CN103690629A - Method for preparing kudzuvine root anti-influenza dispersible tablet - Google Patents
Method for preparing kudzuvine root anti-influenza dispersible tablet Download PDFInfo
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- CN103690629A CN103690629A CN201310716549.6A CN201310716549A CN103690629A CN 103690629 A CN103690629 A CN 103690629A CN 201310716549 A CN201310716549 A CN 201310716549A CN 103690629 A CN103690629 A CN 103690629A
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- radix puerariae
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Abstract
The invention discloses a method for preparing a kudzuvine root anti-influenza dispersible tablet and belongs to the technical field of medicines. The method comprises the following steps: extracting kudzuvine root volatile oil which is pretreated by microwaves by utilizing a volatile oil extractor; preparing extracts of kudzuvine, angelica root, Chinese date and perilla by adopting flash extraction and microwave assisted enzymolysis; performing the ultrafine pulverizing treatment on the extracts, and mixing the extracts with the kudzuvine root volatile oil to obtain a main active component; and finally preparing the dispersible tablet by using starch and dextrin as a filler, talc powder as a lubricant, lactose, sodium alginate and sodium carboxymethyl starch as adhesives and disintegrating agents. The dispersible tablet is rich in kudzuvine root component, has an excellent health-care function, has the effects of relieving exterior syndromes and dispelling cold, warming middle-jiao, arresting vomiting, protecting liver and gall bladder, diminishing inflammation, relieving edema and pain, eliminating phlegm and stopping cough, can be used for treating common cold due to wind-cold, stomach cold vomiting, cold phlehm coughing. The dispersible tablet is scientific in prescription, convenient to take and good in anti-influenza effect; and the preparation process is reasonable, strong in operability and suitable for industrial production.
Description
Technical field
The present invention relates to biological pharmacy technical field, be specifically related to the preparation method of the anti-flu dispersible tablet of a kind of Radix Puerariae.
Background technology
Chinese medicament kudzu-vine root (Bupleurum Chinese DC) is the dry root of umbellate form section Radix Puerariae platymiscium, and tool induces sweat, brings down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI function, cures mainly cold, fever, alternate attack of chill and fever, and the diseases such as costa sternales stomachache, its main component is Radix Puerariae soap former times and Radix Puerariae volatile oil.Drop pills of kudzuvine root system selects first-class northern Radix Puerariae, the pure Chinese medicinal preparation of making. Radix Puerariae, conventional diaphoretic medicine.Another name ground is smoked, mountain dish, mushroom are careless, faggot.Radix Puerariae begins to be loaded in < < Sheng Nong's herbal classic > >, classifies as top grade.Successive dynasties book on Chinese herbal medicine has description to the phytomorph of Radix Puerariae more.< < Bencao Tujing > > carries: " between (Radix Puerariae) modern pass, Shan, rivers and lakes, shortcut all has it, and the silver-colored state person of take is victory.Life in February Seedling, very fragrant, stem is livid purple, and leaf is slightly purple like Folium Bambusae ... open Hemerocallis citrina Baroni July ... root redness of the skin or complexion, like Radix Peucedani and strong.Reed head has red hair as Mus tail, and solely nest elder is good.Adopt root August in February.Radix Puerariae belongs to shrub, 70 centimetres of general high 40 –.Conventionally from base portion, separate several stems, basal part of stem lignifying, top is branch repeatedly.Ye Weikuan or narrow lanceolar, the back side has the longitudinal vein of 7 obvious projections of 5 –, and the stem leaf of basal leaf and bottom has long handle, and blade is larger; The leaf on stem top is little, lanceolar or linear.Umbel often has umbrella 10 – 15, and 3 centimetres of long 2 – of umbrella width, form the panicle of carrying out evacuation; Phyllary 4 – 6, lanceolar, 1 centimetre of long 0.5 –, 3 millimeters of wide 1 –, opisthotonos backward, top is point gradually; Involucel sheet is common 5, minority 7, oval shape lanceolar or lanceolar, 5 millimeters of long 2 –, 2 millimeters of wide 1 –, also opisthotonos backward; Petal is faint yellow.The oval shape of diachenium is oval, oil pipe in every rib groove common 1,3 of minority 2 –.6 – July of florescence, 7 – Augusts of fruit phase.
