CN103720943B - A kind of Chinese medicine for the treatment of gynecological bleeding and preparation method thereof - Google Patents
A kind of Chinese medicine for the treatment of gynecological bleeding and preparation method thereof Download PDFInfo
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Abstract
A kind of Chinese medicine for the treatment of gynecological bleeding and preparation method thereof, this Chinese medicine is made up of following raw material by weight: the Radix Bupleuri of 20 ~ 40 parts, the Herba silenes fortunei of 20 ~ 35 parts, the Radix Salviae Miltiorrhizae of 35 ~ 45 parts, the Radix Paeoniae Alba of 25 ~ 35 parts, five Medulla Tetrapanacis of 35 ~ 45 parts, the cuscuta japonica Choisy of 25 ~ 35 parts, the Os Draconis (calcined) of 20 ~ 35 parts, the Radix Cyathulae of 20 ~ 30 parts, the Pollen Typhae carbon of 20 ~ 30 parts, the Os Sepiae of 20 ~ 25 parts and the sweeting agent of 3 ~ 8 parts and the additive of 3 ~ 5 parts.The Chinese medicine rapid healing gynecological bleeding of this treatment gynecological bleeding and prevention gynecologic blood diseases disease, have and hold back blood hemostasis, blood stasis dispersing and fresh blood promoting, benefiting qi and nourishing blood function, effectively alleviate patient suffering, have no side effect, treating both the principal and secondary aspects of a disease.
Description
Technical field
The invention belongs to Chinese medicine field, be specifically related to a kind of Chinese medicine for the treatment of gynecological bleeding and preparation method thereof.
Background technology
Gynecological bleeding, also known as gynecologic blood diseases, refers to a kind of disease regulating the neuroendocrine system dysfunction of reproduction to cause metrorrhagia, is equivalent to motherland's medical science " metrorrhagia " category.As: menorrhagia, menostaxis, dripping not to the utmost, cycle disorder, dysfunctional uterine hemorrhage, hemorrhage due to placement of IUD, hemorrhage after artificial abortion, postpartum subinvolution of uterus, Endometrial Hyperplasia are hemorrhage, hysteromyoma hemorrhage, ovarian cyst are hemorrhage.Clinical typical commonly encountered diseases, frequently-occurring disease, one of difficult serious symptom that Ye Shi gynecological comparatively pays close attention to.Though the various treatment meanss of primary disease can temporary relief of symptoms in recent years, without breakthrough, still with hormone, operation, anti symptom treatment for primary treatment measure, but curative effect is undesirable, so that a lot of patient relies on hormone for a long time or the hardship of ailing torment of grining and bear it.
Therefore, seek a kind of effective medicine is this area problem to be solved always.
Summary of the invention
For solving the problem, the invention provides a kind of Chinese medicine for the treatment of gynecological bleeding and preparation method thereof, it can rapid healing gynecological bleeding and prevention gynecologic blood diseases disease, alleviates patient suffering, have no side effect, treating both the principal and secondary aspects of a disease, be convenient to gynecological bleeding patient recover and treatment.
The present invention is a kind of Chinese medicine for the treatment of gynecological bleeding for solving the problems of the technologies described above adopted technical scheme, and this Chinese medicine is made up of following raw material by weight: the Radix Bupleuri of 20 ~ 40 parts, the Herba silenes fortunei of 20 ~ 35 parts, the Radix Salviae Miltiorrhizae of 35 ~ 45 parts, the Radix Paeoniae Alba of 25 ~ 35 parts, five Medulla Tetrapanacis of 35 ~ 45 parts, the cuscuta japonica Choisy of 25 ~ 35 parts, the Os Draconis (calcined) of 20 ~ 35 parts, the Radix Cyathulae of 20 ~ 30 parts, the Pollen Typhae carbon of 20 ~ 30 parts, the Os Sepiae of 20 ~ 25 parts and the sweeting agent of 3 ~ 8 parts and the additive of 3 ~ 5 parts.
Preferably, described sweeting agent is Radix Glycyrrhizae, Isosorbide-5-Nitrae, 6-sucralose and maltose alcohol, and its weight ratio is 5 ~ 5.5: 1: 1.
In above-mentioned either a program preferably, described additive is fatty acid cane sugar ester and tertiary sodium phosphate, and its weight ratio is 2.5 ~ 3.5: 1.
