CN103690793B - Drug for treating liver cirrhosis and preparation method of drug - Google Patents
Drug for treating liver cirrhosis and preparation method of drug Download PDFInfo
- Publication number
- CN103690793B CN103690793B CN201310677330.XA CN201310677330A CN103690793B CN 103690793 B CN103690793 B CN 103690793B CN 201310677330 A CN201310677330 A CN 201310677330A CN 103690793 B CN103690793 B CN 103690793B
- Authority
- CN
- China
- Prior art keywords
- grams
- gram
- herba
- radix
- fructus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a drug for treating liver cirrhosis and a preparation method of the drug. The drug is mainly prepared from longhairy antenoron herbs, old bottle gourd ladles, tortoise plastron, solanum xanthocarpum, tangerine leaves, sedum sarmentosum, sculellaria barbata, fennel and other drugs according to a certain weight ratio. The drug disclosed by the invention has the effects of clearing away heat and toxic materials and calming liver wind, and is rapid in taking effects, good in curative effect and free of toxic and side effects when used for treating liver cirrhosis.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of liver cirrhosis and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Liver cirrhosis is clinical common chronic progressive external hepatopathy, is long-term by one or more causes of disease or the diffusivity hepatic injury that formed of repeated action.In China, great majority are posthepatitic cirrhosis, and small part is alcoholic cirrhosis and Cirrhosis In Schistosomiasis.Histopathology there are hepatic necrosis, the regeneration of remaining liver cell nodules, connective tissue proliferation and fiber widely every formation, cause lobules of liver structural deterioration and pseudolobuli formation, liver is out of shape gradually, hardening and develop into liver cirrhosis.In early days because liver compensation more by force can non-evident sympton, stage with liver function injury and portal hypertension for main manifestations, and have multisystem to get involved, often there is the complication such as upper gastrointestinal hemorrhage, hepatic encephalopathy, secondary infection, hypersplenism, ascites, canceration late period.Because Western medicine effectively cannot treat liver cirrhosis, and take Western medicine and have more side effect, costly, therefore there is great demand in the Chinese medicine of people to rapid, effective treatment liver cirrhosis, up to now, also do not find about relevant report of the present invention.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment liver cirrhosis, thus completes the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment liver cirrhosis.
Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.
Herba Lysimachiae selected by medicine of the present invention, Lagenaria siceraria(Molina) Standl.var.depressa Ser. wooden dipper, Carapax et Plastrum Testudinis, Fructus solani xanthocarpi, Folium Citri tangerinae, Herba Sedi, Herba Scutellariae Barbatae, Fructus Foeniculi, Concha Ostreae, Fructus Mori, Aspongopus, Radix Adenophorae, Radix Gentianae, Sargassum, Carapax Trionycis, Fructus Liquidambaris, Herba Artemisiae Annuae, Cortex Lycii, Fructus Gardeniae, Herba Taraxaci, Spora Lygodii, Indigo Naturalis, Exocarpium Benincasae, Fructus Akebiae, Radix hemerocalis plicatae, Gecko, Radix Kansui, Radix Notoginseng, Radix Raphani, Herba Siegesbeckiae, Semen Raphani, Caulis Spatholobi, Herba Dendrobii, Herba Hyperici Japonici, Polyporus medicine carries out combination preparation, each efficacy of drugs is made by these drug regimens to produce synergism, thus effectively can treat liver cirrhosis.Herba Lysimachiae is selected to be because its nature and flavor toil, cool, there is heat clearing away, diuresis, antitussive, detumescence, the function of removing toxic substances, subcutaneous ulcer of harnessing the Yellow River, edema, vesical calculus, malaria, lung abscess, cough, spit blood, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, infantile malnutrition ， Jing Epilepsy, carbuncle, skin ulcer tinea, eczema.Select Lagenaria siceraria(Molina) Standl.var.depressa Ser. wooden dipper to be because its nature and flavor are sweet flat, return lung, small intestine meridian, have diuresis, detumescence, the function of eliminating stagnation, controls the edema of the face, ascites swelling, dysuria.Select Carapax et Plastrum Testudinis to be because its nature and flavor are salty sweet, flat, enter liver, kidney channel, have YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating, the function of strong bone, controls deficiency of kidney yin, hectic fever due to YIN-deficiency consumptive fever, spits blood, epistaxis, chronic cough, seminal emission, metrorrhagia, leukorrhagia, lumbago, the atrophic debility of bones, stirring of wind due to deficiency of YIN, chronic dysentery, chronic malaria, hemorrhoid, non-closure of fontanels jin infants.Select Fructus solani xanthocarpi to be because its nature and flavor toil, temperature, has clearing away heat-damp and promoting diuresis, the function of repercussive pain relieving.Select Folium Citri tangerinae to be because its nature and flavor toil, flat, enter liver channel of foot-Jueyin edema caused by disorder of QI, have soothing the liver, circulation of qi promoting, reduce phlegm, the function of detumescence poison, controls hypochondriac pain, acute mastitis, lung abscess, cough, chest and diaphragm feeling of fullness, hernia.Herba Sedi is selected to be that return liver, gallbladder, small intestine meridian, have eliminating damp-heat, the function of removing toxic substances, controls jaundice due to damp-heat, dysuria, carbuncle skin