JP2014521595A - 抗アポトーシスＢｃｌ阻害剤として有用な置換スルホンアミド - Google Patents
抗アポトーシスＢｃｌ阻害剤として有用な置換スルホンアミド Download PDFInfo
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- JP2014521595A JP2014521595A JP2014512963A JP2014512963A JP2014521595A JP 2014521595 A JP2014521595 A JP 2014521595A JP 2014512963 A JP2014512963 A JP 2014512963A JP 2014512963 A JP2014512963 A JP 2014512963A JP 2014521595 A JP2014521595 A JP 2014521595A
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- Prior art keywords
- phenyl
- och
- alkyl
- methyl
- carbonyl
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- 0 Cc1c(*)[n](*)nc1* Chemical compound Cc1c(*)[n](*)nc1* 0.000 description 60
- BBHSNPATBVORCL-UHFFFAOYSA-N C=CC(C(N(CC1)Cc2c1cccc2)=O)=C Chemical compound C=CC(C(N(CC1)Cc2c1cccc2)=O)=C BBHSNPATBVORCL-UHFFFAOYSA-N 0.000 description 1
- RWKFLPYHDLRHKW-UHFFFAOYSA-N CC(C)(C)OC(c1cc(C(N2Cc3ccccc3CC2)=O)c(C=O)cc1)=O Chemical compound CC(C)(C)OC(c1cc(C(N2Cc3ccccc3CC2)=O)c(C=O)cc1)=O RWKFLPYHDLRHKW-UHFFFAOYSA-N 0.000 description 1
- PRUZDHKVIWLPBX-UHFFFAOYSA-N CC(C)COC(c(cc(cc1)C(OC)=O)c1O)=O Chemical compound CC(C)COC(c(cc(cc1)C(OC)=O)c1O)=O PRUZDHKVIWLPBX-UHFFFAOYSA-N 0.000 description 1
- LITILBAHRRLVGW-UHFFFAOYSA-N CC(C)COC(c1c(B2OC(C)(C)C(C)(C)O2)ccc(C(OC)=O)c1)=O Chemical compound CC(C)COC(c1c(B2OC(C)(C)C(C)(C)O2)ccc(C(OC)=O)c1)=O LITILBAHRRLVGW-UHFFFAOYSA-N 0.000 description 1
- IAAWQLPQHJMLJJ-UHFFFAOYSA-N CC(C=C)C(N(CC1)Cc2c1cccc2)=O Chemical compound CC(C=C)C(N(CC1)Cc2c1cccc2)=O IAAWQLPQHJMLJJ-UHFFFAOYSA-N 0.000 description 1
- PZIICXWIDRTYGZ-UHFFFAOYSA-N CCCC(N(CCc1c2)c1ccc2S(N)(=O)=O)=O Chemical compound CCCC(N(CCc1c2)c1ccc2S(N)(=O)=O)=O PZIICXWIDRTYGZ-UHFFFAOYSA-N 0.000 description 1
- XENBADQVSRJVQI-UHFFFAOYSA-N CCCCN(CCCC)c(nc1-c(ccc(C(NS(c2ccc(cccc3)c3c2)(=O)=O)=O)c2)c2C(N(C2)C(CO)Cc3c2cccc3)=O)ncc1Cl Chemical compound CCCCN(CCCC)c(nc1-c(ccc(C(NS(c2ccc(cccc3)c3c2)(=O)=O)=O)c2)c2C(N(C2)C(CO)Cc3c2cccc3)=O)ncc1Cl XENBADQVSRJVQI-UHFFFAOYSA-N 0.000 description 1
- VQGZCHMXBYOUQI-QVAGMWBUSA-N CCCCN(CCCC)c1nccc(-c(c(C(N(Cc2c(C3)cccc2)/C3=C/O)=O)c2)ccc2C(NS(c(cc2)cc3c2N(CC)CC3)(=O)=O)=O)n1 Chemical compound CCCCN(CCCC)c1nccc(-c(c(C(N(Cc2c(C3)cccc2)/C3=C/O)=O)c2)ccc2C(NS(c(cc2)cc3c2N(CC)CC3)(=O)=O)=O)n1 VQGZCHMXBYOUQI-QVAGMWBUSA-N 0.000 description 1
- IHRPJNDVWBJCEH-UHFFFAOYSA-N CCCCNc(cc1)ccc1C(OC)=O Chemical compound CCCCNc(cc1)ccc1C(OC)=O IHRPJNDVWBJCEH-UHFFFAOYSA-N 0.000 description 1
- NCWOSLIYQNXQTN-UHFFFAOYSA-N CCCCNc(cc1)ccc1Oc(cc1)ccc1Cl Chemical compound CCCCNc(cc1)ccc1Oc(cc1)ccc1Cl NCWOSLIYQNXQTN-UHFFFAOYSA-N 0.000 description 1