In addition, the Chinese medicinal preparation method of this treatment gynecological bleeding, has the following step:
1) clean above-mentioned Radix Bupleuri, Herba silenes fortunei, Radix Salviae Miltiorrhizae, Radix Paeoniae Alba and five Medulla Tetrapanacis mix homogeneously are taken according to above-mentioned weight portion, drying 30 ~ 40 minutes at 55 ~ 60 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 60 ~ 70 mesh sieves;
2) extract 6 ~ 8 hours above-mentioned coarse fodder warm water, extracting solution is condensed into 1: 2, and precipitate with ethanol obtains alcohol deposit fluid in 2 ~ 3 hours, and alcohol precipitation concentration is 50%; By the coarse fodder mix homogeneously after extraction, drying 10 ~ 15 minutes at 65 ~ 75 DEG C, dry limit, limit uniform stirring; Put it into afterwards in slimer and be ground into fines and cross 160 ~ 170 mesh sieves;
3) clean above-mentioned cuscuta japonica Choisy, Os Draconis (calcined), Radix Cyathulae, Pollen Typhae carbon and Os Sepiae mix homogeneously is taken according to above-mentioned weight portion, drying 10 ~ 15 minutes at 60 ~ 65 DEG C, dry limit, limit uniform stirring; Put it into afterwards in slimer and be ground into fines and cross 160 ~ 170 mesh sieves;
4) by step 2) and 3) in fines mix homogeneously, and by the 65% ethanol as solvent reflux, extract, 2 times of this mixing fines 8-10 times amount, each 1.5 ~ 2.5 hours, merging ethanol extract, to be evaporated to containing crude drug amount be 0.4g/ml;
5) combining step 2) in alcohol deposit fluid and step 4) in extracting solution, in suspension, through the rotating speed high speed centrifugation of 2000 ~ 2500r/m after 5 ~ 10 minutes, leave standstill 10 ~ 15 minutes, getting supernatant, to continue to be concentrated into relative density 40 DEG C time be the body of paste of 1.10 ~ 1.12;
6) in above-mentioned body of paste, described sweeting agent is added, add the polyethylene glycol 6000 stearic acid mix homogeneously that weight portion is 0.1 ~ 0.5 again, and add the additive of described weight portion, put steel plate cooling, be ground into granule, add weight portion be 0.1 ~ 0.5 hydroxypropyl cellulose and mix homogeneously, make final tcm product.
Preferably, described final tcm product is tablet, capsule, oral liquid, powder, pill or syrup.
Wherein,
Radix Bupleuri: cold nature, bitter in the mouth, pungent, return Liver Channel, gallbladder meridian; Cure mainly stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus comes off, menoxenia.
Herba silenes fortunei: nature and flavor are pungent puckery, cool; Cure mainly clearing away heat-damp and promoting diuresis, tonify deficiency is invigorated blood circulation; Control urinary tract infection, leucorrhea, dysentery, body is empty after being ill.
Radix Salviae Miltiorrhizae: bitter in the mouth, feeble QI is trembled with fear, nontoxic; Enter the heart, spleen two warp; Promoting blood circulation to restore menstrual flow, evacuation of pus granulation promoting, special regulating menstruation arteries and veins, reason iliacus is ached, and tissue regeneration promoting blood, removes stagnant blood.
Radix Paeoniae Alba: be slightly cold; Bitter, sour, sweet; Return liver, spleen channel; Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.
Five Medulla Tetrapanacis: sour, cold, nontoxic; Cure mainly trusted subordinate's distension, puerperal sweating due to debility, puerperal dysentery, umbilicus abdomen pain.
Cuscuta japonica Choisy: sweet, bitter is flat; Return liver, kidney channel; Heat clearing away, removing heat from blood, diuretic, removing toxic substances; For spitting blood, epistaxis, has blood in stool, metrorrhagia, stranguria with turbid discharge, leukorrhagia, dysentery, jaundice, carbuncle, furuncle, pyretic toxicity miliaria rash.
Os Draconis (calcined): sweet puckery is flat; Enter the heart, liver, kidney, large intestine channel; There is tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, the effect of promoting tissue regeneration and ulcer healing.
Radix Cyathulae: sweet, micro-hardship, flat; Return liver, kidney channel; Function cures mainly: eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome, hematuria stranguria with blood.
