CN103732577B - 作为有效hdac抑制剂的携带内酰胺的硫代衍生物和它们作为药物的用途 - Google Patents

作为有效hdac抑制剂的携带内酰胺的硫代衍生物和它们作为药物的用途 Download PDF

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CN103732577B
CN103732577B CN201280039630.9A CN201280039630A CN103732577B CN 103732577 B CN103732577 B CN 103732577B CN 201280039630 A CN201280039630 A CN 201280039630A CN 103732577 B CN103732577 B CN 103732577B
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oxo
hexyl
phenylcarbamoyl
piperidine
amino
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CN103732577A (zh
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G·詹尼尼
W·卡布里
G·巴蒂斯图齐
D·维尼奥拉
N·丰托
C·皮萨诺
L·韦西
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Alpha Sigma Co Ltd
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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CN201280039630.9A 2011-09-19 2012-09-17 作为有效hdac抑制剂的携带内酰胺的硫代衍生物和它们作为药物的用途 Active CN103732577B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11181832 2011-09-19
EP11181832.4 2011-09-19
PCT/EP2012/068230 WO2013041480A1 (en) 2011-09-19 2012-09-17 New thio derivatives bearing lactams as potent hdac inhibitors and their uses as medicaments

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CN103732577A CN103732577A (zh) 2014-04-16
CN103732577B true CN103732577B (zh) 2017-04-05

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PE20161030A1 (es) 2013-12-03 2016-11-06 Acetylon Pharmaceuticals Inc Combinaciones de inhibidores de histona deacetilasa y farmacos inmunomoduladores
CA2946538A1 (en) 2014-04-04 2015-10-08 Del Mar Pharmaceuticals Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer
WO2016201374A1 (en) * 2015-06-11 2016-12-15 University Of Florida Research Foundation, Incorporated Sulfanide adenosine derivatives and uses thereof
WO2024229406A1 (en) 2023-05-04 2024-11-07 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
TW202530228A (zh) 2023-10-12 2025-08-01 美商銳新醫藥公司 Ｒａｓ抑制劑
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
TW202547461A (zh) 2024-05-17 2025-12-16 美商銳新醫藥公司 Ｒａｓ抑制劑
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors

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IL230717A (en) 2017-01-31
CA2843211A1 (en) 2013-03-28
CN103732577A (zh) 2014-04-16
BR112014006600B1 (pt) 2022-04-19
JP2014531441A (ja) 2014-11-27
EA201400365A1 (ru) 2014-06-30
MX2014003334A (es) 2014-05-21
PL2758371T3 (pl) 2017-01-31
WO2013041480A1 (en) 2013-03-28
PT2758371T (pt) 2016-07-13
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IL230717A0 (en) 2014-03-31
CA2843211C (en) 2019-03-12
EP2758371B1 (en) 2016-06-15
EA023171B1 (ru) 2016-04-29
UA111231C2 (uk) 2016-04-11
EP2758371A1 (en) 2014-07-30
US8927533B2 (en) 2015-01-06
MX369508B (es) 2019-11-11
KR101929774B1 (ko) 2018-12-18
AU2012311640B2 (en) 2017-04-13
BR112014006600A2 (pt) 2017-03-28
ES2579321T3 (es) 2016-08-09
DK2758371T3 (en) 2016-08-01
AU2012311640A1 (en) 2014-02-13
JP6053795B2 (ja) 2016-12-27
US20140200205A1 (en) 2014-07-17
HUE029687T2 (en) 2017-03-28
KR20140066993A (ko) 2014-06-03
PH12014500249A1 (en) 2022-11-23

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