- YPUCXLKSMZDVCC-UHFFFAOYSA-N CCCCc([n](-c(cc1)ccc1-c1ccccc1)nc1C(OCC)=O)c1-c(c(C(N(CC1)Cc2c1cccc2)=O)c1)ccc1C(OC(C)(C)C)=O Chemical compound CCCCc([n](-c(cc1)ccc1-c1ccccc1)nc1C(OCC)=O)c1-c(c(C(N(CC1)Cc2c1cccc2)=O)c1)ccc1C(OC(C)(C)C)=O YPUCXLKSMZDVCC-UHFFFAOYSA-N 0.000 description 1
- QTNBCCJYTPBACC-UHFFFAOYSA-N CCCCc([n](-c(cc1)ccc1O)nc1CO)c1-c(ccc(C(NS(c1cc(cccc2)c2cc1)(=O)=O)=O)c1)c1C(N(CC1)Cc2c1cccc2)=O Chemical compound CCCCc([n](-c(cc1)ccc1O)nc1CO)c1-c(ccc(C(NS(c1cc(cccc2)c2cc1)(=O)=O)=O)c1)c1C(N(CC1)Cc2c1cccc2)=O QTNBCCJYTPBACC-UHFFFAOYSA-N 0.000 description 1
- POIMAWJWTIMQMP-UHFFFAOYSA-N CCCCc([n](-c(cc1)ccc1OCCCO)nc1CO)c1-c(ccc(C(NS(c1cc(cccc2)c2cc1)(=O)=O)=O)c1)c1C(N(CC1)Cc2c1cccc2)=O Chemical compound CCCCc([n](-c(cc1)ccc1OCCCO)nc1CO)c1-c(ccc(C(NS(c1cc(cccc2)c2cc1)(=O)=O)=O)c1)c1C(N(CC1)Cc2c1cccc2)=O POIMAWJWTIMQMP-UHFFFAOYSA-N 0.000 description 1
- JDUHGNNEPMBJAM-UHFFFAOYSA-N CCCCc([n](-c(cc1)ccc1Oc1ccccc1)nc1C(OCC)=O)c1-c(ccc(C(NS(c1ccc(cccc2)c2c1)(=O)=O)=O)c1)c1C(N(CC1)Cc2c1cccc2)=O Chemical compound CCCCc([n](-c(cc1)ccc1Oc1ccccc1)nc1C(OCC)=O)c1-c(ccc(C(NS(c1ccc(cccc2)c2c1)(=O)=O)=O)c1)c1C(N(CC1)Cc2c1cccc2)=O JDUHGNNEPMBJAM-UHFFFAOYSA-N 0.000 description 1
- IZCJFFOLGNJLRT-BGABXYSRSA-N CCCN(CCC)c(nc1-c(ccc(C(NS(c2ccc(cccc3)c3c2)(=O)=O)=O)c2)c2C(N(Cc2c(C3)cccc2)/C3=C/O)=O)ncc1Br Chemical compound CCCN(CCC)c(nc1-c(ccc(C(NS(c2ccc(cccc3)c3c2)(=O)=O)=O)c2)c2C(N(Cc2c(C3)cccc2)/C3=C/O)=O)ncc1Br IZCJFFOLGNJLRT-BGABXYSRSA-N 0.000 description 1
- AHOJTPZHHMJMCW-UHFFFAOYSA-N CCN(CC1)CCC1O Chemical compound CCN(CC1)CCC1O AHOJTPZHHMJMCW-UHFFFAOYSA-N 0.000 description 1
- GJCMPLHRWWWPHN-UHFFFAOYSA-N CCNC1CCN(C)CC1 Chemical compound CCNC1CCN(C)CC1 GJCMPLHRWWWPHN-UHFFFAOYSA-N 0.000 description 1
- VARJMVYCDHQKCG-UHFFFAOYSA-N CCNC1CCNCC1 Chemical compound CCNC1CCNCC1 VARJMVYCDHQKCG-UHFFFAOYSA-N 0.000 description 1
- JLANSMFIFFVVJH-UHFFFAOYSA-N CN(C)CCCOc1cc2cc(S(O)(=O)=O)ccc2cc1 Chemical compound CN(C)CCCOc1cc2cc(S(O)(=O)=O)ccc2cc1 JLANSMFIFFVVJH-UHFFFAOYSA-N 0.000 description 1
- IHDUFVRTWIQNAG-UHFFFAOYSA-N CN(C1)C=NCc2c1cccc2 Chemical compound CN(C1)C=NCc2c1cccc2 IHDUFVRTWIQNAG-UHFFFAOYSA-N 0.000 description 1
- BAVHVCOMIQIYGJ-UHFFFAOYSA-N CN(CCO)CC(C1)NCc2c1cccc2 Chemical compound CN(CCO)CC(C1)NCc2c1cccc2 BAVHVCOMIQIYGJ-UHFFFAOYSA-N 0.000 description 1
- BFLAAQFFOZFSOX-UHFFFAOYSA-N CN(CCOC)C(NC1)=NCc2c1cccc2 Chemical compound CN(CCOC)C(NC1)=NCc2c1cccc2 BFLAAQFFOZFSOX-UHFFFAOYSA-N 0.000 description 1