Pollen Typhae carbon: sweet is flat; Can promoting the circulation of blood repercussive, hemostasis.
Os Sepiae: salty in the mouth, puckery, slightly warm in nature; Return liver, kidney channel; Can astringing to arrest bleeding, treating spontaneous emission and leukorrhagia, antacid sore.
Beneficial effect of the present invention:
1. the Chinese medicine rapid healing gynecological bleeding of this treatment gynecological bleeding and prevention gynecologic blood diseases disease, has and holds back blood hemostasis, blood stasis dispersing and fresh blood promoting, benefiting qi and nourishing blood function, effectively alleviate patient suffering, have no side effect, treating both the principal and secondary aspects of a disease.
2. Chinese medicinal components reasonable mixture ratio of the present invention, clinical efficacy is definite, takes safety.
3. Chinese medicine of the present invention is ingenious make use of Radix Glycyrrhizae and Isosorbide-5-Nitrae, and 6-sucralose is as sweeting agent, and taste is better, taking convenience.
4. the raw material of this Chinese medicine can make full use of the resource of artificial growth, and its raw material resources abundance is guaranteed, and efficiency is high, economic benefit, social benefit are remarkable.
Above-mentioned raw material of Chinese medicine is through to be verified for many years, records and test gained, although their effect is different, but choosing of each Chinese medicine is not random and be, the application is according to the proportioning of each composition of test gained for many years, be not by raw material effect simple superposition of each composition, because the multiple interactivelies such as interpromoting relation in five elements, mutual reinforcement between, mutual restraint between two drugs or the mutual-detoxication may be there is between various raw material of Chinese medicine, and the application have selected above-mentioned raw materials accordingly according to this principle exactly, and the optimum proportioning determined between them, therefore, the application has significant meaning.
Safety research
Chinese medicine of the present invention shows through safety toxicology test: LD50 is 10500mg/kg, and Toxicological evaluation is nontoxic level, has no side effect.
Acute toxicity test
Above-mentioned laboratory sample is made suspension, to be equivalent to the dosage of clinical daily dosage 320 times to mouse stomach administration, at viewing duration, does not find that animal has any toxic reaction.Administration is observed for 30 days, none animal dead; Dissect after sacrifice of animal, its internal organs observe Non Apparent Abnormality.Experiment shows, gastric infusion does not measure median lethal dose(LD 50) of the present invention, and zooperal dosis tolerata is clinical adult's every day 305 times of maximum dose.
Long-term toxicity test for animals
By above-mentioned sample with clinical daily dosage 20 times, the long term administration in 6 months of 50 times, 70 times confession rats, the general activity after the large raticide of two dosage groups, the mental status, hair, feces etc. are showed no obvious abnormalities; Peripheral hemogram before and after administration, comprises erythrocyte, platelet, hemoglobin, packed cell volume all fluctuates within normal range; Obvious impact is showed no on Liver and kidney function index; The content of total protein, albumin, alkali phosphatase no significant difference compared with matched group in animal serum during off-test; Electrocardioscopy is all no abnormal; Each main organs macroscopy has no the morphological changes of various tissue components such as obvious enlargement, hyperemia, necrosis; The weight coefficient of the organs such as the heart, liver, spleen, lung, kidney, thymus, adrenal gland compared with matched group without significant difference; Histopathologic examination is showed no exception.These results suggest that the present invention is safer, without obvious toxic-side effects in tested dosage range.
Pharmacodynamics is tested:
Experiment condition:
Animal: cleaning grade ICR white mice.
Medicine: Chinese medicinal tablet 0.5g/ sheet of the present invention; Medicine: multiple blood health.
Laboratory temperature 18 DEG C-25 DEG C, relative humidity 40%-7%.
Experimental technique and result:
One, on the impact of white mice clotting time
White mice 45, is divided into 3 groups at random, often organizes 15.First group is negative control group, gives and isometric(al) normal saline; Second group is multiple blood health; 3rd group is Chinese medicinal tablet of the present invention.Each group of all gastric infusion, 0.3ml/10g, every day 2 times, continuous 2 days.Last administration is eyeball of mouse blood sampling after 1.5 hours, measures clotting time of mice with slide method.The results are shown in Table 1.