infection because its nature and flavor are sweet, light, cool.Select Herba Scutellariae Barbatae to be that cold, have heat clearing away, the function of removing toxic substances, controls laryngopharynx swelling and pain because its nature and flavor are bitter, scald, traumatic injury, eczema.Select Fructus Foeniculi to be that temperature, returns liver,kidney,spleen, stomach warp, have dispersing cold for relieving pain, the function of regulating qi-flowing for harmonizing stomach because its nature and flavor are pungent, control colic of cold type stomachache, the testis swelling and hanging down of either of the testes, dysmenorrhea, few abdomen cold type of pain, distension and fullness in the abdomen, lack of appetite and vomiting, hydrocele of testis.Select Concha Ostreae to be because its nature and flavor are salty and bitter, cool, enter liver, kidney channel, have yin fluid astringing, YANG hyperactivity suppressing, hidroschesis, the function of arresting seminal emission, Zhi Jing Epilepsy, dizzy, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid discharge, metrorrhagia, leukorrhagia, scrofula, goiter.Select Fructus Mori to be because its nature and flavor are sweet, cold, enter liver, kidney channel, have tonifying liver, kidney tonifying, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., grow the function of liquid, control hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.Select Aspongopus to be because its nature and flavor are salty, temperature, enter liver, kidney channel, have regulating QI to relieve pain, the function of warming middle-JIAO tonifying YANG, control the chest and diaphragm stagnation of QI, gastralgia painful abdominal mass is vexed, spleen-kidney deficiency, and waist knee joint is miserable, sexual impotence.Select Radix Adenophorae to be that be slightly cold, attach to the lung and stomach meridians, have nourishing YIN and clearing away lung-heat, reduce phlegm, the function of QI invigorating, controls lung-heat type cough, deficiency of YIN phthisical cough because its nature and flavor are sweet, dry cough expectorant sticks, deficiency of both vital energy and Yin, restlessness and fever with thirst.Select Radix Gentianae to be that cold, enter liver, gallbladder meridian, have eliminating pathogen in the liver excess-fire, except the function of damp-heat in lower-JIAO, treating the liver is manic through intenseness of heat ， Jing Epilepsy, encephalitis B because its nature and flavor are bitter, headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, carbuncle skin infection, scrotum swells and ache, pudendum pruritus due to damp pathogen.Sargassum is selected to be that cold, enter lung, spleen, kidney channel, have softening the hard mass, expectorant, diuretic, the function expelled the heat-evil, controls scrofula, and goiter is gathered, edema, beriberi, painful and swollen testis because its nature and flavor hardship is salty.Carapax Trionycis is selected to be because its nature and flavor are salty, flat, enter liver, spleen channel, have replenishing YIN and removing heat, suppressing the hyperactive liver to relieve the wind syndrome, the function of hard masses softening and resolving, control consumptive fever hectic fever due to YIN-deficiency, stirring of wind due to deficiency of YIN, malaria with general debility malaria with splenomegaly ， mass in the abdomen mass beside the umbilicus, amenorrhea menometrorrhagia, little Jing Epilepsy.Fructus Liquidambaris is selected to be that current 12 warps, have dispelling wind and removing obstruction in the collateral, the function of promoting urination to remove dampness, harness the river swollen, distension, amenorrhea, and breast is few, contracture of the limbs because its nature and flavor hardship is flat.Herba Artemisiae Annuae is selected to be because its nature and flavor are bitter, micro-pungent, cold, be included into liver, gallbladder meridian, have heat clearing away, expelling summer-heat, except the function of steaming, control epidemic febrile disease, summer-heat, hectic fever due to YIN-deficiency consumptive fever, scabies, pruritus.Optionally Cortex Lycii is because its nature and flavor are sweet, cold, and enter lung, liver, kidney channel, have heat clearing away, the function of removing heat from blood, control asthenia hectic fever night sweat, lung-heat cough with asthma, spit blood, epistaxis, stranguria with blood, quenches one's thirst, hypertension, carbuncle, malignant boil.Select Fructus Gardeniae to be because its nature and flavor are bitter, cold, enter the heart, liver, lung, stomach warp, have heat clearing away, pathogenic fire purging, the function of removing heat from blood, control calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quench one's thirst, conjunctival congestion, pharyngalgia, spit blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprains and swells and ache.Select Herba Taraxaci to be because its property bitter but sweet flavor, cold, enter liver, stomach warp, have heat-clearing and toxic substances removing, the function of diuresis eliminating stagnation, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.Select Spora Lygodii to be because its property slightly sweet flavor, cold, enter small intestinal, urinary bladder channel, have heat-clearing and toxic substances removing, the function of relieving stranguria by diuresis, controls urinary tract infection, lithangiuria, nebulousurine, leucorrhea, hepatitis, oedema due to nephritis, laryngopharynx swelling and pain, mumps, enteritis, dysentery, skin eczema, herpes zoster.Select Indigo Naturalis to be because its nature and flavor are salty, cold, enter liver, lung, stomach