- ALBUJVBOIXVVLS-UHFFFAOYSA-N COC(c(cc1)cc(C(OC)=O)c1O)=O Chemical compound COC(c(cc1)cc(C(OC)=O)c1O)=O ALBUJVBOIXVVLS-UHFFFAOYSA-N 0.000 description 1
- SBWBKMNSRXHBNL-UHFFFAOYSA-N C[O](C)C(c(cc1)cc(C(O)=O)c1O)=O Chemical compound C[O](C)C(c(cc1)cc(C(O)=O)c1O)=O SBWBKMNSRXHBNL-UHFFFAOYSA-N 0.000 description 1
- JJBBVEMYZBMPSO-UHFFFAOYSA-N C[n]1c(COc(cc2)cc3c2ccc(S(N)(=O)=O)c3)ncc1 Chemical compound C[n]1c(COc(cc2)cc3c2ccc(S(N)(=O)=O)c3)ncc1 JJBBVEMYZBMPSO-UHFFFAOYSA-N 0.000 description 1
- KZPZTVKOJSKVBV-UHFFFAOYSA-N C[n]1cnc(C(OC)=O)c1 Chemical compound C[n]1cnc(C(OC)=O)c1 KZPZTVKOJSKVBV-UHFFFAOYSA-N 0.000 description 1
- FWSYEYQXPSSQMV-UHFFFAOYSA-N Cc([nH]nc1C(O)=O)c1Cl Chemical compound Cc([nH]nc1C(O)=O)c1Cl FWSYEYQXPSSQMV-UHFFFAOYSA-N 0.000 description 1
- BJMUOUXGBFNLSN-UHFFFAOYSA-N Cc1cc(cccc2)c2[n]1C Chemical compound Cc1cc(cccc2)c2[n]1C BJMUOUXGBFNLSN-UHFFFAOYSA-N 0.000 description 1
- PUIQJDMLKPCGHS-UHFFFAOYSA-N NS(c(cc1)cc2c1ccc(I)c2)(=O)=O Chemical compound NS(c(cc1)cc2c1ccc(I)c2)(=O)=O PUIQJDMLKPCGHS-UHFFFAOYSA-N 0.000 description 1
- VNDYACKQGIASQI-UHFFFAOYSA-N NS(c1cc(c(OCCCN2CCOCC2)ccc2)c2cc1)(=O)=O Chemical compound NS(c1cc(c(OCCCN2CCOCC2)ccc2)c2cc1)(=O)=O VNDYACKQGIASQI-UHFFFAOYSA-N 0.000 description 1
- KQMSGUQTDAESEV-UHFFFAOYSA-N NS(c1cc(c(OCCN2CCOCC2)ccc2)c2cc1)(=O)=O Chemical compound NS(c1cc(c(OCCN2CCOCC2)ccc2)c2cc1)(=O)=O KQMSGUQTDAESEV-UHFFFAOYSA-N 0.000 description 1
- AGPFQSBHJPESTO-UHFFFAOYSA-N OC(c(cn1)ccc1OCCN1CCOCC1)=O Chemical compound OC(c(cn1)ccc1OCCN1CCOCC1)=O AGPFQSBHJPESTO-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161489865P | 2011-05-25 | 2011-05-25 | |
| US61/489,865 | 2011-05-25 | ||
| PCT/US2012/039094 WO2012162365A1 (en) | 2011-05-25 | 2012-05-23 | Substituted sulfonamides useful as antiapoptotic bcl inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014521595A true JP2014521595A (ja) | 2014-08-28 |
| JP2014521595A5 JP2014521595A5 (enExample) | 2015-07-02 |
Family
ID=46229924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512963A Pending JP2014521595A (ja) | 2011-05-25 | 2012-05-23 | 抗アポトーシスＢｃｌ阻害剤として有用な置換スルホンアミド |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9346795B2 (enExample) |
| EP (1) | EP2714681B1 (enExample) |
| JP (1) | JP2014521595A (enExample) |
| CN (1) | CN103732589B (enExample) |
| WO (1) | WO2012162365A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2025502899A (ja) * | 2021-12-29 | 2025-01-29 | エイル セラピューティクス，インコーポレイテッド | Ｂｃｌ－２阻害薬 |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2859873A1 (en) * | 2011-12-23 | 2013-06-27 | Novartis Ag | Compounds for inhibiting the interaction of bcl2 with binding partners |