Table 1 capsule of the present invention is on the impact (X ± s) of clotting time of mice
Compare with negative control group, * P < 0.05
From table 1, Chinese medicinal tablet of the present invention can shorten clotting time of mice, compares with negative control group, has significant difference (P < 0.05), illustrate that Chinese medicinal tablet of the present invention has hemostasis effect to mice, and it is more excellent to urge coagulating effectiveness compared with second group.
Two, on the impact in white mice bleeding time
White mice 45, is divided into 3 groups at random, often organizes 15.First group is negative control group, gives and isometric(al) normal saline: second group is multiple blood health; 3rd group is Chinese medicinal tablet of the present invention.Each group of all gastric infusion, 0.3ml/10g, every day 2 times, continuous 2 days.Last administration is after 1.5 hours, and apart from tail point, Mus tail is cut off at 1/3 place, measures the bleeding time.The results are shown in Table 2.
Table 2 capsule of the present invention is on the impact (X ± S) in mice bleeding time
Compare with negative control group, * * P < 0.01
From table 2, Chinese medicinal tablet of the present invention can shorten the mice bleeding time, compares with negative control group, has significant difference (P < 0.01).Illustrate that Chinese medicinal tablet of the present invention can shorten the mice bleeding time, and second group of medicament had no significant effect to the mice bleeding time.
Experiment conclusion:
Chinese medicine of the present invention can shorten the bleeding time of mice, and have blood coagulation faster, the advantages such as drug effect is more definite, heavy dose for the treatment of group effect is obvious.
Clinical practice
Case 1: grandson, female, 35 years old is postpartum hemorrhage, and give Chinese medicinal tablet 0.5g/ sheet two panels of the present invention, after taking medicine 1 day, vaginal hemorrhage amount obviously reduces, and without bleeding after taking medicine 3 days, somatosensory is good.
Case 2: Tang, female, 42 years old, is diagnosed as functional disturbance metrorrhagia, and give Chinese medicinal tablet 0.5g/ sheet two panels of the present invention, after taking medicine 2 days, vaginal hemorrhage amount obviously reduces, and without bleeding after taking medicine 5 days, somatosensory is good.
Also do special clinical research with this Chinese medicine in addition.
Object: meet inclusive criteria women's hemorrhage patient 260 example, age 20-50 year, the course of disease 2 months-2 years; Clinical manifestation diagnosis comprises vaginal hemorrhage after functional disturbance metrorrhagia, family planning advice, postpartum hemorrhage, hysteromyoma hemorrhage are abnormal.
Diagnostic criteria: Syndrome Differentiation of Traditional Chinese Medicine, routine blood test, seriation routine and hormones measure, and criterion of therapeutical effect settles the standard according to the efficacy determination in " study of tcm new drug guideline ".Recovery from illness: stop in vaginal hemorrhage 3-5 days after treatment, recovers normal through amount; Effective: to stop in vaginal hemorrhage 5-10 days after treatment, before amount comparatively treatment, reduce by 1/3 or < 100ml; Effective: to stop in vaginal hemorrhage 10 days after treatment, menstrual cycle, all to make moderate progress through amount; Invalid: treatment after vaginal hemorrhage do not stop, menstrual cycle, through amount be not improved.
Method: by the dosage of the Chinese medicinal tablet of this aspect according to 1g/ time, every day respectively once takes to patient sooner or later, follow-up observation in 15 days.
Result: the cure rate for the treatment of is 65%, recovery from illness case 169 example; Obvious effective rate is 23%, effective case 60 example; Effective percentage is 10%, effective case 26 example.Condition-inference all accepts and believe the diagnosis that regular hospital provides.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the invention will be further described.
Embodiment 1
The Chinese medicine for the treatment of gynecological bleeding, is made up of following raw material by weight: 20 parts of Radix Bupleuri, 35 parts of Herba silenes fortuneis, 35 parts of Radix Salviae Miltiorrhizaes, 35 parts of Radix Paeoniae Alba, 35 part of five Medulla Tetrapanacis, 35 parts of cuscuta japonica Choisies, 20 parts of Os Draconis (calcined)s, 30 parts of Radix Cyathulaes, 20 parts of Pollen Typhae carbon, 25 parts of Os Sepiae and 3 parts of sweeting agents and 5 parts of additives.Described sweeting agent is Radix Glycyrrhizae, Isosorbide-5-Nitrae, 6-sucralose and maltose alcohol, and its weight ratio is 5: 1: 1.Described additive is fatty acid cane sugar ester and tertiary sodium phosphate, and its weight ratio is 3.5: 1.