warp, have heat clearing away, removing heat from blood, the function of removing toxic substances, control epidemic febrile disease intenseness of heat, macule, spit blood, spit blood, little Jing Epilepsy, skin ulcer swells, erysipelas, snake bite and insect sting.Select Exocarpium Benincasae to be because its nature and flavor are sweet, cool, enter spleen, lung two warp, have the function that diuretic disappears kind, harness the river swollen, diarrhoea, carbuncle.Select Fructus Akebiae to be because its nature and flavor are sweet, cold, have liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, the function of relieving restlessness diuresis, treating the liver peratodynia, gastric heat food is slow-witted, excessive thirst, dysentery, lumbago, hypochondriac pain, hernia, dysmenorrhea, and uterus drops.Select Radix hemerocalis plicatae to be that flat, nourish blood suppressing the hyperactive liver, and the function of inducing diuresis to remove edema, controls dizziness, tinnitus, cardiopalmus, lumbago because its nature and flavor are sweet, spit blood, epistaxis, large intestine hematochezia, edema, gonorrhea, pharyngalgia, acute mastitis.Select Gecko to be because its nature and flavor are salty, flat, enter lung, kidney channel, have invigorating the lung and the kidney, the function of Dingchuan antitussive, controls asthenia, and consumptive lung disease is breathed heavily and coughed, and spitting of blood, quenches one's thirst, sexual impotence.Select Radix Kansui to be because its property bitter but sweet flavor, cold, poisonous, enter spleen, lung, kidney channel, have removing water retention by purgation drink, removing mass gathers, and logical two functions just, swelling of harnessing the river is expired, prolonged fluid-retention, blocked-up chest, and epilepsy is dysphagic, lumps in the chest and abdomen, constipation and anuresis.Select Radix Notoginseng to be because its property sweet and slightly bitter taste, temperature, enters liver, stomach, large intestine channel, has hemostasis, dissipating blood stasis, and detumescence, the function of analgesic therapy, controls haematemesis, hemoptysis, and epistaxis is had blood in stool, dysentery, metrorrhagia, mass in the abdomen, puerperal blood faints, and retention of lochia falls and flutters blood stasis, traumatic hemorrhage, carbuncle pain.Xuan Herba Siegesbeckiae is that cold, enter liver,spleen,kidney warp, have wind-damp dispelling, relieving rigidity of muscles and joints, the function of blood pressure lowering, controls quadriplegia, bones and muscles pain, weakness of the waist and knees, malaria, acute hepatitis, hypertension, furuncle swelling toxin, traumatic hemorrhage because its nature and flavor are bitter.Optionally human skeleton is that flat, have dispersing lung-QI and dissipating phlegm, help digestion, the function of diuretic, controls cough ant phlegm, stagnation of QI due to dyspepsia, the vexed distending pain of gastral cavity abdomen painful abdominal mass, edema dyspnea with fullness of the chest, fasting dysentery disease because its nature and flavor are sweet pungent.Xuan Herba Siegesbeckiae is that cold, enter liver,spleen,kidney warp, have wind-damp dispelling, relieving rigidity of muscles and joints, the function of blood pressure lowering, controls quadriplegia, bones and muscles pain, weakness of the waist and knees, malaria, acute hepatitis, hypertension, furuncle swelling toxin, traumatic hemorrhage because its nature and flavor are bitter.Semen Raphani is selected to be because its property acrid-sweet flavor, flat, enter lung, stomach warp, have therapeutic method to keep the adverse QI flowing downwards Dingchuan, the function eliminated indigestion and phlegm, control cough phlegm dyspnea, stagnation of QI due to dyspepsia, abdominal distention uncomfortable in chest, heavy after dysentery.Pericarpium Citri Reticulatae is selected to be that temperature, return lung, spleen channel, have regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm, controls fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm because its nature and flavor are bitter, pungent.Select Caulis Spatholobi to be because its property bitter but sweet flavor, temperature, enters the heart, spleen two warp, have invigorate blood circulation, the function of relaxing muscles and tendons, control soreness of waist and knee joint, paralysis and numbness, menoxenia.Select Herba Dendrobii to be because its property slightly sweet flavor is micro-salty, cold, enter to have, lung, kidney channel, have the stomach reinforcing that promotes the production of body fluid, the function of clearing away heat and nourishing YIN, controls consumption of body fluid caused by febrile disease, and xerostomia is tired drinks, deficiency-heat after being ill, and it is dark that the moon hinders order.Herba Hyperici Japonici is selected to be because its nature and flavor are bitter, pungent, flat, return liver, spleen channel, have eliminating damp-heat, the function of dissipating blood stasis for subsidence of swelling, for acute hepatitis, chronic hepatitis, furuncle carbuncle.Select Polyporus to be because its property slightly sweet flavor, flat, enter spleen, kidney, urinary bladder channel, have the function of diuresis eliminating dampness by diuresis, control dysuria, edema distension, beriberi, has loose bowels, and drenches, turbid, leukorrhagia.Rhizoma Alismatis is selected to be that cold, enter kidney, urinary bladder channel, have diuretic, eliminating dampness by diuresis, the function expelled the heat-evil, controls dysuria, edema distension because its nature and flavor are sweet, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.
Detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight
Herba Lysimachiae 12-22 gram of Lagenaria siceraria(Molina) Standl.var.depressa Ser. wooden dipper 10-20 gram of Carapax et Plastrum Testudinis 8-15 gram
Fructus solani xanthocarpi 12-20 gram of Folium Citri tangerinae 8-18 gram of Herba Sedi 8-16 gram
Herba Scutellariae Barbatae 6-15 gram of Fructus Foeniculi 4-12 gram of Concha Ostreae 5-15 gram
Fructus Mori 6-15 gram of Aspongopus 3-8 gram of Radix Adenophorae 6-15 gram
Radix Gentianae 8-15 gram of Sargassum 10-20 gram of Carapax Trionycis 10-20 gram
Fructus Liquidambaris 8-15 gram of Herba Artemisiae Annuae 10-20 gram of Cortex Lycii 6-15 gram
Fructus Gardeniae 5-12 gram of Herba Taraxaci 12-20 gram of Spora Lygodii 10-20 gram
Indigo Naturalis 10-18 gram of Exocarpium Benincasae 12-18 gram of Fructus Akebiae 10-20 gram
Radix hemerocalis plicatae 12-22 gram of Gecko 6-15 gram of Radix Kansui 8-18 gram
Radix Notoginseng 4-8 gram of Radix Raphani 10-20 Ke Herba Siegesbeckiae 12-18 gram
Semen Raphani 8-16 gram of Caulis Spatholobi 10-20 gram of Herba Dendrobii 4-12 gram
Herba Hyperici Japonici 8-18 gram of Polyporus 8-16 gram
Be preferably
Herba Lysimachiae 15 grams of Lagenaria siceraria(Molina) Standl.var.depressa Ser. wooden dippers 12 grams of Carapax et Plastrum Testudinis 10 grams
Fructus solani xanthocarpi 15 grams of Folium Citri tangerinae 10 grams of Herba Sedis 10 grams
Herba Scutellariae Barbatae 8 grams of Fructus Foeniculi 5 grams of Concha Ostreaes 6 grams
Fructus Mori 8 grams of Aspongopuss 4 grams of Radix Adenophoraes 10 grams
Radix Gentianae 10 grams of Sargassums 12 grams of Carapax Trionycis 12 grams
Fructus Liquidambaris 10 grams of Herba Artemisiae Annuaes 12 grams of Cortex Lycii 8 grams
Fructus Gardeniae 8 grams of Herba Taraxacis 15 grams of Spora Lygodii 12 grams
Indigo Naturalis 12 grams of Exocarpium Benincasaes 15 grams of Fructus Akebiaes 12 grams
Radix hemerocalis plicatae 15 grams of Geckos 8 grams of Radix Kansuis 10 grams
Radix Notoginseng 5 grams of Radix Raphani 12 Ke Herba Siegesbeckiaes 15 grams
Semen Raphani 10 grams of Caulis Spatholobis 12 grams of Herba Dendrobiis 6 grams
Herba Hyperici Japonici 10 grams of Polyporus 10 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Herba Lysimachiae: pick clean impurity, sieve dedust bits, dry;
2, Lagenaria siceraria(Molina) Standl.var.depressa Ser. wooden dipper: get crude drug, removing fruit stem and seed, clean stripping and slicing, and dry, the used time smashs to pieces;
3, Carapax et Plastrum Testudinis: soak with clear water, scrape off residual meat, cleans, dries, knock fritter;
4, Fructus solani xanthocarpi: summer, autumn gather, cleans, dries;
5, Folium Citri tangerinae: pick clean impurity, dry;
6, Herba Sedi: removing impurity, silt, cleans;
7, Herba Scutellariae Barbatae: removing impurity, cleans, slightly moistens, cutting, dry;
8, Fructus Foeniculi: get crude drug, removing impurity;
9, Concha Ostreae: clean, dry, pulverize use;
10, Fructus Mori: wash, picks decontamination, extracts long handle, dries;
11, Aspongopus: pick clean impurity, sieve removes earth, or uses with the micro-stir-fry of slow fire;
12, Radix Adenophorae: removing fibrous root, cleans, scrapes off rough bark, dry;
13, Radix Gentianae: pick decontamination, removes residual stem, cleans, runs through rear cutting, dry;
14, Sargassum: pick decontamination, with water slightly drift, slightly dry in the air, cutting, dries;
15, Carapax Trionycis: be soaked in water, removes skin and flesh, cleans, dries;
16, Fructus Liquidambaris: removing impurity, cleans, dries;