Existing cold medicine is mainly with the form of conventional tablet, granule, oral liquid, conventional tablet is often because of disintegrate and the slow abundant absorption that affects medicine of drug-eluting, child, old man and swallow when inconvenient patient takes and have any problem, when drug dose, larger or once take sheet number when many, problem is comparatively outstanding.Though oral liquid taking convenience, less stable, and be difficult for grasping taking dose.And dispersible tablet has the advantage of oral tablet, granule and oral liquid concurrently, good stability, is easy to carry, and taking convenience etc. have dispersion high, and dissolution rate is fast, absorption is fast, and bioavailability is high, and untoward reaction is few; Can swallow, chew, contain and suck, also can be placed in after water disperses and take separately or be equal to clothes with fruit juice, milk, especially be applicable to old man, child and the patient of solid difficulty that swallows.
Therefore the anti-flu dispersible tablet of good Radix Puerariae of preparing a kind of applied widely, assimilation effect, becomes exigence.
Summary of the invention
Not enough for prior art, a kind of preparation method of the good anti-flu dispersible tablet of Radix Puerariae of applied widely, assimilation effect is provided.The method prescription science, taking convenience, anti-flu is effective; Preparation technology is reasonable, and strong operability is applicable to suitability for industrialized production.
Technical scheme of the present invention:
Utilize volatile oil extractor to extract the Radix Puerariae volatile oil after microwave pretreatment, adopt flash extraction, microwave-assisted enzymolysis to obtain Radix Puerariae Radix Angelicae Dahuricae Fructus Jujubae Folium perillae extract; After processing, mixes as main active component with Radix Puerariae volatile oil Radix Puerariae Radix Angelicae Dahuricae Fructus Jujubae Folium perillae extract superfine powder.Using starch and dextrin as filler, and Pulvis Talci, as lubricant, is usingd lactose, sodium alginate and carboxymethyl starch sodium as binding agent, disintegrating agent, prepares dispersible tablet.
Medicine of the present invention is comprised of the Chinese medicine (weight portion) of following proportioning:
50～150 parts of Radix Puerariae volatile oil; 10～30 parts of the Radixs Angelicae Dahuricae; 30～100 parts, Fructus Jujubae; 10～30 parts of Folium Perillaes
The best proportioning of medicine of the present invention following (weight portion) forms:
100 parts of Radix Puerariae volatile oil; 20 parts of the Radixs Angelicae Dahuricae; 70 parts, Fructus Jujubae; 20 parts of Folium Perillaes
1. the extraction of Radix Puerariae volatile oil: take fresh Radix Puerariae as raw material, add 10 times of water making beating after cleaning, the microwave treatment power 800W time is 5～10min, then adopts volatile oil extractor to extract 5h, collects volatile oil.
2. according to above-mentioned given ratio, 1. the medicinal residues and the Radix Angelicae Dahuricae Fructus Jujubae Folium Perillae that in, extract are soaked 15～30min, adopt flash extracter to extract 3 times, extract voltage 80～100V, after extraction, adopt microwave-assisted cellulase degradation, microwave pretreatment power is 600～800W, mixing speed actuator is adjusted to middling speed, processing time 10～30min, treatment temperature is 50～55 ℃, then adding cellulase 0.2%～0.5% (medicinal residues and the Radix Angelicae Dahuricae Fructus Jujubae Folium Perillae percentage by weight) processing time of 20000U/g is 1～2h, centrifugal, 60 ℃ are evaporated to every milliliter and are equivalent to crude drug 2g, slowly add ethanol to determining alcohol to reach 60%, standing over night, the centrifugal supernatant that obtains, 60 ℃ are carried out drying under reduced pressure, reclaim ethanol, concentrated, 80 ℃ of drying under reduced pressure, obtain extractum.
3. extract in 2 is carried out to superfine powder processing, then mix according to 50:1 ratio with Radix Puerariae volatile oil.