The Chinese medicinal preparation method of described treatment gynecological bleeding, has the following step:
1) clean above-mentioned Radix Bupleuri, Herba silenes fortunei, Radix Salviae Miltiorrhizae, Radix Paeoniae Alba and five Medulla Tetrapanacis mix homogeneously are taken according to above-mentioned weight portion, drying 40 minutes at 55 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 60 mesh sieves;
2) extract 8 hours to above-mentioned coarse fodder warm water, extracting solution is condensed into 1: 2, and precipitate with ethanol obtains alcohol deposit fluid in 2 hours, and alcohol precipitation concentration is 50%; By the coarse fodder mix homogeneously after extraction, drying 10 minutes at 75 DEG C, dry limit, limit uniform stirring; Put it into afterwards in slimer and be ground into fines and cross 170 mesh sieves;
3) clean above-mentioned cuscuta japonica Choisy, Os Draconis (calcined), Radix Cyathulae, Pollen Typhae carbon and Os Sepiae mix homogeneously is taken according to above-mentioned weight portion, drying 15 minutes at 60 DEG C, dry limit, limit uniform stirring; Put it into afterwards in slimer and be ground into fines and cross 160 mesh sieves;
4) by step 2) and 3) in fines mix homogeneously, and by the 65% ethanol as solvent reflux, extract, 2 times of this mixing fines 10 times amount, each 1.5 hours, merging ethanol extract, to be evaporated to containing crude drug amount be 0.4g/ml;
5) combining step 2) in alcohol deposit fluid and step 4) in extracting solution, in suspension, through the rotating speed high speed centrifugation of 2500r/m after 5 ~ 10 minutes, leave standstill 10 minutes, getting supernatant, to continue to be concentrated into relative density 40 DEG C time be the body of paste of 1.12;
6) in above-mentioned body of paste, described sweeting agent is added, add the polyethylene glycol 6000 stearic acid mix homogeneously that weight portion is 0.1 again, and add the additive of described weight portion, put steel plate cooling, be ground into granule, add weight portion be 0.5 hydroxypropyl cellulose and mix homogeneously, make final tcm product.
Described final tcm product is tablet, capsule.
Embodiment 2
The Chinese medicine for the treatment of gynecological bleeding, is made up of following raw material by weight: the additive of 40 parts of Radix Bupleuri, 20 parts of Herba silenes fortuneis, 45 parts of Radix Salviae Miltiorrhizaes, 25 parts of Radix Paeoniae Alba, 45 part of five Medulla Tetrapanacis, 25 parts of cuscuta japonica Choisies, 35 parts of Os Draconis (calcined)s, 20 portions of Radix Cyathulaes, 30 parts of Pollen Typhae carbon, 20 parts of Os Sepiae and 8 parts of sweeting agents and 3 parts.Described sweeting agent is Radix Glycyrrhizae, Isosorbide-5-Nitrae, 6-sucralose and maltose alcohol, and its weight ratio is 5.5: 1: 1.Described additive is fatty acid cane sugar ester and tertiary sodium phosphate, and its weight ratio is 2.5: 1.
The Chinese medicinal preparation method of described treatment gynecological bleeding, has the following step:
1) clean above-mentioned Radix Bupleuri, Herba silenes fortunei, Radix Salviae Miltiorrhizae, Radix Paeoniae Alba and five Medulla Tetrapanacis mix homogeneously are taken according to above-mentioned weight portion, drying 30 minutes at 60 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 70 mesh sieves;
2) extract 6 hours to above-mentioned coarse fodder warm water, extracting solution is condensed into 1: 2, and precipitate with ethanol obtains alcohol deposit fluid in 3 hours, and alcohol precipitation concentration is 50%; By the coarse fodder mix homogeneously after extraction, drying 15 minutes at 65 DEG C, dry limit, limit uniform stirring; Put it into afterwards in slimer and be ground into fines and cross 160 mesh sieves;
3) clean above-mentioned cuscuta japonica Choisy, Os Draconis (calcined), Radix Cyathulae, Pollen Typhae carbon and Os Sepiae mix homogeneously is taken according to above-mentioned weight portion, drying 10 minutes at 65 DEG C, dry limit, limit uniform stirring; Put it into afterwards in slimer and be ground into fines and cross 170 mesh sieves;
4) by step 2) and 3) in fines mix homogeneously, and by the 65% ethanol as solvent reflux, extract, 2 times of this mixing fines 8 times amount, each 2.5 hours, merging ethanol extract, to be evaporated to containing crude drug amount be 0.4g/ml;
5) combining step 2) in alcohol deposit fluid and step 4) in extracting solution, in suspension, through the rotating speed high speed centrifugation of 2000r/m after 10 minutes, leave standstill 10 minutes, getting supernatant, to continue to be concentrated into relative density 40 DEG C time be the body of paste of 1.12;
6) in above-mentioned body of paste, described sweeting agent is added, add the polyethylene glycol 6000 stearic acid mix homogeneously that weight portion is 0.1 again, and add the additive of described weight portion, put steel plate cooling, be ground into granule, add weight portion be 0.5 hydroxypropyl cellulose and mix homogeneously, make final tcm product.
