CN103705625A - Traditional Chinese medicine preparation for treating insomnia - Google Patents
Traditional Chinese medicine preparation for treating insomnia Download PDFInfo
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- CN103705625A CN103705625A CN201310725166.5A CN201310725166A CN103705625A CN 103705625 A CN103705625 A CN 103705625A CN 201310725166 A CN201310725166 A CN 201310725166A CN 103705625 A CN103705625 A CN 103705625A
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating insomnia. The medicines such as ginseng, bighead atractylodes rhizome, poria cocos, polygala tenuifolia, semen boitae, Chinese angelica, root of rehmannia, schisandra chinensis, longan aril, nacre mother of pearl, calcined dragon teeth and liquorice are combined, and the medicines are combined with one another, so that the effects of the medicines are synergistic, and the effects of tonifying spleen, nourishing heart and soothing the nerves are effectively achieved. Then the nerves are soothed, and the insomnia is cured. Therefore, the traditional Chinese medicine preparation accords with the principle of syndrome differentiation and treatment in traditional Chinese medicine and is supported by modern pharmacological research, so that the curative effect is obvious. Moreover, the traditional Chinese medicine preparation does not have a toxic or side effect, is stable in long-term curative effect and convenient to take and is worthy of popularization and application.
Description
Technical field
The invention belongs to Chinese medicine technical field, be specifically related to a kind of Chinese medicine preparation for the treatment of of insomnia patients.
Background technology
Along with social development, insomnia become and have a headache after the second largest disease of department of neurology outpatient service, the material providing according to Chinese Medical Association shows, China approximately has 300,000,000 adults to suffer to have a sleepless night and the sleep disorder such as hypersomnia.Although this disease is threat to life not, having a strong impact on people's quality of life.Becoming puzzlement life of elderly person, work and able-bodied a great problem.Present stage is more for the Western medicine kind of having a sleepless night, and sums up and mainly contains: Benzodiazepines, antidepressants, zolpidem, Zopiclone, melatonin, barbital etc.Above various kinds of drug all has insomnia must therapeutic effect, but all exists safety low, has the problems such as residual action and addiction and dependency daytime.Motherland's medicine and pharmacology, in the process of Cure for insomnia, have accumulated abundant theoretical knowledge and clinical experience.The Chinese patent medicine that has on the market at present some treatment primary disease, but onset is slow mostly, uncertain therapeutic efficacy is cut and expensive.Therefore, find a kind of safe and effective, taking convenience, low-cost Chinese medicine preparation become insomniac in the urgent need to.
Summary of the invention
Lot of documents studies confirm that, insomniac is common with deficiency of both the heart and spleen, and deficiency of both the heart and spleen is the basic pathogenesis of insomnia, and invigorating the spleen and benefiting QI, nourishing YIN and benefiting blood, heart tonifying and tranquilizing are its basic therapies.The inventor, through long-term clinical practice, research repeatedly, has found the Chinese medicine preparation (Anshen Wan) of the treatment of insomnia patients of better efficacy finally.The object of the invention is to provide that a kind of side effect is little, treating both the principal and secondary aspects of a disease, can more effective treatment of insomnia patients Chinese medicine preparation.
For achieving the above object, the technical scheme that the present invention takes is that the Chinese medicine preparation of described treatment of insomnia patients is to be made by the former medicine of following weight portion: 10～20 parts of Radix Ginsengs, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 15～25 parts, Poria, 15～25 parts of Radix Polygalaes, 15～25 parts of Semen Platycladi, 10～20 parts of Radix Angelicae Sinensis, 5～15 parts, the Radix Rehmanniae, 3～8 parts of Fructus Schisandrae Chinensis, 15～25 parts of Arillus Longans, 10～20 parts of Concha Margaritiferas, 15～25 parts of calcined DENS DRACONISs, 1～5 part, Radix Glycyrrhizae.
Medicament selection Radix Ginseng of the present invention, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Polygalae, Semen Platycladi, Radix Angelicae Sinensis, the Radix Rehmanniae, Fructus Schisandrae Chinensis, Arillus Longan, Concha Margaritifera, calcined DENS DRACONIS, Radix Glycyrrhizae combines, and makes each efficacy of drugs produce synergism these drug regimens, thereby effectively plays altogether invigorating spleen and nourishing heart, the effect of tranquilizing the mind.