17, Herba Artemisiae Annuae: pick decontamination, removing undesirable root, water drenches and makes profit, cutting, dries;
18, Cortex Lycii: pick decontamination and core, slightly wash, cutting, dry;
19, Fructus Gardeniae: sieve dedust bits, pick decontamination, pulverize and sieve or cut off two ends;
20, Herba Taraxaci: pick decontamination, clean earth, cutting, dries;
21, Spora Lygodii: get crude drug, crosses dusting cover, and sieve gets spore, removing impurity;
22, Indigo Naturalis: pick decontamination, sieves;
23, Exocarpium Benincasae: get crude drug, removing impurity and rotten person of going rotten, wash quickly is clean, stripping and slicing or silk, dry, and sieve removes chip;
24, Fructus Akebiae: clean, slightly soak, moistening is to thoroughly, and section is dried, or cleans and dry, and the used time smashs to pieces;
25, Radix hemerocalis plicatae: autumn excavates root, removes residual stem, cleans, and section, dries;
26, Gecko: removing bamboo chip, clips cephalopodium and squama, dices;
27, Radix Kansui: pick decontamination, rinses with water, pulls out, dries;
28, Radix Notoginseng: pick clean impurity, smash to pieces, grinds or runs through rear section into powder and dry;
29, Radix Raphani: washing, slightly moistens, and the segment of 2.5 centimeter length is cut in top, dries;
30, Herba Siegesbeckiae: pick decontamination, removing undesirable root with always obstruct, first tremble inferior lobe and separately put, stalk is clean, be soaked in water, pull out, run through rear section, dry, then with leaf and even;
31, Semen Raphani: decontamination of winnowing with a dustpan, rinses earth, pulls out, dries, and the used time smashs to pieces;
32, Caulis Spatholobi: run through with water, section, or steam soft after take advantage of fervent sheet, dry;
33, Herba Dendrobii: get dry Herba Dendrobii, saturating with blister about to eighty per cant, stew to moisten, removing undesirable root and black branch, cutting, removing thin film, dries;
34, Herba Hyperici Japonici: removing impurity, cleans, slightly dries in the air, cutting, dry;
35, Polyporus: clean silt particle, soften section, dry.
Two, prepare
1, by the Herba Lysimachiae of described weight, Lagenaria siceraria(Molina) Standl.var.depressa Ser. wooden dipper, Carapax et Plastrum Testudinis, Fructus solani xanthocarpi, Folium Citri tangerinae, Herba Sedi, Herba Scutellariae Barbatae, Fructus Foeniculi, Concha Ostreae, Fructus Mori, Aspongopus, Radix Adenophorae, Radix Gentianae, Sargassum, Carapax Trionycis, Fructus Liquidambaris, Herba Artemisiae Annuae, Cortex Lycii, Fructus Gardeniae, Herba Taraxaci, Spora Lygodii, Indigo Naturalis, Exocarpium Benincasae, Fructus Akebiae, Radix hemerocalis plicatae, Gecko, Radix Kansui, Radix Notoginseng, Radix Raphani, Herba Siegesbeckiae, Semen Raphani, Caulis Spatholobi, Herba Dendrobii, Herba Hyperici Japonici, Polyporus decocts with water twice, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 25 minutes, filter first time decoction liquor.
2, add water the medicinal residues after first time filtration 5 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters and to obtain second time decoction liquor.
3, merge twice decoction liquor, intense fire boils, then uses slow fire boiling 10 minutes, is divided into 3 doses to take.
Medicine of the present invention has the function of heat-clearing and toxic substances removing, suppressing the hyperactive liver to relieve the wind syndrome, is used for the treatment of liver cirrhosis instant effect, good effect.
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.
