CN103705625B - Traditional Chinese medicine preparation for treating insomnia - Google Patents
Traditional Chinese medicine preparation for treating insomnia Download PDFInfo
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- CN103705625B CN103705625B CN201310725166.5A CN201310725166A CN103705625B CN 103705625 B CN103705625 B CN 103705625B CN 201310725166 A CN201310725166 A CN 201310725166A CN 103705625 B CN103705625 B CN 103705625B
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating insomnia. The medicines such as ginseng, bighead atractylodes rhizome, poria cocos, polygala tenuifolia, semen boitae, Chinese angelica, root of rehmannia, schisandra chinensis, longan aril, nacre mother of pearl, calcined dragon teeth and liquorice are combined, and the medicines are combined with one another, so that the effects of the medicines are synergistic, and the effects of tonifying spleen, nourishing heart and soothing the nerves are effectively achieved. Then the nerves are soothed, and the insomnia is cured. Therefore, the traditional Chinese medicine preparation accords with the principle of syndrome differentiation and treatment in traditional Chinese medicine and is supported by modern pharmacological research, so that the curative effect is obvious. Moreover, the traditional Chinese medicine preparation does not have a toxic or side effect, is stable in long-term curative effect and convenient to take and is worthy of popularization and application.
Description
Technical field
The invention belongs to field of traditional Chinese medicine technology, be specifically related to a kind of Chinese medicine preparation for the treatment of of insomnia patients.
Background technology
Along with the development of society, the second largest disease of department of neurology outpatient service after having become and having had a headache of having a sleepless night, the material provided according to Chinese Medical Association shows, China about has 300,000,000 adults to suffer from the sleep disorder such as insomnia and hypersomnia.Although this disease not threat to life, drastically influence the quality of life of people.Becoming puzzlement life of elderly person, work and able-bodied a great problem.Present stage is more for the Western medicine kind of having a sleepless night, and sums up and mainly contains: Benzodiazepines, antidepressants, zolpidem, Zopiclone, melatonin, barbital etc.Above various kinds of drug all has insomnia must therapeutic effect, but it is low all to there is safety, has the problems such as residual action and additive and dependency daytime.Motherland's medicine and pharmacology, in the process of Cure for insomnia, have accumulated abundant theoretical knowledge and clinical experience.Have at present Chinese patent medicines of some treatment primary disease on the market, but slow, the uncertain therapeutic efficacy of onset is cut and expensive mostly.Therefore, find a kind of safe and effective, taking convenience, low-cost Chinese medicine preparation become insomniac in the urgent need to.
Summary of the invention
Lot of documents research confirms, insomniac is common with deficiency of both the heart and spleen, and deficiency of both the heart and spleen is the basic pathogenesis of insomnia, and invigorating the spleen and benefiting QI, nourishing YIN and benefiting blood, heart tonifying and tranquilizing are its basic therapies.The present inventor through long-term clinical practice, repeatedly study, have found the Chinese medicine preparation (Anshen Wan) of the treatment of insomnia patients of better efficacy finally.The object of the invention is to provide that a kind of side effect is little, treating both the principal and secondary aspects of a disease, can the Chinese medicine preparation of more effective treatment of insomnia patients.
For achieving the above object, the technical scheme that the present invention takes is the Chinese medicine preparation of described treatment of insomnia patients is be made up of the former medicine of following weight portion: Radix Ginseng 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, 15 ~ 25 parts, Poria, Radix Polygalae 15 ~ 25 parts, Semen Platycladi 15 ~ 25 parts, Radix Angelicae Sinensis 10 ~ 20 parts, 5 ~ 15 parts, the Radix Rehmanniae, Fructus Schisandrae Chinensis 3 ~ 8 parts, Arillus Longan 15 ~ 25 parts, Concha Margaritifera 10 ~ 20 parts, calcined DENS DRACONIS 15 ~ 25 parts, 1 ~ 5 part, Radix Glycyrrhizae.
Medicament selection Radix Ginseng of the present invention, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Polygalae, Semen Platycladi, Radix Angelicae Sinensis, the Radix Rehmanniae, Fructus Schisandrae Chinensis, Arillus Longan, Concha Margaritifera, calcined DENS DRACONIS, Radix Glycyrrhizae combines, and is made by these drug regimens each efficacy of drugs produce synergism, thus effectively plays invigorating spleen and nourishing heart altogether, the effect of tranquilizing the mind.