| FR2986002B1 (fr) | 2012-01-24 | 2014-02-21 | Servier Lab | Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3008977A1 (fr) * | 2013-07-23 | 2015-01-30 | Servier Lab | Nouveaux derives d'isoindoline ou d'isoquinoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3008978A1 (fr) * | 2013-07-23 | 2015-01-30 | Servier Lab | "nouveaux derives d'indole et de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent" |
| FR3008975A1 (fr) * | 2013-07-23 | 2015-01-30 | Servier Lab | Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3008976A1 (fr) * | 2013-07-23 | 2015-01-30 | Servier Lab | "nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent" |
| CA2957566C (en) * | 2014-08-12 | 2023-08-01 | Daniel Paul Becker | Indoline sulfonamide inhibitors of dape and ndm-1 and use of the same |
| CN104525253B (zh) * | 2014-12-05 | 2017-05-10 | 西华大学 | 三乙烯二胺在催化芳香醛与硝基烃反应生成硝基芳香醇中的催化剂用途 |
| CN104529784B (zh) * | 2014-12-05 | 2017-01-18 | 西华大学 | 一种硝基芳香醇的制备方法 |
| US10195213B2 (en) | 2015-03-13 | 2019-02-05 | Unity Biotechnology, Inc. | Chemical entities that kill senescent cells for use in treating age-related disease |
| CN105693522A (zh) * | 2016-03-10 | 2016-06-22 | 中国农业科学院上海兽医研究所 | 一种对硝基邻甲酚的制备方法 |
| CN108251104B (zh) * | 2018-02-27 | 2019-11-05 | 山东大学 | 一种取代吲哚-2-羧酸类Bcl-2小分子荧光探针及其应用 |
| WO2019166629A1 (en) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Novel compounds |
| SI3788042T1 (sl) | 2018-04-29 | 2025-06-30 | Beigene Switzerland Gmbh | Zaviralci BCL-2 |
| WO2021208963A1 (en) | 2020-04-15 | 2021-10-21 | Beigene, Ltd. | Bcl-2 inhibitor |
| WO2022255778A1 (ko) * | 2021-06-01 | 2022-12-08 | 주식회사 에즈큐리스 | Ｉｌ-33 단백질 저해용 화합물의 스크리닝 방법 및 상기 화합물을 포함하는 알러지성 질환 치료용 약학조성물 |
| US20250304535A1 (en) * | 2024-03-29 | 2025-10-02 | Beigene Switzerland Gmbh | KAT6 Inhibitors |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004529852A (ja) * | 2000-09-20 | 2004-09-30 | アボット・ラボラトリーズ | Ｎ−アシルスルホンアミド系アポトーシス促進剤 |
| JP2010501565A (ja) * | 2006-08-21 | 2010-01-21 | インフィニティ・ディスカバリー・インコーポレイテッド | Ｂｃｌタンパク質と結合パートナーとの相互作用を阻害する化合物および方法 |
| WO2010065824A2 (en) * | 2008-12-04 | 2010-06-10 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19621522A1 (de) | 1996-05-29 | 1997-12-04 | Hoechst Schering Agrevo Gmbh | Neue N-Acylsulfonamide, neue Mischungen aus Herbiziden und Antidots und deren Verwendung |
| US6831193B2 (en) | 2001-05-18 | 2004-12-14 | Abbott Laboratories | Trisubstituted-N-[(1S)-1,2,3,4-Tetrahydro-1-naphthalenyl]benzamides which inhibit P2X3 and P2X2/3 containing receptors |