Insomnia, cures in nationality in ancient times and is called " insomnia ", and " order does not set ", also has and be called " must not crouch " person.Because of overstrain, ponder over too, injure heart spleen, hinder that lack of appetite is indigestion and loss of appetite in spleen, change source is not enough, deficiency of nutrient QI and blood, can not on give, nourish in the heart, hinder in the heart blood secretly consume, mental derangement.Or eipathia asthenia, lose blood puerperal, old people, and deficiency of heart-blood, the heart is become homeless foster, all can cause irritability, and be insomnia.Or insufficiency of the spleen clear YANG failing to ascend, inability of body fluid to function, foul smell, with the passages through which vital energy circulates superinverse centre of punch, is gathered and raw expectorant, and damp-phlegm resistance key, has a sleepless night nose heave.As the < < Jing Yue's complete work > > medium cloud of being insomnia: " naivete and the person of being insomnia, deficiency that must ying-qi also, is sought main blood, and blood deficiency is difficult to nourish heart, the mental derangement of having a guilty conscience." and the < < Lei Zheng Zhi Cai also cloud of > > of being insomnia: " worry impairing spleen, spleen anemia is damaged, and is insomnia year in year out." < < Jing Yue's complete work > > says: " ordinary person ponders over too person with overstrain, must hyperamization liquid consumption die, and state of mind dereliction, so be insomnia." illustrate that old people is more because of experience of life, be worried too, damage heart spleen, change source deficiency, nutrient blood declines few, the not flourish heart of blood, mental derangement, often causes insomnia.The heart being a vital viscus like a king of the body, controlling blood and vessel, main gods, post house mind, therefore insomnia is more close compared with other internal organs with the relation of the heart.On the other hand, among the five elements, the heart, spleen are connected for mothers and sons, and the splenopathy can cause insomnia not to the utmost, and with the passing of time insomnia, secretly consumes painstaking effort, also can cause insufficiency of the spleenly, increase the weight of blood deficiency.Both interact, combined into disease.Therefore primary disease pathogenesis core is: deficiency of both the heart and spleen, negative and positive are lost and handed over.The suitable invigorating spleen and nourishing heart for the treatment of, the method for tranquilizing the mind.Semen Platycladi in Anshen Wan side, sweet in the mouth enters the heart, Liver Channel, the moon that can nourish heart, the blood of the beneficial heart, liver and reach the effect of calming the nerves, is monarch drug; Arillus Longan tool invigorating the heart and spleen, the merit of nourishing blood to tranquillize the mind, is mainly used in for insufficiency of vital energy and blood, forgetful insomnia, severe palpitation; Poria cum Radix Pini's tranquilizing by nourishing the heart, spleen invigorating eliminating dampness and resolving phlegm.Both share restoring normal coordination between the heart and kidney.Ginseng qi-tonifying, makes the prosperous cloudy blood of gas spontaneous, and mind calming Fructus Alpiniae Oxyphyllae again; The sweet pungent tepor of Radix Angelicae Sinensis, nourishing blood and nutrient QI; Four medicines are combined into ministerial drug.Fructus Schisandrae Chinensis assistant is with QI invigorating yin fluid astringing, to help the merit of the raw the moon of QI invigorating; Radix Glycyrrhizae heat clearing away and in, replenishing QI to invigorate the spleen, coordinating the actions of various ingredients in a prescription and for making medicine.All medicines share, and play altogether invigorating spleen and nourishing heart, and the effect of tranquilizing the mind, makes ataraxia, and insomnia is more.
Modern pharmacological research shows: Semen Platycladi decoct can suppress mice autonomic activities, extends the length of one's sleep of the pentobarbital sodium induced mice of threshold dose, and the total soap of Guo Shengmin report Semen Platycladi has that central inhibitory action and effect be must dose dependent.Radix Polygalae all has synergism to barbiturate, and mice, after oral Radix Polygalae extract, has found to extend the active substance of the time of mice pentobarbital sodium sleep in blood and bile.Previous experiments research also finds that Anshen Wan can reduce the DOPAMINE CONTENT IN RABBIT of insomnia model mice, is one of pathomechanism of its sleep state that improves insomnia model mice.
Visible, the present invention had both met the principle of motherland's medical science determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, had again modern pharmacological research support, therefore evident in efficacy; And have no side effect, late result is stable, and taking convenience, is worthy of popularization.
The specific embodiment
The Chinese medicine preparation for the treatment of of insomnia patients of the present invention is to be made by the former medicine of following weight portion: 10～20 parts of Radix Ginsengs, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 15～25 parts, Poria, 15～25 parts of Radix Polygalaes, 15～25 parts of Semen Platycladi, 10～20 parts of Radix Angelicae Sinensis, 5～15 parts, the Radix Rehmanniae, 3～8 parts of Fructus Schisandrae Chinensis, 15～25 parts of Arillus Longans, 10～20 parts of Concha Margaritiferas, 15～25 parts of calcined DENS DRACONISs, 1～5 part, Radix Glycyrrhizae.
Medicine-feeding is fine flour altogether, develop as the watered pill, mono-bag of 24g, 2 times on the one, one time 1 bag.14 days courses for the treatment of.
Embodiment 1: the Chinese medicine preparation for the treatment of of insomnia patients of the present invention is to be made by the former medicine of following weight portion: 10 parts of Radix Ginsengs, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts, Poria, 15 parts of Radix Polygalaes, 15 parts of Semen Platycladi, 10 parts of Radix Angelicae Sinensis, 5 parts, the Radix Rehmanniae, 3 parts of Fructus Schisandrae Chinensis, 15 parts of Arillus Longans, 10 parts of Concha Margaritiferas, 15 parts of calcined DENS DRACONISs, 1 part, Radix Glycyrrhizae.