Insomnia, cures in nationality in ancient times and is called " insomnia " that " order does not set " also has and be called " must not crouch " person.Because overstrain is pondered over too, injure heart spleen, hinder in spleen that then lack of appetite is indigestion and loss of appetite, change source not enough, deficiency of nutrient QI and blood, can not on give, nourish in the heart, hinder in the heart then blood secretly consume, mental derangement.Or eipathia asthenia, puerperal loses blood, old people, deficiency of heart-blood, and the heart is become homeless foster, all can cause irritability, and be insomnia.Or insufficiency of the spleen clear YANG failing to ascend, inability of body fluid to function, foul smell, with the passages through which vital energy circulates superinverse centre of punch, is gathered and raw expectorant, and damp-phlegm resistance key, then have a sleepless night nose heave.As " Jing Yue's complete work is insomnia " medium cloud: " naivete and the person of being insomnia, must ying-qi deficiency also, seek main blood, blood deficiency is then difficult to nourish heart, then mental derangement of having a guilty conscience." and " Lei Zheng Zhi Cai is insomnia " also cloud: " worry impairing spleen, spleen anemia is damaged, and is insomnia year in year out." Jing-Yue Complete Works says: " ordinary person ponders over too person with overstrain, and must hyperamization liquid consumption die, state of mind dereliction, so be insomnia." illustrate old people because of experience of life more, be worried too, damage heart spleen, changes source not enough, and nutrient blood declines few, the not flourish heart of blood, mental derangement, often causes insomnia.The heart being a vital viscus like a king of the body, controlling blood and vessel, main gods, post house mind, therefore insomnia is more close compared with other internal organs with the relation of the heart.On the other hand, among the five elements, the heart, spleen for mothers and sons be connected, the splenopathy can cause insomnia not to the utmost, insomnia with the passing of time, secretly consume painstaking effort, also can cause insufficiency of the spleen, increase the weight of blood deficiency.Both interact, combined into disease.Therefore primary disease pathogenesis core is: deficiency of both the heart and spleen, negative and positive are lost and handed over.The suitable invigorating spleen and nourishing heart for the treatment of, the method for tranquilizing the mind.Semen Platycladi in Anshen Wan side, sweet in the mouth enters the heart, Liver Channel, and can nourish heart the moon, the blood of the beneficial heart, liver and reach the effect of calming the nerves, and is monarch drug; Arillus Longan tool invigorating the heart and spleen, the merit of nourishing blood to tranquillize the mind, is mainly used in for insufficiency of vital energy and blood, forgetful insomnia, severe palpitation; Poria cum Radix Pini's tranquilizing by nourishing the heart, spleen invigorating eliminating dampness and resolving phlegm.Both share restoring normal coordination between the heart and kidney.Ginseng qi-tonifying, makes the prosperous then cloudy blood of gas spontaneous, and mind calming Fructus Alpiniae Oxyphyllae again; The sweet pungent tepor of Radix Angelicae Sinensis, nourishing blood and nutrient QI; Four medicines are combined into ministerial drug.Fructus Schisandrae Chinensis is helped with QI invigorating yin fluid astringing, to help the merit of the raw the moon of QI invigorating; Radix Glycyrrhizae heat clearing away and in, replenishing QI to invigorate the spleen, coordinating the actions of various ingredients in a prescription and for making medicine.All medicines share, and play invigorating spleen and nourishing heart altogether, and effect of tranquilizing the mind, makes ataraxia, and insomnia is more.
Modern pharmacological research shows: Semen Platycladi decoct can suppress mice autonomic activities, extends the length of one's sleep of the pentobarbital sodium induced mice of threshold dose, and Guo Shengmin reports that the total soap of Semen Platycladi has central inhibitory action and effect is must dose dependent.Radix Polygalae all has synergism to barbiturate, and mice, after oral Radix Polygalae extract, has found the active substance of the time that can extend the sleep of mice pentobarbital sodium in blood and bile.Previous experiments research also finds that Anshen Wan can reduce the DOPAMINE CONTENT IN RABBIT of insomnia model mice, is that it improves one of pathomechanism of the sleep state of insomnia model mice.
Visible, the present invention had both met the principle of motherland's medical science determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, had again modern pharmacological research support, therefore evident in efficacy; And have no side effect, late result is stablized, and taking convenience, is worthy of popularization.
Detailed description of the invention
The Chinese medicine preparation for the treatment of of insomnia patients of the present invention is made up of the former medicine of following weight portion: Radix Ginseng 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, 15 ~ 25 parts, Poria, Radix Polygalae 15 ~ 25 parts, Semen Platycladi 15 ~ 25 parts, Radix Angelicae Sinensis 10 ~ 20 parts, 5 ~ 15 parts, the Radix Rehmanniae, Fructus Schisandrae Chinensis 3 ~ 8 parts, Arillus Longan 15 ~ 25 parts, Concha Margaritifera 10 ~ 20 parts, calcined DENS DRACONIS 15 ~ 25 parts, 1 ~ 5 part, Radix Glycyrrhizae.
Medicine-feeding altogether fine flour, develops as the watered pill, 24g mono-bag, 2 times on the one, one time 1 bag.14 days courses for the treatment of.
Embodiment 1: the Chinese medicine preparation for the treatment of of insomnia patients of the present invention is made up of the former medicine of following weight portion: Radix Ginseng 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, 15 parts, Poria, Radix Polygalae 15 parts, Semen Platycladi 15 parts, Radix Angelicae Sinensis 10 parts, 5 parts, the Radix Rehmanniae, Fructus Schisandrae Chinensis 3 parts, Arillus Longan 15 parts, Concha Margaritifera 10 parts, calcined DENS DRACONIS 15 parts, 1 part, Radix Glycyrrhizae.