Described final tcm product is oral liquid, powder.
Embodiment 3
The Chinese medicine for the treatment of gynecological bleeding, is made up of following raw material by weight: 30 parts of Radix Bupleuri, 30 parts of Herba silenes fortuneis, 40 parts of Radix Salviae Miltiorrhizaes, 30 parts of Radix Paeoniae Alba, 40 part of five Medulla Tetrapanacis, 30 parts of cuscuta japonica Choisies, 30 parts of Os Draconis (calcined)s, 25 parts of Radix Cyathulaes, 25 parts of Pollen Typhae carbon, 22 parts of Os Sepiae and sweeting agents of 5 parts and additives of 4 parts.Described sweeting agent is Radix Glycyrrhizae, Isosorbide-5-Nitrae, 6-sucralose and maltose alcohol, and its weight ratio is 5.3: 1: 1.Described additive is fatty acid cane sugar ester and tertiary sodium phosphate, and its weight ratio is 3: 1.
The Chinese medicinal preparation method of described treatment gynecological bleeding, has the following step:
1) clean above-mentioned Radix Bupleuri, Herba silenes fortunei, Radix Salviae Miltiorrhizae, Radix Paeoniae Alba and five Medulla Tetrapanacis mix homogeneously are taken according to above-mentioned weight portion, drying 35 minutes at 58 DEG C, dry limit, limit uniform stirring; Afterwards above-mentioned raw materials is put into pulverizer to be ground into coarse fodder and to cross 65 mesh sieves;
2) extract 7 hours to above-mentioned coarse fodder warm water, extracting solution is condensed into 1: 2, and precipitate with ethanol obtains alcohol deposit fluid in 2.5 hours, and alcohol precipitation concentration is 50%; By the coarse fodder mix homogeneously after extraction, drying 13 minutes at 70 DEG C, dry limit, limit uniform stirring; Put it into afterwards in slimer and be ground into fines and cross 165 mesh sieves;
3) clean above-mentioned cuscuta japonica Choisy, Os Draconis (calcined), Radix Cyathulae, Pollen Typhae carbon and Os Sepiae mix homogeneously is taken according to above-mentioned weight portion, drying 13 minutes at 63 DEG C, dry limit, limit uniform stirring; Put it into afterwards in slimer and be ground into fines and cross 165 mesh sieves;
4) by step 2) and 3) in fines mix homogeneously, and by the 65% ethanol as solvent reflux, extract, 2 times of this mixing fines 9 times amount, each 2 hours, merging ethanol extract, to be evaporated to containing crude drug amount be 0.4g/ml;
5) combining step 2) in alcohol deposit fluid and step 4) in extracting solution, in suspension, through the rotating speed high speed centrifugation of 2300r/m after 5 ~ 10 minutes, leave standstill 13 minutes, getting supernatant, to continue to be concentrated into relative density 40 DEG C time be the body of paste of 1.11;
6) in above-mentioned body of paste, described sweeting agent is added, add the polyethylene glycol 6000 stearic acid mix homogeneously that weight portion is 0.3 again, and add the additive of described weight portion, put steel plate cooling, be ground into granule, add weight portion be 0.3 hydroxypropyl cellulose and mix homogeneously, make final tcm product.
Described final tcm product is pill or syrup.