The animal toxicity test of [test example 1] medicine of the present invention
Get West Germany rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Overdose test group is 25ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's totally 100 examples for medical treatment.
2, diagnostic criteria
Liver cirrhosis there will be the symptoms such as nauseating, inappetence, the whole body are weak, abdominal part distension in early days, and along with disease progression, facial skin tarnishes, blackout; Muscle of thenar and the muscle of hypothenar of palm are rubescent, occur liver palm; The healths such as anterior part of chest, cervical region and face occur that the blood capillary of Aranea shape is protruding above the waist, i.e. spider angioma.Male, also occur the symptoms such as breast swelling, armpit hair and pubes rareness once in a while, brothers' end first joint is to the enlargement of fingernail root in addition, and namely drumstick finger often occurs.During blood test, can there is increasing of serum bilirubin level in majority, occurs " latent jaundice ".The state of an illness further develops again, there will be ascites.Middle and advanced stage then has manifest symptom to occur, comprises plasma-albumin reduction, edema, ascites, yellow cellulitis, hepatic encephalopathy etc. caused by (1) liver function injury; (2) Doppler flow mapping that pylemphraxis and high pressure produce is formed, and comprises splenomegaly, hypersplenism and ascites etc.
3, Therapeutic Method
Selecting above-mentioned medicament, take to patient, every day 2 times, each 1 dose, 30 days is a course for the treatment of, takes three courses for the treatment of continuously.
4, efficacy assessment standard
Effective: the liver cirrhosis state of an illness is controlled, and liver function recovery is normal;
Take a turn for the better: liver cirrhosis disease states alleviates, and patient's Signs improves, and the state of an illness progressively takes a turn for the better;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form):
In above-mentioned treatment, by Drug therapy liver cirrhosis patient 100 example of the present invention, effective 83 examples of result, obvious effective rate is 83%, and take a turn for the better 3 examples, and improvement rate is 3%, and invalid 14 examples, total effective rate is 86%.
Claims (3)
1. treat a medicine for liver cirrhosis, it is characterized in that: it is made up of the crude drug in following weight range:
Herba Lysimachiae 12-22 gram of Lagenaria siceraria(Molina) Standl.var.depressa Ser. wooden dipper 10-20 gram of Carapax et Plastrum Testudinis 8-15 gram
Fructus solani xanthocarpi 12-20 gram of Folium Citri tangerinae 8-18 gram of Herba Sedi 8-16 gram
Herba Scutellariae Barbatae 6-15 gram of Fructus Foeniculi 4-12 gram of Concha Ostreae 5-15 gram
Fructus Mori 6-15 gram of Aspongopus 3-8 gram of Radix Adenophorae 6-15 gram
Radix Gentianae 8-15 gram of Sargassum 10-20 gram of Carapax Trionycis 10-20 gram
Fructus Liquidambaris 8-15 gram of Herba Artemisiae Annuae 10-20 gram of Cortex Lycii 6-15 gram
Fructus Gardeniae 5-12 gram of Herba Taraxaci 12-20 gram of Spora Lygodii 10-20 gram
Indigo Naturalis 10-18 gram of Exocarpium Benincasae 12-18 gram of Fructus Akebiae 10-20 gram
Radix hemerocalis plicatae 12-22 gram of Gecko 6-15 gram of Radix Kansui 8-18 gram
Radix Notoginseng 4-8 gram of Radix Raphani 10-20 Ke Herba Siegesbeckiae 12-18 gram
Semen Raphani 8-16 gram of Caulis Spatholobi 10-20 gram of Herba Dendrobii 4-12 gram
Herba Hyperici Japonici 8-18 gram of Polyporus 8-16 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Herba Lysimachiae 15 grams of Lagenaria siceraria(Molina) Standl.var.depressa Ser. wooden dippers 12 grams of Carapax et Plastrum Testudinis 10 grams
Fructus solani xanthocarpi 15 grams of Folium Citri tangerinae 10 grams of Herba Sedis 10 grams
Herba Scutellariae Barbatae 8 grams of Fructus Foeniculi 5 grams of Concha Ostreaes 6 grams
Fructus Mori 8 grams of Aspongopuss 4 grams of Radix Adenophoraes 10 grams
Radix Gentianae 10 grams of Sargassums 12 grams of Carapax Trionycis 12 grams
Fructus Liquidambaris 10 grams of Herba Artemisiae Annuaes 12 grams of Cortex Lycii 8 grams
Fructus Gardeniae 8 grams of Herba Taraxacis 15 grams of Spora Lygodii 12 grams
Indigo Naturalis 12 grams of Exocarpium Benincasaes 15 grams of Fructus Akebiaes 12 grams
Radix hemerocalis plicatae 15 grams of Geckos 8 grams of Radix Kansuis 10 grams
Radix Notoginseng 5 grams of Radix Raphani 12 Ke Herba Siegesbeckiaes 15 grams
Semen Raphani 10 grams of Caulis Spatholobis 12 grams of Herba Dendrobiis 6 grams
Herba Hyperici Japonici 10 grams of Polyporus 10 grams.