| WO2004082616A2 (en) | 2003-03-18 | 2004-09-30 | Merck & Co. Inc. | Tetrahydropyranyl cyclopentyl heterocylic amide modulators of chemokine receptor activity |
| EP1598341A1 (en) | 2004-05-21 | 2005-11-23 | Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft | DPP-IV inhibitors |
| EP1655283A1 (en) | 2004-11-08 | 2006-05-10 | Evotec OAI AG | 11beta-HSD1 Inhibitors |
| JP2006316054A (ja) | 2005-04-15 | 2006-11-24 | Tanabe Seiyaku Co Ltd | 高コンダクタンス型カルシウム感受性ｋチャネル開口薬 |
| US7601844B2 (en) | 2006-01-27 | 2009-10-13 | Bristol-Myers Squibb Company | Piperidinyl derivatives as modulators of chemokine receptor activity |
| PE20090365A1 (es) | 2007-06-14 | 2009-04-04 | Schering Corp | Imidazopirazinas como inhibidores de proteina quinasa |
| EP2280964B1 (en) | 2008-02-21 | 2012-08-29 | Sanofi | Chlorothiophene-isoxazoles as inhibitors of coagulation factors xa and thrombin |
| DK2254881T3 (da) | 2008-02-21 | 2012-12-10 | Sanofi Sa | Chlorothiophenamides som inhibitorer af koagulationsfaktorerne xa og thrombin |
| US8524947B2 (en) | 2008-02-22 | 2013-09-03 | University Of South Florida | Acylsulfonamides and processes for producing the same |
| CA2720530A1 (en) | 2008-04-11 | 2009-10-15 | Merck Serono S.A. | Sulfonamides |
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2012
- 2012-05-23 JP JP2014512963A patent/JP2014521595A/ja active Pending
- 2012-05-23 EP EP12726525.4A patent/EP2714681B1/en not_active Not-in-force
- 2012-05-23 CN CN201280037247.XA patent/CN103732589B/zh not_active Expired - Fee Related
- 2012-05-23 US US14/122,173 patent/US9346795B2/en active Active
- 2012-05-23 WO PCT/US2012/039094 patent/WO2012162365A1/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004529852A (ja) * | 2000-09-20 | 2004-09-30 | アボット・ラボラトリーズ | Ｎ−アシルスルホンアミド系アポトーシス促進剤 |
| JP2010501565A (ja) * | 2006-08-21 | 2010-01-21 | インフィニティ・ディスカバリー・インコーポレイテッド | Ｂｃｌタンパク質と結合パートナーとの相互作用を阻害する化合物および方法 |
| WO2010065824A2 (en) * | 2008-12-04 | 2010-06-10 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2025502899A (ja) * | 2021-12-29 | 2025-01-29 | エイル セラピューティクス，インコーポレイテッド | Ｂｃｌ－２阻害薬 |
| JP7772431B2 (ja) | 2021-12-29 | 2025-11-18 | エイル セラピューティクス，インコーポレイテッド | Ｂｃｌ－２阻害薬 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012162365A1 (en) | 2012-11-29 |
| EP2714681B1 (en) | 2015-06-24 |
| CN103732589A (zh) | 2014-04-16 |
| US20140135318A1 (en) | 2014-05-15 |
| EP2714681A1 (en) | 2014-04-09 |
| CN103732589B (zh) | 2016-03-30 |
| US9346795B2 (en) | 2016-05-24 |
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