For strengthening the effect of this Chinese medicine, also can add the Pseudobulbus Bletillae (Rhizoma Bletillae) that weight portion is 15 ~ 20 parts again in above-mentioned raw materials, the Fructus Aurantii of the Rhizoma Cyperi of 10 ~ 15 parts and 10 ~ 15 parts; Also can add weight portion is the mouthfeel that second additive of 2 ~ 5 parts improves this Chinese medicine further, and described additive is made up of fatty acid cane sugar ester and stevioside, and weight ratio is 1: 0.5.
In the preparation, by above-mentioned Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Cyperi and Fructus Aurantii, add 10 times amount 70% alcohol reflux 1.5 hours, extract three times altogether, merge extractive liquid, reclaim ethanol.40 DEG C time, be evaporated to relative density of medicine liquid is 1.10 ~ 1.12, with tube centrifuge strictly with the centrifugation remove impurity 10-15 minute of 1000-10500r/m, test of many times shows that such rotating speed is best, both can ensure impurity-eliminating effect, does not destroy the property of medicine of medicinal liquid simultaneously.Then centrifugal liquid and alcohol extraction medicine are got liquid to merge, 40 DEG C are evaporated to relative density of medicine liquid 1.10 ~ 1.12.Then (control hydrojet speed is 2000ml/min to this concentrated solution spray dryer, intake air temperature 120 DEG C, air outlet temperature 80 DEG C) prepare extract powder, after be ground into fines and cross 160 ~ 170 mesh sieves, such fines size is easier to the performance of drug effect.
Afterwards by above-mentioned fines and described Chinese drug preparation step 2 before) in alcohol deposit fluid and step 4) in extracting solution, in suspension, through the rotating speed high speed centrifugation of 2000 ~ 2500r/m after 5 ~ 10 minutes, leave standstill 10 ~ 15 minutes, getting supernatant, to continue to be concentrated into relative density 40 DEG C time be the body of paste of 1.10 ~ 1.12;
Finally, described sweeting agent is added in above-mentioned body of paste, add the polyethylene glycol 6000 stearic acid mix homogeneously that weight portion is 0.1 ~ 0.5 again, and add additive and second additive of described weight portion, put steel plate cooling, be ground into granule, add weight portion be 0.1 ~ 0.5 hydroxypropyl cellulose and mix homogeneously, make final tcm product.。
The Chinese medicine rapid healing gynecological bleeding of this treatment gynecological bleeding and prevention gynecologic blood diseases disease, have and hold back blood hemostasis, blood stasis dispersing and fresh blood promoting, benefiting qi and nourishing blood function, effectively alleviate patient suffering, have no side effect, treating both the principal and secondary aspects of a disease.
Chinese medicinal components reasonable mixture ratio of the present invention, clinical efficacy is definite, takes safety; Ingeniously make use of Radix Glycyrrhizae and Isosorbide-5-Nitrae, 6-sucralose is as sweeting agent, and taste is better, taking convenience.In addition, the raw material of this Chinese medicine can make full use of the resource of artificial growth, and its raw material resources abundance is guaranteed, and efficiency is high, economic benefit, social benefit are remarkable.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (1)
1. treat a Chinese medicine for gynecological bleeding, it is characterized in that this Chinese medicine is made up of following raw material by weight: the Radix Bupleuri of 20 ~ 40 parts, the Herba silenes fortunei of 20 ~ 35 parts, the Radix Salviae Miltiorrhizae of 35 ~ 45 parts, the Radix Paeoniae Alba of 25 ~ 35 parts, five Medulla Tetrapanacis of 35 ~ 45 parts, the cuscuta japonica Choisy of 25 ~ 35 parts, the Os Draconis (calcined) of 20 ~ 35 parts, the Radix Cyathulae of 20 ~ 30 parts, the Pollen Typhae carbon of 20 ~ 30 parts, the Os Sepiae of 20 ~ 25 parts and the sweeting agent of 3 ~ 8 parts and the additive of 3 ~ 5 parts; Described sweeting agent is Radix Glycyrrhizae, Isosorbide-5-Nitrae, 6-sucralose and maltose alcohol, and its weight ratio is 5 ~ 5.5: 1: 1; Described additive is fatty acid cane sugar ester and tertiary sodium phosphate, and its weight ratio is 2.5 ~ 3.5: 1.
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