Embodiment 2: the Chinese medicine preparation for the treatment of of insomnia patients of the present invention is made up of the former medicine of following weight portion: Radix Ginseng 15 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, 20 parts, Poria, Radix Polygalae 20 parts, Semen Platycladi 20 parts, Radix Angelicae Sinensis 15 parts, 10 parts, the Radix Rehmanniae, Fructus Schisandrae Chinensis 5 parts, Arillus Longan 20 parts, Concha Margaritifera 15 parts, calcined DENS DRACONIS 20 parts, 3 parts, Radix Glycyrrhizae.
Embodiment 3: the Chinese medicine preparation for the treatment of of insomnia patients of the present invention is made up of the former medicine of following weight portion: Radix Ginseng 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, 25 parts, Poria, Radix Polygalae 25 parts, Semen Platycladi 25 parts, Radix Angelicae Sinensis 20 parts, 15 parts, the Radix Rehmanniae, Fructus Schisandrae Chinensis 8 parts, Arillus Longan 25 parts, Concha Margaritifera 20 parts, calcined DENS DRACONIS 25 parts, 5 parts, Radix Glycyrrhizae.
Clinical observation material
(1) invention medicine major function and therapeutic domain
1, major function: invigorating the spleen and benefiting QI, nourishing YIN and benefiting blood, heart tonifying and tranquilizing;
2, therapeutic domain: be applicable to insomnia.
(2) clinical observation of medicine of the present invention
Treatment group Drug therapy of the present invention, matched group SHULE ANDING PIAN is treated.Therapeutic outcome: the total effective rate 86.05% of Anshen Wan Cure for insomnia, stable group total effective rate 76.74%, two groups of comparing differences have significance (p < 0.05).
A table 1 liang group effective percentage compares
| Group | n | Cure | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 43 | 16 | 15 | 6 | 6 | 86.05 △ |
| Matched group | 43 | 13 | 16 | 4 | 10 | 76.74 |
Note: △ compares with matched group,
p<0.05, two groups are compared, and difference has significant.
Anshen Wan group curative effect is obviously better than stable group (p < 0.05) as can be seen from Table 1.
Claims (1)
1. a Chinese medicine preparation for treatment of insomnia patients, is characterized in that the Chinese medicine preparation of described treatment of insomnia patients is made up of the former medicine of following weight portion: Radix Ginseng 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, 15 ~ 25 parts, Poria, Radix Polygalae 15 ~ 25 parts, Semen Platycladi 15 ~ 25 parts, Radix Angelicae Sinensis 10 ~ 20 parts, 5 ~ 15 parts, the Radix Rehmanniae, Fructus Schisandrae Chinensis 3 ~ 8 parts, Arillus Longan 15 ~ 25 parts, Concha Margaritifera 10 ~ 20 parts, calcined DENS DRACONIS 15 ~ 25 parts, 1 ~ 5 part, Radix Glycyrrhizae.
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| CN201310725166.5A CN103705625B (en) | 2013-12-25 | 2013-12-25 | Traditional Chinese medicine preparation for treating insomnia |
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| CN201310725166.5A CN103705625B (en) | 2013-12-25 | 2013-12-25 | Traditional Chinese medicine preparation for treating insomnia |
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| CN103705625A CN103705625A (en) | 2014-04-09 |
| CN103705625B true CN103705625B (en) | 2015-07-15 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101130007A (en) * | 2007-09-14 | 2008-02-27 | 尹克华 | Traditional Chinese medicine for treating neurasthenia insomnia |
| CN101485796A (en) * | 2008-01-14 | 2009-07-22 | 北京亚东生物制药有限公司 | Chinese medicinal composition for treating insomnia as well as preparation method and quality control method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101130007A (en) * | 2007-09-14 | 2008-02-27 | 尹克华 | Traditional Chinese medicine for treating neurasthenia insomnia |
| CN101485796A (en) * | 2008-01-14 | 2009-07-22 | 北京亚东生物制药有限公司 | Chinese medicinal composition for treating insomnia as well as preparation method and quality control method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 失眠症的中医药论治;钱彦方等;《北京中医药大学学报》;20031130;第26卷;第79-82页 * |
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Inventor after: Fang Jiaxuan Inventor after: Zhang Haiyan Inventor after: Chen Chunhua Inventor after: Cheng Ganlu Inventor after: Zhao Zengqiang Inventor after: Liang Guina Inventor after: Wei Yan Inventor before: Fang Jiaxuan Inventor before: Xiao Yuehong Inventor before: Chen Chunhua Inventor before: Cheng Ganlu Inventor before: Zhao Zengqiang Inventor before: Liu Hongbo Inventor before: Niu Guoying |
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Free format text: CORRECT: INVENTOR; FROM: FANG JIAXUAN XIAO YUEHONG CHEN CHUNHUA CHENG GANLU ZHAO ZENGQIANG LIU HONGBO NIU GUOYING TO: FANG JIAXUAN ZHANG HAIYAN CHEN CHUNHUA CHENG GANLU ZHAO ZENGQIANG LIANG GUINA WEI YAN |
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