3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Herba Lysimachiae: pick clean impurity, sieve dedust bits, dry;
(2) Lagenaria siceraria(Molina) Standl.var.depressa Ser. wooden dipper: get crude drug, removing fruit stem and seed, clean stripping and slicing, and dry, the used time smashs to pieces;
(3) Carapax et Plastrum Testudinis: soak with clear water, scrape off residual meat, cleans, dries, knock fritter;
(4) Fructus solani xanthocarpi: summer, autumn gather, cleans, dries;
(5) Folium Citri tangerinae: pick clean impurity, dry;
(6) Herba Sedi: removing impurity, silt, cleans;
(7) Herba Scutellariae Barbatae: removing impurity, cleans, slightly moistens, cutting, dry;
(8) Fructus Foeniculi: get crude drug, removing impurity;
(9) Concha Ostreae: clean, dry, pulverize use;
(10) Fructus Mori: wash, picks decontamination, extracts long handle, dries;
(11) Aspongopus: pick clean impurity, sieve removes earth, or uses with the micro-stir-fry of slow fire;
(12) Radix Adenophorae: removing fibrous root, cleans, scrapes off rough bark, dry;
(13) Radix Gentianae: pick decontamination, removes residual stem, cleans, runs through rear cutting, dry;
(14) Sargassum: pick decontamination, with water slightly drift, slightly dry in the air, cutting, dries;
(15) Carapax Trionycis: be soaked in water, removes skin and flesh, cleans, dries;
(16) Fructus Liquidambaris: removing impurity, cleans, dries;
(17) Herba Artemisiae Annuae: pick decontamination, removing undesirable root, water drenches and makes profit, cutting, dries;
(18) Cortex Lycii: pick decontamination and core, slightly wash, cutting, dry;
(19) Fructus Gardeniae: sieve dedust bits, pick decontamination, pulverize and sieve or cut off two ends;
(20) Herba Taraxaci: pick decontamination, clean earth, cutting, dries;
(21) Spora Lygodii: get crude drug, crosses dusting cover, and sieve gets spore, removing impurity;
(22) Indigo Naturalis: pick decontamination, sieves;
(23) Exocarpium Benincasae: get crude drug, removing impurity and rotten person of going rotten, wash quickly is clean, stripping and slicing or silk, dry, and sieve removes chip;
(24) Fructus Akebiae: clean, slightly soak, moistening is to thoroughly, and section is dried, or cleans and dry, and the used time smashs to pieces;
(25) Radix hemerocalis plicatae: autumn excavates root, removes residual stem, cleans, and section, dries;
(26) Gecko: removing bamboo chip, clips cephalopodium and squama, dices;
(27) Radix Kansui: pick decontamination, rinses with water, pulls out, dries;
(28) Radix Notoginseng: pick clean impurity, smash to pieces, grinds or runs through rear section into powder and dry;
(29) Radix Raphani: washing, slightly moistens, and the segment of 2.5 centimeter length is cut in top, dries;
(30) Herba Siegesbeckiaes: pick decontamination, removing undesirable root with always obstruct, first tremble inferior lobe and separately put, stalk is clean, be soaked in water, pull out, run through rear section, dry, then with leaf and even;
(31) Semen Raphani: decontamination of winnowing with a dustpan, rinses earth, pulls out, dries, and the used time smashs to pieces;
(32) Caulis Spatholobi: run through with water, section, or steam soft after take advantage of fervent sheet, dry;
(33) Herba Dendrobii: get dry Herba Dendrobii, saturating with blister about to eighty per cant, stew to moisten, removing undesirable root and black branch, cutting, removing thin film, dries;
(34) Herba Hyperici Japonici: removing impurity, cleans, slightly dries in the air, cutting, dry;
(35) Polyporus: clean silt particle, soften section, dry;
(2) prepare
(1) by the Herba Lysimachiae of described weight, Lagenaria siceraria(Molina) Standl.var.depressa Ser. wooden dipper, Carapax et Plastrum Testudinis, Fructus solani xanthocarpi, Folium Citri tangerinae, Herba Sedi, Herba Scutellariae Barbatae, Fructus Foeniculi, Concha Ostreae, Fructus Mori, Aspongopus, Radix Adenophorae, Radix Gentianae, Sargassum, Carapax Trionycis, Fructus Liquidambaris, Herba Artemisiae Annuae, Cortex Lycii, Fructus Gardeniae, Herba Taraxaci, Spora Lygodii, Indigo Naturalis, Exocarpium Benincasae, Fructus Akebiae, Radix hemerocalis plicatae, Gecko, Radix Kansui, Radix Notoginseng, Radix Raphani, Herba Siegesbeckiae, Semen Raphani, Caulis Spatholobi, Herba Dendrobii, Herba Hyperici Japonici, Polyporus decocts with water twice, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 25 minutes, filter first time decoction liquor,
(2) add water the medicinal residues after first time filtration 5 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters and to obtain second time decoction liquor;
