | Trisubstituted-N-[(1S)-1,2,3,4-Tetrahydro-1-naphthalenyl]benzamides which inhibit P2X3 and P2X2/3 containing receptors |
| CA2519297A1 (en) | 2003-03-18 | 2004-09-30 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity |
| EP1598341A1 (en) | 2004-05-21 | 2005-11-23 | Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft | DPP-IV inhibitors |
| EP1655283A1 (en) | 2004-11-08 | 2006-05-10 | Evotec OAI AG | 11beta-HSD1 Inhibitors |
| JP2006316054A (ja) | 2005-04-15 | 2006-11-24 | Tanabe Seiyaku Co Ltd | 高コンダクタンス型カルシウム感受性ｋチャネル開口薬 |
| US7601844B2 (en) | 2006-01-27 | 2009-10-13 | Bristol-Myers Squibb Company | Piperidinyl derivatives as modulators of chemokine receptor activity |
| WO2008156614A2 (en) | 2007-06-14 | 2008-12-24 | Schering Corporation | Imidazopyrazines as protein kinase inhibitors |
| EP2280964B1 (en) | 2008-02-21 | 2012-08-29 | Sanofi | Chlorothiophene-isoxazoles as inhibitors of coagulation factors xa and thrombin |
| JP5422570B2 (ja) | 2008-02-21 | 2014-02-19 | サノフイ | 凝固第Ｘａ因子及びトロンビンの阻害剤としてのクロロチオフェン−アミド類 |
| WO2009105751A1 (en) | 2008-02-22 | 2009-08-27 | University Of South Florida | Acylsulfonamides and processes for producing the same |
| AR071310A1 (es) | 2008-04-11 | 2010-06-09 | Merck Serono Sa | Sulfonamidas |
| UA108193C2 (uk) | 2008-12-04 | 2015-04-10 | Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань |
-
2012
- 2012-05-23 WO PCT/US2012/039094 patent/WO2012162365A1/en not_active Ceased
- 2012-05-23 US US14/122,173 patent/US9346795B2/en active Active
- 2012-05-23 EP EP12726525.4A patent/EP2714681B1/en not_active Not-in-force
- 2012-05-23 JP JP2014512963A patent/JP2014521595A/ja active Pending
- 2012-05-23 CN CN201280037247.XA patent/CN103732589B/zh not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008024337A2 (en) * | 2006-08-21 | 2008-02-28 | Infinity Discovery, Inc. | Compounds and methods for inhibiting the interaction of bcl proteins with binding partners |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2714681A1 (en) | 2014-04-09 |
| US20140135318A1 (en) | 2014-05-15 |
| US9346795B2 (en) | 2016-05-24 |
| EP2714681B1 (en) | 2015-06-24 |
| WO2012162365A1 (en) | 2012-11-29 |
| CN103732589A (zh) | 2014-04-16 |
| JP2014521595A (ja) | 2014-08-28 |
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