Embodiment 2: the Chinese medicine preparation for the treatment of of insomnia patients of the present invention is to be made by the former medicine of following weight portion: 15 parts of Radix Ginsengs, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts, Poria, 20 parts of Radix Polygalaes, 20 parts of Semen Platycladi, 15 parts of Radix Angelicae Sinensis, 10 parts, the Radix Rehmanniae, 5 parts of Fructus Schisandrae Chinensis, 20 parts of Arillus Longans, 15 parts of Concha Margaritiferas, 20 parts of calcined DENS DRACONISs, 3 parts, Radix Glycyrrhizae.
Embodiment 3: the Chinese medicine preparation for the treatment of of insomnia patients of the present invention is to be made by the former medicine of following weight portion: 20 parts of Radix Ginsengs, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 25 parts, Poria, 25 parts of Radix Polygalaes, 25 parts of Semen Platycladi, 20 parts of Radix Angelicae Sinensis, 15 parts, the Radix Rehmanniae, 8 parts of Fructus Schisandrae Chinensis, 25 parts of Arillus Longans, 20 parts of Concha Margaritiferas, 25 parts of calcined DENS DRACONISs, 5 parts, Radix Glycyrrhizae.
Clinical observation material
(1) invention medicine major function and therapeutic domain
1, major function: invigorating the spleen and benefiting QI, nourishing YIN and benefiting blood, heart tonifying and tranquilizing;
2, therapeutic domain: be applicable to insomnia.
(2) clinical observation of medicine of the present invention
Treatment group Drug therapy of the present invention, matched group is treated by SHULE ANDING PIAN.Therapeutic outcome: the total effective rate 86.05% of Anshen Wan Cure for insomnia, 76.74%, two group of comparing difference of stable group total effective rate has significance (p < 0.05).
Table 1 liang group effective percentage comparison
| Group | n | Cure | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 43 | 16 | 15 | 6 | 6 | 86.05 △ |
| Matched group | 43 | 13 | 16 | 4 | 10 | 76.74 |
Note: △ and matched group comparison,
p<0.05, two groups of comparisons, difference has significant.
Anshen Wan group curative effect is obviously better than stable group (p < 0.05) as can be seen from Table 1.
Claims (1)
1. a Chinese medicine preparation for treatment of insomnia patients, the Chinese medicine preparation that it is characterized in that described treatment of insomnia patients is to be made by the former medicine of following weight portion: 10～20 parts of Radix Ginsengs, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 15～25 parts, Poria, 15～25 parts of Radix Polygalaes, 15～25 parts of Semen Platycladi, 10～20 parts of Radix Angelicae Sinensis, 5～15 parts, the Radix Rehmanniae, 3～8 parts of Fructus Schisandrae Chinensis, 15～25 parts of Arillus Longans, 10～20 parts of Concha Margaritiferas, 15～25 parts of calcined DENS DRACONISs, 1～5 part, Radix Glycyrrhizae.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310725166.5A CN103705625B (en) | 2013-12-25 | 2013-12-25 | Traditional Chinese medicine preparation for treating insomnia |
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| CN201310725166.5A CN103705625B (en) | 2013-12-25 | 2013-12-25 | Traditional Chinese medicine preparation for treating insomnia |
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| CN103705625A true CN103705625A (en) | 2014-04-09 |
| CN103705625B CN103705625B (en) | 2015-07-15 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101130007A (en) * | 2007-09-14 | 2008-02-27 | 尹克华 | Traditional Chinese medicine for treating neurasthenia aypnia |
| CN101485796A (en) * | 2008-01-14 | 2009-07-22 | 北京亚东生物制药有限公司 | Chinese medicinal composition for treating insomnia as well as preparation method and quality control method thereof |
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- 2013-12-25 CN CN201310725166.5A patent/CN103705625B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101130007A (en) * | 2007-09-14 | 2008-02-27 | 尹克华 | Traditional Chinese medicine for treating neurasthenia aypnia |
| CN101485796A (en) * | 2008-01-14 | 2009-07-22 | 北京亚东生物制药有限公司 | Chinese medicinal composition for treating insomnia as well as preparation method and quality control method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 钱彦方等: "失眠症的中医药论治", 《北京中医药大学学报》 * |
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Inventor after: Fang Jiaxuan Inventor after: Zhang Haiyan Inventor after: Chen Chunhua Inventor after: Cheng Ganlu Inventor after: Zhao Zengqiang Inventor after: Liang Guina Inventor after: Wei Yan Inventor before: Fang Jiaxuan Inventor before: Xiao Yuehong Inventor before: Chen Chunhua Inventor before: Cheng Ganlu Inventor before: Zhao Zengqiang Inventor before: Liu Hongbo Inventor before: Niu Guoying |
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Free format text: CORRECT: INVENTOR; FROM: FANG JIAXUAN XIAO YUEHONG CHEN CHUNHUA CHENG GANLU ZHAO ZENGQIANG LIU HONGBO NIU GUOYING TO: FANG JIAXUAN ZHANG HAIYAN CHEN CHUNHUA CHENG GANLU ZHAO ZENGQIANG LIANG GUINA WEI YAN |
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