4. using starch and dextrin as filler, Pulvis Talci, as lubricant, is usingd lactose, sodium alginate and carboxymethyl starch sodium as binding agent, disintegrating agent, prepares dispersible tablet.According to medicine: adjuvant is that 1:1 ratio is selected adjuvant, adds 30% starch, 30% dextrin, 10% lactose, 5% calcium carbonate, 5% sodium alginate, carboxymethyl starch sodium 5%, Pulvis Talci 5%, after medicine and adjuvant fully mix, granulates with 75% ethanol moistening, cross 20 mesh sieves, 60 ℃ of drying under reduced pressure, granulate, adopts tablet machine compacting dispersible tablet.
Beneficial effect of the present invention is:
1, the anti-flu dispersible tablet of Radix Puerariae provided by the present invention composition is rich in Radix Puerariae composition, there is good health care, there is the effect of the cold expelling that induces sweat, warming middle-JIAO to arrest vomiting, hepatic cholagogic, anti-inflammatory, repercussive and analgesic, preventing phlegm from forming and stopping coughing, can control anemofrigid cold, gastrofrigid vomiting, cold-phlegm cough.
2, the anti-flu dispersible tablet of Radix Puerariae provided by the present invention prescription science, taking convenience, anti-flu is effective; Preparation technology is reasonable, and strong operability is applicable to suitability for industrialized production.
The specific embodiment
Below in conjunction with embodiment, technical scheme of the present invention is further illustrated, specific embodiment does not limit the present invention.
Embodiment 1:
1. the extraction of Radix Puerariae volatile oil: take fresh Radix Puerariae as raw material, add 10 times of water making beating after cleaning, the microwave treatment power 800W time is 10min, then adopts volatile oil extractor to extract 5h, collects volatile oil.
2. Radix Puerariae is 150 parts, 30 parts of the Radixs Angelicae Dahuricae, 100 parts, Fructus Jujubae, 30 parts of Folium Perillaes are soaked 15～30min, adopt flash extracter to extract 3 times, extract voltage 100V, after extraction, adopt microwave-assisted cellulase degradation, microwave pretreatment power is 700W, mixing speed actuator is adjusted to middling speed, processing time 30min, treatment temperature is 50～55 ℃, then adding cellulase 0.2%～0.5% (medicinal residues and the Radix Angelicae Dahuricae Fructus Jujubae Folium Perillae percentage by weight) processing time of 20000U/g is 1～2h, centrifugal, 60 ℃ are evaporated to every milliliter and are equivalent to crude drug 2g, slowly add ethanol to determining alcohol to reach 60%, standing over night, the centrifugal supernatant that obtains, 60 ℃ are carried out drying under reduced pressure, reclaim ethanol, concentrated, 80 ℃ of drying under reduced pressure, obtain extractum.
3. extract in 2 is carried out to superfine powder processing, then mix according to 50:1 ratio with Radix Puerariae volatile oil
4. according to medicine: adjuvant is that 1:1 ratio is selected adjuvant, adds 30% starch, 30% dextrin, 10% lactose, 5% calcium carbonate, 5% sodium alginate, carboxymethyl starch sodium 5%, Pulvis Talci 5%, after medicine and adjuvant fully mix, with 75% ethanol moistening, granulate, cross 20 mesh sieves, 60 ℃ of drying under reduced pressure, granulate, adopt tablet machine, the dispersible tablet that compacting diameter is 9mm.
Embodiment 2:
1. the extraction of Radix Puerariae volatile oil: take fresh Radix Puerariae as raw material, add 9 times of water making beating after cleaning, the microwave treatment power 800W time is 10min, then adopts volatile oil extractor to extract 5h, collects volatile oil.
2. Radix Puerariae is 100 parts, 20 parts of the Radixs Angelicae Dahuricae, 70 parts, Fructus Jujubae, 20 parts of Folium Perillaes are soaked 20min, adopt flash extracter to extract 3 times, extract voltage 90V, after extraction, adopt microwave-assisted cellulase degradation, microwave pretreatment power is 800W, mixing speed actuator is adjusted to middling speed, processing time 10～30min, treatment temperature is 50～55 ℃, then adding cellulase 0.2%～0.5% (medicinal residues and the Radix Angelicae Dahuricae Fructus Jujubae Folium Perillae percentage by weight) processing time of 20000U/g is 1～2h, centrifugal, 60 ℃ are evaporated to every milliliter and are equivalent to crude drug 2g, slowly add ethanol to determining alcohol to reach 60%, standing over night, the centrifugal supernatant that obtains, 60 ℃ are carried out drying under reduced pressure, reclaim ethanol, concentrated, 80 ℃ of drying under reduced pressure, obtain extractum.