(3) merge twice decoction liquor, intense fire boils, then uses slow fire boiling 10 minutes, is divided into 3 doses to take.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310677330.XA CN103690793B (en) | 2013-12-13 | 2013-12-13 | Drug for treating liver cirrhosis and preparation method of drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310677330.XA CN103690793B (en) | 2013-12-13 | 2013-12-13 | Drug for treating liver cirrhosis and preparation method of drug |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103690793A CN103690793A (en) | 2014-04-02 |
| CN103690793B true CN103690793B (en) | 2015-05-27 |
Family
ID=50352563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310677330.XA Expired - Fee Related CN103690793B (en) | 2013-12-13 | 2013-12-13 | Drug for treating liver cirrhosis and preparation method of drug |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103690793B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104367713A (en) * | 2014-11-19 | 2015-02-25 | 青岛祥翔生物医药科技有限公司 | Traditional Chinese medicine for treating liver yang into wind syndrome type liver disease |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101293083A (en) * | 2007-04-29 | 2008-10-29 | 郭维宪 | Pharmaceutical composition and preparation method thereof |
-
2013
- 2013-12-13 CN CN201310677330.XA patent/CN103690793B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101293083A (en) * | 2007-04-29 | 2008-10-29 | 郭维宪 | Pharmaceutical composition and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 仝小林教授治疗肝硬化经验;周强,等;《世界中西医结合杂志》;20111231;第6卷(第6期);741-743,762 * |
| 李昕,等.基于临床报道的407例肝炎肝硬化典型病例的治疗方药分析.《天津中医药》.2012,第29卷(第6期),600-605. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103690793A (en) | 2014-04-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103736034B (en) | A kind of medicine for the treatment of cholecystitis and preparation method thereof | |
| CN101953922B (en) | Chinese medicinal composition for treating constipation | |
| CN103638386A (en) | Medicament for treating wind-cold-dampness arthralgia and preparation method of medicament | |
| CN103638502B (en) | Medicament for treating behcet disease and preparation method of medicament | |
| CN103656406B (en) | One treats phthisical medicine and preparation method thereof | |
| CN103977306A (en) | Medicament for treating hepatitis B and preparation method thereof | |
| CN105343490A (en) | Medicine for treating haemorrhoids and preparation method of medicine | |
| CN103690793B (en) | Drug for treating liver cirrhosis and preparation method of drug | |
| CN103417893B (en) | Medicine curing pain in waist and lower extremities and preparation method thereof | |
| CN103735916B (en) | A kind of medicine for the treatment of the nephrotic syndrome and preparation method thereof | |
| CN103638464B (en) | Medicine for treating chronic hepatitis and preparation method of medicine | |
| CN103768465B (en) | A kind of medicine for the treatment of hypochondriac pain and preparation method thereof | |
| CN103751658B (en) | A kind ofly treat medicine of the hepatitis B that damp-heat accumulation causes and preparation method thereof | |
| CN103830630B (en) | A kind of medicine for the treatment of thromboangiitis obliterans and preparation method thereof | |
| CN103611028B (en) | Medicine for treating pneumonia and preparation method thereof | |
| CN103656589B (en) | Drug for treating viral myocarditis and preparation method thereof | |
| CN103263575A (en) | Medicine for treating headache and preparation method thereof | |
| CN103638248B (en) | Medicine for treating gonarthromeningitis and preparation method of medicine | |
| CN105381409A (en) | Medicine for treating cholelithiasis and preparation method of medicine | |
| CN105456928A (en) | Drug for treating rheumatoid arthritis and preparation method thereof | |
| CN105412830A (en) | Medicine for treating acute icteric hepatitis and preparation method thereof | |
| CN105395947A (en) | Medicine treating prostatitis and preparation method thereof | |
| CN105079354A (en) | Traditional Chinese medicinal liquor for relaxing channels and relieving pain | |
| CN105012656A (en) | Chinese herbal medicine solution capable of curing cervical spondylosis, arthritis and osteoproliferation and preparation method of Chinese herbal medicine solution | |
| CN104189308A (en) | Wine for relaxing tendons, clearing damp and relieving pain |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150527 Termination date: 20151213 |
|
| EXPY | Termination of patent right or utility model |