3. extract in 2 is carried out to superfine powder processing, then mix according to 50:1 ratio with Radix Puerariae volatile oil
4. according to medicine: adjuvant is that 1:1 ratio is selected adjuvant, adds 30% starch, 30% dextrin, 10% lactose, 5% calcium carbonate, 5% sodium alginate, carboxymethyl starch sodium 5%, Pulvis Talci 5%, after medicine and adjuvant fully mix, with 75% ethanol moistening, granulate, cross 20 mesh sieves, 60 ℃ of drying under reduced pressure, granulate, adopt tablet machine, the dispersible tablet that compacting diameter is 10mm.
Embodiment 3:
1. the extraction of Radix Puerariae volatile oil: take fresh Radix Puerariae as raw material, add 10 times of water making beating after cleaning, the microwave treatment power 800W time is 5min, then adopts volatile oil extractor to extract 5h, collects volatile oil.
2. Radix Puerariae is 50 parts, 10 parts of the Radixs Angelicae Dahuricae, 30 parts, Fructus Jujubae, 10 parts of Folium Perillaes are soaked 15min, adopt flash extracter to extract 3 times, extract voltage 100V, after extraction, adopt microwave-assisted cellulase degradation, microwave pretreatment power is 600W, mixing speed actuator is adjusted to middling speed, processing time 10min, treatment temperature is 50～55 ℃, then adding cellulase 0.2%～0.5% (medicinal residues and the Radix Angelicae Dahuricae Fructus Jujubae Folium Perillae percentage by weight) processing time of 20000U/g is 1～2h, centrifugal, 60 ℃ are evaporated to every milliliter and are equivalent to crude drug 2g, slowly add ethanol to determining alcohol to reach 60%, standing over night, the centrifugal supernatant that obtains, 60 ℃ are carried out drying under reduced pressure, reclaim ethanol, concentrated, 80 ℃ of drying under reduced pressure, obtain extractum.
3. extract in 2 is carried out to superfine powder processing, then mix according to 50:1 ratio with Radix Puerariae volatile oil
4. according to medicine: adjuvant is that 1:1 ratio is selected adjuvant, adds 30% starch, 30% dextrin, 10% lactose, 5% calcium carbonate, 5% sodium alginate, carboxymethyl starch sodium 5%, Pulvis Talci 5%, after medicine and adjuvant fully mix, with 75% ethanol moistening, granulate, cross 20 mesh sieves, 60 ℃ of drying under reduced pressure, granulate, adopt tablet machine, the dispersible tablet that compacting diameter is 9mm.
Claims (5)
1. a preparation method for the anti-flu dispersible tablet of Radix Puerariae, is characterized in that: utilize volatile oil extractor to extract the Radix Puerariae volatile oil after microwave pretreatment, adopt flash extraction, microwave-assisted enzymolysis to obtain Radix Puerariae Radix Angelicae Dahuricae Fructus Jujubae Folium perillae extract; Radix Puerariae, the Radix Angelicae Dahuricae, Fructus Jujubae, Folium perillae extract superfine powder are mixed as main active component with Radix Puerariae volatile oil after processing; Using starch and dextrin as filler, and Pulvis Talci, as lubricant, is usingd lactose, sodium alginate and carboxymethyl starch sodium as binding agent, disintegrating agent, prepares dispersible tablet; Medicine of the present invention is comprised of the Chinese medicine (weight portion) of following proportioning: 50～150 parts of Radix Puerariae volatile oil; 10～30 parts of the Radixs Angelicae Dahuricae; 30～100 parts, Fructus Jujubae; 10～30 parts of Folium Perillaes.
2. the preparation method of the anti-flu dispersible tablet of Radix Puerariae according to claim 1, is characterized in that: the described best proportioning of medicine (weight portion) consists of: 100 parts of Radix Puerariae volatile oil; 20 parts of the Radixs Angelicae Dahuricae; 70 parts, Fructus Jujubae; 20 parts of Folium Perillaes.
3. the preparation method of the anti-flu dispersible tablet of Radix Puerariae according to claim 1, it is characterized in that: the extraction of Radix Puerariae volatile oil: take fresh Radix Puerariae as raw material, after cleaning, add 10 times of water making beating, the microwave treatment power 800W time is 5～10min, then adopt volatile oil extractor to extract 5h, collect volatile oil.
4. the preparation method of the anti-flu dispersible tablet of Radix Puerariae according to claim 1, it is characterized in that: the medicinal residues and the Radix Angelicae Dahuricae Fructus Jujubae Folium Perillae that during Radix Puerariae volatile oil extracts, extract are soaked 15～30min, adopt flash extracter to extract 3 times, extract voltage 80～100V, after extraction, adopt microwave-assisted cellulase degradation, microwave pretreatment power is 600～800W, mixing speed actuator is adjusted to middling speed, processing time 10～30min, treatment temperature is 50～55 ℃, then adding cellulase 0.2%～0.5% (medicinal residues and the Radix Angelicae Dahuricae Fructus Jujubae Folium Perillae percentage by weight) processing time of 20000U/g is 1～2h, centrifugal, 60 ℃ are evaporated to every milliliter and are equivalent to crude drug 2g, slowly add ethanol to determining alcohol to reach 60%, standing over night, the centrifugal supernatant that obtains, 60 ℃ are carried out drying under reduced pressure, reclaim ethanol, concentrated, 80 ℃ of drying under reduced pressure, obtain extractum.
5. the preparation method of the anti-flu dispersible tablet of Radix Puerariae according to claim 1, is characterized in that: using starch and dextrin as filler, Pulvis Talci, as lubricant, is usingd lactose, sodium alginate and carboxymethyl starch sodium as binding agent, disintegrating agent, prepares dispersible tablet; According to medicine: adjuvant is that 1:1 ratio is selected adjuvant, adds 30% starch, 30% dextrin, 10% lactose, 5% calcium carbonate, 5% sodium alginate, carboxymethyl starch sodium 5%, Pulvis Talci 5%, after medicine and adjuvant fully mix, granulates with 75% ethanol moistening, cross 20 mesh sieves, 60 ℃ of drying under reduced pressure, granulate, adopts tablet machine compacting dispersible tablet.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104905350A (en) * | 2015-05-20 | 2015-09-16 | 西北农林科技大学 | A folium perillae active ingredient containing beverage and a preparation method thereof |
| CN105343500A (en) * | 2015-11-25 | 2016-02-24 | 济南舜祥医药科技有限公司 | Compound anti-cold dispersible tablet containing rhizoma et radix notopterygii and preparation method of compound anti-cold dispersible tablet containing rhizoma et radix notopterygii |
| CN105395826A (en) * | 2015-11-25 | 2016-03-16 | 济南舜祥医药科技有限公司 | Radix bupleuri compound anti-cold dispersible tablets and preparing method thereof |
| CN114306435A (en) * | 2022-01-26 | 2022-04-12 | 福建省周嘉福生物医药有限公司 | Traditional Chinese medicine formula for physical therapy of sauna room and physical therapy method |
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| CN102580042A (en) * | 2012-03-20 | 2012-07-18 | 河南九势制药股份有限公司 | Traditional Chinese medicine composition for treating wind-cold type of common cold and preparation method of traditional Chinese medicine composition |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104905350A (en) * | 2015-05-20 | 2015-09-16 | 西北农林科技大学 | A folium perillae active ingredient containing beverage and a preparation method thereof |
| CN105343500A (en) * | 2015-11-25 | 2016-02-24 | 济南舜祥医药科技有限公司 | Compound anti-cold dispersible tablet containing rhizoma et radix notopterygii and preparation method of compound anti-cold dispersible tablet containing rhizoma et radix notopterygii |
| CN105395826A (en) * | 2015-11-25 | 2016-03-16 | 济南舜祥医药科技有限公司 | Radix bupleuri compound anti-cold dispersible tablets and preparing method thereof |
| CN114306435A (en) * | 2022-01-26 | 2022-04-12 | 福建省周嘉福生物医药有限公司 | Traditional Chinese medicine formula for physical therapy of sauna room and physical therapy method |
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Application publication date: 20140402 |